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All Journal bionature The Indonesian Accounting Review PROSIDING SEMINAR KIMIA Jurnal Surya Medika JURNAL ATOMIK JURNAL PENDIDIKAN TAMBUSAI Kinetika Multilateral: Jurnal Pendidikan Jasmani Dan Olahraga Jurnal PENEROKA: Kajian Ilmu Pendidikan Bahasa dan Sastra Indonesia PharmaCine : Journal of Pharmacy, Medical and Health Science MARAS : Jurnal Penelitian Multidisplin ANDIL Mulawarman Journal of Community Engagement Al-Mizan : Jurnal Ekonomi Syariah
Nur Aina
STIE Perbanas Surabaya
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Journal : PROSIDING SEMINAR KIMIA

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REVIEW ARTIKEL: SKIRINING FITOKIMIA DAN AKTIVITAS FARMAKOLOGIS TANAMAN KRATOM (Mitragyna speciosa Korth) Aina, Nur; Saleh, Chairul; Marliana, Eva
PROSIDING SEMINAR KIMIA Vol 3 No 1 (2024): Prosiding SNK 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Kratom (Mitragyna speciosa korth) is one of the plants found in forest areas in Indonesia. Phytochemical screening and pharmacological activity of kratom plants (Mitragyna speciosa Korth) have been conducted. Some studies show kratom plants contain secondary metabolites, namely alkaloids, flavonoids, saponins, triterpenoids, tannins and terpenoid-steroids. Literature studies show kratom leaves have strong antioxidant activity with IC50 values <50 ppm. Kratom leaves have antinonceptive activity in the dichloromethane fraction at doses of 70 mg/kgBB (51%), 140 mg/kgBB (81%) and 280 mg/kgBB (86%). Antimicrobial activity against staphylococcuc pidermidis bacteria with a concentration of 5% (7.23 mm) 10% (10.50 mm), 15% (11.78 mm), 20% (12.63 mm) and 25% (13.69 mm). Stems and roots of kratom plants have antibacterial activity against propionibacterium acnes bacteria, stem concentration 5% (5.71 mm ± 0.40), 10% (6.75 mm ± 0.26) and 15% (6.78mm ± 0.29), on roots 5% (5.4 mm ± 0.12), 10% (5.8 ± 0.08) and 15% (6.21 mm ± 0.36). Anti-inflammatory activity with a dose of kratom extract 0.5 mg/grBB (46.37 mm ± 10.04), 1 mg/grBB (32.33 mm ± 11.24), 2mg/grBB (26.69 mm ± 6.57). Acute toxicity test in the reflux method LC50 value of 71.08 ppm while the maceration method LC50 value of 143, 50 the results shown are included in the toxic category. Keywords: Mitragyna speciosa korth, Mitragyna, phytochemical screening
Co-Authors ., Fatria Aini, Wirdatul Amin, Jaksen M. Andi Harmawati Novriani HS Anindita, Lisda Mauli Arif, Mhd. Aslamiah Aslamiah Chairul Saleh Cinantya, Celia Dewi, Fretika Utami Effendy, Sahrul Elmustian Eva Marliana, Eva Irawan Rusnadi Islawati Novia Putri, Inke Nur Azizah Nurul Hasanah Uswati Dewi Oslan Jumadi Rahmadhani, Nabila Rossa, Briliantina Setiyo Utomo St. Fatmah Hiola Syamsiar, Syamsiar Wahyuni, Putri Trisna Waltin, Muhammad Zamriati, Neldia ‘Aini, Wirdatul