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All Journal Journal of Biomedicine and Translational Research Smart Medical Journal Indonesian Journal of Medicine Jurnal Respirologi Indonesia Jurnal Kedokteran Universitas Palangka Raya Respiratory Science Narra J Kieraha Medical Journal Cermin Dunia Kedokteran
Jatu Aphridasari
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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The Role of Omega-3 on the IL-6 Levels, Malondialdehyde, and Clinical Improvement in Adults with Community-Acquired Pneumonia Astarini, Dewi; Aphridasari, Jatu; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 44 No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.402

Abstract

Background: Acute lung parenchymal infection, known as pneumonia, can be carried on by multiple microorganisms, including bacteria, viruses, fungi, and parasites. Globally, community-acquired pneumonia is a major factor of morbidity, mortality, and health issues. Malondialdehyde (MDA) is a marker of oxidative stress in pneumonia patients, and interleukin 6 (IL-6) is a marker of inflammatory process. Effect of Omega-3 as an immunomodulator, anti-inflammatory, and antioxidant may be implemented as adjunctive therapy in patient with community-acquired pneumonia.Methods: Clinical trial research with a true experimental method and pretest-posttest design. The study involved 30 community-acquired pneumonia patients who were admitted at Moewardi Hospital in Surakarta and Dr. Soehadi Prijonegoro Hospital in Sragen from August to September 2022 by consecutive sampling. The control group (n=15) received standard therapy, and the treatment group (n=15) received standard therapy plus Omega-3 at a dose of 1600 mg/day. IL-6 and MDA levels were measured when the subject was admitted to the hospital and there was clinical improvement.Results: There was a significant difference in reduced IL-6 levels (P=0.001), decreased MDA levels (P=0.001), and the duration of clinical improvement (P=0.042) between the treatment group and the control group. There was a moderate correlation between the decrease in IL-6 (R=0.480) and MDA (R=0.459), while the duration of clinical improvement had a strong correlation (R=0.756) in the treatment group.Conclusion: Supplementation of Omega-3 was effective in reducing IL-6, MDA levels, and the duration of clinical improvement in community-acquired pneumonia patients.
The Relation between D-Dimer, Hs-CRP, and ACE Inhibitor to Severity, Reinfection, and Mortality of COVID-19 Patients Thomas, Novita Silvana; Aphridasari, Jatu; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 44 No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.465

Abstract

Background: COVID-19 reinfection has been found, although the data is not clear yet. Pandemic conditions bring about limited facilities and infrastructure, so biomarkers are an option. Research on biomarkers and the use of ACE inhibitor drugs in COVID-19 patients has not been widely conducted in Indonesia.Methods: This was a retrospective cohort study that used medical record data of confirmed COVID-19 patients treated at dr. Moewardi General Hospital for the period of January to March 2022. Surviving patients were observed for reinfections until November 2022.Results: This study involved 524 medical records of confirmed COVID-19 patients. After exclusion and inclusion criteria, 517 medical records were obtained. D-Dimer cut-off values of ≥2435 were significantly related to severity (OR=2.05; 95% CI=1.38-3.06; P≤0.001) and mortality (OR=2.89; 95% CI=1.95-4.27; P≤0.001) of COVID-19 patients. Hs-CRP levels ≥4.59 were significantly associated with mortality in COVID-19 patients (OR=1.82; 95% CI=1.23-2.69; P=0.003). The use of ACE inhibitors (OR=0.55; 95% CI=0.33-0.89; P=0.015) was a protective factor from mortality but increased the risk of reinfection (OR=3.11; 95% CI=1.16-8.36; P=0.034). Conclusion: D-Dimer and Hs-CRP biomarkers could be considered as predictor biomarkers for the severity and mortality of COVID-19 patients. Although the use of ACE inhibitors increased the risk of reinfection, it reduced the risk of mortality due to COVID-19.
Comparison of NEWS, SIRS, and qSOFA Score as Predictors of Mortality and Length of Stay in Patients Pneumonia with Sepsis Harsini, Harsini; Alfarizi, Aditya; Aphridasari, Jatu; Raharjo, A Farih; Reviono, Reviono
Jurnal Respirologi Indonesia Vol 44 No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.505

Abstract

Background: Pneumonia is a major health problem in all age groups and often related with sepsis. In 2021, Surviving Sepsis Campaign Guidelines mentioned several clinical scoring systems to identify patients with potentials of developing sepsis, such as systemic inflammatory response syndrome (SIRS), national early warning score (NEWS), quick sequential organ failure assessment (qSOFA) and sequential organ failure assessment (SOFA). The guideline stated that there is no gold standard for diagnosing sepsis, contradicting The Sepsis-3 Guideline in 2016 that mentioned SOFA score as a gold standard for diagnosing sepsis.Methods: Subjects were all patients with pneumonia and sepsis who were treated in Dr.Moewardi Hospital within 1 January to 31 December 2022. Data from subjects’ medical records were collected to assess their NEWS, SIRS, qSOFA, and SOFA score on the day of admission. Since evaluation of SOFA score needs a number of components requiring laboratory results and takes longer time so they made a simpler tool called qSOFA to avoid delayed treatment of the patients.Results: NEWS is more consistent with SOFA compared to SIRS and qSOFA (Kappa value = 0.726 vs 0.320 vs 0.22; respectively). NEWS, SIRS, and qSOFA were all significantly correlated with mortality (P<0.001) with NEWS having the strongest correlation (r=0.482 vs 0.216 vs 0.175; respectively). Only NEWS showed significant correlation with the length of stay (r=0.129; P<0.001).Conclusion: NEWS was the most consistent score to SOFA compared to SIRS and qSOFA. NEWS was also the best predictor for mortality and was the only score correlated with length of hospital stay.
Comparative Analysis of Copeptin, IL-6, and TNF-α as Predictive Biomarkers for Clinical Outcome in Moderate to Severe COVID-19 Patients Harsini, Harsini; Aphridasari, Jatu; Siregar, Sihsusetyaningtyas Tiominar
Jurnal Respirologi Indonesia Vol 46 No 1 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/mbaw4490

Abstract

Abstract Background: This retrospective clinical study aimed to evaluate the correlation of copeptin, IL-6, and TNF-α levels with the clinical outcomes of patients with moderate to severe COVID-19. Methods: The study included patients who met the selection criteria and provided written informed consent. A sample size of 41 was determined via power analysis to achieve 80% power at a 0.05 significance level. Consecutive sampling was employed to select participants. The study utilized medical records of patients with moderate to severe COVID-19 who underwent copeptin, IL-6, and TNF-α testing. Correlation analyses and Bonferroni corrections were performed using SPSS® ver. 21. Results: Results revealed a moderate positive correlation between copeptin levels and patient outcomes (Bonferroni correlation: 0.597; p < 0.001). A weak positive correlation was observed between IL-6 levels and outcomes (Bonferroni correlation: 0.239; p = 0.055), while a negligible positive correlation was found for TNF-α levels (Bonferroni correlation: 0.140; p = 0.177), which was not statistically significant. Conclusion: Copeptin emerged as a more sensitive biomarker for predicting the outcomes of COVID-19 patients compared to IL-6 and TNF-α. Elevated copeptin levels were associated with a poorer prognosis. Copeptin emerged as the strongest biomarker in this study, likely due to its role as a surrogate for vasopressin release, signaling a severe inflammatory response. Furthermore, its stability in serum renders copeptin a more sensitive biomarker than IL-6 and TNF-α.
Analysis of Risk Factors for Antimicrobial Resistance in Nosocomial Pneumonia Amanda, Larissa; Aphridasari, Jatu; Sutanto, Yusup Subagio
Respiratory Science Vol. 6 No. 2 (2026): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i2.179

Abstract

Background: Antibiotic resistance is often linked to nosocomial pneumonia, one of the most prevalent hospital-acquired illnesses. Determining risk factors is crucial for management and preventative plans. To develop preventative and control measures, this research was conductedto identify the variables linked to antibiotic resistance in nosocomial pneumonia patients. Method: In this retrospective cohort analysis, 237 individuals with nosocomial pneumonia were included. Odds Ratios (OR) were computed for relevant factors after data were evaluated using the chi-square or Fisher’s exact test to find significant relationships between patient characteristics and antibiotic resistance. Results: Of the 237 patients, 58.2% exhibited antibiotic resistance. Several variables were found to be significantly associated with antibiotic resistance: age >59 years (OR=1.68; P=0.049), intensive care unit (ICU) admission (OR=2.65; P=0.002), high care unit (HCU) admission (OR=2.16; P=0.028), history of prior antibiotic use (OR=2.42; P=0.004), and endotracheal tube (ETT) use (OR=2.04; P=0.024). Patients older than 59 years had a 1.68-fold higher risk. Those admitted to the ICU and HCU had 2.65-fold and 2.16-fold higher risks, respectively. Patients with a history of prior antibiotic use had a 2.42-fold increased risk, and those with ETT use had a 2.04-fold increased risk. Conclusion: Older age, admission to intensive care units (ICU/HCU), previous antibiotic use, and endotracheal tube use are significant factors associated with antibiotic resistance in nosocomial pneumonia. These findings highlight key areas for targeted interventions to mitigate resistance.
The Agreement Level of Colorimetric Indicator Paper and pH Meter Examination Compared to Urine Analyzer in Measuring Exudative Pleural Effusion Fluid pH Huda, Muttaqin; Subagio Sutanto, Yusup; Aphridasari, Jatu
Jurnal Respirologi Indonesia Vol 46 No 2 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jqq7dj53

Abstract

Background: Pleural effusion is an abnormal accumulation of fluid in the pleural space, commonly associated with pulmonary infections and malignancies. Measurement of pleural fluid pH is important for diagnosis, therapeutic decision-making, and prognostic evaluation. Various methods are used, including pH meters, indicator papers, and urine analyzers; however, their concordance has not been widely studied in Indonesia. This study aimed to evaluate the agreement of pleural fluid pH results measured using pH meters, indicator papers, and urine analyzers to support appropriate selection of diagnostic methods. Methods: This observational analytic study with a cross-sectional design conducted at Dr. Moewardi General Hospital, Surakarta, from March to June 2025. The sample consisted of 55 patients with exudative pleural effusion who met the inclusion criteria. Pleural fluid pH was measured using three methods: colorimetric indicator paper, a pH meter, and a urine analyzer. Data were analyzed using the kappa coefficient and the Intraclass Correlation Coefficient (ICC) to assess the agreement between methods. Results: The mean pH values of pleural fluid measured by the urine analyzer, pH meter, and colorimetric indicator paper were 8.18 ± 0.47, 8.13 ± 0.46, and 8.15 ± 0.59, respectively. Agreement analysis showed a very strong and statistically significant correlation between the pH meter and urine analyzer (ICC = 0.948; p < 0.001), between the pH strip and urine analyzer (ICC = 0.855; p < 0.001), and between the pH meter and pH strip (ICC = 0.916; p < 0.001). A significant positive correlation was also observed between glucose levels and pH measured by both the urine analyzer and the pH meter. Conclusion: There is good agreement among pH measurements obtained using colorimetric indicator paper, urine analyzer, and pH meter in exudative pleural effusion fluid.
Investigating Factors Influencing Treatment Outcomes of Pulmonary Tuberculosis: A Cross-Sectional Study Based on Community Health Center Registry in Surakarta Bragastio, Muhamad Rico Aldrian Renandri; Suyatmi, Suyatmi; Raharjo, Ahmad Farih; Aphridasari, Jatu
Smart Medical Journal Vol 7, No 3 (2024): December
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v7i3.88225

Abstract

Introduction: Pulmonary tuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis. The successful treatment of pulmonary TB can be influenced by several factors, namely gender, age, body mass index (BMI), and comorbid diseases. This study aims to investigate whether those factors influence the treatment outcome of pulmonary TB patients in Surakarta.Method: This study is an analytical observational study with a cross-sectional design. The research subjects were pulmonary tuberculosis patients treated in 2020-2022 at Ngoresan, Setabelan, and Sibela Community Health Center of Surakarta. The inclusion criteria was pulmonary TB patient over 15 years old. Patients suffering from other pulmonary diseases or with incomplete medical record were excluded.Results: This study involved 101 subjects. Multivariate analysis was conducted using the logistic regression test and bivariate analysis showed that there were not any significant effect of age, BMI, and comorbid diseases observed on treatment outcome with p=0.571, p=0.147, and p=0.13 respectively. Interestingly, gender was found to be significantly influencing the outcome of pulmonary TB treatment (p=0.020)Conclusion: Gender influencing the treatment outcome of pulmonary TB patients in Surakarta. Further study covering more cases across all Community Health Center of Surakarta is required.
Co-Authors . Widardo AA Sudharmawan, AA Adhiputri, Artrien Alfarizi, Aditya Ana Rima Setijadi Apriningsih, Hendrastutik Arifin Arifin Astari Rindu Astuti Astarini, Dewi Bahari, Muh Arif Wira Bragastio, Muhamad Rico Aldrian Renandri Fachry Abda El Rahman Fahlevie, Fahlevie Harnanda, Dicki Harsini Harsini Helmi Fakhruddin Heni Hastuti Huda, Muttaqin Joko, Agus Laqif, Abdurahman Larissa Amanda Marwanta, Sri Mochammad Imron Awalludin Nadiya Aliyah Roselyn Novita Silvana Thomas, Novita Silvana Oktavera Tri Kurniasih Permana, Septian Adi Raharjo, A Farih Raharjo, Ahmad Farih Reviono Reviono Rivan Danuaji Rudiannor, Muhammad Saraswati, Kunti Septiawan, Debree Sidharta, Rina Siregar, Sihsusetyaningtyas Tiominar Siti Munawaroh Soetjahjo, Bintang Subagio Sutanto, Yusup Sumardiyono . Sutanto, Yusup S. Suyatmi Suyatmi widardo, Widardo Widyasanti, Diana Windu Prasetyo, Windu Yusup Subagio Sutanto