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All Journal Jurnal Gizi dan Pangan Jurnal Kedokteran Syiah Kuala Jurnal Farmasi Klinik Indonesia The Indonesian Journal of Occupational Safety and Health Sari Pediatri Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan BERNAS: Jurnal Pengabdian Kepada Masyarakat Cermin Dunia Kedokteran Quality : Jurnal Kesehatan The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Ryan Herardi
Fakultas Kedokteran Universitas Pembangunan Nasional Veteran Jakarta
Religion Agriculture, Biological Sciences & Forestry Humanities Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Hepatoprotective Effect of Parijoto Fruit Extract (Medinilla speciosa Blume) on Male Mice Fed with High-Fat Diet Nabila, Inasa; Thadeus, Maria Selvester; Herardi, Ryan
Jurnal Gizi dan Pangan Vol. 18 No. 1 (2023)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25182/jgp.2023.18.1.21-30

Abstract

This study aims to determine the effectiveness of parijoto fruit extract (Medinilla speciosa Blume) in improving the condition of fatty liver in male balb/c mice (Mus musculus L.) fed with a high-fat diet. Thirty male balb/c mice weighing 20 to 30 g were randomly divided into six groups, i.e: 1) Standard feed and Carboxymethyl Cellulose Sodium or CMC-Na 0.5% (K1); 2) High-fat diet and CMC-Na 0.5% (K2); 3) High-fat diet and simvastatin 0.026 mg/day (K3); 4) High-fat diet and parijoto fruit extract 5.6 mg/20 g BW (P1); 5) High-fat diet and parijoto fruit extract 8.4 mg/20 g BW (P2); 6) High-fat diet and parijoto fruit extract 11.2 mg/20 g BW (P3). Standard feed, high-fat diet, simvastatin, and parijoto fruit extract were administered for 56 days. On the 57th day, the total of 30 mice were terminated and the livers were then removed for H&E staining histopathological slides. Data on the degree of fatty liver on histopathological slides were collected and analyzed using the Kruskal-Wallis test and followed by the Mann-Whitney test. The histopathological analysis showed Medinilla speciosa Blume extract at a dose of 5.6 mg/20 g BW in group P1 prevent the steatosis degree compared to high-fat feed mice in group K2 (p>0.05). Parijoto fruit extract could act as the potential treatment for fatty liver.
Validity and Reliability of the Indonesian Short Form-Leeds Dyspepsia Questionnaire (SF-LDQ) Prasetya, Ignatius Bima; Anas, Desriyadi; Al-Idrus, Syarifah Nur E’zzati; Simatupang, Flouria Stefanny; Herardi, Ryan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025212-218

Abstract

Background: The severity of dyspepsia symptoms is often overlooked despite established definitions and diagnostic criteria. The Short Form-Leeds Dyspepsia Questionnaire (SF-LDQ) is a validated English-language tool designed to evaluate these symptoms. This research focuses on creating and validating an Indonesian version of the SF-LDQ.Methods: The SF-LDQ was translated into Indonesian following standard procedures, including forward-backward translation, cross-checking, and pilot testing. Unselected patients from Dabo Regional Hospital and Dabo Lama Community Health Center (Pusat Kesehatan Masyarakat, or Puskesmas) completed a questionnaire upon enrollment and again after three days via direct follow-up or blinded phone interviews. Reliability was measured through internal consistency (Cronbach’s α) and test-retest analysis (Spearman’s correlation). Meanwhile, validity was evaluated by comparing SF-LDQ scores with Rome IV Criteria-based diagnoses from blinded physicians and analyzing diagnostic performance with ROC curves.Results: A total of 204 participants were included. The Indonesian SF-LDQ exhibited excellent reliability, with Cronbach’s α of 0.875 and Spearman’s correlation of 0.984 (p 0.001). Validity analysis demonstrated an AUC of 0.946 (p 0.001, 95% CI = 0.913–0.978). A cut-off score of 6.5 yielded 87.0% sensitivity and 93.3% specificity.Conclusion: The Indonesian SF-LDQ is a dependable and valid tool for evaluating the frequency and severity of dyspeptic symptoms.
Co-Authors Al-Idrus, Syarifah Nur E’zzati Anas, Desriyadi Annisa Farida Muti Ari Fahrial Syam Augisna, Fadhilah Qostholani Ayu, Laily Afika Basuki Supartono Catarina Budyono, Catarina Citra Ayu Aprilia Erna Harfiani Fatimah Azzahra Hany Yusmaini Haris Widita Hikmah Muktamiroh Ignatius Bima Prasetya, Ignatius Bima Lamya Hisyam Tamimi Lingga Etantyo Praditya Lisa Safira Maria Selvester Thadeus Marlina Dewiastuti, Marlina Mochammad Imron Awalludin Nabila, Inasa Nareswari Izzaturrahman Niniek Hardini Nugrahayu Widyawardani Pritha Maya Savitri Ria Maria Theresa Riezky Valentina Asteri Shahnaz Medina Simatupang, Flouria Stefanny Soroy Lardo Sri Wahyuningsih Subroto, Maruf Hari Tamimi, Lamya Hisyam Taufiq Pasiak