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All Journal Paediatrica Indonesiana Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Mandala of Health : A Scientific Journal Linggamas: Jurnal Pengabdian Masyarakat
Agustina, Nenden Nursyamsi
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Paediatrica Indonesiana

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Effectiveness of short-term modified Atkins diet and classic ketogenic diet in pediatric intractable epilepsy: a systematic review and meta-analysis Maulena, Ufik; Agustina, Nenden Nursyamsi; Mangunatmadja, Irawan
Paediatrica Indonesiana Vol. 65 No. 6 (2025): November 2025
Publisher : Indonesian Pediatric Society

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Abstract

Background Dietary treatments such as the classic ketogenic diet (cKD) and the modified Atkins diet (MAD) have shown promise in the medical management of refractory epilepsy. Objective To investigate the efficacy of the modified Atkins diet and classic ketogenic diet in managing intractable epilepsy in children by systematic review and meta-analysis. Methods This systematic review followed the preferred reporting items for systematic review and meta-analysis (PRISMA). We carried out an overview on Google Scholar, Scopus, and PubMed to find pertinent studies. Only researches that directly compared cKD and MAD were included in this study. A random-effect model was used to calculate pooled effect sizes as risk ratios (RRs) with 95% confidence intervals (CIs). The primary outcome was seizure frequency reduction (SFR) >50%. Secondary outcomes included SFR >90% and seizure freedom. Results Of 1,013 articles screened, 7 studies with a total of 455 patients (214 on MAD and 241 on cKD) met the inclusion criteria. There were no significant differences in the proportion of patients with seizure frequency reduction (SFR >50% (RR 1.12; 95%CI 0.70 to 1.80; P=0.64), SFR >90% (RR 0.83; 95%CI 0.57 to 1.20; P=0.33, respectively), or those who were seizure free (RR 1; 95%CI 0.7 to 1.42; P=0.99, respectively). However, each study in our review revealed that both cKD and MAD groups achieved significantly more SFR >50%,  SFR >90%, and seizure-free than before the diet. No improvement were seen in these outcomes after diet intervention. Conclusion In managing refractory childhood epilepsy, the efficacy of cKD and MAD are not significantly different.
Stunting severity and developmental outcomes in early childhood in Central Java, Indonesia Santosa, Qodri; Hapsari, Ariadne Tiara; Agustina, Nenden Nursyamsi; Oliviany, Windy; Roestijawati, Nendyah; Muntafiah, Alfi
Paediatrica Indonesiana Vol. 65 No. 6 (2025): November 2025
Publisher : Indonesian Pediatric Society

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Background Stunting in early childhood remains a critical global health issue, particularly in low- and middle-income countries such as Indonesia. Defined by height-for-age below -2 standard deviations from the WHO growth standards, stunting indicates chronic malnutrition and is linked to impaired developmental outcomes, including cognitive and motor delays. Objective  To elucidate the specific areas of development most affected by stunting and to identify potential sociodemographic and health-related factors that may contribute to the observed developmental disparities among these children. Methods A cross-sectional comparative study was conducted in Central Java, Indonesia, involving 144 stunted children. Stunting severity was categorized as stunted or severely stunted. Standardized anthropometric measurements and developmental assessments using the Denver II tool were performed, focusing on four domains: personal-social interaction, fine motor skills, language acquisition, and gross motor skills. Data were analyzed using the Mann-Whitney and Chi-square tests with a significance level of P < 0.05. Results Children in the severely stunted group exhibited a significantly higher prevalence of fine motor delays compared to the stunted group (17.0% vs. 4.1%, respectively; P=0.013). No significant differences were observed in other developmental areas. Sociodemographic and health factors were comparable across both groups. Conclusion  Severe stunting is significantly associated with delayed fine motor development. Furthermore, as sociodemographic and health factors are comparable across groups, these findings underscore the urgency of implementing targeted nutritional interventions and routine developmental monitoring to mitigate the adverse effects of stunting on early childhood growth and development.
Co-Authors Agus Fitrianto, Agus Alfi Muntafiah Ariadne Tiara Hapsari Burkon, Lily Kusumasita Darmawan, Anton Budhi Dwi Utami Anjarwati Fahrizal, Eky Danu Irawan Mangunatmadja Krisniawati, Nia Kusdaryanto, Wahyu Dwi Maulena, Ufik Nafiisah, Nafiisah Naufalin, Rafa Nendyah Roestijawati Oliviany, Windy Qodri Santosa, Qodri Sulastri Sulastri Susilarto, Aris Dwi Syamsiedi, Naluri Widyaningsih Widhi, Anriani Puspita Karunia Ning Windiya, Fajar