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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Mandala Pharmacon Indonesia Majalah Farmasetika Jurnal Ilmiah Farmasi Farmasyifa Journal of Pharmaceutical and Health Research Jurnal Riset Farmasi Bandung Conference Series: Pharmacy
Syafnir, Livia
Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Islam Bandung
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Formulation of Green Tea Spray Gel as Supportive Therapy for Diabetic Foot Infection Priani, Sani Ega; Efrida, Delfiana Aura; Aryani, Ratih; Mulkiya, Kiki; Syafnir, Livia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.54042

Abstract

Diabetic foot infection (DFI) is a common complication of diabetes, most frequently caused by Staphylococcus aureus. Green tea contains antibacterial compounds and may serve as a potential supportive therapy for DFI. This study aimed to develop a spray gel formulation containing green tea ethanol extract and evaluate its antibacterial activity against S. aureus. The extract was obtained using 96% ethanol through the reflux method and subsequently tested for antibacterial activity using the agar well diffusion method. The extract was incorporated into a spray gel formulation with Viscolam MAC 10 as the gelling agent. The resulting spray gels were evaluated for their physical properties and antibacterial activity. Green tea extract demonstrated antibacterial activity against S. aureus with a minimum inhibitory concentration (MIC) of 0.1%. Furthermore, the ethanol extract was successfully formulated into a spray gel using 5% Viscolam MAC 10, meeting quality requirements in terms of organoleptic properties, pH, viscosity, spray pattern, spray weight, drying time, and adhesion time. Formulations containing 0.75% and 1% GTE exhibited potent antibacterial activity against S. aureus. In conclusion, a green tea–based spray gel formulation with good physical characteristics and potent antibacterial activity has been successfully developed.
Network Pharmacology-Guided Identification of Antiaging Targets of Lavandula Flower Bioactives Using LC–MS/MS and Molecular Simulation Approaches Syafnir, Livia; Fajarwati, Kania; Faizal, Ibnu Dharsono; Fakih, Taufik Muhammad
MPI (Media Pharmaceutica Indonesiana) Vol. 8 No. 1 (2026): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v8i1.8597

Abstract

Lavandula flowers are widely used in cosmetic and dermatological formulations, yet the molecular basis of their antiaging activity remains incompletely understood. This study aimed to elucidate the antiaging potential of lavandula flower bioactives through LC–MS/MS-based metabolite profiling integrated with network pharmacology and molecular docking analysis. Metabolites were characterized using LC–MS/MS and annotated based on accurate mass and fragmentation patterns. Predicted targets of selected metabolites were obtained using in silico target prediction and intersected with antiaging-related genes to construct protein–protein interaction networks and identify key regulatory pathways. Molecular docking was performed to evaluate binding affinity and interaction modes between prioritized metabolites against JAK2. LC–MS/MS analysis revealed a diverse chemical profile dominated by carveol (16.12%), methylumbelliferone (8.77%), camphor (3.97%), and two late-eluting high-molecular-weight metabolites contributing 29.86% and 35.36% of the total peak area. Network pharmacology highlighted convergence on kinase-driven signaling, extracellular matrix regulation, inflammatory response, and oxidative stress pathways relevant to skin aging. The docking results against JAK2 showed that the substituted pyridin-4-ol derivative exhibited the strongest affinity among Lavandula metabolites (ΔG = −8.81 kcal/mol), followed by the piperidinyl-substituted trienone (ΔG = −7.92 kcal/mol), while methylumbelliferone (ΔG = −5.93 kcal/ mol) and ferulic acid (ΔG = −5.53 kcal/mol) displayed moderate binding. Lavandula flower bioactives exhibit antiaging potential through multitarget modulation of signaling and matrix-associated proteins, supported by quantitative metabolite profiling and docking-validated target engagement.
Co-Authors Abdurrasyid Fadhlurrahim Adinda Fitri Salsabila Ainul Fatihah Halim Aqila Dliya Zhafira Delvinie Angelia Kusdianty Dhiyaa Ramadina Ismaila Putri Djaelani Efrida, Delfiana Aura Eky Bagus Wahyudi Erlisa Irawati Putri Fairuz Rifdah Permanasari Faizal, Ibnu Dharsono Fajarwati, Kania Fakhrul Akbar Arrahim Faqih Radina G.C. Eka Darma Geofanny Mozataufika Gita Cahya Eka Darma Halim, Ainul Fatihah Indra Topik Maulana Inge Aprianti Kiki Mulkiya Kiki Mulkiya Kiki Mulkiya Y Kiki Mulkiya Yuliawati Livi Kharisma Wibawa Lulu Mumtaz Lyan Nurlianti Lutfiah Mentari Luthfika Dewi Meytha Putri Dewanty Miaranti Tia Azhariani Mohammad Ihsan Abdurrozak Muhammad Daffa Adilah Muhammad Fadhil Safari Muhammad Ichsan Nurfahmi Mulkiya, Kiki Nola Nurmala Nur'andhini Putri, Clarisa Ananda Radina, Faqih Raihan Tresna Munggaran Ratih Aryani, Ratih Renata Jilan Azzahra Sonjaya Reza Abdul Kodir Rifa Safira Rizza F. Nurasyfa Robby Prayitno Salma Sadilla Salma Sayyidatunnisa salsabila soedradjat Sani Ega Priani Satyawati Setianty, Tia Nur Siska Aulia Sri P. Fitraningsih Sri Peni Fitrianingsih Sri Puan Hanum Tasya Luthfiyyah Taufik Muhammad Fakih Thyazen Abdo Hizam Alhakimi Via Pujiah Vinda Maharani Patricia Wini Dwiyunianti Yani Lukmayani