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All Journal Health and Medical Journal Jurnal Ners Journal of Social Research
Murastami, Ammarilis
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Investigating The Impact of Pruritus on The Quality of Life of the Elderly in Surakarta Nursing Home Oktavriana, Triasari; Mawardi, Prasetyadi; Murastami, Ammarilis; Murasmita, Alamanda; Pradestine, Sesia; Putri, Osdatilla Esa; Lidjaja, Lifesia Natali; Alia, Vrenda; Kusumasari, Nila
Health and Medical Journal Vol 7, No 1 (2025): HEME January 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i1.1641

Abstract

Background: The elderly population has been growing rapidly in recent decades. Research has shown that the prevalence of itching (pruritus) increases with age, with 20.8% of individuals aged 60-69 years experiencing it, 22.9% for those aged 70-79 years, and 26% for those aged 75 years and above. Assessing the skin's barrier function by measuring transepidermal water loss (TEWL) using a tool called a Tewameter is important for objectively evaluating dry skin, which is the most common cause of itching in the elderly. It's important to understand how itching affects the quality of life of the elderly, particularly in nursing homes. Objective: This study aims to determine how itching affects the quality of life of the elderly in nursing homes in Surakarta City, especially at PMI Peduli and Aisyiyah Nursing Homes. Methods: This research used an observational, cross-sectional design. Data was collected through interviews using the 5D itch scale questionnaire, and the quality of life was measured using the DLQI (Dermatology Life Quality Index) questionnaire. TEWL levels were also measured using a Tewameter. Results: 29 subjects participated in the interviews, with 69% being women and 31% being men. Most subjects were aged 60-69 years (41%), and the most common comorbidity was hypertension (41%). The 5D Itch Scale questionnaire revealed that itching affected the subjects for less than 6 hours daily (66%), and during the last 2 weeks, itching did not significantly impact the subjects' activities, including sleep, hobbies, housework, and work (51%-69%). The most common location of itching was the back (14%). The DLQI data showed that itching had a severe impact on the subjects (65.5%), followed by a moderate impact (24.1%), and a very severe impact (10.3%). TEWL data indicated that all subjects had an increase of >10 g/h/m2. Conclusion: The study found that itching had a mild impact on the lives and activities of the subjects in general, lasting for less than 6 hours a day. The statistical results showed a positive and significant relationship between the intensity of itching and the quality of life of the elderly with pruritus.
Profile of Skin Diseases in The Ederley at Nursing House Surakarta Mawardi, Prasetyadi; Oktavriana, Triasari; Murastami, Ammarilis; Murasmita, Alamanda; Pradestine, Sesia; Esa Putri, Osdatilla Esa; Lidjaja, Lifesia Natali; Alia, Vrenda; Kusumasari, Nila
Health and Medical Journal Vol 7, No 1 (2025): HEME January 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i1.1640

Abstract

Background: The elderly population has been rapidly increasing over the past few decades. In Indonesia, the percentage of elderly residents is 8.75% of the total population. Aging is an unavoidable process, but it requires care to ensure a good quality of life for the elderly. One of the issues affecting the quality of life in the elderly is skin aging. Skin aging causes various complaints, especially itching or pruritus, which can reduce the quality of life for the elderly. Knowledge of the pathophysiology of skin diseases and skin aging, as well as the factors that affect them, particularly skin hydration, is necessary. This research is expected to be beneficial for medical professionals as well as family members of the elderly. The elderly residents at Wreda Griya PMI Peduli and Aisyiyah Nursing Home come from various regions and economic backgrounds. Therefore, the researchers consider the nursing home to be an appropriate place to conduct this study, as it can represent the elderly population from diverse backgrounds across Indonesia.Objective: This study aims to analyze the various skin disease profiles at the Griya PMI Peduli and Aisyiyah nursing homes in the city of Surakarta. Methods: This type of research is a survey using an observational study method with a descriptive design. Results: There were a total of 45 subjects at the Wreda PMI Peduli and Aisyiyah Nursing Home in Surakarta. Among them, 34 subjects had skin complaints, while 11 subjects were excluded because they did not have any skin complaints (7 subjects) or were uncooperative (4 subjects). The most common diagnosis was xerosis cutis (53%). The majority of patients did not have comorbidities (65%), with the most common comorbidity being hypertension (26%). Conclusion: The results of this study indicate that all the main skin complaints among the elderly at Panti Wreda in Kota Surakarta were dominated by itching or pruritus, with xerosis cutis being the primary etiology of pruritus in the elderly subjects of the study, accounting for 53%.
Cluster Differentiation 133 Expression in Patients With Basal Cell Carcinoma: an Immunohistochemical Review Utama, Rahmat Firdaus Dwi; Dharmawan, Nugrohoaji; Murastami, Ammarilis; Mulianto, Nurrachmat; Setyawan, Novan Adi
Journal of Social Research Vol. 4 No. 10 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i9.2802

Abstract

Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer in humans, developing on skin exposed to ultraviolet light and rarely metastasizing. Cancer stem cell markers such as CD133 have been extensively studied in various malignancies, but their expression in BCC remains controversial and has not been widely studied in Indonesia. Determine the difference in CD133 expression between BCC patients and normal skin. Analytical observational study with a case control design was conducted at Dr. Moewardi General Hospital in Surakarta from April to July 2025. The sample included 13 BCC tissues and 13 normal skin controls taken by consecutive sampling from paraffin blocks from 2021-2024. CD133 immunohistochemical staining was performed with Allred scoring by a single pathologist on at least four random fields of view. Descriptive analysis presented demographic characteristics and Allred scores, while the Chi square test was used to compare CD133 expression between groups with significance at p < 0.05. The mean CD133 Allred score was 7.15 ± 0.56 in KSB tissue and 7.31 ± 0.48 in normal skin. Strongly positive CD133 expression was found in 12/13 BCC patients and 13/13 normal skin. Chi square analysis showed no significant difference in CD133 expression between the BCC and normal skin groups (p=0.308). CD133 expression based on the Allred score did not differ significantly between BCC tissue and normal skin, indicating that CD133 is not useful as a single marker for the diagnosis or prognosis of KSB
Nevus Unius Lateris with Hemophilia: A rare case report Murastami, Ammarilis; Fiqnasyani, Siti Efrida; Widyastuti, Zilpa; Dharmawan, Nugrohoaji
Health and Medical Journal Vol 5, No 3 (2023): HEME September 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v5i3.1314

Abstract

Latar Belakang: Nevus Unius Lateris (NUL) adalah kelainan bawaan jaringan kulit langka, ditandai distribusi lesi unilateral mengikuti garis Blaschko. Lesi ditemukan pada tahun pertama kehidupan dengan bercak coklat kekuningan, batas yang jelas, dan permukaan verukosa. Pemeriksaan multidisiplin dianjurkan untuk menegakkan diagnosis dan memberikan penatalaksanaan yang tepat. Terapi bertujuan untuk mengangkat dan menghancurkan lesi hiperkeratosis dengan pembedahan/non-pembedahan. Elektrokauter dapat menjadi pilihan untuk membantu mencegah perdarahan setelah operasi dermatologis, terutama hemofilia. Kasus: Tn. A, 24 tahun, pekerjaan wiraswasta, datang dengan keluhan utama beberapa plak yang meninggi di belakang lehernya. Keluhan pertama muncul sebagai bintik pada usia 6 tahun dan naik perlahan, dan menyebar luas. Pasien memiliki riwayat hemofilia A. Pemeriksaan dermatologis, beberapa nodul verukosa hiperpigmentasi bertangkai dengan batas teratur, garis yang jelas tersusun secara linier mengikuti garis Blaschko di daerah coli posterior. Hasil pemeriksaan dermoskopi menunjukkan pola sirkular hiperpigmentasi dengan struktur epidermis eksofitik dan pola serebriform. Pemeriksaan histopatologi menunjukkan hiperkeratosis, akantosis, papilomatosis minimal, dan deposit melanin dengan kepadatan ringan-sedang. Pasien didiagnosis dengan nevus unius lateris dan diterapi bedah listrik. Pasien diberikan antibiotik sistemik oral dan analgesik selama lima hari setelah prosedur dan disarankan untuk kontrol pada hari ketiga, dan pengangkatan jahitan dilakukan pada hari ketujuh. Kesimpulan: Beberapa perawatan medis dan bedah telah dicoba, tetapi tidak ada pengobatan yang ideal atau dapat diterima secara universal. Namun, kekambuhan dapat terjadi berbulan-bulan atau bertahun-tahun setelah pengangkatan lesi dengan metode apa pun. Terapi dengan bedah listrik dapat dipilih untuk membantu mencegah perdarahan yang mungkin terjadi setelah prosedur melalui target hemostasis dan untuk kerusakan jaringan superfisial.
Peran Mikrobiom pada Sifilis Benedikta Lauda; Murastami, Ammarilis
Jurnal Ners Vol. 10 No. 1 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.51681

Abstract

Syphilis is a chronic sexually transmitted infection caused by Treponema pallidum, which can progress to neurosyphilis when it affects the central nervous system. Recently, the role of the human microbiome, the community of microorganisms living in the body has gained attention in understanding the pathogenesis of syphilis. The genital microbiota, particularly those dominated by Lactobacillus, help maintain mucosal balance and protect against infection. Imbalance in the microbiota, or dysbiosis, such as a decrease in Lactobacillus and an increase in anaerobic bacteria like Prevotella and Gardnerella, has been shown to raise the risk of sexually transmitted infections, including HIV and syphilis. In women, Lactobacillus maintains an acidic vaginal pH and suppresses inflammation, while the dominance of anaerobic bacteria can trigger proinflammatory cytokine production that promotes pathogen colonization. In men, a penile microbiota rich in anaerobes has also been linked to a higher risk of infection. Recent studies suggest that alterations in the gut microbiota may contribute to the progression of neurosyphilis, with increased Akkermansia levels associated with immune activation and inflammation. The complex interaction between the microbiome, immune system, and T. pallidum influences disease progression and treatment response. A deeper understanding of this relationship may lead to new strategies for preventing and managing syphilis..
Co-Authors Alia, Vrenda Benedikta Lauda Dharmawan, Nugrohoaji Esa Putri, Osdatilla Esa Fiqnasyani, Siti Efrida Lidjaja, Lifesia Natali Murasmita, Alamanda Nila Kusumasari Novan Adi Setyawan Nurrachmat Mulianto Pradestine, Sesia Prasetyadi Mawardi Putri, Osdatilla Esa Triasari Oktavriana Utama, Rahmat Firdaus Dwi Widyastuti, Zilpa