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All Journal Publika Jurnal Akta Kesmas Indonesia: Jurnal Ilmiah Kesehatan Masyarakat AGRIPEAT Al-Ard: Jurnal Teknik Lingkungan Indian Journal of Forensic Medicine & Toxicology Warta Perkaretan BIOMA : Jurnal Biologi dan Pembelajarannya Journal Philosophy of Law Jurnal Ilmu Sosial, Pendidikan Dan Humaniora Jurnal Penelitian Rumpun Ilmu Teknik Journal of Business Management and Islamic Banking Dhabit : Jurnal Pendidikan Islam Journal of Marine Resources and Coastal Management Jurnal Sains Farmasi dan Kesehatan Tarbi: Jurnal Ilmiah Mahasiswa GABBAH : Jurnal Pertanian Dan Perternakan
MISBAKHUL MUNIR
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Journal : Jurnal Sains Farmasi dan Kesehatan

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Pembuatan Gel Antiseptik Berbasis Ekstrak Etanol Buah Rhizophora apiculata sebagai Alternatif Antibakteri terhadap Staphylococcus aureus dan Escherichia coli: Studi In Vitro Ani latifah; Misbakhul munir
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

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Abstract

Rhizophora apiculata is a mangrove species whose fruit is known to contain secondary metabolites such as flavonoids, tannins, saponins, alkaloids, terpenoids, phenolics, and steroids, which have potential as natural antibacterial agents. This study aims to evaluate the antibacterial activity of hand sanitizer gel formulated with ethanol extract of R. apiculata fruit using the disk diffusion method against Staphylococcus aureus and Escherichia coli, and to determine the best formulation among three extract concentrations: F1 (5%), F2 (10%), and F3 (15%). Extraction was carried out by maceration using 96% ethanol, yielding an extract with a rendement of 37.5%. Phytochemical screening confirmed the presence of flavonoids, tannins, alkaloids, saponins, phenolics, terpenoids, and steroids. Antibacterial activity tests showed inhibition zones against S. aureus of 4.20 mm, 4.20 mm, and 4.35 mm for F1, F2, and F3, respectively, and against E. coli of 4.23 mm, 4.33 mm, and 4.37 mm. The F3 formulation, with 15% extract, exhibited the highest antibacterial activity and was determined to be the most effective. With stable physical characteristics, skin-safe pH, and proven antibacterial activity, R. apiculata fruit extract shows great potential as an active ingredient in eco-friendly hand sanitizer formulations.
Co-Authors Adi Pranoto Alchemi Putri Juliantika Kusdiana Ani Latifah Anita Risgiani Darmawan Asnan Nurul Habib Barolym Tri Pamungkas Bestari, Titis Putri Dery Alfian Saputra Dia Ayu Milatina Dian Sari Maisaroh dimas bagus lisdiyantoro Djauhari Djauhari Dwi Sarwani Sri Rejeki Eko Teguh Pribadi Erna Kusumawati Eva Agustina Faizah, Hanik Firman Rezaldi Funsu Andiarna Hanik Faizah Hemastuti Arini Heru Suryaningtyas Ika Nurjanah Ipul Saifullah Linggar Dwi Kinasih Machfudz Ali majidah, nurfitriyah Maskun Kurniawan Mauludiyah Moch. Irfan Hadi Muhammad Miftahussurur Muna Fauziah Nadlir Nadlir Purwo Sri Rejek Ratna Fitry Yenny Rizal Rohmatulloh Saibil, Defi Insani Saiful Bahri SITI FATIMAH Sugiono Sugiono Suyamto Suyamto Yuliana Kolo