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All Journal Jurnal Kesehatan Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Co-Value : Jurnal Ekonomi, Koperasi & Kewirausahaan Eduvest - Journal of Universal Studies Jurnal Kesehatan Komunitas Indonesia
Masrul Basyar
Unknown Affiliation
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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A Case of Concurrent COPD Exacerbation, Osteoporosis, and Fracture: Unveiling the Interplay Fadhilla Annisa Efendi; Masrul Basyar; Deddy Herman; Yessy Susanty Sabri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1257

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition with systemic effects, including an increased risk of osteoporosis and fractures. This case report presents a patient with acute COPD exacerbation, osteoporosis, and vertebral fractures, highlighting the complex interplay between these conditions. Case presentation: A 68-year-old male patient presented with acute exacerbation of COPD. He had a history of smoking, hypertension, and a previous diagnosis of pulmonary tuberculosis. Clinical examination revealed signs of respiratory distress, and imaging confirmed emphysema, pneumonia, osteoporosis, and vertebral fractures. The patient received treatment for COPD exacerbation and osteoporosis, showing improvement in respiratory symptoms and pain. Conclusion: This case underscores the importance of recognizing the association between COPD, osteoporosis, and fractures. Early diagnosis and appropriate management of these co-morbidities are crucial for improving patient outcomes and quality of life.
Epidermal Growth Factor Receptor Expression and Mutations as Diagnostic and Predictive Biomarkers in Lung Cancer: A Literature Review Munir, Sri Melati; Harahap, Wirsma Arief; Basyar, Masrul; Hilbertina, Noza
Jurnal Kesehatan Komunitas Indonesia Vol 6 No 1: April 2026
Publisher : Al-Hijrah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58545/jkki.v6i1.712

Abstract

Lung cancer remains a leading cause of cancer-related mortality worldwide, with diagnostic challenges due to nonspecific symptoms and limitations in tissue sampling. Molecular biomarkers, particularly Epidermal Growth Factor Receptor (EGFR), have gained attention for improving diagnostic accuracy and understanding tumor biology. EGFR plays a critical role in regulating cell proliferation, differentiation, and survival through multiple signaling pathways. This study aims to analyze the role of EGFR expression as a diagnostic biomarker in lung cancer by reviewing its biological function, molecular mechanisms, and clinical relevance. This study used a literature review approach by collecting relevant articles from databases such as PubMed, Scopus, and Google Scholar. Keywords including “EGFR,” “lung cancer,” and “biomarker” were used to identify studies discussing EGFR expression and its diagnostic value. EGFR overexpression and mutations are frequently found in lung cancer, especially non-small cell lung cancer. Activation of EGFR triggers signaling pathways such as MAPK, PI3K, and STAT, promoting tumor proliferation and survival. Detection methods, including immunohistochemistry, PCR, and FISH, are widely used. EGFR expression has shown potential as a diagnostic biomarker and provides important information for targeted therapy. EGFR expression plays a significant role in lung cancer diagnosis and offers potential as a diagnostic biomarker. However, variations across populations and tumor subtypes require careful interpretation in clinical applications.
The Effect of Anesthesia on TGF-β Levels in Lung Tumor Patients Undergoing Bronchoscopy: A Literature Review Johannas; Efrida; Basyar, Masrul; Darwin, Eryati
Jurnal Kesehatan Komunitas Indonesia Vol 6 No 1: April 2026
Publisher : Al-Hijrah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58545/jkki.v6i1.713

Abstract

Lung cancer remains the leading cause of cancer-related mortality worldwide, with persistently low survival rates. Bronchoscopy is an essential diagnostic procedure in patients with lung tumors and often requires anesthesia to improve comfort and procedural success. Emerging evidence suggests that anesthetic agents and techniques may influence tumor biology through modulation of immune responses and inflammatory mediators. Transforming Growth Factor-Beta (TGF-β) is a multifunctional cytokine involved in cell proliferation, differentiation, immune regulation, and extracellular matrix remodeling, and plays a critical role in cancer progression. This literature review aims to evaluate current evidence regarding the effects of anesthetic agents and techniques on TGF-β levels and their implications for tumor biology in patients with lung tumors undergoing bronchoscopy. A narrative literature review approach was used to analyze scientific publications exploring the relationship between anesthesia, immune modulation, cytokine alterations, and cancer progression, particularly focusing on inhalational and intravenous anesthetics. Surgical stress and anesthetic exposure can alter immune responses through activation of neuroendocrine pathways, leading to cytokine imbalance and immunosuppression. TGF-β exhibits dual roles in cancer, acting as a tumor suppressor in early stages and a tumor promoter in advanced stages. Inhalational anesthetics may enhance tumor progression, whereas intravenous anesthetics such as propofol may have immunomodulatory effects. Anesthetic techniques may influence tumor-related pathways, including TGF-β; however, evidence remains limited and inconsistent, requiring further well-designed studies.
Co-Authors Andani E Putra Asman Manaf Dina Fitri Fauzia Efrida Efrida Efrida Ellyza Nasrul Eryati Darwin Fadhilah, Dwi Rizki Fadhilla Annisa Efendi Fenty Anggrainy Hadya Gorga Haikal Basyar Harahap, Wirsma Arief Henny Mulyani Herman, Deddy Johannas Julizar Nazar Khairudin Hamdani M Haikal Metha Arsilita Hulma Mizarti, Dessy Netti Suharti Noza Hilbertina, Noza Oea Khairsyaf Prima O Damhuri Putra, Rizki Amrika R.A Ananda Nuriman Revi Sofiana Martantya Rizky Amelia Rosi Maulini Russilawati Shabrina Izzati Sri Melati Munir Susanti Sabri4, Yessy Susanti Sabri Vicennia Serly Yessy Susanty Sabri