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Journal : Mukhtabar: Journal of Medical Laboratory Technology

Erythrocyte Index and Mentzer Index in Fathers of Thalassemia Patients Rhama Adiguna; Doni Setiawan; Undang Ruhimat; Rahayu Nirmatul Mutmainah
Mukhtabar Journal of Medical Laboratory Technology Vol 1 No 1 (2023): Mukhtabar: Journal of Medical Laboratory Technology (April 2023)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/mjmlt.v1i1.219

Abstract

Background & Objective Thalassemia is a blood disorder caused by genetic factors that cause the globin chain in hemoglobin to not function normally. It is the most common hereditary disease in the world and in Ciamis Regency in 2021 there were 191 patients. Thalassemia prevention is carried out by screening to identify thalassemia carriers. Hematological examination in the form of erythrocyte index (MCV, MCH, MCHC) and mentzer index has been known to determine thalassemia screening.  The purpose of this study was to determine the description of erythrocyte index and mentzer index in thalassemia patient's father. Method The method used in this study is descriptive method. The population in this study were members of POPTI (Parents Association of Thalassemia Patients) Ciamis Regency. The sample in this study were 30 samples. Result Based on the results of the study obtained the results of erythrocyte index (MCV, MCH) low (MCHC) normal and Mentzer index obtained the results of 20 samples (66%) suspected as thalassemia carrier, 5 samples (17%) suspected iron deficiency anemia and according to the reference value there were 5 samples (17%). Conclusion The results of a study conducted on 30 fathers of thalassemia patients showed that 83% of fathers of thalassemia patients had MCV and MCH values below the normal threshold and 73% had normal MCHC values. Furthermore, from the results of the Mentzer index examination, it is known that 66% of the fathers of thalassemia patients are suspected of having minor thalassemia, 17% are suspected of having iron deficiency anemia disorders and 17% have a normal Mentzer index.
Reumatoid Factor Examination in Thalassemia Patients Doni Setiawan; Via Oktaviani Hiytulmadani; Atun Farihatun
Mukhtabar Journal of Medical Laboratory Technology Vol 1 No 1 (2023): Mukhtabar: Journal of Medical Laboratory Technology (April 2023)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/mjmlt.v1i1.227

Abstract

Background & Objective  Patients with thalassaemia major with severe anaemia must receive blood transfusions for life. Giving continuous blood transfusions can cause iron accumulation in body tissues so that it can conclude complications, one of which is rheumatoid arthritis due to iron deposition in synovial tissue. This study is to determine the results of rheumatoid factor examination in thalassaemia patients with blood transfusion therapy. Method the research used is descriptive. The sampling technique uses incidental with a large number of samples as many as 66. Result Based on the results of the study obtained positive results as many as 11 (17%) people with an average Rheumatoid Factor level of 29 IU/mL, and negative results as many as 55 (83%) people. Conclusion Thalassaemia patients with blood transfusion therapy show the risk of rheumatoid arthritis with positive results of rheumatoid factor examination.