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All Journal Althea Medical Journal Acta Biochimica Indonesiana Cendana Medical Journal Journal of Comprehensive Science Blantika : Multidisciplinary Journal

Indriarini, Desi

Unknown Affiliation

Author-ID : 2187040

Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Electrical & Electronics Engineering Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Public Health

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UJI AKTIVITAS ANTI BAKTERI EKSTRAK ETANOL DAUN KEMANGI (Ocimum sanctum L.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus SECARA IN VITRO Ballo, Natasya Detami Sheline; Indriarini, Desi; Amat, Anita Lidesna Shinta Shinta
Cendana Medical Journal Vol 9 No 1 (2021): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Penyakit infeksi merupakan salah satu penyebab morbiditas dan mortalitas penduduk dunia yang menyebabkan penurunan kualitas hidup penduduk di negara berkembang maupun di negara maju. Salah satu agen penyebab infeksi adalah bakteri Staphylococcus aureus (S. aureus). Oleh sebab itu, dibutuhkan pengobatan terhadap infeksi yang disebabkan oleh Staphylococcus aureus dengan menggunakan antibiotik. Namun apabila penggunaan antibiotik tidak tepat maka akan menimbulkan resistensi antibiotik. Oleh sebab itu, diperlukan pengobatan alternatif lainnya yaitu pengobatan menggunakan tanaman herbal. Salah satu tumbuhan yang dapat digunakan sebagai tanaman obat adalah daun kemangi (Ocimum sanctum L.). Tujuan penelitian ini untuk mengetahui aktivitas antibakteri ekstrak daun kemangi terhadap pertumbuhan Staphylococcus aureus. Metode penelitian True experiment design dengan rancangan penelitian Posstest Only Control Group Design. Aktivitas antibakteri ekstrak etanol 70% daun kemangi diuji menggunakan metode dilusi cair. Sampel penelitian terdiri dari 9 kelompok perlakuan terdiri atas kontrol positif (sefazolin), kontrol negatif (aquades),ekstrak etanol 70% daun kemangi dengan konsentrasi 100%, 80%, 70%, 40%, 20%, 10%, dan 5% dengan tiga kali pengulangan. Hasil Uji Kolmogorov Smirnov menunjukkan p=0,194 yang berarti terdapat aktivitas antibakteri ekstrak etanol 70% daun kemangi terhadap bakteri Staphylococcus aureus. Kesimpulan dari penelitian ini ekstrak etanol 70% daun kemangi (Ocimum sanctum L.) memiliki aktivitas antibakteri terhadap Staphylococcus aureus dengan nilai Konsentrasi Hambat Minimum (KHM) dan Konsentrasi Bunuh Minimum (KBM) berturut-turut sebesar 80% dan 100%.

UJI AKTIVITAS EKSTRAK ETANOL DAUN KEMANGI (OCIMUM SANCTUM L.) TERHADAP PERTUMBUHAN BAKTERI ESCHERICHIA COLI SECARA IN VITRO Klau, Maria Luz Clarita; Indriarini, Desi; Nurina, Rr.Listyawati
Cendana Medical Journal Vol 9 No 1 (2021): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Penyakit infeksi masih menjadi permasalahan kesehatan bagi negara-negara di dunia. Salah satu mikroorganisme bakteri penyebab penyakit infeksi adalah Escherichia coli. Upaya pengobatan penyakit infeksi hinggga saat ini masih menggunakan antibiotik, namun penggunaan antibiotik dapat menimbulkan dampak resistensi antibiotik, juga efek samping di bidang kesehatan serta biaya kesehatan yang meningkat sehingga dapat digunakan alternatif lewat penggunaan tanaman herbal. Salah satu tanaman herbal yang dapat digunakan adalah kemangi. Tanaman ini mempunyai kandungan kimia diantaranya minyak atsiri, alkaloid, fenol, saponin, tanin, triterpenoid dan steroid yang beberapa diantaranya memiliki aktivitas antibakteri. Tujuan penelitian ini untuk menguji aktivitas antibakteri dari ekstrak etanol daun kemangi terhadap pertumbuhan bakteri Escherichia coli. Metode jenis penelitian yang digunakan adalah true experimental design dengan rancangan penelitian posttest only control group test. Pengujian aktivitas antibakteri dari ekstrak etanol daun kemangi menggunakan metode dilusi cair. Sampel penelitian terdiri dari kontrol positif siprofloksasin, kontrol negatif aquades, dan kelompok konsentrasi 100%, 80%, 60%, 40%, 20%, 10%, 5%, 2,5%, 1,25% dengan tiga kali pengulangan untuk setiap kelompok. Hasil pengujian tidak didapatkan adanya aktivitas antibakteri ekstrak etanol daun kemangi terhadap bakteri Escherichia coli pada hasil uji di setiap konsentrasi menunjukkan adanya pertumbuhan bakteri di setiap pengulangan dari konsentrasi 100%, 80%, 60%, 40%, 20%, 10%, 5%, 2,5% dan 1,25%. Kesimpulan dari penelitian ini di dapat bahwa ekstrak etanol daun kemangi (Ocimum sanctum L.) tidak memiliki aktivitas antibakteri terhadap bakteri Escherichia coli

HUBUNGAN TINGKAT KECACATAN DAN TINGKAT DEPRESI TERHADAP KUALITAS HIDUP PENDERITA KUSTA DI RUMAH SAKIT LEPRA DAMIAN LEWOLEBA Mukin, Yohanes Matius Demo; Buntoro, Ika Febianti; Indriarini, Desi; Setiono, Kresnawati Wahyu
Cendana Medical Journal Vol 10 No 2 (2022): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v10i2.9148

Background : Leprosy is a infectious disease caused by Mycobacterium leprae. Leprosy provides physical impact such as disability and psychosicial impact like depression that affect to quality of life leprosy patient. Objective : To know the correlation between disability and depression level with quality of life leprosy patient in Hospital of Leprosy Damian Lewoleba Methods : This research use observational analytical method with cross sectional approach and the sample consisted of 30 patients. Sampling technique used was total sampling. Result : The result of univaraite analysis obtained 63,3 % of leprosy patient with disability level 0, 16,7 % of leprosy patient with disability level 1 and 20,0 % leprosy patient with disability level 2. Also found 3,3 % leprosy patient not depressed, 63,4 % mild depression and 33,3 % moderate depression. For quality of life found 36,7 % good quality and 63,3 % poor quality. Data was analyzed using Spearman Rank test and obtained the value p = 0,008 and p = 0,019. Conclusion : There was a correlation between disability and depression level with quality of life leprosy patientd. The prevention of disability and mental therapy should be improved quality of life leprosy patient.

UJI AKTIVITAS ANTIBAKTERI AIR REBUSAN CAMPURAN BATANG SERAI, DAUN SIRIH DAN RIMPANG JAHE TERHADAP PERTUMBUHAN Escherichia coli Ginting, Aditya Karsa Imanuel; Indriarini, Desi; Setianingrum, Elisabeth; Amat, Anita Shinta
Cendana Medical Journal Vol 11 No 2 (2023): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v11i2.13892

Background: Diseases that caused by E. coli bacteria such as urinary tract infections, prostatitis, pelvic inflammation, infections of the lining of the brain in newborns and diarrhea or digestive tract infections. Treatment of this disease still uses antibiotics which over time will become resistant, with the expensive medical costs and the side effects that can be obtained later so it can be sought with alternative herbal plants such as lemongrass stem, betel leaf and ginger rhizome, which are some of them have antibacterial activity. Objectives: To test the antibacterial activity of mixture boiled water of lemongrass stem (Cymbopogan citratus), betel leaf (Piper betle) and ginger rhizome (Zingiber officinale) against the growth of Escherichia coli bacteria. Method: The type of research used is a true experimental design with research design used is a posttest only control group test. Testing the antibacterial activity of mixture boiled water of lemongrass stem, betel leaf and ginger rhizome using the liquid dilution method. The research sample consisted of ciprofloxacin as positive control, aquades as negative control, and concentration groups of 100%, 50%, 25%, 12.5%, `6.25%, 3.12%, 1.56% with three repetitions for each group. Result: Based on the results of bacterial testing with dilution method using the mixture boiled water of lemongrass stem, betel leaf and ginger rhizome, the minimum resist rate test results were obtained at concentration 100% and there was no minimum killing rate. Conclusion: The mixture boiled water of lemongrass stem, betel leaf and ginger rhizome did not have antibacterial activity against the growth of Escherichia coli.

Dose-dependent nephroprotective effects of turmeric extract against diclofenac-induced kidney injury in rats Amapiran, Renya Rosari; Amat, Anita Lidesna Shinta; Indriarini, Desi; Hietingwati, Syeben HE; Nugraheni, Tri
Acta Biochimica Indonesiana Vol. 8 No. 2 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Non-steroidal anti-inflammatory drugs, particularly diclofenac sodium, are widely prescribed but can cause nephrotoxicity through oxidative stress mechanisms. Turmeric (Curcuma longa L.) contains curcumin and other bioactive compounds with potent antioxidant properties that may protect against drug-induced kidney damage. Objective: To evaluate the dose-dependent effects of turmeric ethanol extract on kidney histopathology in rats with established diclofenac sodium-induced nephrotoxicity. Methods: Twenty-eight male Sprague Dawley rats were randomly divided into four groups: normal control, diclofenac (10 mg/kg for 7 days), and two treatment groups receiving diclofenac followed by turmeric extract at 100 mg/kg or 200 mg/kg for 14 days. Kidney histopathology was assessed using the Arsad scoring system by a blinded pathologist. Results: Significant differences existed between groups (p < 0.001). The negative control exhibited severe kidney damage with hydropic degeneration, granular casts, and cellular casts (mean score: 2.78 ± 0.24). Treatment with 100 mg/kg showed partial improvement (1.65 ± 0.31), while 200 mg/kg demonstrated substantial improvement approaching normal histology (0.52 ± 0.18) with only minimal residual damage. Conclusion: Turmeric extract demonstrates significant dose-dependent nephroprotective effects against diclofenac-induced kidney damage, with 200 mg/kg providing superior protection, suggesting potential therapeutic applications in mitigating NSAID-induced nephrotoxicity.

Efektivitas Metode Peer Teaching dalam Pelatihan Psychological First Aid terhadap Peningkatan Prosocial Behavior Intention Mahasiswa Universitas Nusa Cendana Sia, Irmanuwela; Handoyo, Nicholas Edwin; Indriarini, Desi; Wijaya, R. Pasifikus Christa
Cendana Medical Journal Vol 13 No 2 (2025): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v13i2.23351

Abstract Prosocial behavior, such as helping others, plays a crucial role in supporting mental health, especially among college students who often face psychological challenges and require social support. Psychological First Aid (PFA) is one form of psychosocial support that peers can provide, and peer teaching—where students teach fellow students—is considered an effective method to foster prosocial behavior intentions while enhancing mutual support. This study aimed to evaluate the effectiveness of the peer teaching method in PFA training to increase prosocial behavior intention among students at Nusa Cendana University. A quasi-experimental design with a pre-test–post-test control group was used, involving 88 students grouped through cluster sampling into experimental group I (n=3), experimental group II (n=22), and a control group (n=63). Data were collected online using the Prosocial Tendencies Measure questionnaire and analyzed with repeated measures ANOVA. The results showed no significant differences in pre- and post-test scores across the groups (p-value within subjects = 0.360; between subjects = 0.632). These findings indicate that PFA training using the peer teaching method did not significantly improve prosocial behavior intention. It is recommended that future training incorporate practical field experiences with organizations such as hospitals or disaster response agencies to improve real-world impact.

Activity Test of Anti-Dandruff Shampoo Preparation of Fragrant Pandan Leaf Extract (Pandanus Amaryllifolius Roxb.) Against the fungus Malassezia Furfur Pallo, Arini Aprili; Pakan, Prisca Deviani; Indriarini, Desi; Riwu, Magdarita
Journal of Comprehensive Science Vol. 5 No. 2 (2026): Journal of Comprehensive Science
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jcs.v5i2.4022

Dandruff is a scalp disorder caused by Malassezia furfur fungus, often treated with anti-dandruff shampoos. However, synthetic active ingredients in such shampoos may cause side effects like scalp irritation, dryness, or allergies. As an alternative, herbal formulations using fragrant pandan leaves (Pandanus amaryllifolius Roxb.), known for their antifungal properties, can be developed. The objective of this study was to determine and analyze the best Fragrant pandan (Pandanus amaryllifolius Roxb.) leaf extract shampoo formulation and its antifungal activity against Malassezia furfur. The type of research conducted was a true experimental study with a Post-Test Only Control Group Design. In this study, there were treatment groups given a shampoo preparation of fragrant pandanus leaf extract at concentrations of 30%, 50%, and 70%, a negative control group of a shampoo base, and a positive control group of a shampoo containing 1% selenium sulfide under the brand name Selsun. The analysis used was the One-Way ANOVA test. The shampoo preparation of fragrant pandanus leaf extract demonstrated antifungal activity against Malassezia furfur, with inhibition zones obtained at a 30% concentration (15.83 mm), 50% concentration (18.68 mm), 70% concentration (21.89 mm), positive control (21.36 mm), and negative control (0 mm). The 70% Fragrant pandan (Pandanus amaryllifolius Roxb.) leaf extract shampoo preparation is the best formulation because it exhibits optimal physical characteristics and produces the greatest inhibition against Malassezia furfur.

Co-Authors Amat, Anita Shinta Anita Lidesna Shinta Amat Artawan, I Made Ballo, Natasya Detami Sheline Ginting, Aditya Karsa Imanuel Girsang, Gary Efraim Hietingwati, Syeben HE Ika Febianti Buntoro Kedang, Yoannita Kaneka Klau, Maria Luz Clarita Koamesah, Sangguana M J Koamesah, Sangguana Marten Jacobus Kresnawati Wahyu Setiono Lenggu, Claritha Kaci Louis Levina Sari Setianingrum, Elisabeth Luh Komang Ayu Shinta Dewi, Ni Megariani, Maria Anggelina Mukin, Yohanes Matius Demo Nicholas Edwin Handoyo Nor, Theresia Avilla Nugraheni, Tri Nurina, Rr. Listyawati PAKAN, PRISCA DEVIANI Pallo, Arini Aprili Riwu, Magdarita Rosari, Renya Sasputra, I Nyoman Seran, Nana Angelia Setianingrum, Elisabeth Setianingrum, Elisabeth Levina Sari Sia, Irmanuwela Sun, Diana Maximiliany Ugha, Kandida Bibiana Wijaya, Darlene Monica Wijaya, R. Pasifikus Christa Woda, Rahel Rara Wungouw, Herman Pieter Louis

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