Article Per Year (5 Year)
p-Index From 2020 - 2025
2.024
P-Index
This Author published in this journals
All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Pengabdian UntukMu NegeRI ALCHEMY Jurnal Penelitian Kimia JURNAL PHOTON Molekul: Jurnal Ilmiah Kimia Acta Chimica Asiana Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Pengabdian kepada Masyarakat Nusantara
Rahmiwati Hilma
Jurusan Kimia FMIPA Universitas Muhammadiyah Riau
Religion Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Nursing Physics Public Health Social Sciences

Published : 23 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 23 Documents
Search

 1   2   3 
AKTIVITAS ANTIRADIKAL BEBAS SENYAWA TURUNAN CALKON DAN TURUNAN BENZOTIAZEPIN Sulismayati -; Jasril -; Christine Jose; Rahmiwati Hilma
Sistem Informasi Vol 4 No 2 (2014): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v4i2.174

Abstract

Senyawa calkon merupakan flavonoid rantai terbuka dengan cincin aromatik yang dihubungkan oleh tiga atom karbon dengan system α, β karbonil keton tidak jenuh. Calkobn juga merupakan senyawa antara untuk membuat senyawa lain salah satunya adalah benzotiazepin. Benzotiazepin adalah senyawa heterosiklik yang mengandung nitrogen dan sulfur. Hasil uji aktivitas anti radikal bebas dari senyawa calkon Y1 dan senyawa benzotiazepin Bt1 memperlihatkan aktivitas yang sangat lemah, ditandai dengan nilai IC50 yang lebih besar dari 1000 ppm jika dibandingkan dengan standar yang digunakan yaitu vitamin C dengan nilai IC50 33,539 ppm. Hal ini mungkin disebabkan karena tidak adanya substituen ataupun gugus yang dapat menyumbangkan proton pada kedua senyawa hasil sintesis sehingga menyebabkan kedua senyawa tersebut tidak aktif sebagai antiradical bebas.
SIFAT TOKSISITAS SENYAWA TURUNAN CALKON (E)-1-(NAFTALEN-1-IL)-3-(NAFTALEN)PROP-2-1-ON Rahmiwati Hilma; Jasril -; Hilwan Yuda Teruna; Hasmalina Nasution
Sistem Informasi Vol 4 No 2 (2014): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v4i2.183

Abstract

Calkon merupakan salah satu metabolit sekunder golongan flavonoid yang dapat ditemukan pada tumbuh-tumbuhan dan dikenal mempunyai berbagai macam aktivitas diantaranya adalah sebagai antimikroba, anti kanker, sitotoksitas, anti kolera, anti inflamasi dan anti tumor. Pada penelitian ini dilakukan uji toksisitas terhadap senyawa calkon (E)-1-(naftalen-1-il)-3-(naftalen)prop-2-1-on (C) yang telah murni menggunakan metoda Brine Shrimps lethality Test (BSLT) dan Uji Anti kanker menggunakan metoda MTT terhadap sel kanker murine leukemia P-388. Dari hasil penelitian didapat nilai LC50= 0,3256 μg/mL untuk aktivitas toksisitas, dan nilai LD50 ˃ 100 μg/mL untuk aktivitas sitotoksik. yang menunjukkan bahwa senyawa calkon yang dihasilkan menunjukkan sifat toksisitas dan sitotoksik yang sedang. Ini dikarenakan senyawa calkon (C) yang disintesis tidak mempunyai gugus substituent yang bisa mendorong pergerakan elektronnya. Selain pengaruh dari gugus substituen, tingkat toksisitas dan sitotoksik senyawa calkon juga dipengaruhi adanya halangan sterik.
OPTIMUM CONDITION OF BIOETANOL PRODUCTION VIA ACIDIC HYDROLYSIS FROM PINEAPLE (Ananas comosus Merr.) PEEL WASTE IN KUALU VILLAGE-KAMPAR Rahmiwati Hilma; Unggul Akbar; - Prasetya
Sistem Informasi Vol 7 No 02 (2017): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v7i02.519

Abstract

Bioethanol is an alternative and potential fuel derived from plants, which has the ability to reduce CO2 emissions. It contains sugar that can be utilized and processed into bioethanol. This study aims to produce bioethanol from pineapple peel (Ananas comosus Merr.) through acidic hydrolysis and fermentation process using Sacharomyces cereviceae. This research was expected to know the optimum condition of S. Cereviceae mass and the time of fermentation on the conversion of pineapple peel into bioethanol towards amount and content of ethanol produced. The hydrolysis was using sulfuric acid (H2SO4), fermented with variations yeast 20, 40 and 60 gram and 2, 4 and 6 days of time variations. The resulting bioethanol was purified using a distillation process, then analyzed by gas chromatography. The results showed that optimum ethanol content was obtain in yeasts 20 and 40 grams and 2 days of fermentation. The resulting ethanol content was 26.3% and 24.6%.
POTENSI SILASE KULIT JAGUNG SEBAGAI BAHAN PAKAN FERMENTASI Rahmiwati Hilma; Agustina Wulandari; - Wahyuningsih
Sistem Informasi Vol 8 No 01 (2017): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v8i01.547

Abstract

Sumber daya perikanan darat saat ini sangat menjanjikan untuk mencukupi kebutuhan nasional akan bahan pangan berbasis protein tinggi. Pakan merupakan salah satu unsur penting dalam kegiatan budidaya yang menunjang pertumbuhan dan kelangsungan hidup ikan budidaya. Mahalnya harga pakan dapat diatasi salah satunya dengan membuat pakan buatan sendiri menggunakan metode yang sederhana dengan memanfaatkan sumber-sumber bahan baku yang murah, mudah didapat, mudah diolah dan mengandung zat gizi yang diperlukan. Pada pembuatan pakan diharapkan menghasilkan pakan yang memiliki kandungan gizi yang tinggi, salah satu caranya adalah dengan fermentasi. Pembuatan pakan ikan fermentasi pada penelitian ini diawali dengan pembuatan silase kulit jagung menggunakan probiotik ikan yang telah diaktifasi menggunakan molase dan dilanjutkan dengan pencampuran silase kulit jagung dengan batang pisang, kotoran kambing, dedak padi, abu sekam dan probiotik ikan yang telah diaktifasi dengan 3 variasi komposisi (pakan A, B, C) dan difermentasi selama 28 hari. Data yang diperoleh dianalisis secara statistic menggunakanan alisis Rancangan Acak Lengkap (RAL) dan perbedaan antara perlakuan diuji dengan uji Tukey. Analisisuji F pada variasi 3 komposisi menunjukkan perbedaan yang nyata (P<0,05) terhadap kadar air, abu, protein, lemak, serat dan karbohidrat. Pakan C fermentasi merupakan komposisi terbaik dengan kadar air 78,36 ± 78,36 %, kadar abu 10,69 ± 0,06 %, kadar protein 4,15 ± 0,05 %, kadar lemak 0,56 ± 0,01 %, kadar serat 3,03 ± 0,01 % dan kadar karbohidrat 3,30 ± 0,00 %.
AKTIVITAS ANTIMIKROBA DAN ANTIDIABETES EKSTRAK ETANOL BIJI BUAH CEMPEDAK HUTAN (Artocarpus integer (Thunb) Merr) Rahmiwati Hilma; Erna Puspita Dewi; Haiyul Fadhli
Sistem Informasi Vol 8 No 2 (2018): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v8i2.713

Abstract

Secara empiris biji buah jempedak hutan Artocarpus integer (Thunb) Merr telah digunakan oleh masyarakat Kampar (Propinsi Riau) sebagai obat tradisional untuk mengobati diare dan obat untuk penyakit diabetes. Beberapa ekstrak tanaman genus Artocarpus telah diteliti memiliki khasiat sebagai antimikroba dan antidiabetes. Berdasarkan uji fitokimia, ektsrak etanol biji buah A.integer (Thunb) Merr mengandung beberapa senyawa metabolit sekunder seperti: terpenoid, alkaloid, saponin, fenolik, tanin dan flavonoid. Pada penelitian ini dilakukan uji aktivitas anti bakteri, antijamur dan antidiabetes ekstrak etanol biji buah Artocarpus integer (Thunb) Merr. Uji aktivitas antibakteri dan antijamur dilakukan dengan metode difusi agar dengan mengukur zona hambat ekstrak. Uji aktivitas antidiabetes dilakukan dengan mengukur % inhibisi ekstrak terhadap enzim α-glukosidase secara in vitro. Hasil pengujian menunjukkan bahwa ekstrak biji cempedak A. integer (Thunb) Merr aktif sebagai antibakteri, antijamur dan antidiabetes. Ekstrak etanol biji buah A.integer (Thunb) Merr memiliki daya hambat terhadap E. coli sebesar 9,89 mm (konsentrasi 3%), 10,41 mm (konsentrasi 5%), dan 11,98 mm (konsentrasi 7%). Daya hambat terhadap S. aureus sebesar: 10,27 mm (konsentrasi 3%), 12,15 mm (konsentrasi 5%), dan 13,17 mm (konsentrasi 7%), Daya hambat terhadap C. Albicansy sebesar: 8,71 mm (konsentrasi 3%), 12,96 mm (konsentrasi 5%), dan 19,49 mm (konsentrasi 7%). Hasil uji aktivitas antidiabetes menunjukkan bahwa pada konsentrasi 100 ppm ekstrak etanol biji buah A.integer (Thunb) Merr memiliki % inhibisi sebesar 19,45 % dengan nilai IC50 sebesar 301,23 ppm.
EKSTRAKSI DAN OPTIMASI VITAMIN E DARI FRAKSI NON POLAR CRUDE PALM OIL (CPO) Rahmiwati Hilma; Anggi Fisi Anggita; Ihsan Ikhtiarudin
Sistem Informasi Vol 9 No 1 (2018): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v9i1.1077

Abstract

Vitamin E has many benefits for human health. Besides being known as supplements, vitamin E is known to have activities as an anticancer compound, preventing premature aging, preventing cardiovascular diseases and other degenerative diseases. In this study carried out the extraction and optimization process of vitamin E from sample non-polar fraction of fresh CPO. The extraction process was carried out by saponification reaction, vitamin E optimization was carried out on the non-polar fraction with the addition of methanol, then to the oil fraction added 2-propanol (1%) in hexane. From the fresh CPO samples used, it was seen that the samples met the quality standards of fresh CPO. From the results of extraction and optimization of vitamin E, it was found that the yield was quite large (52.77%). Characterization results with TLC and analyzed with UV light at a wavelength of 254 and 366 nm seen vitamin E still has 2 stains, the possibility was tocopherol and tootrienol which was usually components contained in vitamin E.
Design of New 2,4-Substituted Furo [3,2-B] Indole Derivatives as Anticancer Compounds Using Quantitative Structure-Activity Relationship (QSAR) and Molecular Docking Jufrizal Syahri; Nurul Hidayah; Rahmiwati Hilma; Beta Achromi Nurohmah; Emmy Yuanita
Molekul Vol 15, No 1 (2020)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (346.15 KB) | DOI: 10.20884/1.jm.2020.15.1.582

Abstract

This study aimed to propose new indole derivatives as anticancer through Quantitative Structure-Activity Relationship (QSAR) and molecular docking method. The best predicted anticancer activity of indole derivatives was recommended based on the QSAR equation. A data set consist of 18 indole derivatives from literature with anticancer activity against the A498 cell line was used to generate a QSAR model equation. The data set was divided randomly into training (14) and test (4) set compounds. The structure of indole compound was optimized first using AM1 semi-empirical methods, and the descriptors involved were analyzed using Multiple Linear Regression (MLR). The best QSAR equation obtained was Log IC50 = 65.596 (qC2) + 366.764 (qC6) – 92.742 (qC11) + 503.297 (HOMO) – 492.550 (LUMO) – 76.966. Based on the QSAR model, varying electron-withdrawing groups in C2 and C6 atom, as well as adding electron-donating groups in C11 were proposed could increase the anticancer activity of the indole derivatives. The QSAR analysis showed that compound 15 has the best predicted anticancer activity, supported by molecular docking results that showed hydrogen bond interaction with essential amino acids to build anticancer activity such as MET769, THR830, and THR766 residues.
Evaluation of the Antibacterial Activity of the Jackfruit Parasite Leaf Plant Extract (Macrosolencochinchinensis (Lour.) van Tiegh) with Vitro and In Silico approach Rahmiwati Hilma; Suma Rahmani Harahap; Jufrizal Syahri
Acta Chimica Asiana Vol. 5 No. 2 (2022)
Publisher : The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v5i2.141

Abstract

In traditional Melayu Riau medicine, the jackfruit parasite plant, also known as Macrosolen cochinchinensis (Lour.) van Tiegh, has been utilized as a remedy for coughs, a treatment for cancer, a diuretic, and to speed up the recovery process after giving birth. Through in vitro and in silico testing, this investigation aims to learn more about the bioactive components and antibacterial activity of n-hexane, ethyl acetate, and ethanol obtained from the extracts of the jackfruit parasite plant (Macrosolen cochinchinensis (Lour.) van Tiegh. The disc diffusion method was used for the in vitro testing, and the molecular docking method was used for the in silico testing. Both were conducted against Staphylococcus aureus ATCC 12600 and Escherichia coli ATCC 25922. Each sample extract was prepared in three different concentrations (10%, 30%, and 50%), while chloramphenicol was used as the positive control. Inhibition zones of the extract against E. coli bacteria were found to be as follows: 6 mm, 8.4 mm, and 10.6 mm for the n-hexane extract; 8.2 mm, 10.7 mm, and 15.6 mm for the ethyl acetate extract; and 6 mm, 7.1 mm, and 14.1 mm for the methanol extract. The results of the test to determine the extract's antibacterial activity were as follows: The following is a list of the zones of inhibition that the extract has against S. aureus bacteria: 6 mm, 7.5 mm, and 13.7 mm in diameter for the extract of n-hexane; 12.8 mm, 14.2 mm, and 19.2 mm in diameter for the extract of ethyl acetate. Test results of 7.2 mm, 9.3 mm, and 15.3 mm were obtained for the methanol extract. In accordance with the findings of the study, the ethyl acetate extract of jackfruit parasite leaves exhibited the highest level of antibacterial activity, as measured by an inhibition zone diameter of 19.2 mm, when tested on S. aureus bacteria. In the meantime, the results of molecular docking of punicalin and rutin, which have been reported to have activity against proteins 6GOS.pdb and 1OJZ.pdb, have potential as antibacterials because they form 5 and 9 hydrogen bonds with important amino acids of the target protein, with cDOCKER values of -57.9239 and -88.3993, respectively. It suggests that punicalin and rutin can inhibit the growth of bacteria.
Workshop Sertifikasi Pranata Laboratorium Untuk Guru Sains Tingkat SLTA Se-Provinsi Riau Sri Hilma Siregar; Prasetya Prasetya; Hasmalina Nasution; Rahmiwati Hilma; Fitra Perdana; Rahmadini Syafri; Jufrizal Syahri
Jurnal Pengabdian UntukMu NegeRI Vol 7 No 1 (2023): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v7i1.4932

Abstract

Saat ini banyak sekolah tingkat SLTA se-Provinsi Riau dan sekitarnya tidak memiliki pranata laboratorium pendidikan yang berkompeten dibidangnya. Hal ini menyebabkan banyak sekolah yang memiliki laboratorium tapi tidak digunakan secara maksimal, dan siswa siswi tidak dapat melaksanakan praktikum yang semestinya di laboratorium. Laboratorium hanya menjadi tempat pajangan alat peraga dan instrumentasi. Berdasarkan hal tersebut, kami merasa perlu memfasilitasi para pranata laboratorium pendidikan dengan memberikan pelatihan pengelolaan dan penggunaan laboratorium untuk praktikum siswa siswi di sekolah. Sehingga dihasilkan lulusan yang berkompeten. Kegiatan dirancang dalam bentuk pengembangan wawasan keilmuan melalui pemberian berbagai teori selama 2 hari dan dilanjutkan dengan praktik dan penugasan pada 2 hari berikutnya. Materi yang diberikan kepada peserta diantaranya tentang inovasi hasil penelitian, pengenalan dan pengelolaan laboratorium, praktikum ciri-ciri reaksi kimia, hokum kekekalan massa, reaksi zat makanan. pemahaman dan kemampuan guru terhadap materi pelatihan, yang nantinya dapat digunakan sebagai acuan dalam melaksanakan praktikum di laboratorium sekolah. Kegiatan workshop ini mendapat sambutan yang baik dari peserta dan berhasil dengan baik. Keadaan ini dapat dilihat dari kehadiran peserta yang hampir mencapai 100%. Peserta terdiri guru dan pranata laboratrium pendidikan ingkat SLTA se-Provinsi Riau.
Fruit Stalk Extract from Chili Peppers (Capsicum annum L.) as a Natural Antioxidant to Inhibit Oxidation in Crude Palm Oil Rahmiwati Hilma; Eka Tri Setya Wulandari; Zaldi Arman
Jurnal Kimia Sains dan Aplikasi Vol 23, No 4 (2020): Volume 23 Issue 4 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2009.897 KB) | DOI: 10.14710/jksa.23.4.124-128

Abstract

Fruit stalk of chili pepper (Capsicum annum L.) so far is still an untapped waste. The content of active compounds in fruit and fruit stalk of chili pepper (C. annum L.) is known to have good antioxidant activity. The purpose of this study was to evaluate the extract of fruit stalk of chili pepper in inhibiting the oxidation of crude palm oil (CPO). In this study, the extraction of fruit stalk of chili pepper (C. annum L.) was carried out with n-hexane (from now on referred to as CHE) solvent and with ethanol solvent (from now on referred to as CEE). CHE and CEE were analyzed for total phenolic and flavonoid analyzes. Next, an evaluation of antioxidant activity was carried out using the DPPH method. The effectiveness test of adding the two extracts to the quality of CPO was carried out for ten days using a Completely Randomized Design (CRD) analysis. The parameters observed were peroxide numbers, free fatty acids, and iodine numbers. Data were analyzed by ANOVA and followed by a Least Significance Different (LSD) test. The results show that the total phenolic value is 0.257 mg QE/g dry weight in CEE and 0.003 mg QE/g dry weight in CHE. Total flavonoid values are 0.155 mg QE/g dry weight in CEE and 0.003 mg QE/g in CHE. IC50 values for DPPH test extract are 223.72 μg/mL in CEE and 953.77 μg/mL in CHE. The test results of the effectiveness of the two extracts against CPO show thin CEE, and CHE significantly (P <0.05) influences to CPO free fatty acids, peroxide number, and iodine number. Both extracts can protect CPO from oxidation. CEE is more effective in maintaining CPO quality for ten days with free fatty acid values (2.1%), peroxide value values 0.48 meq/kg, and iodine number 54.8. Furthermore, this result meets the CPO quality standard, according to SNI-01-2901-2006.
Co-Authors - Wahyuningsih Agustina Wulandari Aisyah Firmathoina Anggi Fisi Anggita Aulia Rizki Ramadhanti Beta Achromi Nurohmah Chainul Fiffah Christine Jose Danu Hamersat Eka Ramadhani Eka Tri Setya Wulandari Emmy Yuanita Erna Puspita Dewi Faradiba Kamilia Fauzi Fitra Perdana Fitri Ayu Nofirda Haiyul Fadhli Hasmalina Nasution Hasmalina Nst Hilwan Yuda Teruna Ihsan Ikhtiarudin Isnaniar Jasril - Jasril Jasril Johan Faladhin Jufrizal Syahri Jufrizal Syahri Nadila Zikra Nasution, Annio Indah Lestari Netti Gustina Nurlaili Nurlaili Nurlailli Nasution Nurul Hidayah Olif Syahbella Prasetya Prasetya Prasetya Prasetya Prasetya Prasetya Putri Khorely Rahmadini Syafri Rahmayani Indah Putri Rahmayani Indah Putri Rahmita Syafitri Retno Hidayati Sri Hilma Siregar Sulismayati - Suma Rahmani Harahap Trisiwi Kusuma Ningrum Unggul Akbar Wirdati Irma Yeni Yernita Zaldi Arman