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All Journal Narra J GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Heca Journal of Applied Sciences Malacca Pharmaceutics Indonesian Journal of Case Reports Grimsa Journal of Science Engineering and Technology
Imelda, Eva
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Public Health Veterinary

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Through a Hazy Lens: A Teen’s Surprising Struggle with Juvenile Cataracts Imelda, Eva; Jannah, Siti Rain; Annisa, Thyfa; Adev, Sarra Mutiara; Toshniwal, Navneet Shamsundar
Indonesian Journal of Case Reports Vol. 2 No. 2 (2024): December 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v2i2.250

Abstract

A juvenile cataract is a condition in which the eye's lens gets cloudy, affecting children and teenagers and considerably impairing vision. It accounts for approximately 5% to 20% of childhood blindness worldwide. A 16-year-old male patient came with his parents to the Pediatric Ophthalmology and Strabismus Department of RSUD dr. Zainoel Abidin with complaints of blurred vision in both eyes. The patient admitted that his visual acuity was deteriorating, and he had difficulty seeing the blackboard when the teacher explained it at school. There were no factors that aggravated or relieved the patient's complaints. The ophthalmologic examination showed the visual acuity of both eyes was 6/30, and the bilateral lenses were opaque. The patient was diagnosed with juvenile cataract oculi dextra et sinistra. Subsequently, the patient was planned for aspiration irrigation with intraocular lens (IOL) insertion in both eyes, membranectomy, primary posterior capsulectomy (PPC), and anterior vitrectomy (AV). Following the surgery, the visual acuity of both his eyes was improved to 6/7 and 6/10. The patient was also prescribed oral and topical antibiotics and topical anti-inflammatories to prevent infection and persistent inflammation after surgery. After surgery, the patient was also planned for optical rehabilitation one month postoperatively by being prescribed glasses with the best correction of 6/6 in both eyes.
Evaluation of Machine Learning Methods for Identifying Carbonic Anhydrase-II Inhibitors as Drug Candidates for Glaucoma Noviandy, Teuku Rizky; Imelda, Eva; Idroes, Ghazi Mauer; Suhendra, Rivansyah; Idroes, Rinaldi
Malacca Pharmaceutics Vol. 3 No. 1 (2025): March 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v3i1.271

Abstract

Glaucoma is a leading cause of irreversible blindness, primarily managed by lowering intraocular pressure (IOP). Carbonic Anhydrase-II (CA-II) inhibitors play a crucial role in this treatment by reducing aqueous humor production. However, existing CA-II inhibitors often suffer from poor selectivity, side effects, and limited bioavailability, highlighting the need for more efficient and targeted drug discovery approaches. This study uses machine learning-driven Quantitative Structure-Activity Relationship (QSAR) modeling to predict CA-II inhibition based on molecular descriptors, significantly enhancing screening efficiency over traditional experimental methods. By evaluating multiple machine learning models, including Support Vector Machine, Gradient Boosting, and Random Forest, we identify SVM as the most effective classifier, achieving the highest accuracy (83.70%) and F1-score (89.36%). Class imbalance remains challenging despite high sensitivity, necessitating further improvements through resampling and hyperparameter optimization. Our findings underscore the potential of machine learning-based virtual screening in accelerating CA-II inhibitor identification and advocate for integrating AI-driven approaches with traditional drug discovery techniques. Future directions include deep learning enhancements and hybrid machine learning-docking frameworks to improve prediction accuracy and facilitate the development of more potent and selective glaucoma treatments.
Early Intervention in Unilateral Retinoblastoma: A 2-Year-Old’s Journey Through Enucleation and Evidence-Based Care Imelda, Eva; Adev, Sarra Mutiara; Jannah, Siti Rain; Toshniwal, Nikhil
Indonesian Journal of Case Reports Vol. 3 No. 1 (2025): June 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v3i1.290

Abstract

Retinoblastoma is a neoplasm that arises from the retina and is frequently observed in pediatric patients, with a high degree of morbidity, particularly in underdeveloped nations. The classification of this tumor is based on its spread (intraocular and extraocular) and location (unilateral, bilateral, trilateral, and quadrilateral). Unilateral retinoblastoma is the most prevalent form, accounting for 60–70% of cases. A 2-year-old female patient was brought to the Eye Clinic of the Pediatric and Strabismus Department of Dr. Zainoel Abidin Regional Hospital by her parents with a complaint of a white spot in the center of her left eye, accompanied by decreased visual acuity for 3 months. A subsequent examination, using ultrasound (USG), revealed a mass at the base of the retina, accompanied by calcification and infiltration into the vitreous. An orbital scan revealed intraocular calcification, exclusively in the left eye. The patient was diagnosed with unilateral leukocoria OS et causa retinoblastoma grade E. Subsequent treatment plans included OS enucleation and EUA (Examination Under Anesthesia) procedures. Following the EUA procedure, no mass was identified in the right eye. An anatomical pathology examination revealed no spread to the optic nerve; therefore, chemotherapy was not given.
Managing the Maze: Advanced Approaches to Pediatric Cataract Complications Imelda, Eva; Jannah, Siti Rain; Adev, Sarra Mutiara; Toshniwal, Nikhil
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 1 (2025): April 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i1.80

Abstract

Complicated cataract is a condition characterized by opacification of the crystalline lens due to intraocular diseases, particularly inflammatory conditions and other abnormalities. It often affects younger age groups, leading to visual impairment that typically requires surgical intervention. A 3-year-old girl presented with complaints of white spots in both eyes for one week. Following a physical examination and ultrasonography, she was diagnosed with bilateral complicated cataracts. The patient was scheduled for procedures including synechiolysis and irrigation-aspiration. However, due to intraoperative complications, additional procedures were necessary. Postoperatively, the patient was treated with antibiotic and anti-inflammatory medications and underwent optical rehabilitation using spectacles. This case highlights the management of pediatric cataracts and the challenges involved, with particular focus on postoperative optical rehabilitation to prevent amblyopia. Prompt and appropriate treatment of cataracts in children is crucial to clear the visual axis and restore a clear retinal image, thereby preventing the development of amblyopia.
Managing Bilateral Congenital Cataracts in Early Childhood: A Clinical and Surgical Perspective Imelda, Eva; Lathifah, Lakaeisya SY; Lubis, Dara Amalia; Toshniwal, Nikhil; Adev, Sarra Mutiara
Indonesian Journal of Case Reports Vol. 3 No. 2 (2025): December 2025 (In Press)
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v3i2.318

Abstract

Congenital cataract is a leading cause of childhood blindness that demands prompt surgical intervention to prevent irreversible visual impairment. This case report presents an infant with bilateral congenital cataracts whose diagnosis and treatment were delayed beyond the optimal intervention window. The patient underwent cataract extraction using irrigation aspiration, primary posterior capsulotomy, and anterior vitrectomy. Intraocular lens (IOL) implantation was deferred due to considerations of the patient’s age and corneal diameter, and aphakia was managed with high-powered spectacles. Postoperative follow-up revealed improved visual responses, including fixation and following of light and objects, indicating positive visual development. This case highlights the importance of timely identification, appropriate surgical technique, and tailored postoperative visual rehabilitation in managing pediatric cataracts to optimize functional outcomes.
Bilateral Juvenile Cataract in Childhood: A Comprehensive Clinical and Surgical Approach Imelda, Eva; Lubis, Dara Amalia; Lathifah, Lakaeisya SY; Toshniwal, Nikhil; Adev, Sarra Mutiara
Heca Journal of Applied Sciences Vol. 3 No. 2 (2025): September 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v3i2.325

Abstract

Juvenile cataracts, though less common than congenital types, can cause irreversible visual impairment if diagnosis and treatment are delayed. We report a 10-year-old boy with progressive bilateral visual loss, photophobia, and leukocoria over three years, with a positive paternal history suggesting hereditary etiology. Examination revealed dense bilateral lens opacities and markedly reduced visual acuity. The patient underwent sequential aspiration–irrigation with posterior chamber intraocular lens implantation in both eyes. Surgeries were uneventful; however, postoperative vision in the right eye remained limited due to deprivation amblyopia, while the left eye achieved a better functional outcome. Final refraction showed mild residual error, and the patient was continued on visual rehabilitation and amblyopia therapy. This case highlights the importance of early detection and timely surgery in pediatric cataract to prevent permanent visual deficits and optimize outcomes. This report aims to illustrate the impact of delayed intervention on functional vision, daily activities, and educational performance in school-aged children within resource-limited settings.
Co-Authors Adev, Alya Mutiara Adev, Sarra Mutiara Annisa, Thyfa Emka, Erifa Ananda Faizah, Siti Fitria, Ulfa Ghassani, Vania Ghazi Mauer Idroes Gianty, Jauza Aqilla Gunawan, Fany Jannah, Siti Rain Lathifah, Lakaeisya SY Lubis, Dara Amalia Mutia, Ulmiza Putri Nuzhatuddin, Fatimah Raudhatul Jannah Rinaldi Idroes Samira, Cut Putri Sari, Cut Refida Sari, Masitha Dewi Sarra Mutiara Adev Siti Rain Jannah Suhendra, Rivansyah Syahrul Syahrul Teuku Rizky Noviandy Toshniwal, Navneet Shamsundar Toshniwal, Nikhil Zakiaturrahmi, Zakiaturrahmi