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All Journal E-Jurnal Medika Udayana Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Multidisciplinary Science Eduvest - Journal of Universal Studies
Darmaputra, I Gusti Nyoman
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Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Eduvest - Journal of Universal Studies

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Anemia on Chronic Disease in Leprosy Before and After Completing Multi Drug Therapy Setyawati, Ni Kadek; Rusyati, Luh Made Mas; Indira, I Gusti Ayu Agung Elis; Praharsini, I Gusti Ayu Agung; Darmaputra, I Gusti Nyoman; Karmila, I Gusti Ayu Agung Dwi
Eduvest - Journal of Universal Studies Vol. 4 No. 9 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i9.1500

Abstract

Leprosy infection can cause anemia due to chronic disease (ACD). Multidrug therapy (MDT) for leprosy patients can overcome the infection. This study aims to determine the comparison in the incidence of ACD before and three months after MDT to leprosy patients at Prof. Dr. I G.N.G. Ngoerah Central General Hospital. A cross-sectional analytical observational study was conducted using secondary data from medical records of leprosy patients. A total of 142 samples were taken through total sampling. Data taken included gender, domicile, type of leprosy suffered, incidence of ACD, hemoglobin levels, and erythrocyte index before and three months after completing MDT leprosy therapy. Data analysis was carried out with SPSS version 21 using chi-square and paired t tests (dependent t-test), p value <0.05 means significant. The incidence of ACD was significantly higher before leprosy MDT therapy compared to 3 months after completing leprosy MDT therapy (49.3% vs. 16.2%; p value <0.001) with a prevalence ratio of 3.043 (2.021-4.584) CI95%. The mean hemoglobin levels, MCV, MCH, and MCHC levels 3 months after MDT leprosy therapy were significantly higher than before receiving MDT therapy (13.73 ± 1.47 vs. 12.40 ± 2.06 g/dL; p value <0.001), (88.18±7.22 vs. 84.07±9.55 fl; p value<0.001), (28.32±2.76 vs. 26.72±3.17 pg/cell; p value <0.001), (32.03±1.30 vs. 31.69±1.47%; p value<0.001). The incidence of ACD was significantly higher before MDT compared to 3 months after MDT. Mean hemoglobin, MCV, MCH, and MCHC levels were found to be significantly higher 3 months after MDT compared to before receiving MDT.
Co-Authors Adelia Suryani Gunawan, Regina Hendrayanta, Michelle Herman Saputra I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Praharsini I Gusti Ngurah Agung Dewantara Putra Imron Hadi Tamim, Imron Hadi Indira, I Gusti Ayu Agung Elis Ketut Kwartantaya Winaya Kewatiting, Agnes Susanti Luh Made Mas Rusyati Muhammad Yusron Maulana El-Yunusi Ni Kadek Setyawati, Ni Kadek Ni Luh Putu Ratih Vibriyanti Karna Ni Made Dwi Puspawati Nyoman Suryawati Phinari, Handelia Putu Setiani Richard Richard Triatmakusuma, Yogi Wardhana, I Made Winaya, Ketut Kwartantaya