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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Syntax Literate: Jurnal Ilmiah Indonesia Health and Medical Journal Jurnal Cahaya Mandalika Cermin Dunia Kedokteran
Widyastuti, Zilpa
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Phototherapy for Treating Chronic Spontaneous Urticaria Widyastuti, Zilpa; Oktavriana, Triasari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 2 (2025): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.2.2025.147-152

Abstract

Background: Chronic spontaneous urticaria (CSU) is a disease characterized by the onset of wheals, angioedema and/or both for more than 6 weeks. The clinical characteristics of CSU include wheals and flares that are erythematous or skin- colored. The most frequently used medical therapy is second-generation H1 antihistamines followed by first-generation H1 antihistamines. CSU is currently treated with phototherapy utilizing narrowband ultraviolet B (NB-UVB). Case: A 36-year-old woman presented to the Dermatology and Venereology Outpatient Clinic of DR. Moewardi Hospital, Surakarta, with itchy reddish bumps all over her body since 6 months ago. A dermatology examination obtained multiple erythematous-based urticaria varying in size on her anterior and posterior trunks. We treated this patient with a combination of antihistamines and NB-UVB phototherapy at 200 mJ/cm2 weekly for a month. Significant clinical improvement was observed at week 4 of therapy. Discussion: In the treatment of chronic spontaneous urticaria, NB-UVB phototherapy serves as an adjuvant therapy. It acts as a suppressor of the systemic immune response which reduces the release of histamines and pro-inflammatory mediators, prevents mast cell apoptosis in the dermis, and regulates Th1 as well as Th2. The dose may start at 200 mJ/cm2 then increase by 10-20% for each visit. Conclusion: The combination of antihistamines and NB-UVB has a significant effect on treating chronic spontaneous urticaria. 
Korelasi Kadar Vitamin D Serum dan Derajat Keparahan Psoriasis Vulgaris Berdasarkan Skor PASI dan DLQI Pramudita, Adelia Wuri; Mulianto, Nur M Rachmat; Evanti, Annisa Marsha; Widyastuti, Zilpa; Asaduddin, Aiman Hilmi
Health and Medical Journal Vol 6, No 2 (2024): HEME May 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i2.1476

Abstract

Latar Belakang: Derajat keparahan psoriasis vulgaris ditentukan berdasarkan skor Psoriasis Area and Severity Index (PASI) dan Dermatology Life Quality Index (DLQI). Perjalanan psoriasis dapat dipengaruhi oleh abnormalitas sistem imun, kerentanan genetik, lingkungan dan gaya hidup. Vitamin D juga diduga berperan pada perjalanan berbagai penyakit autoimun termasuk psoriasis. Tujuan: Untuk mengetahui korelasi antara kadar vitamin D serum dengan derajat keparahan psoriasis vulgaris berdasarkan skor  PASI dan DLQI. Metode: Penelitian ini merupakan penelitian analitik eksperimental terhadap 10 subjek dan dilakukan pengukuran kadar vitamin D serum dengan metode Enzyme Linked Immunosorbent Assay (ELISA). Data klinis dan derajat keparahan psoriasis vulgaris dilakukan dengan skoring PASI dan DLQI. Data dianalisis secara deskriptif dan disajikan dalam tabel distribusi frekuensi. Pengolahan data menggunakan uji statistik Spearman untuk menilai korelasi antara kadar vitamin D serum dengan derajat keparahan psoriasis vulgaris berdasarkan skor PASI dan DLQI. Hasil: Analisis data menunjukkan tidak ada korelasi antara kadar vitamin D serum dengan derajat keparahan psoriasis vulgaris berdasarkan PASI (nilai p=0,751 dan koefisien korelasi r=-0,116) dan berdasarkan skor DLQI (nilai p=0,751 dan koefisien korelasi r=-0,116). Kesimpulan: Kadar vitamin D serum tidak berkorelasi dengan derajat keparahan psoriasis vulgaris.
Nevus Unius Lateris with Hemophilia: A rare case report Murastami, Ammarilis; Fiqnasyani, Siti Efrida; Widyastuti, Zilpa; Dharmawan, Nugrohoaji
Health and Medical Journal Vol 5, No 3 (2023): HEME September 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v5i3.1314

Abstract

Latar Belakang: Nevus Unius Lateris (NUL) adalah kelainan bawaan jaringan kulit langka, ditandai distribusi lesi unilateral mengikuti garis Blaschko. Lesi ditemukan pada tahun pertama kehidupan dengan bercak coklat kekuningan, batas yang jelas, dan permukaan verukosa. Pemeriksaan multidisiplin dianjurkan untuk menegakkan diagnosis dan memberikan penatalaksanaan yang tepat. Terapi bertujuan untuk mengangkat dan menghancurkan lesi hiperkeratosis dengan pembedahan/non-pembedahan. Elektrokauter dapat menjadi pilihan untuk membantu mencegah perdarahan setelah operasi dermatologis, terutama hemofilia. Kasus: Tn. A, 24 tahun, pekerjaan wiraswasta, datang dengan keluhan utama beberapa plak yang meninggi di belakang lehernya. Keluhan pertama muncul sebagai bintik pada usia 6 tahun dan naik perlahan, dan menyebar luas. Pasien memiliki riwayat hemofilia A. Pemeriksaan dermatologis, beberapa nodul verukosa hiperpigmentasi bertangkai dengan batas teratur, garis yang jelas tersusun secara linier mengikuti garis Blaschko di daerah coli posterior. Hasil pemeriksaan dermoskopi menunjukkan pola sirkular hiperpigmentasi dengan struktur epidermis eksofitik dan pola serebriform. Pemeriksaan histopatologi menunjukkan hiperkeratosis, akantosis, papilomatosis minimal, dan deposit melanin dengan kepadatan ringan-sedang. Pasien didiagnosis dengan nevus unius lateris dan diterapi bedah listrik. Pasien diberikan antibiotik sistemik oral dan analgesik selama lima hari setelah prosedur dan disarankan untuk kontrol pada hari ketiga, dan pengangkatan jahitan dilakukan pada hari ketujuh. Kesimpulan: Beberapa perawatan medis dan bedah telah dicoba, tetapi tidak ada pengobatan yang ideal atau dapat diterima secara universal. Namun, kekambuhan dapat terjadi berbulan-bulan atau bertahun-tahun setelah pengangkatan lesi dengan metode apa pun. Terapi dengan bedah listrik dapat dipilih untuk membantu mencegah perdarahan yang mungkin terjadi setelah prosedur melalui target hemostasis dan untuk kerusakan jaringan superfisial.
VAGINOSIS BAKTERIALIS DENGAN KOINFEKSI KANDIDIASIS VULVOVAGINALIS Ellistasari, Endra Yustin; Widyastuti, Zilpa; Kasmitasari, Fitri; Wuri P, Adelia
Jurnal Cahaya Mandalika ISSN 2721-4796 (online) Vol. 4 No. 2 (2023): Jurnal Cahaya Mandalika
Publisher : Institut Penelitian Dan Pengambangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jcm.v4i2.1509

Abstract

Background : Bacterial vaginosis (BV) is an infection caused by an imbalance in the amount of normal vaginal flora and pathogenic bacteria. Vulvovaginal candidiasis (VVC) is an infection of candida in the vagina and vulva. Bacterial vaginosisis often accompanied by co-infection of VVC, it is caused by a reduction in the enzyme hydrogen peroxidase (H2O2) which can reduce the ability of leukocytes to fight infections, resulting in co-infection with other pathogens such as Candida sp. Factors that influence VB with co-infection of VVC include lack of hygiene, changing partners, the use of contraceptives in the uterus, the use of antiseptics with fragrances and other diseases such as diabetes mellitus. Case: A 40-year-old woman complaints of vaginal discharge since 3 months, white-gray vaginal discharge, fishy smell, no itching, and no pain during sexual intercourse. Physical examination revealed the presence of vulvar erythema, yellowish white discharge on the vaginal wall and portio cervicalis. Examination of 10% KOH showed the presence of pseudohyphae. Gram examination showed polymorphonuclear cells >50 per large field of view, gram negative rods 75-100 per large field of view, and clue cells >50%. The patient was given metronidazole 500 mg tablet twice a day for 14 days and fluconazole 150 mg single dose. Clinical and laboratory improvement was found on day 7 and recovered on day 14 after administration of therapy. Discussion: Bacterial vaginosis is an infection caused by the growth of anaerobic organisms that causes high morbidity due to their recurrence rate. This infection is often accompanied by a fungal infection such as kandidiasis vulvovaginalis caused by bad hygiene and increased humidity in genital area. The exact diagnosis of VB along with VVC is based on clinical symptoms, microscopic examination and culture. Antibiotics and antifungal drugs are the mainstay therapies for VB with co-infection of VVC.
MORBUS HANSEN PAUSIBASILER TIPE BORDERLINE-BORDERLINE DENGAN LESI TUNGGAL PADA SEORANG ANAK LAKI – LAKI: SATU LAPORAN KASUS JARANG Widhiati, Suci; Widyastuti, Zilpa; Fiqnasyani, Siti Efrida
Jurnal Cahaya Mandalika ISSN 2721-4796 (online) Vol. 4 No. 2 (2023): Jurnal Cahaya Mandalika
Publisher : Institut Penelitian Dan Pengambangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jcm.v4i2.1529

Abstract

Background: Morbus Hansen (MH) is a chronic infectious disease caused by Mycobacterium leprae. Diagnosis of MH was established based on cardinal signs on clinical examination, AFB examination on ear lobe serum and histopathological examinations. Children with single lesion MH (AFB negative) without any neurological complaints are treated with single dose of Rifampicin-Ofloxacin-Minocycline (ROM) combination therapy. This case was reported because of the rarity of children MH and the importance of early diagnosis to avoid disability risks. Case: A 12-year-old boy with single lesion borderline-borderline (BB) paucibacillary MH presented with white-reddish patch on cheeks that getting wider since 2 years ago. Dermatological status obtained in left maxila region showed hypopigmented and hyperpigmented patch with erythematous base, solitary, well defined, 0.5x1.5 cm in size with central clearing forming a punched out lesion. Bacteriological and histopathological examinations with Hematoxylin-Eosin and Fite-Faraco staining showed AFB negative result, but serological examination of anti-PGL-1 antibodies showed high titers (IgM=845 u/ml, IgG=1004 u/ml). The patient was given single dose of Rifampicin 450mg, Ofloxacin 400mg, Minocycline 100mg (ROM) and atopiclair® lotion applied to the lesion twice a day. Evaluation on the third week showed improvement with disappearance of redness and punched out lesion. Discussion: Patient in this case is a rare incident because it occured in children with no contact history and had never lived in MH endemic area. Because of Mycobacterium leprae’s transmission route is still not known, other factors such as genetics, immunity, environmental conditions and non-human vectors need more attention in breaking the chain of MH transmission.
Pengaruh Derajat Keparahan Terhadap Kejadian Resistensi Doksisiklin pada Penderita Akne Vulgaris Widyastuti, Zilpa; Kariosentono, Harijono; Kusumawardani, Arie
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i3.14731

Abstract

Tujuan penelitian ini adalah untuk mengetahui pengaruh derajat keparahan akne vulgaris (AV) terhadap kejadian resistensi antibiotik doksisiklin. Penelitian ini merupakan penelitian observasional analitik dengan desain cross-sectional yang berlokasi di poliklinik kulit dan kelamin RSUD Dr. Moewardi, pada bulan Agustus hingga September 2023. Subjek pada penelitian ini penderita AV derajat sedang-berat. Derajat keparahan AV dinilai menggunakan sistem skoring Global Acne Grading System (GAGS), sedangkan kejadian resistensi doksisiklin dinilai dengan menggunakan metode disc diffusion. Terdapat sebanyak 31 subyek pada penelitian ini dengan AV derajat sedang-berat. Terdapat sebanyak 3 subjek (9,68%) yang mengalami resistensi doksisiklin. Hasil analisis data menunjukkan bahwa terdapat pengaruh yang signifikan dari derajat keparahan AV terhadap kejadian resistensi doksisiklin pada C. acnes (p = 0,041). Secara umum, dapat disimpulkan bahwa derajat keparahan AV berpengaruh terhadap timbulnya resistensi doksisiklin pada C. acnes.
Mekanisme Pertahanan Mukokutan terhadap Infeksi Candida: Analisis Pramudita, Adelia Wuri; Kariosentono, Harijono; Evanti, Annisa Marsha; Widyastuti, Zilpa
Cermin Dunia Kedokteran Vol 52 No 3 (2025): Oftalmologi dan Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i3.1157

Abstract

Candida albicans is a commensal organism that can may become invasive and fatal under certain circumstances. Several genetic variations in the human genome towards susceptibility to Candida infections have been identified. There are a number of genes associated with Candida virulence factors, host environment, and immune response. C-type lectin receptors (CLRs) are characterized by leucine-rich and nucleotidebinding domains that can detect intracellular signals through various types of cytoplasmic domains. CLRs are family of PRRs that bind glycan through recognition of extracellular carbohydrate and mediate intracellular signaling through various type of cellular domains, resulting in a decrease of neutrophils and facilitating the occurrence of fungal infections. This study review the genetic determinant of defense mechanisms and immune deficiencies against Candida infection.
Co-Authors Annisa Marsha Evanti Asaduddin, Aiman Hilmi Dharmawan, Nugrohoaji Ellistasari, Endra Yustin Fiqnasyani, Siti Efrida Kariosentono, Harijono Kasmitasari, Fitri Kusumawardani, Arie Mulianto, Nur M Rachmat Murastami, Ammarilis Pramudita, Adelia Wuri Triasari Oktavriana Widhiati, Suci Wuri P, Adelia