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All Journal Jurnal Biomedika dan Kesehatan Jurnal Indonesia Sosial Sains
THABIT, JIHAN SAMIRA
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Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences

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Perbandingan Respons Antibodi setelah Vaksinasi COVID-19 antara Individu dengan dan tanpa Komorbiditas Bella, Isa; Khariri, Khariri; Hartanti, Monica Dwi; Sisca, Sisca; Thabit, Jihan Samira; Effendi, Ida; Devita, Arleen; Robertus, Thomas
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Background Vaccination is a Crucial public health strategy for reducing the transmission of viral infections and protecting populations from severe illness. COVID-19 vaccines have played a significant role in decreasing the incidence and mortality rates linked to the virus. However, immune responses to vaccination may differ among individuals, especially those with comorbidies that could alter immune function. This study aimed to compare antibody responses in adults with and without comorbidities, 18 months after receiving the COVID-19 vaccine. Methods This was a cohort study with two sampling time points: before vaccination and 18 months after vaccination. The study was conducted in Yogyakarta, Indonesia. Data were collected through self-administered questionnaires and venous blood sampling. Antibody titers were measured to evaluate the humoral immune response in participants with and without comorbidities. Results Before vaccination, the highest proportion of positive antibody titers was found among females (40.2%), individuals aged 18–44 years (44.7%), those with a senior high school education (48.1%), and individuals with normal body weight (44.3%). A Comparison of antibody levels at baseline and 18 months after vaccination between groups with and without comorbidities showed no statistically significant difference, with a p-value of 0.992.   Conclusions Although no significant difference was found in antibody responses between individuals with and without comorbidities, comorbid conditions may still influence immune response depending on their type and severity. These findings suggest the need for further research to examine the specific effects of various comorbidities on long-term vaccine-induced immunity.
Exploring the Relationship Between Sod1, 2 And 3 Gene Polymorphisms With Post-Covid19 Symptoms Thabit, Jihan Samira; Sisca, Sisca; Hartanti, Monica Dwi; Prasetyaningsih, Noviani; Kogoya, Alvionita; Devita, Arleen; Bela, Isa; Effendi, Ida
Jurnal Indonesia Sosial Sains Vol. 5 No. 04 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i04.1097

Abstract

The coronavirus disease 19 (COVID-19) has become a challenge for the media world. Even though they have been declared cured, some Covid-19 survivors still have health complaints. Abnormal symptoms, signs, or clinical parameters that persist two weeks or more after the onset of COVID-19 and do not return to their initial healthy state are potentially considered long-term effects of the disease. Although such changes are primarily reported in people with severe and critical illness, lasting effects also occur in individuals with mild infections that do not require hospitalization. This study aims to explore the role of antioxidants on the pathogenesis of Covid19 and its relationship with SOD1, 2 and 3 genomic variations. Getting alternative biomarkers for long covid19 detection. Research Method: The research sample is blood and questionnaires that will be taken from respondents affected by Covid19 a maximum of 6 months before data collection is held. Furthermore, DNA isolation, DNA amplification, cutting with restriction enzymes, and DNA band documentation with gel electrophoresis will be carried out. Symptoms related to systemic are the most common symptoms found in respondents with Long Covid19. A total of 8 respondents had systemic related symptoms, namely weakness, lethargy and sweating, while skin-related complaints were found in three respondents and one respondent had lung-related complaints. The average SOD activity value of respondents was 2.19 U/ml. In this study, more symptoms of long COVID-19 were found associated with systemic and cardiovascular symptoms. The complaints were not differentiated by the sex of the respondents. The output draft will be processed immediately after getting other results.
Co-Authors Bela, Isa Bella, Isa Devita, Arleen Effendi, Ida Khariri Khariri Kogoya, Alvionita Monica Dwi Hartanti, Monica Dwi Prasetyaningsih, Noviani Robertus, Thomas Sisca Sisca, Sisca