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All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Pengabdian UntukMu NegeRI ALCHEMY Jurnal Penelitian Kimia JURNAL PHOTON Molekul: Jurnal Ilmiah Kimia Acta Chimica Asiana DEVOTE: Jurnal Pengabdian Masyarakat Global
Rahmiwati Hilma
Universitas Muhammadiyah Riau
Religion Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Nursing Physics Social Sciences Other

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Pengukuran Total Fenolik, Flavonoid, Aktivitas Antioksidan dan Antidiabetes Ekstrak Etil Asetat Daun Katemas (Euphorbia heterophylla, L.) Secara In Vitro dan In Silico Melalui Inhibisi Enzim α-Glukosidase Rahmiwati Hilma; Netti Gustina; Jufrizal Syahri
ALCHEMY Jurnal Penelitian Kimia Vol 16, No 2 (2020): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.16.2.40087.240-249

Abstract

Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antioksidan dan antidiabetes ekstrak etil asetat daun katemas (Euphorbia heterophylla L.) secara in vitro dan in silico melalui inhibisi terhadap enzim α-glukosidase. Pada penelitian ini ekstraksi sampel dilakukan menggunakan maserasi bertingkat, dimulai dengan n-heksana, selanjutnya dengan etil asetat. Ekstrak etil asetat yang didapatkan dilakukan pengujian kuantitiatif total fenolik dan flavonoid. Uji aktivitas antioksidan terhadap ekstrak dilakukan menggunakan metode DPPH. Uji aktivitas antidiabetes terhadap ekstrak dilakukan secara in vitro dan in silico melalui inhibisi terhadap enzim α-glukosidase menggunakan akarbose sebagai standar. Uji aktivitas antidiabetes terhadap kandungan senyawa bioaktif ekstrak secara in silico atau molecular docking menggunakan software Discovery Studio 4.1. Hasil penelitian menunjukkan bahwa nilai total fenolik dari ekstrak adalah 4,24 mg GAE/g berat kering dan nilai flavonoid total adalah: 3,22 mg KE/g berat kering. Hasil uji aktivitas antioksidan ekstrak didapatkan nilai IC50 sebesar 37,56 µg/mL, digolongkan sebagai aktivitas antioksidan yang sangat kuat. Hasil uji aktivitas antidiabetes secara in vitro didapatkan nilai IC50 sebesar 138,63 µg/mL. Hasil molecular docking memperlihatkan bahwa senyawasenyawa aktif yang terdapat didalam ekstrak mampu membentuk ikatan hidrogen antara ligan dengan reseptor, tapi lebih sedikit jika dibandingkan dengan akarbose.Measurement of Total Phenolic, Flavonoids, Antioxidant and Antidiabetic Activity of Catemas Leaf Ethyl Acetate Extract (Euphorbia heterophylla L.) by In Vitro and In Silico through Enzim α-Glucosidase Inhibition. This study aims to determine the antidiabetic activity of katemas (Euphorbia heterophylla L.) ethyl acetate extract in vitro and in silico through inhibition of the αglucosidase enzyme. In this study, the sample extraction was carried out by multilevel maceration, starting with n-hexane, then with ethyl acetate. The ethyl acetate extract obtained was quantitatively tested by total phenolic and flavonoids. The antioxidant activity of the extract was tested using the DPPH method. The antidiabetic activity of the extract was examined through inhibiting the enzyme αglucosidase in vitro using a microplate reader and in silico (molecular docking) using Discovery Studio 4.1 software. The results showed that the total phenolic value of the extract was 4.24 mg GAE/g of dry weight, and the total flavonoid value was 3.22 mg KE/g of dry weight. Antioxidant activity test obtained IC50 of 37,56 µg/mL, classified as verry strong antioxidant. The in vitro antidiabetic test examined that IC50 is 138.63 µg/mL. The results of molecular docking showed that the active compounds in the extracts are able to form hydrogen bonds between ligand and receptor; however, the amount was less than the hydrogen bonds formed by acarbose.
EVALUASI PRAKTIKUM KIMIA UNTUK GURU SEKOLAH MENENGAH SE-RIAU: KAJIAN KEPUASAN DAN PENGUATAN KOMPETENSI PRAKTIS Meidita Kemala Sari; Hasmalina Nasution; Sri Hilma Siregar; Prasetya Prasetya; Jufrizal Syahri; Rahmiwati Hilma; Rahmadini Syafri; Desi Asda Mora; Putri Apriliani Khorely
Devote: Jurnal Pengabdian Masyarakat Global Vol. 5 No. 2 (2026): Devote : Jurnal Pengabdian Masyarakat Global, June 2026
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/devote.v5i2.6039

Abstract

The Assisted School Program, launched by the Department of Chemistry at Universitas Muhammadiyah Riau (UMRI), aims to enhance the laboratory skills of high school chemistry teachers in Riau Province. The program addresses the need for stronger practical skills and a better understanding of laboratory safety, given limited access to modern equipment and current experimental methods in schools. Its primary goal is to provide teachers with technical and pedagogical competencies through project-based laboratory training in Laboratory Safety, Volumetric Analysis, Gravimetric Analysis, UV-Vis Spectrophotometry, and Adsorption.The program combined theoretical lectures, hands-on laboratory demonstrations, and pre- and post-test evaluations to measure knowledge gains. Twenty chemistry teachers from different schools in Riau participated. Results showed a significant improvement in post-test scores and high satisfaction levels. The overall service quality received an average rating of 4.95 out of 5, with the UV-Vis Spectrophotometry and Adsorption session achieving the highest satisfaction score of 4.80. No significant differences were found among schools, indicating the program’s equitable impact. These results demonstrate that the Assisted School Program effectively improves teachers’ professional competence, promotes safer, more modern laboratory practices, and provides a strong foundation for sustainable collaboration among universities, schools, and industry.
Bioactivity Profile, Toxicity Screening, and Biopolymer Film Application of Biosynthesized Silver Nanoparticles from Trema orientalis Leaf Extract Aghniya Naziefa; Rahmiwati Hilma; Mustika Widuri Bulan; Dwi Rosalinda; Jufrizal Syahri
Jurnal Kimia Sains dan Aplikasi Vol 29, No 7 (2026): Volume 29 Issue 7 Year 2026
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.29.7.491-504

Abstract

This study utilizes green nanotechnology by employing Trema orientalis leaf extract (TO-EE) as a natural bioreductant to synthesize silver nanoparticles (AgNPs-TO) and apply them in biopolymer film-based food packaging. AgNPs were synthesized using a stirrer method and characterized by UV-Vis, FTIR, XRD, PSA, and TEM. UV-Vis confirmed nanoparticle formation with a λmax at 430 nm (SPR). FTIR indicated phenolic and carbonyl groups in the reduction of Ag+ to Ag0. XRD showed a face-centered cubic silver structure with minor AgCl presence. PSA revealed an average size of 56.46 nm with high polydispersity (>0.5), while TEM showed spherical, heterogeneous particles. Antioxidant activity (DPPH) showed IC50 values of 128.40 µg/mL (AgNPs-TO) and 75.59 µg/mL (TO-EE). Anti-photooxidation tests in a linoleic acid system demonstrated that AgNPs-TO and BP/AgNPs-TO films suppressed hydroperoxide formation. Preliminary BSLT screening showed an LC50 <1000 ppm, and 5 ppm AgNPs were selected for incorporation into the biopolymer film. The additional AgNPs-TO also affects the physical properties of the biopolymer film. These results indicate that AgNPs-TO are promising as active agents in environmentally friendly food packaging.
Antibacterial Edible Film Based on Trema orientalis Leaf Extract: In Silico, In Vitro, and Toxicity Screening M. Rafshan Jani; Rahmiwati Hilma; Jufrizal Syahri; Aznan Hafiz Rizda; Dwi Muthia Sari
Jurnal Kimia Sains dan Aplikasi Vol 29, No 7 (2026): Volume 29 Issue 7 Year 2026
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.29.7.515-522

Abstract

Antibacterial edible films based on natural extracts have gained attention as sustainable alternatives for food packaging. Leaf extract of Trema orientalis contains bioactive compounds, including flavonoids, phenolics, alkaloids, terpenoids, and saponins, with potential antibacterial activity. The extract was obtained using ethanol and characterized by LC–MS, which identified 16 compounds, with an extraction yield of 16.45%. Edible films were prepared using a polyvinyl alcohol (PVA)–polyethylene glycol (PEG) matrix and characterized by FTIR, SEM, and physical–mechanical analyses. The incorporation of the extract improved the film properties, including thickness, water resistance, and tensile strength. Antibacterial activity against S. aureus and E. coli increased with extract concentration, reaching a maximum inhibition zone of 13.3 ± 0.58 mm at 60% extract concentration. Molecular docking against DNA gyrase B of E. coli (6F86) and S. aureus (4URM) identified compound 5 (−8.04 kcal/mol) and compound 13 (−7.94 kcal/mol) as the strongest-binding compounds toward their respective target proteins, indicating their potential contribution to the antibacterial activity of the extract. Toxicity evaluation using the Brine Shrimp Lethality Test (BSLT) yielded an LC50 value of 1976 ppm, indicating that the extract was non-toxic. These findings demonstrate that Trema orientalis extract-based edible films exhibit promising antibacterial properties and have potential as environmentally friendly active food packaging materials.
Co-Authors - Wahyuningsih Aghniya Naziefa Agustina Wulandari Anggi Fisi Anggita Aznan Hafiz Rizda Beta Achromi Nurohmah Chainul Fiffah Christine Jose Desi Asda Mora Dwi Muthia Sari Dwi Rosalinda Eka Ramadhani Eka Tri Setya Wulandari Emmy Yuanita Erna Puspita Dewi Fhadilla Sahara Fitra Perdana Haiyul Fadhli Hasmalina Nasution Hasmalina Nst Hilwan Yuda Teruna Ihsan Ikhtiarudin Isnaniar Jasril - Jasril Jasril Jufrizal Syahri Jufrizal Syahri Jufrizal Syahri Jufrizal Syahri Jufrizal Syahri M. Rafshan Jani Meidita Kemala Sari Mustika Widuri Bulan Nasution, Annio Indah Lestari Netti Gustina Nurlaili Nurlaili Nurlaili Nurlaili Nurlailli Nasution Nurul Hidayah Olif Syahbella Prasetya Prasetya Prasetya Prasetya Putri Apriliani Khorely Putri Khorely Rahmadini Syafri Rahmayani Indah Putri Rahmita Syafitri Sri Hilma Siregar Sulismayati - Suma Rahmani Harahap Trisiwi Kusuma Ningrum Unggul Akbar Wirdati Irma Yeni Yernita Zaldi Arman