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All Journal Jurnal Ilmiah Farmasi Jurnal Sains dan Teknologi Farmasi Jurnal Penelitian Sains Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan JMM (Jurnal Masyarakat Mandiri) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kreativitas PKM Ensiklopedia of Journal Jurnal Ilmiah Bakti Farmasi Aptekmas : Jurnal Pengabdian Kepada Masyarakat Sejahtera: Jurnal Inspirasi Mengabdi Untuk Negeri Cakrawala: Jurnal Pengabdian Masyarakat Global Jurnal Pendidikan dan Pengabdian Masyarakat Jurnal Kabar Masyarakat Transformasi Masyarakat : Jurnal Inovasi Sosial dan Pengabdian Harmoni Sosial : Jurnal Pengabdian Dan Solidaritas Masyarakat Indonesia Bergerak: Jurnal Hasil Kegiatan Pengabdian Masyarakat Aksi Nyata : Jurnal Pengabdian Sosial dan Kemanusiaan
Ade Arinia Rasyad
Sekolah Tinggi Ilmu Farmasi Bhakti Pertiwi
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Pengaruh PENGARUH PEMBERIAN JUS KOMBINASI DAGING BUAH NANAS (Ananas comusus (L.) Merr.) DAN UMBI LOBAK PUTIH (Raphanus satius L.) TERHADAP PENURUNAN KADAR ASAM URAT TIKUS PUTIH JANTAN HIPERURISEMIA Kurniawati, Reka; Rasyad, Ade Arinia; Lely, Nilda; Imanda, Yunita Listiani
Jurnal Ilmiah Farmasi Vol. 22 No. 2 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss2.art19

Abstract

Background: Hyperuricemia is defined as a condition in which serum uric acid levels exceed 7 mg/dL in men and 6 mg/dL in women. First-line management typically involves lifestyle modification and non-pharmacological interventions. One such intervention includes the administration of a combination juice made from pineapple flesh (Ananas comosus (L.) Merr.) and white radish (Raphanus sativus L.), both of which contain flavonoids capable of inhibiting xanthine oxidase activity. Objective: This study aimed to investigate the effect of the combination of pineapple and white radish juice on serum uric acid levels in male Wistar rats with hyperuricemia. Methods: The study employed a pre- and post-test control group design involving five groups (n = 5 per group). Group I served as the negative control and received a placebo; Group II served as the positive control and received allopurinol; Group III received pineapple juice; Group IV received white radish juice; and Group V received a combination of both juices. Serum uric acid levels were measured before and after the treatment period, and the percentage reduction was calculated. Statistical analysis was performed using the Kruskal-Wallis test followed by the Mann-Whitney U test for pairwise comparisons. Result: The percentage reductions in uric acid levels were as follows: negative control group, 39.8%; positive control group, 49.67%; pineapple juice group, 34.75%; white radish juice group, −5.12%; and combination juice group, 15.5% (p<0.05). Conclusion: In conclusion, administration of pineapple juice alone demonstrated a greater reduction in uric acid levels than the combined juice.
Co-Authors Ahmad Fatoni Aisah Aisah Alex Ferianto Anwar, Wiwin Oktaviani Apriani, Yosi Ayu Lestari Deni Noviza Deni Noviza Muslim Dewi Patmayuni Doddy Rusli Doddy Rusli Egata, Neisa Ensiwi Munarsih, Ensiwi Erjon Erjon Erjon, . Frelis Setya Nanda hartawan, hartawan Herda Perlia Hilma, Hilma Imanda, Yunita Listiana Intan, Rizka Kurniawati, Reka Lasmaryna Sirumapea Lidia Lidia Lilik Pranata Listiani Imanda, Yunita M. Arif Afrizal Masayu Azizah Masayu Rosyidah Mauizatul Hasanah, Mauizatul Noprizon Novriyanti, Selly Nurlisa Hidayati Nurlisa Hidayati Nurlisa Hidayati Nurlisa Hidayati Nurlisa i Hidayat Putra Asa Nugraha Putra Mahendra Renaldi Armande Rendowaty, Agnes Reza Agung Sriwijaya Ricardo, Wahyu Muhammad Rika Ratna Sari Risya Melinda Rizki Wahyudi Sari Meisyayati, Sari Selly Novriyanti Siti Nurhidyah Sundari, Ayu Agita Tita Harliana Wiwin A. Oktaviani Yasmin Hamdani Yeni Sri Wahyuni Yenni Sri Wahyuni Yenni Sri Wahyuni Yopi Rikma Sari Yosi Apriani, Yosi Yunita Listiani Imanda