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Pilot Study Efektifitas Media Video Animasi Terhadap Tingkat Depresi Pasien Kanker Serviks Diagnosa Awal Dwi Fitriyanti; Mardiyono Mardiyono; Yuriz Bakhtiar
Indonesian Journal of Nursing Research (IJNR) Vol 2, No 1 (2019)
Publisher : Universitas Ngudi Waluyo

Cervical cancer is the cancer that most often attacks women after breastcancer throughout the world. Around the world every two minutes or everyhour a woman dies from cervical cancer. Every patient newly diagnosed withcervical cancer needs to know information about cervical cancer that canaffect the patient's psychological changes in the form of depression. Thepurpose of this study was to determine the effectiveness of education withanimation media to reduce the depression level of cervical cancer patientswith early diagnosis. The method of this research is a pilot study(preliminary study) or testing the feasibility of animation video media on thelevel of depression. Respondent samples in the animated video media trialincluded 10 intervention samples and 10 control samples. The results of theanimation video media research are feasible to be used in subsequent studiesin cervical cancer patients with an initial diagnosis of depression. Dataanalysis using the Wilcoxon Sign Rank Test showed that there was asignificant difference in the level of depression before and after being giveneducation using the animation video media in the intervention group with avalue of p = 0.005 while in the control group with a value p = 0.102. Theconclusion of this study is that the animation video media is feasible to beused in subsequent studies and can effectively be given to cervical cancerpatients with an initial diagnosis of depression.

The Effect of Circuit Training on Concentration of Medical Students in Diponegoro University Tiwik Budi Hastari; Yuriz Bakhtiar; Dimas Sindhu Wibisono; Zainal Muttaqin
Diponegoro International Medical Journal Vol 1, No 1 (2020): July
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v1i1.7746

Background. Concentration has an important role that influences the success of the learning process. The higher the concentration of students in learning, the more effective learning and teaching processes are carried out. One of the benefits of exercise is the improvement of concentration. Lack of time and motivation to do physical exercise are some reasons why people do less exercise. Circuit Training is an exercise that does not require a lot of time and is becoming a trend now.Objective: To find out the effect of the Circuit Training on the concentration level of students at Medical Faculty of Diponegoro University.Method. This research was a quasi-experimental study with pre and post-test design, where research subjects were divided into two groups, there are the control group and the treatment group. The research subjects were 28 male students at Medical Faculty of Diponegoro University. The treatment group had given Circuit Training for 6 weeks. In one week there were 3 meetings where each training session was done in 3 circuits/cycle and each circuit consisted of 8 movements. The indicator assessed in this study was the level of concentration measured using the Digit Symbol Substitution Test (DSST) before and after Circuit Training for 6 weeks. The results were analyzed using SPSS.Results. The score of concentration in the treatment group increased with a pre-test score 64,93 ± 6,38 and post-test score 76,29 ± 5,74. Significant results (p = 0.001) were obtained in the pre and post-test treatment groups.Conclusion. Circuit training for 6 weeks can increase the concentration score of students at Medical Faculty of Diponegoro University.

The Effectiveness of Cognitive Behavioral Therapy (CBT) To Decreased Depression in Woman Patients with Cancer included cervical cancer and breast cancer Dwi Fitriyanti; Mardiyono Mardiyono; Yuriz Bakhtiar
JNKI (Jurnal Ners dan Kebidanan Indonesia) (Indonesian Journal of Nursing and Midwifery) Vol 6, No 3 (2018): NOVEMBER
Publisher : Alma Ata University Press

The highest cancers in Indonesia in women are breast cancer and cervical cancer. Both are the most common cancers in women and the highest cause of death in women. Some woman patients with newly diagnosed of breast cancer or cervical cancer will experience depression. most patients newly diagnosed with cancer, less than 6 months reported a feeling of depression of 91.4%. An effective intervention to reduce the level of depression is to provide cognitive behavioral therapy (CBT) interventions. CBT is a psychotherapy recommended for treating depression in patients with breast cancer and cervical cancer. The objective of this study to review the effects of CBT on decreasing depression in woman patients with cancer including cervical cancer and breast cancer. This study is a systematic review. We search articles from EBSCOhost, Google Scholar, Pubmed, and Science Direct database which published from 2008 till 2018. RCTs are included in this review. Four RCTs included in this study. CBT interventions are carried out differently for each article, in general, each session is given for 60-90 minutes with a different number of sessions. Outcome measured in 3 articles was more than one variable (not only depression) and one article only measured the level of depression. Cognitive behavioral therapy can be used for woman patients with breast cancer and cervical cancer who are depressed. Future research to the effectiveness of CBT in reducing depression in woman patients specifically in newly diagnosed with cervical cancer is needed to confirm the evidence

Effects of Ozonized Aloe Vera Oil on Full-Thickness Excision Wound Healing: In Vivo Study Evan Sebastian Gunawan; Muhamad Thohar Arifin; Yuriz Bakhtiar; Yan Wisnu Pradjoko; Muhammad Nur
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.588

Background. Disruption to the healing process of these wounds will consume large resources and will often require long-term medical management. Aloe vera oil is rich in anthraquinone compounds, especially emodin and chrysophanol. Anthraquinones have potent anti-inflammatory effects, which have the potential to activate various growth factors and chemokines and initiate angiogenesis processes that play a major role in wound healing. The ability of ozone to trigger mild oxidative stress plays an important role in triggering a cascade of cytokines and chemokines, including the initiation of vascular endothelial growth factor (VEGF) proteins that play a role in the initiation of angiogenesis. Methods: This study is an in vivo experimental study. A total of 60 rats were divided into 10 treatment and control groups. The treatment group was given ozonized aloe vera oil 600 mg/mL, 1200 mg/mL and 1800 mg/mL. Furthermore, the assessment of VEGF and new blood vessel formation was carried out. Data analysis was performed using SPSS version 25 software with univariate and bivariate tests. Results: The administration of ozonized aloe vera oil was able to increase the expression of VEGF, and the number of new blood vessels in the excision wound tissue. Conclusion: Ozonized aloe vera oil is effective in promoting excision wound tissue repair in vivo.

Pilot Study Efektifitas Media Video Animasi Terhadap Tingkat Depresi Pasien Kanker Serviks Diagnosa Awal Dwi Fitriyanti; Mardiyono Mardiyono; Yuriz Bakhtiar
Indonesian Journal of Nursing Research (IJNR) Vol. 2 No. 1 (2019)
Publisher : Program Studi S1 Keperawatan Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijnr.v2i1.225

Cervical cancer is the cancer that most often attacks women after breastcancer throughout the world. Around the world every two minutes or everyhour a woman dies from cervical cancer. Every patient newly diagnosed withcervical cancer needs to know information about cervical cancer that canaffect the patient's psychological changes in the form of depression. Thepurpose of this study was to determine the effectiveness of education withanimation media to reduce the depression level of cervical cancer patientswith early diagnosis. The method of this research is a pilot study(preliminary study) or testing the feasibility of animation video media on thelevel of depression. Respondent samples in the animated video media trialincluded 10 intervention samples and 10 control samples. The results of theanimation video media research are feasible to be used in subsequent studiesin cervical cancer patients with an initial diagnosis of depression. Dataanalysis using the Wilcoxon Sign Rank Test showed that there was asignificant difference in the level of depression before and after being giveneducation using the animation video media in the intervention group with avalue of p = 0.005 while in the control group with a value p = 0.102. Theconclusion of this study is that the animation video media is feasible to beused in subsequent studies and can effectively be given to cervical cancerpatients with an initial diagnosis of depression.

Ekstraksi Ciri Epilepsi pada rekaman EEG berdasarkan ciri rata-rata, standardeviasi dan kurtosis Siswandari Noertjahjani; Aisyah Lahdji; Zainal Muttaqin; Yuriz Bakhtiar
Prosiding Seminar Nasional Unimus Vol 2 (2019): Tantangan Implementasi Hasil Riset Perguruan Tinggi untuk Industrialisasi
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Epilepsi didefinisikan sebagai suatu sindrom yang ditandai oleh gangguan fungsi otak yang bersifat sementara dan paroksismal, yang memberi manifestasi berupa gangguan, atau kehilangan kesadaran, gangguan motorik, sensorik, psikologik, dan sistem otonom, serta bersifat episodik. Penyakit epilepsi yang tidak ditangani segera dapat merusak otak. Pendukung diagnosis epilepsi adalah dengan menggunakan EEG. Untuk membedakan pola sinyal EEG epilepsi dan normal diperlukan suatu ciri untuk masing masing pola. Ciri yang akan dipakai untuk mewakili sinyal EEG berasal dari 3 ciri statistik yaitu rata-rata, standar deviasi dan kurtosis dengan 11 elektroda FP1 (Front Polar 1), FP2 (Front Polar 2), F7 (Frontal), F3, Fz, F4, F8, T3 (Temporal), T6, P3, P4 (Parietal 4).Hasil menunjukkan nilai standar deviasi pada penyandang epilepsi lebih tinggi dari pada ciri rata- rata dan kurtosis yaitu nilai tertinggi diatas 500. Kata Kunci : rata-rata, standar deviasi, kurtosis, epilepsi

Platelet-Rich Plasma for Burn Wound Healing in Preclinical Models: A Systematic Review of Efficacy and Biomolecular Mechanisms George Dyland De Ussy Whandyra; Udadi Sadhana; Yuriz Bakhtiar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1398

Background: Burn injuries represent a major global health issue, with complex pathophysiology that often leads to significant morbidity. Platelet-rich plasma (PRP) has been identified as a potential therapeutic agent due to its high concentration of growth factors that promote tissue renewal. This review synthesizes preclinical evidence on the efficacy of PRP for burn wounds. Methods: This systematic review followed PRISMA guidelines, searching PubMed, Scopus, and ScienceDirect for animal studies on PRP for burn wounds. The primary outcomes were wound healing, fibroblast scores, and VEGF/EGF levels. The SYRCLE tool was used for risk of bias assessment. Results: Eleven studies involving 526 animals were included. The risk of bias across studies was generally high or unclear, primarily due to poor reporting of randomization and blinding. Macroscopically, PRP was reported to accelerate wound closure in partial-thickness burns within 4-7 days and in full-thickness burns from day 8 onward. On a biomolecular level, PRP was associated with increased fibroblast scores and elevated tissue concentrations of VEGF and EGF from the first day post-treatment (P<0.05 in multiple studies). Conclusion: While the included studies suggest PRP may enhance healing, definitive conclusions are precluded by the high risk of bias and methodological heterogeneity across the preclinical evidence base.

Beyond the Species Barrier: A Systematic Review and Risk of Bias Assessment on the Efficacy, Safety, and Translational Potential of Xenogenic Platelet-Rich Plasma for Wound Healing Kharisma Naufal Yudantono; Udadi Sadhana; Yuriz Bakhtiar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1400

Background: Chronic wounds represent a significant clinical burden. Autologous platelet-rich plasma (PRP) is an effective but patient-limited therapy. Xenogenic PRP (xPRP), derived from animal sources, offers a potential off-the-shelf, scalable alternative. This review synthesizes the current preclinical and early clinical evidence on the efficacy and safety of xPRP for wound healing. Methods: A systematic search was conducted in PubMed, Scopus, ScienceDirect, and Google Scholar up to July 2025, with no publication date restrictions, following PRISMA guidelines. Studies evaluating xPRP on wound healing outcomes in in vivo, in vitro, or ex vivo models were included. Two independent reviewers performed study selection, data extraction, and risk of bias assessment using the SYRCLE tool for animal studies and a modified QUIN tool for in vitro studies. Data were synthesized narratively due to heterogeneity. Results: Eleven studies met the inclusion criteria, comprising ten animal and three in vitro investigations (two studies reported both components). Evidence from porcine, bovine, and deer xPRP sources consistently demonstrated significant improvements in wound closure rates, re-epithelialization, angiogenesis, and collagen deposition compared to saline controls. Porcine xPRP, for instance, accelerated wound closure by up to 45% over controls in diabetic rodent models. However, when compared to autologous PRP, xPRP generally showed slightly inferior, though still positive, outcomes. Immunogenic responses were minimal and localized, with no systemic adverse events reported. Risk of bias assessment revealed that while most studies had clear objectives, many were at high risk of bias due to a lack of randomization, allocation concealment, and blinded outcome assessment. Conclusion: Xenogenic PRP demonstrates considerable promise as a bioactive therapeutic for wound healing, promoting key regenerative processes with a reassuring preliminary safety profile. However, the current evidence base is limited by methodological inconsistencies and a high risk of bias. Future research must prioritize standardized preparation protocols and methodologically rigorous, large-animal and human clinical trials to validate its translational potential.

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