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All Journal HAYATI Journal of Biosciences MEDISAINS Majalah Obat Tradisional Science and Technology Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Pendidikan Kimia (JPKim) Jurnal Aisyah : Jurnal Ilmu Kesehatan COMMUNITY : Jurnal Pengabdian Kepada Masyarakat JIFI (Jurnal Ilmiah Farmasi Imelda) Nurse and Holistic Care JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Natural Jurnal Kesehatan Farmasi Malahayati International Journal of Nursing and Health Science
IKHTIARI, REFI
Department Of Biomedical Sciences, Faculty Of Medicine, Universitas Prima Indonesia, Medan, 20118, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Acute Toxicity Test of Lancing Leaf Extract (Solanum Mauritianum Scop.) as Well as Determination of Ld50 Values and Histopathology in Male Mice (Wistar Rat) Afifah Ikhwan; Erny Tandanu; Ali Napiah Nasution; Refi Ikhtiari
Jurnal Penelitian Pendidikan IPA Vol 11 No 6 (2025): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i6.10776

Abstract

The purpose of this study is to find out about the acute toxicity test and analysis of its activity on lancing leaves. This research method is an experimental method including sampling and sample processing, extract making, acute toxicity tests, research on toxic symptoms in animals, organ harvesting, organ weighing, organ histopathology examination and data analysis with Statistical Program Service Solution (SPSS).  The research was conducted at the Integrated Development and Research Laboratory of Andalas University from September 2024 to December 2024. The tools used in this study are Rotary evaporator (Buchi R-210 Rotavapor), separation funnel, oven (Memmert), furnace, analytical scale (SF-400), decigator, mortar and pestle, porcelain cruce, Moisture Analyzer, Hot plate, Uv-Visible lamp (Camag), dark bottle, funnel, infusion bottle (500 ml and 100 ml), glass beaker (Pyrex), drip plate, rack and test tube, measuring cup (Pyrex), measuring flask,  spatels, stirring rods, droppers, ointment pots, object glass, KLT chambers, capillary pipes, syringes, sondes, animal cages, animal feeding and drinking places. The animals that will be used in this study are healthy male white rats aged 2-3 months with a body weight of 200-300 g and have never been used for experiments as many as 25 animalsAn LD50 value was obtained with a mild toxic value (>2000 mg/KgBB – 5000 mg/KgBB) against the acute toxicity test of lancing leaf extract (Solanum Mauritianum Scop.) in male rats. There was no significant difference between groups (p>0.05) in the body and BOR of male rats compared to the control group after administration of lancing leaf extract (Solanum Mauritianum Scop.).
AKSI TIGA PILAR: LOGISTIK CEPAT, GIZI TEPAT, DAN PEMBERIAN LAYANAN TRAUMA UNTUK TANGGAP BENCANA DI LANGKAT (SUMATERA UTARA) Purba, Windania; Ikhtiari, Refi; Ginting, Rapael
COMMUNITY : Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 1 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/community.v6i1.9416

Abstract

The flood disaster that struck the Tanjung Pura area of ​​Langkat Regency, North Sumatra, had a significant impact on the social, economic, health, and psychological well-being of the community. Limited access to basic necessities, decreased nutritional quality, and the emergence of psychological trauma, particularly among vulnerable groups such as children, the elderly, and pregnant women, are key issues requiring rapid and integrated response. This community service activity aims to provide a disaster response through a Three-Pillar Action approach: Rapid Logistics, Appropriate Nutrition, and Trauma Services. The implementation method was participatory, encompassing preparation and coordination with local partners, core activities such as the distribution of logistical assistance and nutritious food, and trauma healing services. The program concluded with monitoring and evaluation. The aid distributed included basic food packages, hygiene kits, clothing, and psychosocial support for the affected community. Results from the activity indicate that this program was able to meet the community's basic needs quickly and effectively, improve nutritional intake, especially for vulnerable groups, and help reduce stress and trauma caused by the disaster. Thus, the Three Pillars Action approach has proven effective as a holistic and sustainable disaster response model in supporting the physical and psychological recovery of affected communities. ABSTRAK Bencana banjir yang melanda wilayah Tanjung Pura, Kabupaten Langkat, Sumatera Utara, menimbulkan dampak signifikan terhadap kehidupan sosial, ekonomi, kesehatan, dan kondisi psikologis masyarakat. Terbatasnya akses terhadap kebutuhan dasar, menurunnya kualitas asupan gizi, serta munculnya trauma psikologis, khususnya pada kelompok rentan seperti anak-anak, lansia, dan ibu hamil, menjadi permasalahan utama yang memerlukan penanganan cepat dan terintegrasi. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan respons tanggap bencana melalui pendekatan Aksi Tiga Pilar, yaitu Logistik Cepat, Gizi Tepat, dan Pemberian Layanan Trauma. Metode pelaksanaan dilakukan secara partisipatif melalui tahapan persiapan dan koordinasi dengan mitra setempat, pelaksanaan kegiatan inti berupa distribusi bantuan logistik dan pangan bergizi, serta layanan trauma healing, dan diakhiri dengan monitoring serta evaluasi kegiatan. Produk bantuan yang disalurkan meliputi paket sembako, perlengkapan kebersihan, kebutuhan sandang, serta dukungan psikososial bagi masyarakat terdampak. Hasil kegiatan menunjukkan bahwa program ini mampu memenuhi kebutuhan dasar masyarakat secara cepat dan tepat sasaran, meningkatkan pemenuhan gizi terutama bagi kelompok rentan, serta membantu mengurangi tingkat stres dan trauma akibat bencana. Dengan demikian, pendekatan Aksi Tiga Pilar terbukti efektif sebagai model penanganan tanggap bencana yang holistik dan berkelanjutan dalam mendukung pemulihan fisik dan psikologis masyarakat terdampak.
PENGARUH JENIS PELARUT TERHADAP AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT KAYU RARU (Cotylelobium melanoxylon (Hook.f) Pierre) MELALUI UJI DPPH Sibagariang, Nurhadijah; Bangar, Roy Indrianto; Ikhtiari, Refi
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2181

Abstract

STUDI FORMULASI GEL EKSTRAK KULIT RARU (COTYLELOBIUM MELANOXYLON PIERRE) SEBAGAI AGEN ANTIBAKTERI gulo, Michelle Veronica Gulo; Bangar, Roy Indrianto; Ikhtiari, Refi
Jurnal Kesehatan Farmasi Vol 8 No 1 (2026): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v8i1.3748

Abstract

Acne is a skin condition affecting adolescents and young adults, characterized by an imbalance in the skin microbiome, excessive sebum production, and the accumulation of keratin, triggered by the bacteria Propionibacterium acnes, a significant pathogenic factor. Acne can be treated with antibiotics, but long-term antibiotic use can have side effects if used incorrectly. Raru wood has pharmacological potential due to its content of secondary metabolites such as flavonoids, tannins, saponins, and triterpenoids. Raru bark extract was developed into a gel dosage form to optimize its treatment effectiveness. The purpose of this study was to determine the gel formulation and antibacterial effectiveness of raru bark extract in the gel preparation. The research method was experimental, involving the formulation and evaluation of the gel, as well as testing its antibacterial activity using the disc method at a concentration of 3%, negative controls, and positive controls.
ANALYSIS OF HEALTH WORKER AND PEER SUPPORT GROUP INFLUENCE ON ANTIRETROVIRAL (ARV) ADHERENCE AT DR. DJASAMEN SARAGIH GENERAL HOSPITAL, PEMATANGSIANTAR Girsang, Jakasmir; Nababan, Tiarnida; ikhtiari, Refi
Nurse and Holistic Care Vol. 6 No. 1 (2026): Nurse and Holistic Care
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/nhc.v6i1.8462

Abstract

Background: The low success of antiretroviral (ARV) therapy at Dr. Djasamen Saragih Regional Hospital is reflected in the small number of People Living with HIV (PLHIV) who achieve viral load suppression. This problem is strongly suspected to be related to the low level of medication adherence. Objective: To analyze the effect of support from health workers and Peer Support Groups (PSGs) on ARV adherence at Dr. Djasamen Saragih Regional Hospital.Methods: This study used a cross-sectional design. The study population was all PLHIV, totaling 229 people, with a sample size of 71 people taken through a purposive sampling method. Data were analyzed bivariate and multivariate to determine the relationship between variables and the odds ratio of patient adherence.Results: Bivariate analysis showed a significant relationship between support from health workers (p=0.000) and peer support (p=0.001) on ARV adherence. The results of the multivariate analysis showed that support from healthcare workers was the dominant factor, where PLHIV who received such support had a 7.830 times greater chance of adherence than those who did not receive support. In addition, peer support increased the chance of adherence by 4.729 times for patients.Conclusion: External support, both from medical personnel and the peer social environment, significantly determined the adherence behavior of PLHIV in undergoing therapy. The management of Dr. Djasamen Saragih Regional General Hospital is advised to improve the communication competency of healthcare workers and strengthen strategic collaboration with peer communities in Pematangsiantar City to optimize patient therapy outcomes.
Linking MDA Levels and Blood Glucose in Streptozotocin-Induced Rat Diabetes: Implications for Diabetic Complications and Therapeutic Strategies Evelyn Angie; Ermi Girsang; Refi Ikhtiari
Jurnal Penelitian Pendidikan IPA Vol 10 No 6 (2024): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i6.7220

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels resulting from insulin deficiency or resistance. Streptozotocin, a potent diabetogenic agent, is commonly employed to induce experimental diabetes by selectively damaging pancreatic beta cells, resulting in insulin deficiency and hyperglycemia. Elevated Malondialdehyde (MDA) levels, indicative of oxidative stress and lipid peroxidation, are closely linked to diabetic complications. This study aimed to investigate the association between MDA levels and blood glucose in Streptozotocin-induced rat diabetes, shedding light on potential therapeutic strategies. Spectrophotometric analysis was utilized to quantify MDA levels in rat tissues, providing insights into the extent of oxidative damage. The results revealed a significant correlation between MDA levels and blood glucose, highlighting the role of oxidative stress in diabetic pathogenesis. These findings underscore the importance of targeting oxidative stress in diabetes management to prevent complications. In conclusion, the study emphasizes the relevance of monitoring MDA levels as a biomarker for assessing oxidative stress in diabetic conditions and guiding therapeutic interventions.
The relationship between HbA1c levels and erythrocyte sedimentation rate in type 2 diabetes mellitus patients based on hypertension status Hotmaria Simanullang; Tiarnida Nababan; Refi Ikhtiari
Malahayati International Journal of Nursing and Health Science Vol. 9 No. 3 (2026): Volume 9 Number 3
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v9i3.2856

Abstract

Background: Measuring random or fasting blood glucose levels does not fully reflect the quality of long-term blood glucose control. Therefore, more accurate monitoring of glycemic status in patients with diabetes mellitus is performed through the HbA1c test. This test is used as an indicator of successful diabetes mellitus control and to minimize the risk of cardiovascular complications and improve patients' quality of life. Purpose: To determine the relationship between HbA1c levels and erythrocyte sedimentation rate (ESR) values ​​in type 2 Diabetes Mellitus patients based on hypertension status at the Bunda Thamrin Medical Laboratory, Medan. Method: A quantitative approach was employed with a descriptive correlational analytical design. The population was 70 patients with type 2 diabetes mellitus, with a sample size of 70 obtained through a specific sampling method. Data on HbA1c levels and ESR values ​​were analyzed to determine their relationship to the patients' hypertension status. Results: No significant differences in HbA1c levels (p=0.746) or ESR values ​​(p=0.259) were found between the hypertensive and normotensive patient groups. However, a clinically significant trend was found in ESR values, with the hypertensive group having a higher proportion of normal ESR values ​​(p=0.066). Conclusion: No significant differences were found between HbA1c levels and ESR values ​​based on hypertension status. Nevertheless, HbA1c has the potential to be an indirect predictor of inflammatory status. Optimal glycemic control remains crucial to reduce the risk of cardiovascular complications through anti-inflammatory mechanisms, especially in patients with hypertension who require more comprehensive management.
Co-Authors Afifah Ikhwan AHMAD RAIF Ali Napiah Nasution Ananda Putra ARFANI ARFANI Bangar, Roy Indrianto Chrismis Novalinda Ginting Chrismis Novalinda Ginting Chrismis Novalinda Ginting Djamin Kartarino Ermi Girsang Erny Tandanu Erny Tandanu Erny Tandanu Evelyn Angie Evelyn Angie Fioni Chandra Fiska Maya Wardhani Ginting, Chrismis Novalinda Girsang, Jakasmir gulo, Michelle Veronica Gulo Hairus Abdullah Handoko, Erwin Harahap, Viora Rezky Heryani, Dyah Wijiana Hotmaria Simanullang Lister, I Nyoman Ehrich Martinus Ahmad Raif Maya Wardhani, Fiska Nardi, Leo Nasution, Ali Napiah Nazimuddin Putri, Nadya Purba, Windania Raif, Martinus Ahmad Rapael Ginting Sahna Ferdinand Ginting Sahna Ferdinand Ginting Sari, Laura Kartika Sibagariang, Nurhadijah Silvia Fransisca Stephanie Renata Yosefa Tiarnida Nababan Timotius Agung Soripada Tri Lestari Simangunsong Viora Rezky Harahap William Leslie Yensuari, Yensuari