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All Journal Medical Laboratory Technology Journal AcTion: Aceh Nutrition Journal Jaringan Laboratorium Medis An-Nadaa: Jurnal Kesehatan Masyarakat Tropical Health and Medical Research Journal Jurnal Rakat Sehat : Pengabdian Kepada Masyarakat Jurnal Karya Generasi Sehat
Insana, Aima
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Religion Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Journal : Medical Laboratory Technology Journal

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Salıva pH, Carıes and OHI-S Score in Stuntıng Pre-School Chıldren in The Swamp Area Utami, Naning Kisworo; Andrestian, Meilla Dwi; Insana, Aima
Medical Laboratory Technology Journal Vol. 11 No. 2 (2025): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i2.688

Abstract

Stunting remains a major global health issue and is associated with impaired physical and cognitive development, as well as increased susceptibility to oral diseases such as dental caries. Environmental factors, including acidic peatland water, may further aggravate oral health conditions among children living in swamp areas. This study aimed to analyze the relationship between salivary pH, dental caries severity (def-t index), and oral hygiene status (OHI-S) in preschool children with stunting living in peatland regions of South Kalimantan, Indonesia. An analytical observational study with a cross-sectional design was conducted involving 32 preschool children aged 2–5 years residing in the working area of the Martapura Timur Public Health Center. Data collection included clinical examination of caries using the WHO criteria, salivary pH measurement with a Krisbow digital pH meter, and assessment of oral hygiene using the Simplified Oral Hygiene Index (OHI-S). Statistical analysis was performed using the Spearman correlation test. The results showed that salivary pH ranged from 5.5 to 7.0, def-t scores ranged from 2 to 8 (mean = 5.34 ± 1.78), and OHI-S scores were 0.00 in 22 children (68.7%) and >0.00 in 10 children (31.3%). A significant association was found between salivary pH and dental caries severity (p = 0.005; α = 0.05), indicating that lower salivary pH is associated with higher caries prevalence. In conclusion, stunted preschool children in peatland areas exhibited acidic salivary conditions and a high caries burden despite relatively good oral hygiene status. These findings highlight the importance of integrating nutritional rehabilitation and oral health education programs to reduce the risk of dental caries in children living in environmentally vulnerable swamp regions.
Antithrombotic Activity and Hemolysis Pattern of Fibrinolytic Protease-Producing Bacterial Isolates from the Coast of Tanjung Dewa, South Kalimantan Lutpiatina, Leka; Dwiyanti, Ratih Dewi; Insana, Aima; Rizal, Muhammad; Mufid, Muhammad
Medical Laboratory Technology Journal Vol. 11 No. 2 (2025): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i2.689

Abstract

Cardiovascular disease is a leading cause of death worldwide, with thrombosis playing a key role in the pathological process. Conventional antithrombotic therapy often causes side effects, necessitating alternatives based on biological resources. Marine microorganisms are known to produce fibrinolytic protease enzymes that can degrade fibrin and prevent blood clot formation. This study aimed to evaluate the differences in antithrombotic activity and hemolysis patterns of fibrinolytic protease-producing bacterial isolates obtained from the coast of Tanjung Dewa Beach, South Kalimantan. A total of 15 isolates were obtained from seawater, beach sand, mollusks, crabs, and barnacles, and then subjected to colony morphology identification, Gram staining, and spore observation. Proteolytic activity testing using Skim Milk Agar media showed that all isolates had proteolytic activity with varying indices, with PSR1 showing the highest index (3.4). Furthermore, fibrinolytic testing using the fibrin plate assay method showed that 10 isolates were capable of degrading fibrin, with AL8 and SP2 showing the highest fibrinolytic indices (3.12 and 3.11, respectively). Antithrombotic testing using the clot lysis method revealed that AL7 and SP1 exhibited the highest lysis percentages (82.05% and 88.88%, respectively). Anticoagulant activity, as determined by the Lee-White method, showed that SP2 significantly prolonged the coagulation time (142 seconds, 49.65%). Hemolysis pattern testing revealed variations in activity, with AL8 and PSR1 classified as gamma-hemolytic and therefore potentially safer. Statistical analysis showed no significant differences between isolates in terms of antithrombotic activity, anticoagulant activity, or hemolysis pattern (p > 0.05). These findings suggest that coastal bacterial isolates from Tanjung Dewa Beach, particularly AL8 and SP2, have the potential to serve as safe, natural antithrombotic agents, supporting the development of biomedical therapies for cardiovascular disease.
Co-Authors Ahmad Muhlisin Dewi Dwiyanti, Ratih Erfan Roebiakto, Erfan Habibah, Siti Noor Hafidh, Muhammad Ipniliati, Eva Khairir Rizani, Khairir leka lutpiatina, leka Meilla Dwi Andrestian, Meilla Dwi Mufid, Muhammad MUHAMMAD RIZAL Noraini Noraini, Noraini Nur Ain Mirandayanti Nurlailah Nurlailah, Nurlailah Pinto Laksono, Fransiskus Xaverius Agung Putri Wulandari, Rima Putri, Noorlaily Rabiatul Adawiyah Ratih Dewi Dwiyanti, Ratih Dewi Rifqoh Rifqoh Rifqoh, Rifqoh Rizkiyah, Risa SATRIYAS ILYAS Ulfah, Putriana Utami, Naning Kisworo Wahdah Norsiah, Wahdah Wulandari, Eka Dwi