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. Widardo
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Perbedaan Prevalensi Obesitas antara Etnis Jawa, Tionghoa, dan Arab pada Anak Sekolah Menengah Pertama di Surakarta Murti, Zenia Purnama; Moelyo, Annang Giri; Widardo, .
Nexus Kedokteran Komunitas Vol 2, No 3 (2013): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background:Obesitycauses many health problems in childhoodsuch ascardiovasculardisease, diabetes, musculoskeletaldisorders, cancersthat causemorbidity and mortalityin adulthood. Ethnicity is a risk factor for obesity. Ethnicity affect eating habits, genetic, amount of energy expenditure, fat distribution and tendency of obese in a child. The aim of this study was to analyze prevalence of obesity in Junior High School Children in Surakarta based on ethnic differences (Javanese, Chinese, and Arabian). Methods:This was a cross-sectional analytic study to 395 students of 8th grade in SMP Negeri 4 Surakarta, SMP Bintang Laut Surakarta, and SMP Diponegoro Surakarta (junior high school) that consist of Javanese, Chinese, and Arabian. Samples were collected by purposive sampling technique. Inclusion criteriaswere students of 8thgrade,parentshave thesameethnicity, and signed an informed consent. Exclusion criterias werechildrenwithedema, have achronicillness, taking medicationlong-termandconditions ofhandicapped.The questionnaire was used to know the ethnic of the child. Body mass index was used to define obesity status with Z-score >+2 SD based on  World Health Organization in 2007 growth chart. Data were analyzed by Chi-Square test. Results:This research shows 246 (63%) subjects were Javanese, 79 (20%) subjects were Chinese, and 70 (17%) subjects were Arabian.  Twenty seven subjects (6.84%) were obese and threehundred andsixty-eight subjects (93.16%) were not obese. Obese prevalence was 4.5 % among Javanese, 8.9 % among Chinese, and 12.9 % among Arabian.It shows a significant differences in the prevalence of obesity among the three ethnics (p=0,036; p < 0.05). Conclusions:There are significant differences in the prevalence of obesity among Javanese, Chinese, and Arabian Ethnic in junior high school children in Surakarta. Keywords:ethnicity, obesity, children
Perbedaan Intelligence Quotient (IQ) Anak Obes dan Tidak Obes Usia Sekolah Dasar di SD Kristen Manahan Surakarta Wibawati, Magdalena; Karini, Suci Murti; Widardo, .
Nexus Kedokteran Komunitas Vol 2, No 3 (2013): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.115 KB)

Abstract

Background: Prevalence of obesity has increased over the last 20 years and become world’s health problems. Obesity in children may cause medical and psychosocial consequences, which can influence their Intelligence Quotient. The aim of this research is to determine whether the difference of Intelligence Quotient existed in obese and non-obese children in Manahan Christian Primary School Surakarta. Methods: This research is an analytic observational study with cross sectional approach. Sample was collected by simple random sampling. Based on the anthropometric measurement of 2nd until 5th grade students in Manahan Christian Primary School Surakarta, 30 samples were collected for each group (obese and non-obese children). Intelligence Quotient test were performed using Culture Fair Intelligence Test (CFIT) 2A by the students who become research sample. Data were analyzed with unpaired t-test by Statistical Product and Serve Solution (SPSS) 21 for Mac. Results: Mean score of Intelligence Quotient in the obese children is 105.29, while in the non-obese children is 105.82. Result of unpaired t test showed the probability of 0.849 (p > 0.05). It means the significance value of the difference between the two groups was not significant. Conclusions: There is no difference of Intelligence Quotient (IQ) between obese and non-obese children in Manahan Christian Primary School Surakarta. Keywords: Intelligence Quotient, obese children, non-obese children 
Perbedaan Ankle Brachial Index (ABI) pada Pasien Diabetes Melitus Tipe 2 Obese dan Normal Weight di RSUD Dr. Moewardi Miranti, Biltinova Arum; Sugiarto, .; Widardo, .
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Peripheral Arterial Disease (PAD) is one of the complications of type 2 diabetes mellitus. Obesity is a risk factor of PAD and it is estimated 80 - 90% of patients with type 2 diabetes mellitus are overweight or obese. ABI is a simple method for diagnosing PAD and the ABI value of < 0.9 means that the patient suffers PAD. The aims of this study are to know the difference of ABI between obese and normal weight patients with type 2 diabetes mellitus in Dr. Moewardi Hospital and the correlation between ABI and the Body Mass Index (BMI). Methods: This study is an analytical observation by means of cross sectional approach. The subjects were patients of Dr. Moewardi Hospital registered from April to July 2013, suffering type 2 diabetes mellitus. Subjects were selected through purposive sampling. The data were obtained by measuring the patients’ BMI, examining the patients’ ABI and checking the patients’ medical record. The data were analyzed by the unpaired t test, significant if p value < 0.05, and by Spearman correlation test through SPSS 20.0 Statistic program for Windows. Results: Data were taken from 33 subjects consisting of 11 obese patients and 22 normal weight patients suffering type 2 diabetes mellitus. The result obtained shows that 9 patients were included in the borderline category of ABI values, 6 (66.7%) patients were obese and 3 (33.3%) patients had normal weight. The unpaired t test shows that the mean of ABI of obese vs normal weight patients with type 2 diabetes mellitus is 0.98 ± 0.06 vs 1.01 ± 0.06, p = 0.221. The Spearman correlation test between ABI and BMI shows p = 0.028 and r = -0.384. Conclusions: The study suggested that there is no significant difference mean of ABI between obese and normal weight patients with type 2 diabetes mellitus in Dr. Moewardi Hospital. However, based on the interpretation of ABI values ​​obtained, the percentage of subjects with lower ABI values ​​was found greater in obese patients with type 2 diabetes mellitus (66.7%). There is correlation between ABI and BMI. Keywords: ABI, obese type 2 diabetes mellitus, normal weight type 2 diabetes mellitus  
Hubungan antara Penggunaan Obat Nyamuk dengan Tingkat Kontrol Asma Astuti, Astari Rindu; Aphridasari, Jatu; Widardo, .
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Asthma is a chronic inflammatory disorder of the airways with episodic symptoms such as cough, shortness of breath, wheezing, and uplifted chest. Mosquito repellent consists of chemical synthetic chemical materials that can prevent mosquito’s bite towards. This study is to find out if there is or not any correlation between mosquito repellent usage and rate of asthma control. Methods: This study was an analytic observational study using cross sectional approach conducted on May to July 2013. Sixty samples were taken by using purposive sampling from outpatients who visited Pulmonary Clinics of Local Public Hospital Dr. Moewardi and fulfilled the inclusive criteria. The data was collected via interview by using a set of questionnaire. The data was then analyzed using Chi-Square test on Statistical Product and Service Solution (SPSS) 20.00 for Windows. Results: There is no significant correlation between mosquito repellent usage and rate of asthma control. From the Chi-Square test result, it was obtained that the significance value is p = 0,817. Conclusions: Based on this research, it can be concluded that there is no correlation between mosquito repellent usage and rate of asthma control. Keywords: mosquito repellent, rate of asthma control  
Perbandingan Stres yang Dirasakan Pasien Asma dan Pasien PPOK di RSUD Dr.Moewardi Yunita, Amelia; Setijadi, Ana Rima; Widardo, .
Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Asthma is a chronic inflammatory disorder of the airways with episodic symptom such as cough, shortness of breath, wheeze, and uplifted chest. Chronic Obstructive Pulmonary Disease (COPD) is a disease which is characterized by airflow limitation that is not fully revesible and associated with an abnormal inflammatory response of the lung to noxious particles or gases. This study aimed to compared the perceived stress between asthma patients and COPD patients. This analytic study was observational using cross-sectional approach. A sample of 60 study subjects was selective by purposive sampling from outpatient who visited Pulmonary Clinic, RSUD Dr. Moewardi and fulfill the intrinsic criteria. The data was collected by interview using a set of questioner. The data was analyzed using Chi Square test on SPSS 20 for windows. This study showed that asthma patients had a low stress level, which is 60%. While, in COPD patients had high stress level, which is 63.33%. (p=0.002, OR= 7.5) There is a statistically significant difference perceived stress between asthma patients and COPD patients. COPD patients had higher stress level compared to asthma patients. 
Hubungan Pemberian ASI Eksklusif dengan Kejadian Penyakit Alergi pada Anak Wardhani, Annisa; Harsono, Ganung; Widardo, .
Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Allergy defined as hipersensitivity reaction started by immunological mechanism through exposure of allergen to atopic individues. Atopy is genetical tendencies to produce IgE that has been exposed to allergen. Allergic disease that commonly found  in children are atopic eczema, asthma bronchial and  allergic rhinitis.  Whereas food allergy and cow’s milk allergy are the first allergic disease that could occur for the first time in children. For the past few years, the incidence of allergic disease is increased rapidly, on domestic and global scale. As the result, the prevention of  this disease become very important. There are many methods has been done, such as exclusive breatfeeding, avoidance of risk factor and tobacco smoke exposure, and probiotic administration, but the result is remain controversial. This study aims to find out the correlation between exclusive breastfeeding and occurence of allergic disease in children. Methods: This is an analytical survey study using case control approach which was conducted on May-July 2013 in Dr. Moewardi Hospital. The sample was taken using purposive sampling and used rule of thumb to take the amount of sample. Occurence of allergic disease is classified as independent variable and exclusive breastfeeding is classified as dependent variable. The children parents that agree to be taken as a sample signed informed consent and filled the questionnaire. The data about diagnosis was required from medical record. 70 samples of research were obtained and analyzed by using Chi Square test followed by the multivariate logistic regression analysis. Results: Bivariat analysis using Chi Square test showed significant correlation between exclusive breastfeeding with the occurence of allergic disease in children with p<0.05. Exclusive breastfeeding Crude OR was 0.351. By using multivariate logistic regression analysis were obtained adjusted OR = 0.214, p = 0.016 (p<0.05), and 95% CI = 0.061-0.751 for independent variable exclusive breastfeeding. Conclusions: There is a significant correlation between exclusive breastfeeding with the occurence of allergic disease in children (p = 0.016). The OR = 0.214 showed that exclusive breastfeeding is a protective factor against allergic disease in children. Keywords: Exclusive Breastfeeding, Allergic Disease, Atopy  
Hubungan antara Faktor Risiko Perdarahan dengan Kejadian Perdarahan Postpartum di RSUD Dr. Moewardi Surakarta Tahun 2012 Amanda, Larissa; Sunaryo, Rustam; Widardo, .
Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Maternal mortality rate in Indonesia is relatively high compared to the other Asian countries. Postpartum hemorrhage is one of the major cause of maternal mortality. The increase in risk factors for hemorrhage in pregnancy and labor is known to contribute to the increase in cases of postpartum hemorrhage.  The objective of this research was to know the correlation between risk factors for hemorrhage and occurrence of postpartum hemorrhage in Dr. Moewardi Hospital Surakarta in 2012. Methods: This research used descriptive analytical study by the case control approach. Case group was patients with postpartum hemorrhage in Dr. Moewardi Hospital Surakarta in 2012. Sample of the case group was taken by purposive sampling. Control group was postpartum patients in Dr. Moewardi Hospital Surakarta in 2012 who didn’t experience of postpartum hemorrhage. Sample of the control group was randomly selected by simple random sampling from 45 patients who had spontaneus labor and 45 patients who had sectio caesarean which met the criteria of purposive sampling. This research was conducted by collecting data from 55 medical records of patients in case and control groups. The collected data were analyzed with Chi Square and logistic regression formulas. Results: The result of statistical analysis revealed significant diferrences between case and control groups for methods of labour with p values = 0,001 and r = 0,405. The results of statistical analysis for age, parity, anemia, birthweight and severe preeclampsia revealed no significant differences between case and control groups with each p values = 0,566, 0,423, 0,401 and 0,161. There were no eclampsia and polihidramnios patient in case and control groups. Conclusions: The results of this research revealed that there were a correlation between spontaneous labor with episiotomy, elective caesarean section, emergency caesarean section, assisted vaginal delivery with episiotomy and occurence of postpartum hemorrhage in Dr. Moewardi Hospital in 2012. Keywords: postpartum hemorrhage, risk factors for hemorrhage. 
Uji Sitotoksik Ekstrak Curcumin Pada Kultur Sel Limfosit T Penderita Systemic Lupus Erythematosus (SLE) Mustikasari, Hanif; Febrinasari, Ratih Puspita; Widardo, .
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease that causes chronic inflammation in multiorgan, in which its etiology and pathogenesis are unclear. Curcumin has been found to have a selective cytotoxic effects on various types of cancer cells through induction of apoptosis on the various pathways. This study aimed to demonstrate whether curcumin extract had cytotoxic effects on T lymphocytes autoreactivity of patients with SLE. Methods: This research was an experimental laboratory with post test only controlled group design. Samples were using cell cultures of T lymphocytes from the veins blood of a patient with SLE and normal people. Each of T lymphocytes cell culture consisted of media control (KM), cells control (KS), the positive control with cyclophosphamide (KP1), and a group treated with curcumin extract (KP2). Curcumin extracts and cyclophosphamide were divided into 8 serial doses (50 µg/mL, 25 µg/mL, 12.5 µg/mL, 6.25 µg/mL, 3.125 µg/mL, 1.5625 µg/mL, 0.78125 µg/mL, 0.390625 µg/mL). Cell inhibition was calculated based on a percentage (%) of cell viability. Then, the data was analyzed using probit analysis to determine the dose of IC50 with SPSS for Window Release 17.0. Results: The result of cell inhibition probit analysis (IC50) on T lymphocytes cell culture of patients with SLE using curcumin extract was active (score 3) and T lymphocytes cell culture of patients with SLE using cyclophosphamide was moderately active (score 2).While, T lymphocytes cell culture of normal people using curcumin extract was active (score 3) and T lymphocytes cell culture of normal people using cyclophosphamide was moderately active (score 2). Conclusions: Curcumin extract had cytotoxic effect on T lymphocytes cell culture of SLE. The cytotoxic effect of curcumin extract on T lymphocytes cell culture of patients with SLE was stronger than cyclophosphamide.   Keywords: curcumin extract, cytotoxic, SLE
Perbedaan Ankle Brachial Index (ABI) pada Pasien Diabetes Melitus Tipe 2 Obese dan Normal Weight di RSUD Dr. Moewardi Miranti, Biltinova Arum; Sugiarto, .; Widardo, .
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Abstract

Background: Peripheral Arterial Disease (PAD) is one of the complications of type 2 diabetes mellitus. Obesity is a risk factor of PAD and it is estimated 80 - 90% of patients with type 2 diabetes mellitus are overweight or obese. ABI is a simple method for diagnosing PAD and the ABI value of < 0.9 means that the patient suffers PAD. The aims of this study are to know the difference of ABI between obese and normal weight patients with type 2 diabetes mellitus in Dr. Moewardi Hospital and the correlation between ABI and the Body Mass Index (BMI). Methods: This study is an analytical observation by means of cross sectional approach. The subjects were patients of Dr. Moewardi Hospital registered from April to July 2013, suffering type 2 diabetes mellitus. Subjects were selected through purposive sampling. The data were obtained by measuring the patients’ BMI, examining the patients’ ABI and checking the patients’ medical record. The data were analyzed by the unpaired t test, significant if p value < 0.05, and by Spearman correlation test through SPSS 20.0 Statistic program for Windows. Results: Data were taken from 33 subjects consisting of 11 obese patients and 22 normal weight patients suffering type 2 diabetes mellitus. The result obtained shows that 9 patients were included in the borderline category of ABI values, 6 (66.7%) patients were obese and 3 (33.3%) patients had normal weight. The unpaired t test shows that the mean of ABI of obese vs normal weight patients with type 2 diabetes mellitus is 0.98 ± 0.06 vs 1.01 ± 0.06, p = 0.221. The Spearman correlation test between ABI and BMI shows p = 0.028 and r = -0.384. Conclusions: The study suggested that there is no significant difference mean of ABI between obese and normal weight patients with type 2 diabetes mellitus in Dr. Moewardi Hospital. However, based on the interpretation of ABI values ​​obtained, the percentage of subjects with lower ABI values ​​was found greater in obese patients with type 2 diabetes mellitus (66.7%). There is correlation between ABI and BMI. Keywords: ABI, obese type 2 diabetes mellitus, normal weight type 2 diabetes mellitus  
Perbedaan Intelligence Quotient (IQ) Anak Obes dan Tidak Obes Usia Sekolah Dasar di SD Kristen Manahan Surakarta Magdalena Wibawati; Suci Murti Karini; . Widardo
Nexus Kedokteran Komunitas Vol 2, No 3 (2013): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.115 KB)

Abstract

Background: Prevalence of obesity has increased over the last 20 years and become worlds health problems. Obesity in children may cause medical and psychosocial consequences, which can influence their Intelligence Quotient. The aim of this research is to determine whether the difference of Intelligence Quotient existed in obese and non-obese children in Manahan Christian Primary School Surakarta. Methods: This research is an analytic observational study with cross sectional approach. Sample was collected by simple random sampling. Based on the anthropometric measurement of 2nd until 5th grade students in Manahan Christian Primary School Surakarta, 30 samples were collected for each group (obese and non-obese children). Intelligence Quotient test were performed using Culture Fair Intelligence Test (CFIT) 2A by the students who become research sample.Data were analyzed with unpaired t-test by Statistical Product and Serve Solution (SPSS) 21 for Mac. Results: Mean score of Intelligence Quotient in the obese children is 105.29, while in the non-obese children is 105.82. Result of unpaired t test showed the probability of 0.849 (p > 0.05). It means the significance value of the difference between the two groups was not significant. Conclusions: There is no difference of Intelligence Quotient (IQ) between obese and non-obese children in Manahan Christian Primary School Surakarta. Keywords: Intelligence Quotient, obese children, non-obese children
Co-Authors . Balgis . Sugiarto Amelia Yunita Ana Rima Setijadi Ana Rima Setijadi Annang Giri Moelyo Annang Giri Moelyo Arsita Eka Prasetyawati Astari Rindu Astuti Biltinova Arum Miranti Egtheastraqita Chithivema Evi Kusumawati Ganung Harsono Ganung Harsono Hanif Mustikasari Jatu Aphridasari Larissa Amanda Magdalena Wibawati MARIA BINTANG Melinda Didi Yudhanti Putri Nur Kumalasari Raharjo Kuntoyo Ratih Puspita Febrinasari Ratih Puspita Febrinasari Rustam Sunaryo Rustam Sunaryo Slamet Riyadi Suci Murti Karini Suci Murti Karini Zenia Purnama Murti