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Journal : Journal of Science and Applicative Technology

Land Suitability for Ciplukan (Physalisangulata L.)Using Multicriteria Analysis Nur Adliani; Nirmawana Simarmata; . Heriasnyah
Journal of Science and Applicative Technology Vol 2 No 1 (2019): ICoSITeR Special Edition
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.386 KB) | DOI: 10.35472/281454

Abstract

The study investigated the suitable land of Ciplukan (Physalisangulata L.), which is a source of medicine ingredient to lower the level of blood sugar. Ciplukan generally grows among wild plants. The objective of this research is to describe the characteristics of the land to grow ciplukan based on the land suitability. The class of land suitability is obtained by matching the physical character and chemistry from botanical garden land and overlaying appropriate maps with the requirements of growing ciplukan with ArcGIS. The class of suitability land acquired in the Botanical Gardens that earned the score of 6 to 8 is an area that does not suitable to cultivate the plants ,with the size 52,189Ha. The score of the lesser appropriate classification was of 9 to 11 with the size of area 180,966Ha. The score of 12 has the size of area 49,111Ha. The score of 12 fulfills 4 parameters. If all the land were suitable, then it would worth 3.9 to 11. The parameters which were not corresponding at all is the value of score was 6 to8. The actual area at the Botanical Garden land was 80 Ha. So, some parts of the land can be used to grow ciplukan.
Pembuatan sediaan beads alginat dengan metode gelasi ion yang dapat mengapung di lambung Nur Adliani
Journal of Science and Applicative Technology Vol 1 No 1 (2017): Journal of Science and Applicative Technology August Chapter
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (980.227 KB) | DOI: 10.35472/281469

Abstract

Conventional drug delivery systems have a shorter residence time in the stomach that causes less optimal drug absorption, the presence of food in the stomach also affects the absorption of the drug in the gastrointestinal tract so that it takes a drug that can stay and last longer in the stomach without being affected by the emptying process Stomach. In this study beads preparations are made that can stay and float so that lasts longer in the stomach. Alginate-containing beads are formulated by gelation method in which the alginate solution is dropped into a calcium chloride solution to form beads. The effects of oil type and alginate on morphological forms and buoyancy characteristics have been optimized. Beads containing alginate and paraffin can float on a gastric medium simulation for 240 minutes. The presence of paraffins can maintain the integrity and release of alginate beads during contact with the gastric medium. The SEM results describe the paraffin forming globules on the entire surface of the beads. Beads also show the ability to be able to float depending on the concentration of paraffin used.
Penambatan molekul senyawa turunan orizanol terhadap enzim 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reduktase Syaikhul Aziz; Nur Adliani; Sukrasno Sukrasno
Journal of Science and Applicative Technology Vol 4 No 1 (2020): Journal of Science and Applicative Technology June Chapter
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (618.567 KB) | DOI: 10.35472/jsat.v4i1.191

Abstract

Oryzanol has been reported to reduce serum total cholesterol (hypolipidemic agent) by inhibiting HMG-CoA reductase, an enzyme responsible for the metabolic pathway that produces cholesterol and isoprenoid. The purpose of this experiment is to determine the inhibition activity of oryzanol derivatives on HMG-CoA reductase by molecular docking. Four structure of oryzanol derivatives, Lanosteryl-ferulate, Brassicasteryl-ferulate, Lupeol-ferulate, and Cholesteryl-ferulate were used as ligands for molecular docking. The HMG-CoA reductase structure was obtained from protein data bank and the study was performed using AutoDock Tools as a molecular docking software. All oryzanol derivatives show binding affinity against HMG-CoA reductase. Lupeol-ferulate was predicted to be the best inhibitory activity against HMG-CoA reductase because of molecular docking.