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All Journal Jurnal Kesehatan Indonesia Muhammadiyah Journal of Nutrition and Food Science (MJNF) Muhammadiyah Journal of Geriatric Muhammadiyah Medical Journal Jurnal Pengabdian Masyarakat Medika
Tubarad, Gladys Dwiani Tinovella
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Muhammadiyah Medical Journal

 1 
Correlation between Interleukin-6 with D-dimer and C-reactive protein Levels in Patients with Confirmed COVID-19 Severe Criteria Gemintang, Ghea Setia; Wiratmoko, Raden Mirsyam Ratri; Tubarad, Gladys Dwiani Tinovella
Muhammadiyah Medical Journal Vol 5, No 2 (2024): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.5.2.69-75

Abstract

Background: In Coronavirus Disease 2019 (COVID-19) severe criteria, cytokine storm conditions are often found, and there will be an increase in Interleukin-6 as a cytokine and CRP as an acute phase protein induced by IL-6. In COVID-19 patients with severe criteria, coagulation disorders can also be found, characterized by an increase in the D-dimer value. Purpose: To determine the correlation between IL-6, D-dimer, and CRP levels in patients with confirmed COVID-19 severe criteria at Bunda Margonda General Hospital in 2021. Methods: This research was an analytical observation study with a cross-sectional approach, using secondary data from medical records of patients with confirmed COVID-19 severe criteria at Bunda Margonda General Hospital in 2021. Results: The number of patients with confirmed COVID-19 severe criteria was primarily male (59%), aged 46-55 years (33%), with degree of severity with severe criteria in 100 patients, increased IL-6 (91%), increased D-dimer levels (90%), increased CRP levels (95%). There was a correlation between increased IL-6 with D-dimer levels (p-value 0,005) and a correlation between increased IL-6 with CRP levels (p-value of 0,000). A simultaneous and significant relationship was found between IL-6, D-dimer, and CRP levels in severe COVID-19 criteria. COVID-19 patients with severe criteria were more commonly found in males in the 46-55-year age group with increased IL-6, D-dimer, and CRP values. Conclusion: There was a correlation between increased IL-6 and D-dimer and CRP levels in COVID-19 patients with severe criteria at Bunda Margonda General Hospital in 2021.
Descriptive Study: Attitude and Behaviour Regarding Oral Corticosteroid Use in Bebita Clinic Cicurug, Sukabumi in 2019 Nabila, Audia Nizhma; Tubarad, Gladys Dwiani Tinovella; Azzahra, Vanianissa
Muhammadiyah Medical Journal Vol 3, No 1 (2022): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.3.1.10-18

Abstract

Background: Corticosteroids are derivatives of steroid hormones that have the effect of inhibiting the inflammatory response. Glucocorticoid is the type of corticosteroid that is easy to obtain and has a high anti-inflammatory effect. Therefore, glucocorticoids are often used in various therapies. However, the use of this drug should be monitored since its side effects can be harmful to the health as paralytic effects or even lethal effects. Purposes: This study aims to determine the behavior of using oral corticosteroids in patients at the Bebita Cicurug Clinic, Sukabumi. Methods: This is a descriptive quantitative research study. Data collection was done from September to December 2019. The respondents of this study were 96 subjects of Bebita Cicurug Clinic with a history of oral glucocorticoid usage. The data was taken using a questionnaire and medical records. Result: The most widely used glucocorticoid type is Methylprednisolone 4 mg and dexamethasone 0,5 mg. Overall, 89.6% of respondents used corticosteroids for a week or less. A total of 21.9% had tried to get corticosteroids without a prescription (self-medication), and all of them didn't get restricted on purchasing corticosteroids. Conclusion: In general, patients in this study had good behavior in using corticosteroids (using steroids according to a doctor's prescription), but 21.9% had tried to get corticosteroids without a prescription, and all of them didn't get restricted on purchasing corticosteroids. Doctors and health workers must clearly explain prescribed drugs' benefits and side effects, especially in patients with chronic diseases. Then ensure that the patient has understood the benefits and side effects of the medications used.
Co-Authors Ahmad Muchlis Aziza, Nurita Azzahra, Vanianissa Chahyani, Wiwit Ida Gemintang, Ghea Setia Hastuti, Murni Sri Heriyanto, Mochammad Junaidy M. Mansyur Romi Meddy Setiawan Mitayani Purwoko, Mitayani Muhammad Perdana Airlangga, Muhammad Perdana Nabila, Audia Nizhma Nauli, Anggi Novitasari, Erlina Krisdianita Pandhita, Gea Prakoso, Denny Anggoro Putra, Chendra Perdana Rima January Rudiyanto, Waluyo Sabrina, Annaya Noor Sari, Tirta Prawita Shabrina, Fida' Alia Sriningsih, Solikah Sukarno, Rizky Triutami SULISTIYANI SULISTIYANI Syafruddin, Amir tri wahyuni Utami, Meita Dwi Wiratmoko, Raden Mirsyam Ratri Yanuarita Tursinawati, Yanuarita