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All Journal HAYATI Journal of Biosciences MEDISAINS Majalah Obat Tradisional Science and Technology Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Pendidikan Kimia (JPKim) Jurnal Aisyah : Jurnal Ilmu Kesehatan Nurse and Holistic Care JKKI : Jurnal Kedokteran dan Kesehatan Indonesia International Journal of Health and Pharmaceutical (IJHP) Jurnal Natural
IKHTIARI, REFI
Department Of Biomedical Sciences, Faculty Of Medicine, Universitas Prima Indonesia, Medan, 20118, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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In vivo study of cardioprotective effect of bay leaf (Syzygium polyanthum) extract Ikhtiari, Refi; Sari, Laura Kartika; Nasution, Ali Napiah; Ginting, Chrismis Novalinda; Handoko, Erwin; Lister, I Nyoman Ehrich
MEDISAINS Vol 20, No 1 (2022)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v20i1.12502

Abstract

Background: The excessive use of chemotherapy drugs such as doxorubicin might induce cardiovascular diseases. Heart-specific biomarker enzymes such as LDH and BNP indicated the early signs of cardiotoxicity. However, there is no report on the effect of bay leaf on LDH and BNP nor its bioactive compounds and histopathology analysis.Objective: This study aims to determine the cardioprotective effect of Ethanol Extract of Bay Leaf (EEBL) based on phytochemical analysis, LDH and BNP levels, and cardiac histology of rats administered with doxorubicin.Methods: About 24 Wistar rats were divided into six groups treated with 100 mg/kg BW, 300 mg/kg BW, and 500 mg/kg BW of EEBL with CMC-Na 0.5 %, vitamin E, and doxorubicin. Preconditioning was 14 days, followed by 21 days of intraperitoneal administration. LDH and BNP parameters were measured on days 1st, 7th, 14th, and 20th. Histology analysis was conducted on day 21st.Results: Dark green EEBL showed sufficient physical quality and properties for practical application in pharmacy. EEBL has significantly affected LDH, BNP, and cardio recovery dose-dependent. The most effective doses were observed at 500 mg/kg BW, and its performance is not statistically different from those of the commercial vitamin E. The histopathological images revealed significant improvements in interstitial edema, wavy fibers, hemorrhage, intracellular vacuole, and inflammatory cell infiltration. Here we report six bioactive compounds obtained from EEBL have cardioprotective effects; Neophytadiene, squalane, phytol, methyl palmitate, stigmasterol, and  9,12-Octadecanoic acid methyl ester.Conclusion: This study has shown the promising potential of bay leaf extract as a cardioprotector with sufficient quality pharmacological standards.
The Effect of Giving Coffee Pulp Extract Cream on the Healing of Cut Wounds in Wistar Rats Juita, Anggun; Ikhtiari, Refi; Tandanu, Erny; Claudia Malau, Reghita
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025 (Indonesia - Turkey - Malaysia - Australia - Iran)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.409

Abstract

Humans need skin to protect their internal organs, such as muscles, nerves, and bones, from disease. This study examines the effect of coffee grounds extract cream on wound healing in Wistar rats. This study is an experimental laboratory study. The research design used a post-test with a control group design or control on samples based on treatment groups to analyze the effect of coffee grounds extract on wound healing and skin histopathology in male Wistar white rats. According to the results of the study, coffee grounds extract accelerated wound healing in Wistar white rats, as shown by the average differences of 2.5%, 5%, and 10%. This study shows that coffee grounds extract contains saponins, alkaloids, flavonoids, and tannins. Research on skin histopathology on the best fibroblast tissue found that 10% coffee grounds extract cream was the most helpful in developing connective tissue in injured skin. The findings of this study are expected to help other researchers explore the effects of coffee grounds extract on skin collagen formation.
Acute Toxicity Test of Lancing Leaf Extract (Solanum Mauritianum Scop.) as Well as Determination of Ld50 Values and Histopathology in Male Mice (Wistar Rat) Ikhwan, Afifah; Tandanu, Erny; Nasution, Ali Napiah; Ikhtiari, Refi
Jurnal Penelitian Pendidikan IPA Vol 11 No 6 (2025): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i6.10776

Abstract

The purpose of this study is to find out about the acute toxicity test and analysis of its activity on lancing leaves. This research method is an experimental method including sampling and sample processing, extract making, acute toxicity tests, research on toxic symptoms in animals, organ harvesting, organ weighing, organ histopathology examination and data analysis with Statistical Program Service Solution (SPSS).  The research was conducted at the Integrated Development and Research Laboratory of Andalas University from September 2024 to December 2024. The tools used in this study are Rotary evaporator (Buchi R-210 Rotavapor), separation funnel, oven (Memmert), furnace, analytical scale (SF-400), decigator, mortar and pestle, porcelain cruce, Moisture Analyzer, Hot plate, Uv-Visible lamp (Camag), dark bottle, funnel, infusion bottle (500 ml and 100 ml), glass beaker (Pyrex), drip plate, rack and test tube, measuring cup (Pyrex), measuring flask,  spatels, stirring rods, droppers, ointment pots, object glass, KLT chambers, capillary pipes, syringes, sondes, animal cages, animal feeding and drinking places. The animals that will be used in this study are healthy male white rats aged 2-3 months with a body weight of 200-300 g and have never been used for experiments as many as 25 animalsAn LD50 value was obtained with a mild toxic value (>2000 mg/KgBB – 5000 mg/KgBB) against the acute toxicity test of lancing leaf extract (Solanum Mauritianum Scop.) in male rats. There was no significant difference between groups (p>0.05) in the body and BOR of male rats compared to the control group after administration of lancing leaf extract (Solanum Mauritianum Scop.).
THE ROLE OF SOCIAL SUPPORT AND EDUCATION LEVEL IN ADHERENCE TO ANTI-RETROVIRAL (ARV) DRUGS IN HIV/AIDS PATIENTS: NARATIVE REVIEW Girsang, Jakasmir; Nababan, Tiarnida; Ikhtiari, Refi
Nurse and Holistic Care Vol. 5 No. 2 (2025): Nurse and Holistic Care
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/nhc.v5i2.7601

Abstract

Background: Adherence to antiretroviral (ARV) therapy is essential for effective HIV/AIDS management. Social support and patients’ education levels have been shown to influence treatment adherence. Objective: To review the role of social support and education in adherence to ARV medication among people living with HIV/AIDS (PLWHA). Methods: This study is a narrative literature review. Articles were retrieved from Google Scholar using predefined inclusion and exclusion criteria. The quality of the selected studies was assessed using the JBI Critical Appraisal Checklist, and findings were synthesized thematically. Results: Ten articles met the inclusion criteria (n = 10). Most studies reported that family support and higher education levels were positively associated with better adherence to ARV therapy. Conclusion: Social support and education are key determinants of ARV adherence. Interventions that emphasize patient education and family involvement are recommended to improve treatment outcomes in PLWHA.
Linking MDA Levels and Blood Glucose in Streptozotocin-Induced Rat Diabetes: Implications for Diabetic Complications and Therapeutic Strategies Angie, Evelyn; Girsang, Ermi; Ikhtiari, Refi
Jurnal Penelitian Pendidikan IPA Vol 10 No 6 (2024): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i6.7220

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels resulting from insulin deficiency or resistance. Streptozotocin, a potent diabetogenic agent, is commonly employed to induce experimental diabetes by selectively damaging pancreatic beta cells, resulting in insulin deficiency and hyperglycemia. Elevated Malondialdehyde (MDA) levels, indicative of oxidative stress and lipid peroxidation, are closely linked to diabetic complications. This study aimed to investigate the association between MDA levels and blood glucose in Streptozotocin-induced rat diabetes, shedding light on potential therapeutic strategies. Spectrophotometric analysis was utilized to quantify MDA levels in rat tissues, providing insights into the extent of oxidative damage. The results revealed a significant correlation between MDA levels and blood glucose, highlighting the role of oxidative stress in diabetic pathogenesis. These findings underscore the importance of targeting oxidative stress in diabetes management to prevent complications. In conclusion, the study emphasizes the relevance of monitoring MDA levels as a biomarker for assessing oxidative stress in diabetic conditions and guiding therapeutic interventions.
Co-Authors AHMAD RAIF Ahmad Raif Ahmad Raif Martinus Ananda Putra Angie, Evelyn ARFANI ARFANI Chrismis Novalinda Ginting Chrismis Novalinda Ginting Chrismis Novalinda Ginting Claudia Malau, Reghita Djamin Kartarino Edward Valentino Butar-Butar Erny Tandanu Erny Tandanu Evelyn Angie Fioni Chandra Firman Erdona Sebayang Fiska Maya Wardhani Ginting, Chrismis Novalinda Girsang, Ermi Girsang, Jakasmir Hairus Abdullah Handoko, Erwin Harahap, Viora Rezky Heryani, Dyah Wijiana Ikhwan, Afifah Juita, Anggun Lister, I Nyoman Ehrich Martinus Ahmad Raif Maya Wardhani, Fiska Nardi, Leo Nasution, Ali Napiah Nazimuddin Putri, Nadya Raif, Martinus Ahmad Sahna Ferdinand Ginting Sahna Ferdinand Ginting Sari, Laura Kartika Silvia Fransisca Stephanie Renata Yosefa Tandanu, Erny Tiarnida Nababan Timotius Agung Soripada Tri Lestari Simangunsong Viora Rezky Harahap William Leslie Yensuari, Yensuari