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All Journal Jurnal Teknologi Pendidikan Madrasah Jurnal Kartika Kimia
Asisah, Asisah
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education

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PERKEMBANGAN BIOLOGIS, MOTORIK, KOGNITIF, DAN SOSIOEMOSIONAL (PADA MASA ANAK-ANAK) Umajjah, Nur Thahirah; Angraeni, Nia; Asrika, Asrika; Jannah, Raudhatul; Rifkah, Aqila; Agustin, Wanni; Yunita, Yunita; Intan, Intan; Erna, Erna; Bunga, Bunga; Asisah, Asisah; Indah, Indah; Wahyuni, Rahayu; Syahwaliyah, Putri; Amelia, Riska; Qolbi, Nurul; Annisa, Nur Ainun
Jurnal Teknologi Pendidikan Madrasah Vol 4 No 2 (2021): Jurnal Teknologi Pendidikan Madrasah
Publisher : IAI Al-Mawaddah Warrahmah Kolaka

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Abstract

Biological includes changes in body shape and size such as the growth of the brain, muscles, nervous system, bone structure, increase in height and weight. Motor development is a term used to describe the behavior of movements carried out by the human body. Cognitive development is the stages of changes that occur in the span of human life to understand, process information, solve problems and know something. Socio-emotional or emotional development in childhood is marked by the emergence of evaluative emotions that are recognized as pride, shame, and guilt, where the emergence of these emotions indicates that children have begun to understand and use social rules and norms to assess their behavior
Computational Study of Phytopharmaceutical Antidiabetes Potential of Gorontalo Traditional Medicine Plants La Kilo, Akram; Aman, La Ode; Asisah, Asisah; Ischak, Netty Ino; Paputungan, Mardjan; Alio, La
Jurnal Kartika Kimia Vol 6 No 1 (2023): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v6i1.202

Abstract

Diabetes Mellitus (DM) was a disease characterized by the occurrence of hyperglycemia. This study aimed to analyze the activity of compounds in traditional medicinal plants as potential anti-diabetic candidates using the MM method and to analyze the interactions of compounds contained in traditional medicinal plants that could be used as anti-diabetic drugs. The methods used were Molecular docking and Molecular dynamics, with the Aldose reductase 2HV5 receptor and the ligand ZST. Based on the research findings, the active compounds identified as potential anti-diabetic drugs were Calebin_A and alpha_tocotrienol. Docking method validation on Protein 2HV5 using the natural ligand ZST showed an RMSD of 0.66 Å. The best results from molecular docking were obtained with Calebin_A, which had a binding affinity of -11.3 kcal/mol, and alpha_tocotrienol, which had a binding affinity of -11.2 kcal/mol. The results of the molecular dynamics method on the best complexes were evaluated by considering the changes in system energy, system temperature, pressure, RMSD, RMSF, and binding free energy (∆G). The standard ligand ZST had a value of -30.43 kcal/mol, the test ligand calebin_A had a value of -34.48 kcal/mol, and alpha_tocotrienol had a value of -39.46 kcal/mol.
Co-Authors Agustin, Wanni Akram La Kilo Angraeni, Nia Annisa, Nur Ainun Asrika, Asrika Bunga, Bunga Erna Erna, Erna Indah Indah Intan Intan La Alio La Ode Aman Mardjan Paputungan Netty Ino Ischak Nur Thahirah Umajjah, Nur Thahirah QOLBI, NURUL Raudhatul Jannah Rifkah, Aqila Riska Amelia Syahwaliyah, Putri Wahyuni, Rahayu Yunita Yunita