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All Journal Majalah Farmaseutik Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati JFM (Jurnal Farmasi Malahayati) Jurnal Pengabdian Farmasi Malahayati (JPFM) Jurnal Ilmiah Wahana Pendidikan Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Pengabdian Pada Masyarakat Journal of World Future Medicine, Health and Nursing Science: Indonesian Journal of Science
Nurkhalika, Rachmi
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IDENTIFIKASI INTERAKSI OBAT POTENSIAL PADA PERESEPAN PASIEN HIPERTENSI DI PUSKESMAS HAJI PEMANGGILAN Lestari, Yovita Endah; Nurkhalika, Rachmi; Samor, Vania Amanda
JFM (Jurnal Farmasi Malahayati) Vol 7, No 2 (2024)
Publisher : Jurnal Farmasi Malahayati (JFM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jfm.v7i2.16610

Abstract

Interaksi obat menjadi salah satu permasalahan dalam peresepan yang memiliki lebih dari lima macam obat didalam satu resep. Hal ini bisa menyebabkan obat yang diresepkan tidak dapat bekerja secara optimal. Pasien dengan penyakit hipertensi mempunyai resiko yang tinggi untuk mengalami interaksi obat. Hal ini berhubungan dengan komplikasi yang sering terjadi pada pasien hipertensi. Penelitian ini dilakukan secara non eksperimental dengan rancangan penelitian deskriptif. Pengambilan data secara retrospektif dari data rekam medik dan resep pasien hipertensi pada bulan November 2022 – Januari 2023 di Puskesmas Haji Pemanggilan, Lampung Tengah. Hasil penelitian menunjukkan karateristik pasien terbanyak pada jenis kelamin perempuan sebesar 111 (52,4%)  dan usia lansia (> 50 tahun) sebesar 133 (63,4%). Resep yang memiliki potensi mengalami interaksi obat sebanyak 90 resep (42,8%)  dari 210 resep. Gambaran pada potensi interaksi obat terbanyak masuk kedalam kategori moderate sebanyak 61 kasus (42,8%) dan terdapat 76 kasus (84,5%) interaksi obat berdasarkan mekanisme farmakodinamik.
PENGENALAN APOTEKER CILIK (APOCIL) SISWA SDN 17 GEDONG TATAAN KABUPATEN PESAWARAN Syafitri, Shela; Nurkhalika, Rachmi; Larasati, Shela Ajeng; S, Septi Nurhaliza
Jurnal Pengabdian Farmasi Malahayati (JPFM) Vol 6, No 2 (2023)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jpfm.v6i2.13636

Abstract

Apoteker cilik merupakan sebuah gagasan sebagai upaya dalam membangkitkan eksistensi profesi apoteker yang lebih nyata. Penjelasan tersebut menjadi dasar penting diadakannya branding profesi apoteker sejak dini terutama dikalangan siswa sekolah dasar. Kegiatan ini berupa edukasi apoteker cilik terkait penggunaan obat yang mengangkat tema bersama apoteker mengenali obat sejak usia dini, sehingga sasaran kegiatan ini bagi para siswa SD disejumlah sekolah yang telah dipilih. Tujuan dari sosialisasi ini yakni untuk dapat memberikan pemahaman dan pengenalan akan Apoteker Cilik (Apocil) kepada siswa SDN 17 Gedong Tataan Kabupaten Pesawaran juga untuk menambah pengetahuan siswa mengenai macam-macam sediaan obat dan cara penanganan obat yang baik dan benar. Metode yang digunakan yaitu metode ceramah dengan memaparkan tentang pengenalan apoteker, apoteker cilik dan pengenalan obat-obat pada anak-anak dan diperoleh hasil yaitu terdapat peningkatan yang signifikan (p-value 0,000) antara pengetahuan sebelum dilakukan penyuluhan (Pre-Test) didapat rata – rata sebesar 54,10 dengan Standar Deviasi (SD) 17.158. Pada saat setelah dilakukan penyuluhan (Post-Test) diperoleh rata – rata sebesar 97,75 dengan Standar Deviasi (SD) 5.495.
STUDI BIOINFORMATIKA KONSTITUEN MAYOR Centella asiatica DALAM MEMODULASI KECEMASAN DAN DEPRESI Samor, Vania Amanda; Nurkhalika, Rachmi; Lestari, Yovita Endah; Husein, Saddam
Jurnal Medika Malahayati Vol 7, No 4 (2023): Volume 7 Nomor 4
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v7i4.12752

Abstract

Konstituen mayor Centella asiatica (CA) memiliki banyak manfaat farmakologis dan diduga dapat mempengaruhi kondisi kecemasan dan depresi, namun jalur persinyalan molekuler belum sepenuhnya dipahami. Studi ini bertujuan untuk mengeksplorasi target potensial mekanisme konstituen mayor melalui pendekatan bioinformatika. Prediksi protein yang dimodulasi oleh konstituen mayor CA dilakukan dengan SwissTargetPrediction 2019 dan STITCH 5.0 yang kemudian dilakukan analisis irisan dengan gen depresi dan kecemasan yang diperoleh dari GeneCards. Analisis interaksi protein-protein dilakukan dengan STRING 11.5 dan ditelusuri ketermungkinan jalur persinyalan gen dengan WebGestalt 2019. Melalui studi diketahui bahwa konstituen mayor CA (asiaticoside) berpotensi memodulasi kondisi kecemasan dan depresi melalui jalur persinyalan BDNF. Studi lebih lanjut diperlukan untuk mengeksplorasi potensi terapi konstituen mayor CA dengan model depresi dan kecemasan.
CASE REPORT: EPIGASTRIC PAIN Mende, Juniarto; Elvionita, Cindy; Nurkhalika, Rachmi; Taborat, Miranda; Jane Sanggel, Mariyo; Pasaribu, Ezra
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 1 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i1.990

Abstract

A male patient (76 years) complained of heartburn since last night, pain scale of 7 to 8 (very disturbing). Examination of vital signs found increased blood pressure, and the patient's condition was still experiencing abdominal pain and or heart ulcers. The early admission diagnosis was epigastric pain. Gastroscopy examination revealed multiple nodules on the border of the corpus and fundus, antral erosive gastritis and hypotonia pylori. On anatomic pathological study, gastric mucosa results were obtained: Granulative chronic inflammation, degenerative proliferative. Investigations showed a decrease in hemoglobin, hematocrit, and sodium levels. The main diagnosis is anthral erosive gastritis. Secondary diagnoses are hypotonia pylori, hypertension, hyperthyroidism and hyponatremia. Therapy given cliad (clidium/chlordiazepoxide) 1 tab/8 hours, infusion of 3% NaCl 100 mL/24 hours, alprazolam one tab/24 hours, injection of pantoprazole 1 amp/24 hours, rebamipide one tab/8 hours, amlodipine one tab /24 hours, thyrozol ½ tab/24 hours, amitryptiline one tab/12 and lioresal 10 mg/12 hours. Education is provided, such as avoiding and changing eating or drinking patterns like spicy foods and coffee drinks. Eat smaller meals more often than 2 or 3 large meals. Pharmacists play an important role in monitoring heartburn pain scales and sodium levels.
Trend Antimicrobial Resistance Patterns in Patients with Septic at The Intensive Care Unit : A Five years Retrospective Study Nurkhalika, Rachmi; Sari, Ika Puspita; Nuryastuti, Titik
Majalah Farmaseutik Vol 19, No 4 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i4.76105

Abstract

Sepsis is a potentially fatal medical condition characterized by decreased organ function, lower mortality, and increased resistance. Antibiotic resistance can develop as a result of overuse and inappropriate indications. The WHO AWaRe classification categorizes antibiotics based on their potency and potential impact on antimicrobial multidrug resistance (AMR). This classification will make it easier to organize and select antibiotics, as well as reduce the occurrence of resistance. The goal of this study was to identify the pattern of bacterial resistance to antibiotics in septic patients from 2017-2021, as categorized by the WHO AWaRe classification. This study used a descriptive, non-experimental design and was carried out at the UGM Academic Hospital. The information was collected retrospectively from the medical records of patients diagnosed with sepsis in the intensive care unit and treated between January 2017-December 2021, who fulfilled the inclusion and exclusion criteria. According to the resistance pattern between 2017-2021, the gram-negative bacteria that caused sepsis were 55 isolates. The most common bacteria causing sepsis were Pseudomonas aeruginosa and Acinetobacter baumannii. When compared to antibiotics in the reserve category (meropenem and vancomycin), antibiotics in the access category (penicillin and/or beta-lactam inhibitors and first-generation cephalosporins), experienced the most resistance.
The Role of artificial intelligence in the Development of Innovative Drugs and Therapies for the Future of Health Judijanto, Loso; Nurkhalika, Rachmi; Anurogo, Dito; Andari, Soetji; Muntasir, Muntasir
Journal of World Future Medicine, Health and Nursing Vol. 2 No. 1 (2024)
Publisher : Yayasan Pendidikan Islam Daarut Thufulah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v2i1.666

Abstract

The development of artificial intelligence (AI) technology has made significant contributions to the healthcare field, especially in the development of innovative drugs and therapies. The combination of computational sophistication and AI data analysis has enabled researchers to identify complex patterns in biomedical data, accelerate drug discovery time, and facilitate therapy personalization. This research aims to explore the important role of AI in drug development and innovative therapies to create a better future of healthcare. This involves an analysis of various AI methods and techniques used in drug development as well as the application of AI in personalized therapy for society. This study was conducted by conducting a literature review and analyzing the latest research and developments in the application of AI in drug and therapy development. The results showed that AI has opened new opportunities in drug development by accelerating the process of drug target identification, molecular simulation, and optimization of clinical trials. Meanwhile, in therapeutics, AI enables better personalization through analysis of patient clinical data and prediction of response to specific treatments. This opens up the potential for the development of more effective and targeted therapies. With the development of AI technology, the development of innovative drugs and therapies has become more efficient and effective. The application of AI in healthcare offers the potential to create a more personalized, precise, and comprehensive healthcare future. The collaboration between medical science and AI technology will lead to more innovative and affordable health solutions for the people. Thus, the role of AI in the development of innovative drugs and therapies is recognized as one of the key pillars in creating a better future of healthcare.
Edukasi Peningkatan Kesadaran Penyakit Menular Seksual pada Warga Binaan Lembaga Pemasyarakatan Perempuan Kelas IIA Way Hui Bandar Lampung Nurkhalika, Rachmi; Samor, Vania Amanda; Lestari, Yovita Endah; Husein, Saddam
Jurnal Pengabdian Pada Masyarakat Vol 9 No 2 (2024): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v9i2.725

Abstract

Warga binaan pada lembaga pemasyarakatan merupakan kelompok yang sangat rentan terhadap berbagai permasalahan, mulai dari permasalahan sosial, fisik, maupun mental. Salah satu bahaya kesehatan yang kerap terjadi di lembaga pemasyarakatan adalah bahaya terinfeksi penyakit menular seksual (PMS), hal ini berkaitan dengan riwayat terdahulu warga binaan terkait aktivitas seksualnya. Kejadian penyimpangan seksual juga tidak dapat dihindari dan meningkatkan resiko terjadinya PMS. Sehingga kegiatan ini ditujukan untuk mengedukasi warga binaan Lapas Kelas IIA Way Hui Bandar Lampung guna meningkatkan pengetahuan mereka terkait PMS. Metode edukasi dilakukan dengan ceramah dan diskusi. Peserta berjumlah 62 orang dengan demografi yang berbeda-beda dan sejumlah 13% warga binaan memiliki riwayat PMS. Melalui kegiatan edukasi diperoleh perubahan yang signifikan terkait tingkat pengetahuan warga binaan dari mayoritas mendapat skor 5 (24%) menjadi 10 (61%) dengan nilai p0.00<0.05. Melalui hasil dapat disimpulkan bahwa intervensi edukasi mampu meningkatkan pengetahuan warga binaan terhadap masalah PMS. Inmates in correctional institutions are vulnerable to the wide range social, physical, and mental health issues. One of the health risks that frequently happens in correctional institutions is the risk of sexually transmitted infections (STIs), which is tied to the inmates' prior history of sexual behavior. Sexual aberrations are unavoidable and raise the danger of STIs. As a result, the aim of this program is to educate women inmates of the Way Hui Class IIA Correctional Facility in Bandar Lampung about PMS. Lectures and thorough discussions were used as the method. There were 62 participants from various demographics, with 13% of the inmates having history of STIs. Significant changes in the inmates’ level of knowledge were obtained after education intervention from the majority receiving a score of 5 (24%) to 10 (61%) with a value of p 0.00<0.05. Based on the findings, it can be concluded that given educational intervention can improve inmates’ knowledge of STIs.
Hubungan Peran Keluarga Terhadap Tingkat Kepatuhan Pengobatan Pasien Hipertensi Di Puskesmas X Lampung Tengah Sari, Cicih Ratna; Nurkhalika, Rachmi; Nofita, Nofita
Jurnal Ilmiah Wahana Pendidikan Vol 10 No 20 (2024): Jurnal Ilmiah Wahana Pendidikan
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.14271684

Abstract

The prevalence of hypertension is increasing worldwide, according to the World Health Organization (WHO), but high blood pressure is still a health problem for a relatively large population. In 2015, there were around 1.13 billion people suffering from high blood pressure. Cases of hypertension are also increasing every year; it is estimated that in 2025, around 1.5 billion people will suffer from hypertension and around 9.4 million people will die from hypertension and its complications every year. The purpose of this study was to determine the relationship between the role of the family and the level of compliance of hypertensive patients in consuming anti-hypertensive drugs at the X Health Center in Central Lampung. This research method is a non-experimental study with a cross-sectional research design. The results showed that physical activity had a p-value of 0.000 (<0.05), which means it has a relationship with adherence to taking medication, and the role of the family had a p-value of 0.048 (<0.05), meaning there is a positive relationship between the role of the family and adherence to taking medication. significant.
Tingkat Pengetahuan Dan Kesadaran Mahasiswa Klaster Non-Kesehatan Universitas Malahayati Bandar Lampung Terhadap Penggunaan Antibiotik Nurhayati, Dwy; Samor, Vania Amanda; Nurkhalika, Rachmi
Jurnal Ilmiah Wahana Pendidikan Vol 10 No 22 (2024): Jurnal Ilmiah Wahana Pendidikan
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.14562288

Abstract

Antibiotic are overused and protected can make individual more susceptible to disease, leading to more complicated treatment due to development of bacterial antibiotic rasistancy. Lack of students understanding of antibiotics can increase the incidence of antibiotic resistancy because students are a source of information for society. Relying on that, this study aim to determine level of knowledge and awareness towards antibiotics resistancy and their correlation to demographic status of non-health cluster students at Universitas Malahayati Bandar Lampung. The study was conducted cross-sectionally, with descriptive and analysis with SPSS. Based on the results health cluster students at the University of Malahayati Bandar Lampung had a good level of knowledge (62%) and awareness (74%) of the antibiotics use, even though they did not study health, science non-health students have a sofficient level of knowledge. The Chi-square analysis showed that there was no relationship (p≥0.05) between students' demographic characteristics (age, gender and faculty) and the level of knowledge and awareness.
Hubungan Kepatuhan Penggunaan Antidiabetik Oral Pada Pasien Diabetes Mellitus Tipe II Terhadap Kualitas Hidup Pasien Di Rumah Sakit Harapan Bunda Dewi, Fransiska Ariana; Nurkhalika, Rachmi; Saputri, Gusti Ayu Rai
Jurnal Ilmiah Wahana Pendidikan Vol 10 No 22 (2024): Jurnal Ilmiah Wahana Pendidikan
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.14568844

Abstract

Type 2 Diabetes Mellitus (DM) is a serious and chronic disease characterized by high blood glucose levels. The successful management of DM is influenced by several factors, including patient adherence in taking medication, which in turn can reduce morbidity and mortality and improve the patient's quality of life. The purpose of this study was to determine the relationship between adherence to the use of oral antidiabetics in patients with type 2 diabetes mellitus at Harapan Bunda Hospital, Lampung Tengah. This research method is a non-experimental study with a cross-sectional research design. The results of the study obtained a compliance p-value of 0.001 (<0.05) which means there is a strong comelation between medical adhenence and patients quality of life.
Co-Authors Andari, Soetji Clarista, Helaria Eren Dewi, Fransiska Ariana Dito Anurogo, Dito Elvionita, Cindy Ika Puspita Sari Istikomah, Nabila Judijanto, Loso Juniarto Mende Larasati, Shela Ajeng Lestari, Yovita Endah Mariyo Jane Sanggel Muntasir, Muntasir Nofita, Nofita Nurhayati, Dwy Oktavia, Friska Pasaribu, Ezra Putra, Muhammad Satria Mandala S, Septi Nurhaliza Saddam Husein, Saddam Sakinah Sakinah Samor, Vania Amanda Saputri, Gusti Ayu Rai Sari, Cicih Ratna Sejati, Gusti Purnama Syafitri, Shela Taborat, Miranda Thursina, Cut Syarifa Tiana, Helda Titik Nuryastuti Wijaya, I Gusti Ngurah Satria