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All Journal Indonesian Journal of Chemistry Journal of Sport Coaching and Physical Education BERNAS: Jurnal Pengabdian Kepada Masyarakat Kolaborasi Jurnal Pengabdian Masyarakat Jurnal Kesehatan Amanah Jurnal Pengabdian kepada Masyarakat Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Riset Informasi Kesehatan Faedah: Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia Al Mu'azarah: Jurnal Pengadian kepada Masyarakat Jurnal Sistem Informasi Komputer dan Teknologi Informasi ACTIVE: Journal of Physical Education, Sport, Health and Recreation
Agustin, Ayu Tri
Universitas Dr. Soebandi Jember
Religion Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Jurnal Kesehatan Amanah

 1 
Uji Potensi Senyawa Bioaktif Ekstrak Antosianin Jagung Ungu sebagai Inhibitor Cyclin-Dependent Protein Kinase 6 (CDK6) Ayu Tri Agustin; Anas Fadli Wijaya
Jurnal Kesehatan Amanah Vol. 7 No. 2 (2023): Oktober: Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v7i2.758

Abstract

Cancer is characterized by uncontrolled cell proliferation. The upregulation and activation of the Cyclin-Dependent Protein Kinase 6 (CDK6) signaling pathway can induce unregulated breast cancer cell proliferation. Therefore, CDK6 inhibition continues to be developed as a potential target for drug design and development to treat breast cancer. This study aims to predict the biofunction of anthocyanin compounds from purple corn extract as inhibitors of Cyclin-Dependent Protein Kinase 6 (CDK6) using an in silico approach. The research methods included data mining, ligand and receptor preparation, molecular docking, docking visualization, and data analysis. Our results indicate that six compounds from purple corn extract (cyanidin, cyanidin 3-glucoside, pelargonidin-3-glucoside, pelargonidin, peonidin, and peonidin-3-glucoside) can bind to CDK6 at the C-terminal and N-terminal domains. The binding pattern suggests that cyanidin, cyanidin 3-glucoside, pelargonidin-3-glucoside, pelargonidin, peonidin, and peonidin-3-glucoside interact with CDK6 residues in the same manner as Palbociclib (control). This finding indicates that compounds from purple corn have the potential to act as competitive CDK6 inhibitors. Peonidin-3-glucoside exhibited the lowest binding energy of -282.5 kcal/mol, approaching that of Palbociclib (-329.4 kcal/mol).
Uji Potensi Senyawa Bioaktif Ekstrak Antosianin Jagung Ungu sebagai Inhibitor Cyclin-Dependent Protein Kinase 6 (CDK6) Ayu Tri Agustin; Anas Fadli Wijaya
Jurnal Kesehatan Amanah Vol. 8 No. 2 (2024): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v8i2.761

Abstract

Cancer is characterized by uncontrolled cell proliferation. The upregulation and activation of the Cyclin-Dependent Protein Kinase 6 (CDK6) signaling pathway can induce unregulated breast cancer cell proliferation. Therefore, CDK6 inhibition continues to be developed as a potential target for drug design and development to treat breast cancer. This study aims to predict the biofunction of anthocyanin compounds from purple corn extract as inhibitors of Cyclin-Dependent Protein Kinase 6 (CDK6) using an in silico approach. The research methods included data mining, ligand and receptor preparation, molecular docking, docking visualization, and data analysis. Our results indicate that six compounds from purple corn extract (cyanidin, cyanidin 3-glucoside, pelargonidin-3-glucoside, pelargonidin, peonidin, and peonidin-3-glucoside) can bind to CDK6 at the C-terminal and N-terminal domains. The binding pattern suggests that cyanidin, cyanidin 3-glucoside, pelargonidin-3-glucoside, pelargonidin, peonidin, and peonidin-3-glucoside interact with CDK6 residues in the same manner as Palbociclib (control). This finding indicates that compounds from purple corn have the potential to act as competitive CDK6 inhibitors. Peonidin-3-glucoside exhibited the lowest binding energy of -282.5 kcal/mol, approaching that of Palbociclib (-329.4 kcal/mol).
Co-Authors Aisyah Salsabila Oktivani Yunita Alisa Alfiya Makki Alisyah Pratiwi Anas Fadli Wijaya Anggit Wicaksono Anisa, Mutiara Nur Anna Safitri Atmanegara, Stivani Yanti Azizah, Agtika Yasyfa Nur Azizah, Zahroh Nur Cahyaning Dewi Kusuma Wardani Candra, Adiska Rani Ditya Destiawan, Rian Anggia Dewangga Yudhistira Dewi, Dyah Mustika Chandra Dhea Adelina Br Ginting Dian Eka Setyaningtyas Diana Nadhifah Dwi Gusmalawati Eko Julianto Elnaja, Dinar Anisa Faidatur Rohma Fatchiyah Fatchiyah Hayati, Farhatul Hidayati, Sholihatil Humaidah, Fitria Humairoh, Riska Tsamarah Jaya, Heru Sipta Julianus, Julianus Made Suandika Maimunah Maimunah Maralodia Almira Lubis Martina, Ina Mufidah, Hartalina Muflihah, Ahdiah Imroatul Muhammad Rizky Suryadinata Nur Halimatus Sa’diyah Permatasari, Shafira Restu PRAMBAYUN, ARIF Purwanti, Ananda Kamila Nurcahya Putra, Zulkarnain Permana Riranto, Jepri Risnitasari, Mithaqul Shinta Mayasari Sigit Purwanto Siti Aisyah Soedjatmiko Sulton Auliya Syahrial Dwi Meidiansyah Tandiyo Rahayu Taufiki Nurul Yahya Wulan Ratna Nur Kholidiya Yuli Arif Tribudi