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All Journal Poltekita : Jurnal Ilmu Kesehatan Jurnal Prima Medika Sains Jurnal Health Sains Jurnal Kesehatan Tambusai COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Buletin Kedokteran dan Kesehatan Prima Ranah Research : Journal of Multidisciplinary Research and Development JURNAL KELUARGA SEHAT SEJAHTERA
Fibrini, Dewi
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Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary Other

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Comparison of Secretome Dental Pulp Stem Cell And Mebo Ointment on The Amount of Fibroblast and Collagen In Superficial Dermal Burns Loviana Hasibuan, Soya; Fibrini, Dewi; Tjipta, Arya; Ruspita, Intan; Yolanda, Eva
Jurnal Health Sains Vol. 5 No. 9 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i9.1368

Abstract

Secretome Dental Pulp Stem Cells have been proposed as a new alternative for wound burn. The aim of this study is to compare Secretome Dental Pulp Stem Cells and MEBO ointment against several fibroblasts and collagen in the healing process of superficial dermal burns. This study used a post-test only controlled group design by using 15 rats that were given superficial dermal burned wounds. Rats were divided into a negative control group of NaCl 0.9% (K1), a treatment group of MEBO (K2), and a treatment group of DPSCs-secretome (K3). Histopathology was done on the 5th, 14th, and 21st days post-induction wound burn. Network-prepared histopathology by colouring Messon Trichomes. Then, it was observed under a microscope with 200x magnification. Scoring in a way semi-qualitative for assessing fibroblasts and collagen. The total score of fibroblasts in the MEBO group was higher than the DPSCs-secretome group on day 5th. In comparison, the score for increasing the amount of collagen in the DPSCs-secretome group on days 5th and 14th was higher than the MEBO group. DPSCs-secretome has better effectiveness in increasing the amount of collagen but not better in increasing fibroblasts compared to MEBO.
Co-Authors Ayuarianti, Ayuarianti Dalimunthe, Anita Rosari Edlin, Edlin Fioni, Fioni Fitriani, Anche Pratiwi Francesco, Francesco Intan Ruspita, Intan Lina, Juliana Loviana Hasibuan, Soya Lumbantobing, Christina JRE. Manulang, Ony Veronika Meldawati Meldawati Olidya, Desyoma Purba, Desi Natalia Rapael Ginting Reh Malem br Karo Rumahorbo, Novynsqi Saragih, Agnes Fransisca Siagian, Masryna Silaen, Mangatas Sinurat, Jhon Patar Siregar, Abdul Rahman Maulana Tjipta, Arya Wijaya, Johana Fransiska Yolanda, Eva Yulizal, Ok