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All Journal Jurnal Biologi Tropis Yumary: Jurnal Pengabdian kepada Masyarakat Cendana Medical Journal Jurnal Asuhan Ibu dan Anak
Koamesah, Sangguana Marthen Jacobus
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Effect of Bay Leaf Extract (Syzygium polyanthum) on The Histopathological Appearance of Large Intestine of White Rats (Rattus novergicus) Induced by Ibuprofen Balbesi, Patrick David Altissimo; Damanik, Efrisca M. Br.; Koamesah, Sangguana Marthen Jacobus; Hutasoit, Regina M.
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11206

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs), particularly Ibuprofen, are widely used for their analgesic and anti-inflammatory properties. However, irrational or prolonged use may lead to gastrointestinal injury, including NSAID-induced colitis, due to the inhibition of protective prostaglandins in the mucosa. Syzygium polyanthum (bay leaf) extract contains flavonoids, tannins, saponins, and essential oils with antioxidant and anti-inflammatory properties, making it a potential agent for improving mucosal damage in the colon. Objective to determine the effect of bay leaf (Syzygium polyanthum) extract on the histopathological features of the colon in Sprague Dawley rats induced with Ibuprofen. This study was an experimental laboratory research using a posttest-only control group design. Thirty male Sprague Histopathological assessment of the colon was performed across five fields of view using the scoring system. Data were analyzed using the Kruskal–Wallis test followed by the Mann–Whitney test. The positive control group exhibited severe mucosal damage with extensive epithelial erosion and inflammatory infiltration. The P1 group (50 mg/kgBW) showed moderate improvements, while the P2 group (150 mg/kgBW) demonstrated reduced inflammation and ulceration. The highest dose group, P3 (250 mg/kgBW), showed the most prominent mucosal recovery, with significantly milder lesions compared to other groups. Bay leaf extract significantly improves the histopathological condition of the colon in Ibuprofen-induced rats. Higher doses of the extract result in better mucosal healing and reduced tissue damage.
Hubungan Inisiasi Menyusu Dini (IMD) Dengan Keberhasilan Pemberian Asi Eksklusif Pada Bayi Pirhi, Marescoti Olivera; Koamesah, Sangguana Marthen Jacobus; Su , Djie To Rante; Buntoro, Ika Febianti
Jurnal Asuhan Ibu dan Anak Vol. 11 No. 1 (2026): Jurnal Asuhan Ibu dan Anak
Publisher : Universitas 'Aisyiyah Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33867/JAIA.704

Abstract

Kematian bayi masih menjadi permasalahan kesehatan global. Angka kematian bayi di Indonesia mengalami peningkatan sebanyak 12.779 kasus pada tahun 2023. Memberikan ASI eksklusif dan melakukan Inisiasi Menyusu Dini (IMD) setelah kelahiran ialah upaya yang efektif dalam menurunkan risiko kematian pada bayi. Namun, proporsi pemberian ASI eksklusif secara global menurut World Health Organization masih sebesar 48%. Di Indonesia, proporsi pelaksanaan ASI eksklusif menurun dari 67,74% di tahun 2019 menjadi 63,9% di tahun 2023, termasuk di Kota Kupang. Pelaksanaan IMD di Kota Kupang juga menunjukkan penurunan serta hasil penelitian sebelumnya masih memiliki temuan yang belum konsisten terkait relasi antara IMD dan ASI eksklusif. Kajian ini dilakukan untuk memahami keterkaitan antara IMD dan keberhasilan pemberian ASI eksklusif di Kota Kupang. Kajian dengan pendekatan cross-sectional ini, dilaksanakan di Puskesmas Sikumana, Oesapa, dan Pasir Panjang pada Juli–Agustus 2025. Data dikumpulkan dari 96 responden melalui kuesioner, lalu dianalisis dengan uji Chi-Square. Hasil memperlihatkan bahwa 84,4% tidak melaksanakan praktik IMD pada bayinya, sementara hanya 15,6% yang melaksanakan IMD. Di antara responden yang melaksanakan IMD tersebut, mayoritas (93,3%) responden berhasil memberikan ASI eksklusif. Uji Chi-Square memperlihatkan nilai p = 0,004 yang berarti terdapat hubungan yang signifikan antara IMD dan keberhasilan pemberian ASI eksklusif di Kota Kupang. Edukasi terkait manfaat dan cara pemberian IMD dan ASI Eksklusif serta hubungan antar keduanya perlu diberikan kepada orang tua mulai dari masa kehamilan ibu hingga bayi mulai menyusui
Co-Authors ., Veronica Arley Sadra Telussa Balbesi, Patrick David Altissimo Charina, Maria Selviana Damanik, Efrisca M. Br. Dwita Anastasia Deo Fahri, Rifka Annisa Folamauk, Conrad Liab Hendricson Hutasoit, Regina M. Hutasoit, Regina Marvina Ika Febianti Buntoro Kehi Lau, Cindy Anna Maria Muntasir, Muntasir Nicholas Edwin Handoyo ningsih, Iswa Nurina, Rr. Listyawati PAKAN, PRISCA DEVIANI Pirhi, Marescoti Olivera Ratu, Kristian Sabawali, Jeremias Awang Bagas Sagita, Sidarta Sidauruk, Debora Maryke Idawati Su , Djie To Rante Sumbayak, Anastasia Emma Reinaita Wea, Aulia Rahmah Wijoyo, Adinda Savely Kend Amara Woda, Rahel Rara Wungouw, Herman Pieter L Wungouw, Herman Pieter Louis Wungouw, Herman Pieter Pieter Louis