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All Journal Biology, Medicine, & Natural Product Chemistry Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE Open Access Indonesian Journal of Medical Reviews Berkala Penelitian Hayati Jurnal Ilmu Kebidanan dan Kesehatan
Sutandar, Vivi Hendra
Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Potency of endophytic fungi from Nauclea orientalis L. as antioxidant producer Elisa Nurnawati; Hary Widjajanti; Vivi Hendra Sutandar; Maulida Harwati; Eka Amelia; Siti Alharzsa; Nina Tanzerina
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 27 No 1 (2021): December 2021
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869//bphjbr.27.1.20216

Abstract

Nauclea orientalis L. is widely distributed in Indonesia. Secondary metabolites such as flavonoids, polyphenols, and saponins are abundant in the bark of N. orientalis L. These compounds have the potential to act as antioxidants. Endophytic fungi, through genetic transfer and coevolution, can produce the same metabolites as their host plant. As a result, understanding the potential of endophytic fungi from N. orientalis L. to produce antioxidant compounds that can be developed is critical. According to the findings of this study, twelve isolates have the potential to produce secondary metabolites with antioxidant properties. Three isolates had high antioxidant activity: DB2 was identified as Aspergillus minisclerotigenes with an IC50 of 21 g/mL containing tannins, terpenes, and flavonoids, AB3 as Colletotrichum perseae with an IC50 of 31 g/mL containing tannins and terpenoids, and AB1 as Diaporthe tulliensis with an IC50 of 48 g/mL containing tannins. The secondary metabolite group has the potential to be developed into an antioxidant agent
GLUT4 as A Protein Target for T2DM Therapy with Natural Compounds Sutandar, Vivi Hendra; Saleh, Mgs. Irsan; Maritska, Ziske
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.289-293

Abstract

WHO reported 1.9 million death cases of diabetes patients in 2019. Diabetes is caused by damage in the pancreas which resulted in a lack of insulin or insulin resistance. Medication for T2DM mainly focuses on lowering blood glucose and treating affected organs. Current medications are still lacking, thus research is needed in finding novel medications to accommodate T2DM. This paper aims to present the current research on potential plant extract in increasing GLUT4 translocation in diabetes conditions. insulin resistance state affecting GLUT4 translocation which is important in affecting glucose uptake. Some research shows that plant extract proved to be potential in increasing the translocation of GLUT4 and helping lowering blood glucose levels.
GLUT4 as A Protein Target for Type 2-Diabetes Mellitus Therapy With Natural Compounds Vivi Hendra Sutandar; Mgs. Irsan Saleh; Ziske Maritska
Sriwijaya Journal of Medicine Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i1.154

Abstract

WHO reported 1.9 million death cases of diabetes patients in 2019. Diabetes is caused by damage in the pancreas which resulted in a lack of insulin or insulin resistance.  Medication for Type 2-Diabetes Mellitus (T2DM) mainly focuses on lowering blood glucose and treating affected organs. Current medications are still lacking; thus research is needed in finding novel medications to accommodate T2DM. This paper aims to present the current research on potential plant extract in increasing GLUT4 translocation in diabetes conditions. insulin resistance state affecting GLUT4 translocation which is important in affecting glucose uptake. Some research shows that plant extract proved to be potential in increasing the translocation of GLUT4 and helping lowering blood glucose levels.
HUBUNGAN ANTARA UMUR DAN PARITAS IBU DENGAN KEJADIAN PERSALINAN PRETERM DI RSUD KOTA PRABUMULIH TAHUN 2023 Novitasari; Sutandar, Vivi Hendra; Juninta, Tania
Jurnal Ilmu Kebidanan dan Kesehatan (Journal of Midwifery Science and Health) Vol. 16 No. 01 (2025): Jurnal Ilmu Kebidanan dan Kesehatan (Journal of Midwifery Science and Health)
Publisher : Sekolah Tinggi Ilmu Kesehatan Bakti Utama Pati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52299/jks.v16i01.405

Abstract

Penurunan angka kematian bayi di Indonesia turun jauh hingga 90% dalam 50 tahun atau sejak 1971 hingga 2020. Dalam 1 dekade atau dari tahun 2010 sampai 2020, penurunan kematian bayi di Indonesia mencapai 35% (BPS). Penelitian ini bertujuan untuk mengetahui apa yang menyebabkan terjadinya kelahiran preterm di RSUD Prabumulih di tahun 2023. Penelitian ini menggunakan Deskriptif Analitik dengan menggunakan pendekatan Cross Sectional. Populasi ini adalah keseluruhan ibu bersalin yang berjumlah 2.242 orang. Sampel berjumlah 339 responden. Pada Analisa univariat didapatkan ibu yang mengalami kejadian persalinan preterm sebanyak 114 responden (28,6%) dan yang tidak mengalami kejadian persalinan preterm sebanyak 285 responden (71,4%). Paritas ibu yang berisiko akan mengalami persalinan preterm berjumlah 192 responden (56,6%) dan paritas ibu yang tidak beresiko akan mengalami kejadian persalinan preterm berjumlah 147 responden (43,4%). Analisa bivariat menunjukkan umur ibu mempunyai hubungan yang bermakna dengan kejadian persalinan preterm (p value 0,000), sedangkan paritas ibu tidak mempunyai hubungan yang bermakna dengan kejadian persalinan preterm (p value 0,407). Kesimpulan adalah bahwa ada hubungan antara umur dengan kejadian persalinan preterm dan tidak ada hubungan antara paritas dengan kejadian persalinan preterm di RSUD Kota Prabumulih Tahun 2023.
Potency of Karamunting (Rhodomyrtus tomentosa) Leaf Extract as Antidiabetic for Type 2 Diabetes: A Systematic Review Sutandar, Vivi Hendra; Saleh, M. Irsan; Lusiana, Evi; Parisa, Nita; Tamzil, Nia Savitri
Biomedical Journal of Indonesia Vol. 11 No. 3 (2025): Vol 11, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i3.273

Abstract

Type 2 diabetes mellitus (T2D) is a chronic metabolic disorder characterized by reduced insulin sensitivity and inadequate insulin secretion, leading to elevated blood glucose levels. Standard treatment relies on synthetic drugs, which can cause adverse effects in some patients. Rhodomyrtus tomentosa, a plant native to Indonesia and widely used in traditional medicine, is being explored as a natural alternative for diabetes management due to its potential antidiabetic properties. This review compiles recent findings on its therapeutic potential. A systematic literature search was conducted in August 2024 in PubMed, Wiley Online Library, ScienceDirect, Cochrane Library, ProQuest, and Google Scholar using the keywords “Rhodomyrtus tomentosa” and “antidiabetic.” Of 774 screened articles, five met the inclusion criteria (2014–2024). The studies employed in vitro, in vivo, and in silico approaches, focusing mainly on fruits and leaves. Results indicate that R. tomentosa may help control blood glucose by inhibiting α-glucosidase and α-amylase, enzymes critical in carbohydrate digestion. Bioactive compounds such as phloroglucinols and meroterpenes were frequently identified. However, most evidence comes from laboratory models, with limited animal research and no clinical trials. The risk of bias was moderate, often due to incomplete reporting. While findings suggest R. tomentosa is a promising natural candidate for diabetes treatment, its therapeutic value remains unconfirmed. More robust in vivo studies and human clinical trials are essential to clarify its mechanisms, safety, pharmacokinetics, and efficacy. This review serves as a basis for future research and highlights the need for rigorous studies to validate its clinical potential.
Potential of Naringin in Reducing Aorta Lesion Atherosclerosis in Hypercholesterolemia: A Systematic Review Sutandar, Vivi Hendra
Open Access Indonesian Journal of Medical Reviews Vol. 2 No. 1 (2022): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v2i1.150

Abstract

Hypercholesterolemia is a condition that affects cholesterol levels because of the increase of LDL. Hypercholesterolemia is connected to atherosclerosis disease, which causes the blockage of blood flow. Naringin is a flavonoid primarily found in the citrus family and proved to have various benefits, one of which is antiatherogenic. The article searching was done in PubMed, Wiley Online Library, Cochrane, ProQuest, ScienceDirect, and Google Scholar databases. The final three studies about naringin supplementation in animals models are assessed. Naringin had an antiatherogenic effect and decreased the aorta lesion in atherosclerosis by several different mechanisms.
Co-Authors Eka Amelia Elisa Nurnawati Evi Lusiana Hary Widjajanti Juninta, Tania Maulida Harwati Mgs. Irsan Saleh, Mgs. Irsan Muhammad Irsan Saleh Nina Tanzerina Nita Parisa NOVITASARI Saleh, M. Irsan Siti Alharzsa Ziske Maritska