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All Journal CHEMPUBLISH JOURNAL Jurnal Kartika Kimia
Sowe, Momodou Salieu
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education

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PENGARUH METODE MASERASI DAN SOKHLASI TERHADAP KANDUNGAN SENYAWA ANTIOKSIDAN DAUN Pluchea indica L. DENGAN METODE LC-MS Afidatul Muadifah; Tilarso, Dara Pranidya; Sowe, Momodou Salieu; Tarigan, Indra Lasmana; Ngibad, Khoirul; Yuliantari, Sonia Devi
Chempublish Journal Vol. 8 No. 2 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i2.36869

Abstract

Pluchea indica L. is a plant have some secondary metabolite compounds namely flavonoids, alkaloids, tannins, saponins, terpenoids, and phenols that have antioxidants activity. The purpose of this study was to compare the content of antioxidant compounds analyzed using LC-MS and determine the relationship of antioxidant activity through the DPPH test on P. indica leaves extracted by maceration and soxhlation. The extracts from maceration and soxhlation of P. indica leaves were analyzed using LC-MS to determine the composition of the compounds contained therein then continued with the antioxidant activity test using the DPPH method. In the antioxidant activity test using DPPH, each extract was made 3 variations of concentration, namely 10 ppm, 50 ppm, and 100 ppm, and measured based on the absorbance of DPPH at a wavelength of 515 nm using a UV-vis spectrometer. The results of analysis using LC-MS on macerated extracts of P. indica leaves are 112 compounds consisting of flavonoids 72.4841%, phenols 9.00625%, terpenoids 6.11827%, alkaloids 6.99075%, tannins 2.2256%, and saponins 2.04458%. The Soxhlet extraction contained 116 compounds consisting of flavonoids 67.14345%, phenols 8.95854%, terpenoids 13.82165%, alkaloids 5.35637%, tannins 2.53305%, and saponins 0.2969%. The results of the antioxidant activity test using DPPH on maceration extracts have an IC50 value of 76.7576 and soxhlation 62.580 ppm. Both maceration and soxhlation extracts of P. indica leaves contain compounds that have high antioxidant potential and have good antioxidant activity, namely in the strong antioxidant category. However, the soxhlation extract has more compounds and a lower IC50 value. Thus, the more antioxidant compounds contained in an extract, the lower the IC50 value so that the better the antioxidant activity.
Comparative Study of Macerated and Soxhlet-Extracted Moringa Oleifera Leaf Extracts: LC-MS-Based Metabolomic Profiling, Antioxidant Activity, and In Silico Target Prediction Muadifah, Afidatul; Sulastri, Sulastri; Sowe, Momodou Salieu; Lintang, Anggun; Warni, Tri
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.36870

Abstract

Moringa leaves (Moringa oleifera L.) are rich in secondary metabolites such as flavonoids, alkaloids, tannins, saponins, and terpenoids, which function as natural antioxidants. This study aimed to analyze the metabolite profile of M. oleifera leaf extracts obtained through two extraction techniques using LC-MS, evaluate their antioxidant activity via the DPPH assay, and predict the interaction between NADPH oxidase (as a receptor) and key plant-derived compounds through molecular docking. LC-MS results indicated that the maceration method yielded 101 secondary metabolites, with flavonoid derivatives comprising 70.99% of the extract, dominated by five key compounds including Kaempferol 3-O-robinobioside and Luteolin-7-glucoside. In contrast, the Soxhlet method resulted in 83 identified compounds, with a higher proportion of flavonoids (75.61%), and prominent compounds including quercetin-3-O-glucoside and Kaempferol 3-(6G-malonylneohesperidoside). Antioxidant testing with DPPH at concentrations of 10, 50, and 100 ppm revealed the Soxhlet extract had a stronger activity (IC₅₀ = 14.328 ppm) compared to the macerated extract (IC₅₀ = 32.092 ppm), with statistically significant differences (p < 0.05). Molecular docking demonstrated that Kaempferol 3-(6G-malonylneohesperidoside) exhibited the strongest binding affinity to NADPH oxidase (-10.1 kcal/mol), followed by other flavonoid derivatives. These findings underscore the antioxidant potential of M. oleifera, particularly from Soxhlet extraction, and suggest its promising application in pharmaceutical development as a natural antioxidant source.
Secondary Metabolites of The Fabaceae Plant Family A Review of Extraction Methods, Molecules and Bioactivity Sowe, Momodou Salieu; Etonihu, Anayo Christian; Tarigan, Indra Lasmana; Muadifah, Afidatul
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.36964

Abstract

Traditional medicine helps manage and treat various illnesses worldwide, particularly in Africa and Asia. For example, Traditional Indonesian Medicine (Jamu), Traditional Indian Medicine (Ayurveda), and Traditional African Medicine use a range of indigenous herbs to treat health conditions like fevers, malaria, diarrhea, diabetes mellitus, Asthma, and hypertension. Alkaloids, flavonoids, saponins, terpenoids, and polyphenols are bioactive substances with anti-inflammatory, antibacterial, and antioxidant effects in plants. The Fabaceae family consists of flowering plants, peas, legumes, woody trees, and shrubs. Fabaceae plants are widely used across Africa and Asia for traditional medicinal purposes. In addition, Fabaceae plants have significant economic value as a source of wood for the timber industry. This review highlights extraction methods, isolated molecules, and antimicrobial and antioxidant activity of Fabaceae plants found in Africa and Asia. We also detailed secondary metabolite molecules extracted from Fabaceae plant body parts and their identified bioactivities. This review compiles scientific information on the phytochemicals and pharmacological properties of plants in the Fabaceae family that could be useful for future drug candidate investigations.
Uji Efektivitas Antioksidan Moisturizer Ekstrak Daun Randu (Ceiba Pentandra (L.) Gaertn.) dengan Metode DPPH Muadifah, Afidatul; Tilarso, Dara Pranidya; Putri, Amalia Eka; Sowe, Momodou Salieu
Chempublish Journal Vol. 8 No. 1 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i1.33234

Abstract

Dry skin can often cause psychological discomfort. Moisturizer is a preparation that is used to improve dry skin. Kapok plant (Ceiba pentandra L. Gaertn) can be used as an active ingredient of moisturizer and can be used as a treatment, where the chemical content in kapok leaves are flavonoids, saponins, alkaloids, phenolic compounds, tannins and terpenoids as antioxidants. This study aims to determine the antioxidant activity of kapok leaf extract and moisturizer preparations with DPPH method using UV-Vis spectrophotometer, physical quality of preparations and antioxidant activity of moisturizer preparations using DPPH method. Kapok leaf extract was made in various concentrations, namely 20 ppm, 40 ppm and 60 ppm. The IC50 value of kapok leaf extract is 67.4007 ppm which has strong antioxidant activity. Then variations in the concentration of kapok leaf extract were put into the formulation of moisturizer preparations, the results of moisturizer preparations of kapok leaf extract and vitamin C met the requirements of the physical quality test. The moisturizer preparation was continued and tested for antioxidant activity using the DPPH method with ascorbic acid as a comparison. The results of the IC50 value on the kapuk leaf extract moisturizer preparation are 110.065 ppm which is classified as having moderate antioxidant activity and while the vitamin C moisturizer preparation is 9.8417 ppm which is classified as having very strong antioxidant activity.
Co-Authors Afidatul Muadifah Dhian Eka Wijaya Etonihu, Anayo Christian Indra Lasmana Tarigan Lintang, Anggun Muadifah, Afidatul Ngibad, Khoirul Puspitasari, Ratih Dyah Putri, Amalia Eka Ramadhan, Iham Ifandi Sinurat, Julius Alvin Novensius Sulastri Sulastri Tilarso, Dara Pranidya Warni, Tri Yuliantari, Sonia Devi