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All Journal Majalah Kedokteran Bandung Althea Medical Journal Acta Pharmaceutica Indonesia Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Ilmu Faal Olahraga Indonesia eJournal Kedokteran Indonesia
Novi Vicahyani Utami
Departemen Farmakologi Dan Terapi, Fakultas Kedokteran, Universitas Padjajaran, Bandung
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Efek Ekstrak Etanol Daun Gynura procumbens dalam Menghambat Peningkatan Kadar Trigliserida Tikus Model Hipertrigliseridemia Yunita Puji Astuti; Novi Vicahyani Utami; Tiene Rostini
Acta Pharmaceutica Indonesia Vol. 39 No. 1 & 2 (2014)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Hipertrigliseridemia penting diperhatikan karena merupakan faktor resiko independen penyakit diabetes melitus. Salah satu tanaman obat yang dipercaya masyarakat dapat menurunkan kadar lipid adalah tanaman sambung nyawa (Gynura procumbens). Penelitian eksperimental dilakukan untuk mengetahui efek ekstrak etanol daun sambung nyawa dalam menghambat peningkatan kadar trigliserida darah tikus model hipertrigliseridemia. Tikus jantan galur Wistar sebanyak 24 ekor, umur 2-3 bulan, berat 200-300 gram, dibagi 6 kelompok: kelompok I (makanan standar + air), kelompok II (diet tinggi lemak [DTL] + propiltiourasil [PTU] 0,01%+ larutan carboxymetyl cellulosa 1%), kelompok III (DTL+ PTU 0,01%+ ekstrak 50 mg/kgBB), kelompok IV (DTL+ PTU 0,01%+ ekstrak 150 mg/kgBB), kelompok V (DTL + PTU 0,01% + ekstrak 300 mg/kgBB) dan kelompok VI (DTL + PTU 0,01%+ gemfibrozil 54 mg/kgBB). Kadar trigliserida diukur setelah satu minggu adaptasi (sebelum perlakuan) dan setelah dua minggu perlakuan. Data hasil penelitian dianalisis dengan uji Kruskal-Wallis dan Mann-Whitney. Hasil penelitian menunjukkan bahwa ekstrak etanol daun sambung nyawa dosis 50 mg/kgBB, 150 mg/kgBB dan 300 mg/kgBB memiliki efek menghambat peningkatan kadar trigliserida darah tikus model hipertrigliseridemia (p<0,05). Ketiga dosis memiliki efek yang sebanding. Ekstrak etanol daun sambung nyawa menghasilkan efek yang sebanding dengan gemfibrozil dosis 54 mg/kgBB (p>0,05). Kesimpulan penelitian ini adalah ekstrak etanol daun sambung nyawa memiliki efek menghambat peningkatan kadar trigliserida darah tikus model hipertrigliseridemia. Efek tersebut sebanding dengan efek gemfibrozil 54 mg/kgBB.Kata kunci: Gynura procumbens, sambung nyawa, ekstrak, trigliserida, hipertrigliseridemiaAbstractHypertriglyceridemia is an important condition as risk factor for diabetes mellitus, which shows an increasing prevalence annualy. People believed that herbs such Gynura procumbens act as herbal medicine for hypertriglyceridemia. The experimental study was conducted to know the effect of Gynura procumbens ethanolic extract in inhibiting the increase of blood triglyceride level of hypertriglyceridemic rats model. Twenty four male Wistar rats aged 2-3 months (200-300 grams), were divided into 6 groups: group I (standard food + water), group II (high lipid diet + propylthiouracil 0,01% + carboxymetil celullosa solvent 1%), group III (high lipid diet + propylthiouracil 0.01% + extract 50 mg/kg), group IV (high lipid diet + propylthiouracil 0.01% + extract 150 mg/kg), group V (high lipid diet + propylthiouracil 0.01% + extract 300 mg/kg), and group VI (high lipid diet + propylthiouracil 0.01% + gemfibrozil 54 mg/kg). The triglyceride level was measured: one week after adaptation (before treatment) and two weeks after treatment. The data was analyzed using Kruskal-Wallis test and Mann-Whitney test. The results of the study indicated that Gynura procumbens ethanolic extract of 50 mg/kg, 150 mg/kg, and 300 mg/kg had effect in inhibiting the increase of the blood triglyceride level of hypertriglyceridemic rats model (p<0,05). The variation of the three doses indicated a similar effect. Gynura procumbens ethanolic extract and gemfibrozil 54 mg/kg gave a similar effect (p>0,05). In conclusion, Gynura procumbens ethanolic extract has an effect in inhibiting the increase of blood triglyceride level of hypertriglyceridemic rats model. It has similar effect to gemfibrozil 54 mg/kg.Keywords: Gynura procumbens, extract, triglyceride, hypertriglyceridemia
EFFECT OF TRUWINIST INTERDIGITAL METHOD IN KNOWLEDGE AND SKILL OF SELECTING DRUG AND WRITING PRESCRIPTION OF ASTHMA DRUG Truly Deti Rose Sitorus; Eggy Raynaldi Rachman Nurhadi; Novi Vicahyani Utami; Muhammad Hasan Bashari
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 10, No 3 (2021): November
Publisher : Asosiasi Institusi Pendidikan Kedokteran Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpki.52738

Abstract

Background: Medical error is any kind of unplanned or out of procedure medical action. Some of them are error in selecting and prescribing drug  which might cause the disease to remain, worse, or death. Prescribing error can be prevented by giving better education about pharmacology. One popular learning methods is blended learning. Truwinist Interdigital Method  is a learning media innovation with bleanded learning concept designed subjects in audiovisual form. Truwinist Interdigital Method was accessible at university’s learning management system. This study aimed to evaluate the improvement of student’s pharmacological learning outcome upon Truwinist Interdigital  Method. The learning outcome was students knowledge and skill on prescribing asthmatic drug. Methods: A experimental research was conducted with pretest and posttest  design. Subjects were 148 medical students of Universitas Padjadjaran who were given Truwinist Interdigital Method. The learning outcome was observed using pre-test and post-test score  and tested using Wilcolson test. Results: Students’ knowledge score increased from average of 34.70±15.43 to 86.01±10.80. Students’ skill score increased from average of 25.31±12.76 to 76.93±10.66. The result showed students’ learning outcome increased  significantly (p<0,001). Conclusion: Knowledge and prescribing skill Students’ asthmatic drug increase  after using bleanded learning with Truwinist Interdigital Method.  
Tingkat Pengetahuan dan Rasionalitas Penggunaan Obat Secara Swamedikasi pada Mahasiswa Fakultas Kedokteran Universitas Padjajaran Kuswinarti Kuswinarti; Novi Vicahyani Utami; Naufal Fadhillah Sidqi
eJournal Kedokteran Indonesia Vol. 10 No. 2 - Agustus 2022
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.10.147.138-43

Abstract

Swamedikasi menjadi salah satu pilihan masyarakat yang dapat memberikan dampak positif dan negatif pada kesehatan. Tujuan penelitian ini untuk mengetahui tingkat pengetahuan dan rasionalitas penggunaan obat secara swamedikasi. Penelitian ini menggunakan potong lintang, dilakukan mulai Desember 2021 hingga Januari 2022. Sebanyak 196 responden mahasiswa strata-1Pendidikan Dokter Fakultas Kedokteran Universitas Padjajaran terlibat dalam penelitian ini. Responden dipilih dengan metode sampel acak terstratifikasi. Pengambilan data dilakukan melalui pengisian kuisioner daring yang telah diuji validitas dan reliabilitasnya. Data dianalisis secara univariat menggunakan SPSS versi 20. Hasil penelitian menunjukkan tingkat pengetahuan mahasiswa 62,8% tergolong baik dan 37,2% tergolong kurang. Penggunaan obat secara swamedikasi 67,9% rasional dan 32,1% tidak rasional. Mayoritas tingkat pengetahuan mahasiswa tergolong baik dan mahasiswa rasional dalam menggunakan obat secara swamedikasi. Mahasiswa kedokteran perlu mendapat edukasi lebih terkait swamedikasi agar tidak timbul masalah baru akibat penggunaan obat yang tidak rasional. Kata kunci: swamedikasi,pengetahuan, rasionalitas penggunaan obat, mahasiswa kedokteran.   Level of Knowledge and Rationality of Drug Use by Self-Medication in Student of Faculty of Medicine, Padjajaran University Abstract Self-medication is one of the people’s choices that can have a positive and negative impact on health. The aim of this study was to determine the level of knowledge and rationality of drug use self-medication. This research is a descriptive study with a cross-sectional design, conducted from December 2021 to January 2022. Total respondents (n=196) from undergraduate medical students at Padjajaran University were involved in this study. Respondents were selected using the stratified random sampling method. Data was collected by using a validated questionnaire. Data were analyzed using IBM SPSS version 25. The results showed that the level of knowledge of students 62.8% was classified as good and 37.2% was classified as low. Self-medication use of drugs is 67.9% rational and 32.1% irrational. Based on the research results obtained the majority level knowledge of students was good classified. The majority of students are rational in using self-medication. Medical students need to get more education related to selfmedication so that new problems do not arise due to irrational use of drugs. Keywords: self-medication, knowledge,rationality of drug use, medical students.
Co-Authors A.A. Ketut Agung Cahyawan W Annisa Rahayu Astuti, Yunita Puji Bashari, Muhammad Hasan Dzulfikar D. Lukmanul Hakim Edhyana Sahiratmadja Eggy Raynaldi Rachman Nurhadi Gurwinder Kaur a/p Gurcharan Singh Gurwinder Kaur a/p Gurcharan Singh Hermin Aminah Usman Ida Ayu Putu Sri Widnyani Intan Leonita Intan Leonita, Intan Kuswinarti Kuswinarti Leonardo Lubis Naufal Fadhillah Sidqi Novitri Novitri Novitri, Novitri Nurul Nadiya Binti Abdul Razak Penggoam, Simeon Pramono, Alvinsyah Adhityo Rahayu, Annisa Ramdan Panigoro Tiene Rostini, Tiene Tri Hanggono Achmad Truly Deti Rose Sitorus Yunita Puji Astuti Yusuf Wibisono