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Acute Toxicity Test of Lancing Leaf Extract (Solanum Mauritianum Scop.) as Well as Determination of Ld50 Values and Histopathology in Male Mice (Wistar Rat) Afifah Ikhwan; Erny Tandanu; Ali Napiah Nasution; Refi Ikhtiari
Jurnal Penelitian Pendidikan IPA Vol 11 No 6 (2025): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i6.10776

The purpose of this study is to find out about the acute toxicity test and analysis of its activity on lancing leaves. This research method is an experimental method including sampling and sample processing, extract making, acute toxicity tests, research on toxic symptoms in animals, organ harvesting, organ weighing, organ histopathology examination and data analysis with Statistical Program Service Solution (SPSS). The research was conducted at the Integrated Development and Research Laboratory of Andalas University from September 2024 to December 2024. The tools used in this study are Rotary evaporator (Buchi R-210 Rotavapor), separation funnel, oven (Memmert), furnace, analytical scale (SF-400), decigator, mortar and pestle, porcelain cruce, Moisture Analyzer, Hot plate, Uv-Visible lamp (Camag), dark bottle, funnel, infusion bottle (500 ml and 100 ml), glass beaker (Pyrex), drip plate, rack and test tube, measuring cup (Pyrex), measuring flask, spatels, stirring rods, droppers, ointment pots, object glass, KLT chambers, capillary pipes, syringes, sondes, animal cages, animal feeding and drinking places. The animals that will be used in this study are healthy male white rats aged 2-3 months with a body weight of 200-300 g and have never been used for experiments as many as 25 animalsAn LD50 value was obtained with a mild toxic value (>2000 mg/KgBB – 5000 mg/KgBB) against the acute toxicity test of lancing leaf extract (Solanum Mauritianum Scop.) in male rats. There was no significant difference between groups (p>0.05) in the body and BOR of male rats compared to the control group after administration of lancing leaf extract (Solanum Mauritianum Scop.).

AKSI TIGA PILAR: LOGISTIK CEPAT, GIZI TEPAT, DAN PEMBERIAN LAYANAN TRAUMA UNTUK TANGGAP BENCANA DI LANGKAT (SUMATERA UTARA) Purba, Windania; Ikhtiari, Refi; Ginting, Rapael
COMMUNITY : Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 1 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/community.v6i1.9416

The flood disaster that struck the Tanjung Pura area of Langkat Regency, North Sumatra, had a significant impact on the social, economic, health, and psychological well-being of the community. Limited access to basic necessities, decreased nutritional quality, and the emergence of psychological trauma, particularly among vulnerable groups such as children, the elderly, and pregnant women, are key issues requiring rapid and integrated response. This community service activity aims to provide a disaster response through a Three-Pillar Action approach: Rapid Logistics, Appropriate Nutrition, and Trauma Services. The implementation method was participatory, encompassing preparation and coordination with local partners, core activities such as the distribution of logistical assistance and nutritious food, and trauma healing services. The program concluded with monitoring and evaluation. The aid distributed included basic food packages, hygiene kits, clothing, and psychosocial support for the affected community. Results from the activity indicate that this program was able to meet the community's basic needs quickly and effectively, improve nutritional intake, especially for vulnerable groups, and help reduce stress and trauma caused by the disaster. Thus, the Three Pillars Action approach has proven effective as a holistic and sustainable disaster response model in supporting the physical and psychological recovery of affected communities. ABSTRAK Bencana banjir yang melanda wilayah Tanjung Pura, Kabupaten Langkat, Sumatera Utara, menimbulkan dampak signifikan terhadap kehidupan sosial, ekonomi, kesehatan, dan kondisi psikologis masyarakat. Terbatasnya akses terhadap kebutuhan dasar, menurunnya kualitas asupan gizi, serta munculnya trauma psikologis, khususnya pada kelompok rentan seperti anak-anak, lansia, dan ibu hamil, menjadi permasalahan utama yang memerlukan penanganan cepat dan terintegrasi. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan respons tanggap bencana melalui pendekatan Aksi Tiga Pilar, yaitu Logistik Cepat, Gizi Tepat, dan Pemberian Layanan Trauma. Metode pelaksanaan dilakukan secara partisipatif melalui tahapan persiapan dan koordinasi dengan mitra setempat, pelaksanaan kegiatan inti berupa distribusi bantuan logistik dan pangan bergizi, serta layanan trauma healing, dan diakhiri dengan monitoring serta evaluasi kegiatan. Produk bantuan yang disalurkan meliputi paket sembako, perlengkapan kebersihan, kebutuhan sandang, serta dukungan psikososial bagi masyarakat terdampak. Hasil kegiatan menunjukkan bahwa program ini mampu memenuhi kebutuhan dasar masyarakat secara cepat dan tepat sasaran, meningkatkan pemenuhan gizi terutama bagi kelompok rentan, serta membantu mengurangi tingkat stres dan trauma akibat bencana. Dengan demikian, pendekatan Aksi Tiga Pilar terbukti efektif sebagai model penanganan tanggap bencana yang holistik dan berkelanjutan dalam mendukung pemulihan fisik dan psikologis masyarakat terdampak.

Linking MDA Levels and Blood Glucose in Streptozotocin-Induced Rat Diabetes: Implications for Diabetic Complications and Therapeutic Strategies Evelyn Angie; Ermi Girsang; Refi Ikhtiari
Jurnal Penelitian Pendidikan IPA Vol 10 No 6 (2024): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i6.7220

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels resulting from insulin deficiency or resistance. Streptozotocin, a potent diabetogenic agent, is commonly employed to induce experimental diabetes by selectively damaging pancreatic beta cells, resulting in insulin deficiency and hyperglycemia. Elevated Malondialdehyde (MDA) levels, indicative of oxidative stress and lipid peroxidation, are closely linked to diabetic complications. This study aimed to investigate the association between MDA levels and blood glucose in Streptozotocin-induced rat diabetes, shedding light on potential therapeutic strategies. Spectrophotometric analysis was utilized to quantify MDA levels in rat tissues, providing insights into the extent of oxidative damage. The results revealed a significant correlation between MDA levels and blood glucose, highlighting the role of oxidative stress in diabetic pathogenesis. These findings underscore the importance of targeting oxidative stress in diabetes management to prevent complications. In conclusion, the study emphasizes the relevance of monitoring MDA levels as a biomarker for assessing oxidative stress in diabetic conditions and guiding therapeutic interventions.

The relationship between HbA1c levels and erythrocyte sedimentation rate in type 2 diabetes mellitus patients based on hypertension status Hotmaria Simanullang; Tiarnida Nababan; Refi Ikhtiari
Malahayati International Journal of Nursing and Health Science Vol. 9 No. 3 (2026): Volume 9 Number 3
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v9i3.2856

Background: Measuring random or fasting blood glucose levels does not fully reflect the quality of long-term blood glucose control. Therefore, more accurate monitoring of glycemic status in patients with diabetes mellitus is performed through the HbA1c test. This test is used as an indicator of successful diabetes mellitus control and to minimize the risk of cardiovascular complications and improve patients' quality of life. Purpose: To determine the relationship between HbA1c levels and erythrocyte sedimentation rate (ESR) values in type 2 Diabetes Mellitus patients based on hypertension status at the Bunda Thamrin Medical Laboratory, Medan. Method: A quantitative approach was employed with a descriptive correlational analytical design. The population was 70 patients with type 2 diabetes mellitus, with a sample size of 70 obtained through a specific sampling method. Data on HbA1c levels and ESR values were analyzed to determine their relationship to the patients' hypertension status. Results: No significant differences in HbA1c levels (p=0.746) or ESR values (p=0.259) were found between the hypertensive and normotensive patient groups. However, a clinically significant trend was found in ESR values, with the hypertensive group having a higher proportion of normal ESR values (p=0.066). Conclusion: No significant differences were found between HbA1c levels and ESR values based on hypertension status. Nevertheless, HbA1c has the potential to be an indirect predictor of inflammatory status. Optimal glycemic control remains crucial to reduce the risk of cardiovascular complications through anti-inflammatory mechanisms, especially in patients with hypertension who require more comprehensive management.

Hubungan Shift Konvensional dengan Beban Kerja, Kinerja Perawat dan Kepuasan Pasien di Rumah Sakit RSUD Drs Haji Amri Tambunan Dewi Sartika Br Tarigan; Dwight Mahaputera Marulitua Hutapea; Refi Ikhtiari
Health Research Journal of Indonesia Vol 4 No 5 (2026): Health Research Journal of Indonesia
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/hrji.v4i5.1150

Pendahuluan: Sistem kerja shift pada perawat berpotensi memengaruhi beban kerja, kinerja, dan kepuasan pasien. Hubungan antarvariabel tersebut masih menunjukkan hasil yang bervariasi. Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan shift kerja dengan beban kerja perawat, hubungan kinerja perawat dengan tingkat kepuasan pasien, serta hubungan shift kerja dengan tingkat kepuasan pasien di ruang rawat inap rumah sakit. Metode: hubungan shift kerja dengan tingkat kepuasan pasien di ruang rawat inap rumah sakit. Penelitian ini menggunakan desain cross-sectional dengan responden perawat dan pasien rawat inap. Hasil: Analisis data dilakukan secara deskriptif dan inferensial menggunakan uji Chi-Square dan uji korelasi. Distribusi shift kerja perawat relatif merata, dengan mayoritas bekerja pada shift pagi sebanyak 23 responden (36,5%). Beban kerja perawat sebagian besar berada pada kategori sedang sebanyak 38 responden (60%). Kinerja perawat mayoritas berada pada kategori baik sebanyak 45 responden (71,5%). Tingkat kepuasan pasien menunjukkan bahwa sebagian besar responden merasa puas terhadap pelayanan keperawatan di ruang rawat inap sebanyak 29 responden (46%). Hasil uji Chi-Square menunjukkan terdapat hubungan yang signifikan antara shift kerja dan beban kerja perawat (p = 0,034). Selain itu, terdapat hubungan yang signifikan antara kinerja perawat dan tingkat kepuasan pasien (p = 0,004; r = 0,194). Namun, hasil analisis menunjukkan tidak terdapat hubungan yang signifikan antara shift kerja konvensional dan tingkat kepuasan pasien (p = 0,006). Simpulan: Shift kerja berhubungan signifikan dengan beban kerja perawat, dan kinerja perawat berhubungan signifikan dengan tingkat kepuasan pasien. Namun, shift kerja tidak berhubungan langsung dengan kepuasan pasien, yang mengindikasikan bahwa kepuasan pasien lebih dipengaruhi oleh kualitas kinerja dan pelayanan keperawatan dibandingkan pembagian shift kerja itu sendiri.

The Role of Education Using the Transtheoretical Stages of Change Approach in Digital Substraction Angiography Patients: A Literature Review Trionyta Debora; Dwight Mahaputra Marulitua Hutapea; Refi Ikhtiari
Jurnal Penelitian Perawat Profesional Vol. 7 No. 5 (2025): Oktober 2025, Jurnal Penelitian Perawat Profesional
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jppp.v7i5.1398

Effective health education is crucial to improving procedure outcomes and patient compliance. The Transtheoretical Stages of Change approach has been proven effective in changing health behaviour by tailoring interventions to the patient's psychological readiness. This literature review aims to analyse the role and effectiveness of health education integrated with the Transtheoretical Stages of Change approach in patients undergoing DSA procedures. Method: A literature review was conducted by searching electronic databases such as PubMed, Google Scholar, and ScienceDirect. The search was limited to publications from 2020 to 2025. Results: The review results indicate that the Stages of Change approach is effective in identifying patients' readiness levels. Patients in the precontemplation and contemplation stages require education to raise awareness, while patients in the preparation and action stages require practical information and support to maintain behaviour. Integration of TTM in pre-DSA education significantly reduces anxiety levels, improves compliance with pre-procedure instructions and increases patient satisfaction. Conclusion: Personalised health education using the Transtheoretical Stages of Change framework is a strategic and effective approach to preparing patients for DSA. This approach enables targeted education, thereby improving clinical outcomes and the overall patient experience.

PENGARUH JENIS PELARUT TERHADAP AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT KAYU RARU (Cotylelobium melanoxylon (Hook.f) Pierre) MELALUI UJI DPPH Nurhadijah Sibagariang; Roy Indrianto Bangar; Refi Ikhtiari
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2181

Pelatihan Peer Educator Untuk Mendukung Manajemen Program Kesehatan Remaja dan Rujukan UKS di SMA Negeri 1 Kota Jambi Margareta Pratiwi; Iswadi; Tiarnida Nababan; Refi Ikhtiari
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 4 No. 3 (2026): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 4 Nomor 3 (Januari 202
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v4i3.4907

Permasalahan kesehatan remaja di sekolah sering terlambat terdeteksi karena keterbatasan literasi kesehatan, rendahnya pemanfaatan UKS, serta belum optimalnya sistem rujukan internal sekolah ke UKS maupun layanan kesehatan. Pengabdian masyarakat ini bertujuan meningkatkan kapasitas siswa sebagai peer educator untuk mendukung manajemen program kesehatan remaja dan memperkuat mekanisme rujukan UKS di (nama sekolah), (kota/kabupaten). Kegiatan dilaksanakan melalui tiga tahap, yaitu (1) persiapan: koordinasi dengan pihak sekolah dan UKS, pemetaan kebutuhan, serta penyusunan modul; (2) pelaksanaan: pelatihan peer educator menggunakan metode ceramah interaktif, diskusi kasus, simulasi konseling sebaya, serta praktik alur rujukan UKS; dan (3) pendampingan dan evaluasi: monitoring pelaksanaan edukasi sebaya, penguatan pencatatan sederhana UKS, serta evaluasi hasil. Sasaran kegiatan adalah (jumlah) siswa perwakilan kelas/OSIS/PMR sebagai peer educator, guru pembina UKS, dan petugas UKS. Evaluasi dilakukan dengan pretest–posttest pengetahuan, penilaian keterampilan melalui observasi simulasi (komunikasi, identifikasi masalah, dan rujukan), serta pemantauan output program (jumlah sesi edukasi sebaya, jumlah konsultasi ke UKS, dan ketepatan rujukan). Hasil yang diharapkan adalah peningkatan pengetahuan dan keterampilan peer educator, meningkatnya akses remaja terhadap layanan UKS, serta terbentuknya alur rujukan yang jelas dan terdokumentasi. Program ini berpotensi menjadi model pemberdayaan siswa untuk memperkuat pelayanan UKS dan keberlanjutan program kesehatan remaja di sekolah

Evaluation of Microencapsulated Preparation Formulation of Ethanol Extract of Moringa Leaves (Moringa Oleifera) Nazla Deswita Siregar; Razoki Razoki; Refi Ikhtiari
Jurnal Multidisiplin Sahombu Vol. 6 No. 01 (2026): Jurnal Multidisiplin Sahombu, January 2026
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Indonesia has abundant natural resources, one of which is the moringa plant (Moringa oleifera), known as “The Miracle Tree” due to its high nutritional content and pharmacological properties as an antioxidant, antimicrobial, and anti-inflammatory agent. This study aims to formulate ethanol extract of moringa leaves into microencapsulated preparations to improve the stability of active compounds and protect the active ingredients from stomach acid. The extract was obtained through maceration using 96% ethanol solvent with a yield of 24.42%. The characterization of the crude drug met the Indonesian Herbal Pharmacopoeia standards, and phytochemical screening showed the presence of alkaloids, flavonoids, triterpenoids, steroids, and tannins. The microencapsulation formulation was made using a combination of sodium alginate polymer and chitosan coating with CaCl2 hardening agent in four different extract concentrations. The evaluation of the preparations included stability testing (cycling test), moisture content testing, and buoyancy testing (floating). The stability test results showed that the preparation remained organoleptically stable without significant physical changes during 6 cycles. All formulas met the <5% moisture content requirement, with the 0.75% concentration formula (F4) having the lowest moisture content of 0.26%. In the adhesion test using rat gastric mucosa, the preparation showed good mucoadhesive ability, where the interaction of chitosan in an acidic environment prolonged the retention time of the microcapsules in the stomach. This study concluded that microencapsulation of moringa leaf extract has great potential as a stable and effective drug delivery system.

AKSI TIGA PILAR: LOGISTIK CEPAT, GIZI TEPAT, DAN PEMBERIAN LAYANAN TRAUMA UNTUK TANGGAP BENCANA DI LANGKAT (SUMATERA UTARA) Windania Purba; Refi Ikhtiari; Rapael Ginting
COMMUNITY : Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 1 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/community.v6i1.9416

The flood disaster that struck the Tanjung Pura area of Langkat Regency, North Sumatra, had a significant impact on the social, economic, health, and psychological well-being of the community. Limited access to basic necessities, decreased nutritional quality, and the emergence of psychological trauma, particularly among vulnerable groups such as children, the elderly, and pregnant women, are key issues requiring rapid and integrated response. This community service activity aims to provide a disaster response through a Three-Pillar Action approach: Rapid Logistics, Appropriate Nutrition, and Trauma Services. The implementation method was participatory, encompassing preparation and coordination with local partners, core activities such as the distribution of logistical assistance and nutritious food, and trauma healing services. The program concluded with monitoring and evaluation. The aid distributed included basic food packages, hygiene kits, clothing, and psychosocial support for the affected community. Results from the activity indicate that this program was able to meet the community's basic needs quickly and effectively, improve nutritional intake, especially for vulnerable groups, and help reduce stress and trauma caused by the disaster. Thus, the Three Pillars Action approach has proven effective as a holistic and sustainable disaster response model in supporting the physical and psychological recovery of affected communities. ABSTRAK Bencana banjir yang melanda wilayah Tanjung Pura, Kabupaten Langkat, Sumatera Utara, menimbulkan dampak signifikan terhadap kehidupan sosial, ekonomi, kesehatan, dan kondisi psikologis masyarakat. Terbatasnya akses terhadap kebutuhan dasar, menurunnya kualitas asupan gizi, serta munculnya trauma psikologis, khususnya pada kelompok rentan seperti anak-anak, lansia, dan ibu hamil, menjadi permasalahan utama yang memerlukan penanganan cepat dan terintegrasi. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan respons tanggap bencana melalui pendekatan Aksi Tiga Pilar, yaitu Logistik Cepat, Gizi Tepat, dan Pemberian Layanan Trauma. Metode pelaksanaan dilakukan secara partisipatif melalui tahapan persiapan dan koordinasi dengan mitra setempat, pelaksanaan kegiatan inti berupa distribusi bantuan logistik dan pangan bergizi, serta layanan trauma healing, dan diakhiri dengan monitoring serta evaluasi kegiatan. Produk bantuan yang disalurkan meliputi paket sembako, perlengkapan kebersihan, kebutuhan sandang, serta dukungan psikososial bagi masyarakat terdampak. Hasil kegiatan menunjukkan bahwa program ini mampu memenuhi kebutuhan dasar masyarakat secara cepat dan tepat sasaran, meningkatkan pemenuhan gizi terutama bagi kelompok rentan, serta membantu mengurangi tingkat stres dan trauma akibat bencana. Dengan demikian, pendekatan Aksi Tiga Pilar terbukti efektif sebagai model penanganan tanggap bencana yang holistik dan berkelanjutan dalam mendukung pemulihan fisik dan psikologis masyarakat terdampak.

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