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All Journal Medical Journal of Indonesia Indonesian Journal of Cancer Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Manajemen Pendidikan Dasar, Menengah dan Tinggi [JMP-DMT] GOVERNANCE: Jurnal Ilmiah Kajian Politik Lokal dan Pembangunan Journal Of Khairun Community Services Jurnal Nasional Holistic Science JUrnal Riset Ilmu Pendidikan METAL : Jurnal Sistem Mekanik dan Termal Indonesian Journal Education EDUCTUM: Journal Research Jurnal Penyakit Dalam Indonesia
Zulkifli Amin
Divisi Pulmonologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN dr. Cipto Mangunkusumo, Jakarta, Indonesia
Religion Arts Humanities Automotive Engineering Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Social Sciences Other

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Journal : Jurnal Penyakit Dalam Indonesia

 1 
Pendekatan Diagnosis dan Tatalaksana Sindrom Mirizzi Putra, Ario Perbowo; Christine, Griskalia; Amin, Zulkifli; Fauzi, Achmad
Jurnal Penyakit Dalam Indonesia Vol. 2, No. 3
Publisher : UI Scholars Hub

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Abstract

Penyakit batu empedu telah menjadi masalah kesehatan penting di banyak negara. Estimasi prevalensi penyakit batu saluran empedu yang menyertai penyakit batu empedu adalah sekitar 10-15% dan meningkat dengan usia lanjut. Sindrom Mirizzi adalah komplikasi dari penyakit batu empedu yang jarang terjadi. Karakteristik yang khas yaitu adanya impaksi batu empedu di duktus sistikus atau di leher kandung empedu sehingga menghasilkan obstruksi mekanik di duktus hepatikus dan menghasilkan striktur inflamasi di saluran empedu, sehingga menyebabkan ikterus obstruktif berkelanjutan. Kami laporkan sebuah kasus Sindrom Mirizzi pada laki-laki dewasa yang menyebabkan iketerus obstruktif dengan kolelitiasis.
Peran Prediktif IL-6, IL-10, dan TNF-α Plasma terhadap Gagal Ginjal Akut pada Pasien dengan COVID-19 Derajat Sedang dan Berat Gathmyr, Dewi; Bonar, Maruhum Bonar H; Susilo, Adityo; Harimurti, Kuntjoro; Nainggolan, Ginova; Tagor, Alvin; Shatri, Hamzah; Lesmana, Cosmas Rinaldi Adithya; Amin, Zulkifli
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Introduction. Acute kidney injury (AKI) is associated with higher mortality rate in COVID-19 patients due to inflammation and immune dysregulation. This study aimed to correlate serum levels of IL-6, IL-10, and TNF-α with serum creatinine changes and their roles to predict incidence of acute kidney injury (AKI) in patients with moderate and severe COVID-19. Methods. This prospective cohort study was conducted among patients with moderate to severe COVID-19 in Pertamina Central Hospital Jakarta, Indonesia during November 2020 to January 2021. All serum levels of cytokines (IL-6, IL-10, and TNF-α) and creatinine were collected on the first day and seventh day of hospitalization. They might be collected earlier if the patients died or discharged early. AKI was defined as deterioration in serum creatinine or urine output based on Kidney Disease Improving Global Outcomes (KDIGO) guideline. The correlation between cytokine and creatinine serum level changes were analyzed using Spearman test. Receiver operator characteristic curve was calculated to explore predictive roles of cytokines on AKI incidence. Results. A total of 43 patients were included in the study, with a mean age of 59.3 years (SD 12.59), and the majority were male (74%). The incidence of AKI was 7%. Serum creatinine changes were correlated with serum levels changes IL-10 (r= -0.343; p=0.024), but not for IL-6 (r=-0.198; p=0.202) and TNF-α (r=-0.129, p=0.409). Meanwhile, serum TNF-α level on the first day was able to predict AKI incidence on the seventh day of hospitalization (AUC 85%; p=0.045; 95% CI=0.737 to 0.963). Conclusions. TNF-α on the first day is potential to be predictor on AKI incidence on the seventh day in moderate and severe COVID-19 patients.
Co-Authors Achmad Fauzi Adityo Susilo, Adityo Amanda, Astrid P. Ario Perbowo Putra, Ario Perbowo Bonar, Maruhum Bonar H C Rinaldi A Lesmana Catharina R. Suprapti Chrispian Oktafbipian Mamudi, Chrispian Oktafbipian Dalimunthe, Hamidah Dewi Gathmyr Dewi, Putri Tiara Dimas Priantono, Dimas E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Febriyanti, Wiwit Fitriana N. Rahmawati Ginova Nainggolan Griskalia Christine Gurmeet Singh Hamdi, Ridho Hasna Afifah, Hasna Hilman Z Amin, Hilman Z Irfan Dahnial Iskandar R Iskandar R, Iskandar R Khairun Nisa Kuntjoro Harimurti Lega Putri Utami Lukman Z Amin, Lukman Z Mamudi, Chrispian O. Meiki Eru Putra Pratiwi, Erni Rahmat Rahmat Samio Samio Sunhadji Rubangi Tagor, Alvin Taufika, Ryan TOMMY SUPIT, TOMMY Valy Wulani, Valy Vito Filbert Jayalie, Vito Filbert Widian, Raihan Khairi Wulyo Rajabto Wuryantoro Wuryantoro, Wuryantoro Yani, Endri