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All Journal Jurnal Kedokteran Brawijaya Jurnal Kesehatan Andalas Majalah Kesehatan FKUB Jurnal Respirologi Indonesia Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Medica Hospitalia Respiratory Science Malang Respiratory Journal
Triwahju Astuti
Bagian Paru Fakultas Kedokteran Universitas Brawijaya / Rumah Sakit Umum Dr. Saiful Anwar Malang
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : Malang Respiratory Journal

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The Sleep Disorders And Depression Symptoms Among Hospitalized COVID-19 Patients Febriawati, Juwita; Astuti, Triwahju; Djajalaksana, Susanthy; Listyoko, Aditya Sri
Malang Respiratory Journal Vol. 7 No. 2 (2025): Volume 7 No 2, September 2025 Edition
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2025.007.02.06

Abstract

Introduction: Sleep disorders are found to be associated with hypertension, diabetes, cardiovascular disease and obesity, and can affect quality of life. Evaluation of sleep disorders and risk of depression in hospitalized COVID-19 patients have not been widely studied. The purpose of this study was to identify, evaluate, and analyze of sleep disorders and depression symptoms in hospitalized COVID-19 patients according to their severity and PaO2/FiO2 ratio. Case Report: A total of 35 patients with mild and moderate COVID-19 were given a questionnaire consisting of Epworth Sleepiness Scale (ESS) and Beck Depression Inventory (BDI), which was then analyzed together with the patient's blood gas analysis. Categorical data was compared using Chi Square Test, while the relationship between the continuous variables were measured with Pearson correlation test. A two-sided p value < 0.05 was considered statistically significant. About 42,85% and 62,9% COVID-19 patients were found to have sleep disorders and depression symptoms respectively. There were no significant differences between sleep disorders and the severity of COVID-19 (P=0.118) as well as PaO2/FiO2 ratio (P=0.411). Similarly, depression symptoms was not significantly different according to the severity of COVID-19 and PaO2/FiO2 ratio obtained with P=0.083 and P=0.061 respectively. Correlation test showed no significant correlation between sleep disorders and severity as well as PaO2/FiO2 ratio with r=0,274(p=0,111) and r=0,041(p=0,814) respectively. Likewise, negative correlation was found between depression symptoms and severity of COVID-19 (r=0,218;p=0,258)  as well as PaO2/FiO2 ratio (r=0,078, p=0,057). Conclusion:  In hospitalized COVID-19 patients, sleep disorders and depression were found, but there was no significant differences and correlation between sleep disorders and depression symptoms with the severity of COVID-19 and PaO2/FiO2 ratio.
Immunocytochemistry as a Diagnostic Procedure of Pleural Mesothelioma Trimurtini, Asih; Astuti, Triwahju; Yudhanto, Hendy Setyo; Erawati, Dini Rachma
Malang Respiratory Journal Vol. 2 No. 02 (2020)
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (795.153 KB) | DOI: 10.21776/ub.mrj.2020.002.02.2

Abstract

Background: Mesothelioma is a primary malignant tumor arising from the mesothelial surface of the pleura, peritoneal, tunica vaginalis, and pericardium. Most cases of mesothelioma originate from the pleura. Most patients have a history of asbestos exposure. A common diagnostic problem is distinguishing mesothelioma from adenocarcinoma since both tumors invade the pleura. Immunocytochemistry of calretinin and TTF-1 can be used to establish the diagnosis of mesothelioma.Case: Male, 56 years old presented with chest pain, shortness of breath, cough, and weight loss since 5 months before hospitalization. The patient had a history of occupational exposure to asbestos for 30 years. The movement and breath sounds were decreased as well as dull upon percussion at the right chest. A chest X-ray revealed a right lung tumor with pleural effusion. Thorax CT scan suggested pleural mass in right hemithorax, infiltration to intercostal muscles, and destruction of the 7th right rib, right perihilar lymphadenopathy, right pleural effusion, and liver nodules according to mesothelioma T4N1M1 Stage IV. Infiltrative stenting of the right and inferior lobe of the right lung, infiltrative and obstructive stenting of the medius lobe suggestive of a chronic malignancy and inflammation were found on FOB. Cytologic examination of pleural fluid, sputum, and Washing-and-brushing of FOB were a class II (no malignant cells). USG-guided transthoracic FNAB revealed adenocarcinoma with differential diagnosis of mesothelioma. Immunocytochemistry with calretinin showed positive results and TTF-1 showed a negative result. These confirmed the diagnosis of pleural mesothelioma T4N1M1 Stage IV. The patient showed a stable response from carboplatin/gemcitabine treatment.Keyword : Mesothelioma, Immunocytochemistry, TTF-1, Calrenitin
Co-Authors Agustin Iskandar Anung Sri Handayani David Christianto Dian Nugrahenny Djajalaksana, Susanthy Duta, Garinda Alma Edy Widjajanto Eko Prasetyo Erawati, Dini Rachma Febriawati, Juwita Fransisca Srioetami Tanoerahardjo Garinda Alma Duta Gede Sasmika Suwandi Harun Al Rasyid Karima, Karima Kristin Indriana Lindayanti Sumali Listyoko, Aditya Sri Maimun Z Arthamin Maimun Zulhaidah Arthamin Maimun Zulhaidah Arthamin, Maimun Zulhaidah Mufidatun Hasanah Munthe, Indra Nunuk Sri Muktiati Nunuk Sri Muktiati Putri Wulan Akbar Rahmad Budianto Ria Siska Myrnasari S, Noorhamdani A Sardjono, Teguh Wahyu Sartono, Teguh Rahayu Sumarno . Suryanti Dwi Pratiwi Teguh Rahayu Sartono Tjahyadi, Rizal Muldani Tri Yudani Mardining Raras Tri Yudani MR Trimurtini, Asih Wibi Riawan Yani Jane Sugiri Yudhanto, Hendy Setyo Zam Zam Firmansyah