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All Journal Nexus Kedokteran Klinik Journal of Biomedicine and Translational Research Indonesian Journal of Medicine Jurnal Respirologi Indonesia Jurnal Kedokteran Universitas Palangka Raya Respiratory Science Narra J Kieraha Medical Journal Cermin Dunia Kedokteran
Jatu Aphridasari
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Respiratory Science

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Effect of Body Mass Index, Sputum Conversion Status, and Adverse Drug Events Severity On Health-Related Quality of Life of Drug-Resistant Tuberculosis Patients Kurniawan, Sandy; Aphridasari, Jatu; Raharjo, A Farih
Respiratory Science Vol. 5 No. 2 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i2.168

Abstract

Background: Adherence to treatment guidelines and bacteriological conversion are the main indicators of successful treatment of drug-resistant tuberculosis patients. Evaluation of health-related quality of life (HRQoL) and the effect of treatment on HRQoL are often ignored. HRQoL assessment is an interesting outcome to evaluate and improve. Drug-resistant tuberculosis patients suffer not only from the disease but also from the effects of the treatment. Method: This study used a cross-sectional design to determine the correlation of body mass index (BMI), sputum conversion status, and adverse drug events severity with the HRQoL of drug-resistant tuberculosis patients. Quality of life assessment using the WHOQol-BREf questionnaire. The study was conducted in October 2022 at dr. Moewardi Hospital, Surakarta and Dr. Ario Wirawan, Salatiga. Determination of the sample by total sampling method. Results: HRQoL in 33 study subjects ie, 15 subjects had good HRQoL and 18 subjects had poor HRQoL. The media for each quality of life domain are the physical domain 43.00±6.20, psychological domain 33.21±8.83, social domain 28.21±11.01, and environmental domain 33.45±6.38. Statistical analysis with rank Spearman showed that there were a relationship between BMI (P=0.018), sputum conversion status (P=0.002), and adverse drug events severity (P=0.0001) with HRQoL of drug-resistant tuberculosis patients. Conclusion: BMI, sputum conversion status, and drug adverse events severity affect HRQoL of drug-resistant tuberculosis patients.
Analysis of Risk Factors for Antimicrobial Resistance in Nosocomial Pneumonia Amanda, Larissa; Aphridasari, Jatu; Sutanto, Yusup Subagio
Respiratory Science Vol. 6 No. 2 (2026): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i2.179

Abstract

Background: Antibiotic resistance is often linked to nosocomial pneumonia, one of the most prevalent hospital-acquired illnesses. Determining risk factors is crucial for management and preventative plans. To develop preventative and control measures, this research was conductedto identify the variables linked to antibiotic resistance in nosocomial pneumonia patients. Method: In this retrospective cohort analysis, 237 individuals with nosocomial pneumonia were included. Odds Ratios (OR) were computed for relevant factors after data were evaluated using the chi-square or Fisher’s exact test to find significant relationships between patient characteristics and antibiotic resistance. Results: Of the 237 patients, 58.2% exhibited antibiotic resistance. Several variables were found to be significantly associated with antibiotic resistance: age >59 years (OR=1.68; P=0.049), intensive care unit (ICU) admission (OR=2.65; P=0.002), high care unit (HCU) admission (OR=2.16; P=0.028), history of prior antibiotic use (OR=2.42; P=0.004), and endotracheal tube (ETT) use (OR=2.04; P=0.024). Patients older than 59 years had a 1.68-fold higher risk. Those admitted to the ICU and HCU had 2.65-fold and 2.16-fold higher risks, respectively. Patients with a history of prior antibiotic use had a 2.42-fold increased risk, and those with ETT use had a 2.04-fold increased risk. Conclusion: Older age, admission to intensive care units (ICU/HCU), previous antibiotic use, and endotracheal tube use are significant factors associated with antibiotic resistance in nosocomial pneumonia. These findings highlight key areas for targeted interventions to mitigate resistance.
Co-Authors . Widardo AA Sudharmawan, AA Adhiputri, Artrien Alfarizi, Aditya Ana Rima Setijadi Apriningsih, Hendrastutik Arifin Arifin Astari Rindu Astuti Astarini, Dewi Bahari, Muh Arif Wira Fachry Abda El Rahman Fahlevie, Fahlevie Harnanda, Dicki Harsini Harsini Helmi Fakhruddin Heni Hastuti Joko, Agus Laqif, Abdurahman Larissa Amanda Marwanta, Sri Mochammad Imron Awalludin Nadiya Aliyah Roselyn Novita Silvana Thomas, Novita Silvana Oktavera Tri Kurniasih Permana, Septian Adi Raharjo, A Farih Reviono Reviono Rivan Danuaji Rudiannor, Muhammad Saraswati, Kunti Septiawan, Debree Sidharta, Rina Siregar, Sihsusetyaningtyas Tiominar Siti Munawaroh Soetjahjo, Bintang Sumardiyono . Sutanto, Yusup S. widardo, Widardo Widyasanti, Diana Windu Prasetyo, Windu Yusup Subagio Sutanto