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All Journal Jurnal Dedikasi Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Acta Pharmaceutica Indonesia UNEJ e-Proceeding JRST (Jurnal Riset Sains dan Teknologi) Martabe : Jurnal Pengabdian Kepada Masyarakat Food Science and Technology Journal (Foodscitech) Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Pengabdian UNDIKMA Jurnal Kesehatan Tambusai Jurnal EduHealth Borneo Journal of Pharmacy
Engrid Juni Astuti
Program Studi Farmasi Fakultas Ilmu Kesehatan Universitas Muhammadiyah Malang
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EDUKASI DAGUSIBU DAN PENGENALAN APOTEKER CILIK (APOCIL) Astuti, Engrid Juni; Hidayati, Ika Ratna
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 4, No 3 (2021): Martabe : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v4i3.984-989

Abstract

Peran Apoteker sebagai profesi yang terkait dengan obat sangat penting terutama dalam memberikan edukasi tentang obat-obatan. Kegiatan pengenalan tentang obat  sejak dini sangat diperlukan guna memperkenalkan jati diri apoteker dan tentang obat kepada siswa sekolah Dasar. Edukasi terkait obat yang akan dilakukan di sekolah dasar bertemakan “Pengenalan Apocil dan Dagusibu” di Sekolah Dasar. Minimnya pengetahuan tentang Obat di masyarakat dimulai dengan pemberian pengetahuan sejak dini pada siswa sekolah dasar karena mereka yang nantinya akan menjadi remaja dan mengurangi penyalahgunaan obat di masyarakat seperti yang saat ini banyak sekali terjadi pada siswa sekolah menengah atas ataupun mahasiswa. Target dari kegiatan ini adalah siswa kelas 4,5, dan 6 MI Assalafiyah agar memperoleh wawasan tentang obat secara benar. Kegiatan dilakukan dengan cara pembelajaran online menggunakan beberapa platform, diantaranya : grup whatsapp kelas, google form, dan link youtube. Sebelum diberikan materi maka dilakukan pretes dan postest dari masing-masing materi, ada 2 materi yang diberikan yaitu pengenalan profesi Apoteker, cara penggunaan obat yang benar, dan edukasi DaGuSiB.  Selain itu pengabdian ini diharapkan dapat memotivasi siswa-siswa agar memiliki kesadaran untuk dapat mengawasi teman-teman dikelas lain dalam menggunakan obat dengan benar. Dari hasil kegiatan didapatkan bahwa siswa antusias dalam mengikuti kegiatan pengabdian masyarakat meskipun tidak terjadi peningkatan nilai rata-rata dari pretes (75,8) dan postes (75,3). 
Herbal Soap Production Training Based on Fresh Fruits to Enhance Teachers’ Skills at MI Assalafiyah, Kediri Regency Astuti, Engrid Juni; Hidayati, Ika Ratna; Syifa’, Nailis; Wardoyo, Sri Sunaringsih Ika
Jurnal Pengabdian UNDIKMA Vol. 7 No. 1 (2026): February
Publisher : LPPM Universitas Pendidikan Mandalika (UNDIKMA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/jpu.v7i1.17650

Abstract

This community service program aims to enhance teachers’ skills and creativity in producing natural herbal soaps derived from fresh fruits. The program was implemented at MI Assalafiyah, Kediri Regency, using socialization and hands-on training methods. The training began with the administration of a pre-test, followed by the delivery of instructional materials and practical sessions. A post-test was conducted at the final stage to evaluate participants’ understanding and the skills acquired. The results indicate that the herbal soap–making training was highly beneficial in equipping teachers with new practical skills. A significant improvement in participants’ competencies was observed, as reflected in the increase in mean scores from the pre-test (50.38 ± 19.36) to the post-test (85.33 ± 11.06). Furthermore, this training has the potential to be integrated as an extracurricular activity in schools to support students’ skill development, particularly in herbal soap production.
Discovery of Novel GLUT4 Inhibitors from Kawista (Limonia Acidissima L.) Bioactive Compounds Through in Silico Approaches Muchlisin, M. Artabah; Astuti, Engrid Juni; Cahyani, Aura Lintang Ayu; Andita, Felia Rahma Cahya; Abdillah, Nur Islami Vikri; Inayah, Aghnia Fuadatul; Fakih, Taufik Muhammad
JRST (Jurnal Riset Sains dan Teknologi) Volume 10 No. 1, March 2026: JRST
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/jrst.v10i1.28366

Abstract

GLUT4 (Glucose Transporter Type 4) is a key regulator of glucose homeostasis in muscle and adipose tissues. Although inhibition of GLUT4 may exacerbate hyperglycemia in diabetes, it represents a potential therapeutic strategy in cancer by limiting glucose uptake in cells reliant on aerobic glycolysis (the Warburg effect). Natural secondary metabolites are promising candidates for modulating GLUT4 activity. This study aimed to identify potential GLUT4 inhibitors from bioactive compounds of Limonia acidissima (kawista) using in silico approaches. Secondary metabolites of kawista were screened for ADMET properties and oral bioavailability. Molecular docking was performed against the cryo-EM structure of GLUT4 (PDB ID: 7WSM), followed by 200 ns molecular dynamics simulations for the top-ranked ligands. Structural stability was evaluated using RMSD, RMSF, radius of gyration (Rg), and solvent-accessible surface area (SASA). Binding free energies were calculated using the MM-PBSA method. Docking analysis showed that the native ligand cytochalasin B exhibited strong binding affinity (−9.13 kcal/mol, Ki 202.26 nM). Among 43 kawista metabolites, stigmasterol (−8.6 kcal/mol, Ki 494.04 nM) and lupeol (−7.91 kcal/mol, Ki 1.58 μM) demonstrated the most favorable binding affinities. Molecular dynamics simulations revealed stable protein–ligand complexes, with RMSD values ranging from 2.0 to 3.5 Å. RMSF analysis indicated stable key binding residues (Gln298, Gln299, Asn304, Gly400, Trp428, and Asn427), except for Trp404, which showed higher fluctuation in the lupeol complex. Rg and SASA values remained relatively constant, indicating compact and stable complexes. MM-PBSA analysis confirmed that stigmasterol exhibited the most favorable binding free energy, closely comparable to cytochalasin B. These findings suggest that stigmasterol and lupeol from Limonia acidissima are promising GLUT4 inhibitors, with stigmasterol demonstrating the most stable interaction and favorable binding profile. This study highlights the potential of kawista-derived metabolites as lead compounds for further development of GLUT4-targeted anticancer agents.
Co-Authors Abdillah, Nur Islami Vikri Ahmad Shobrun Jamil Akhmad Aminur Rizqia Andita, Felia Rahma Cahya Bambang Tri Purwanto Bilgis Nurfatiyah, Rize Cahyanang Putria Widianto, Regita Cahyani, Aura Lintang Ayu Dian Ermawati Dina Siti Rahma M. Hentu Dini Fitri Mudhakir, Ainuzahra Dyah Rahmasari Hentu, Dina Siti Rahma M. Hidajah Rachmawati Huda Prastyo, Miftahul Ika Ratna Hidayati Ikka Choirun Nisa, Vasda Ilham, Roha Fakhri Naufal Inayah, Aghnia Fuadatul Ismahanisa Ismail, Wan Januar Rahman Juni Ekowati M. Artabah Muchlisin Muchlisin, M. Artabah Muhammad Ali Zulfikar Nailis Syifa Pertiwi, Cinta Junaidi Putri Purwanto, Septiana Tita Puspitasari, Chenchen Rafikayanti, Agustin Rahman, Januar Rahmana Emran Kartasasmita Riesta Prima Harinastitic Rika, Wenni Fista Roha Fakhri Naufal Ilham Rohmaturrizqi, Arvil Slamet Ibrahim - Sovia Aprina Basukia Syifa’, Nailis Taufik Muhammad Fakih Tazkia Azizid, Nala wahyuni, reni sri Wardoyo, Sri Sunaringsih Ika Yesica, Yeni Zalmi, Syakinatul