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Formulasi dan Evaluasi Sediaan Gummy Candies dari Sari Ganggang Hydrilla (Hydrilla Verticillata L.) yang Tumbuh di Perairan Danau Toba Mandike Ginting; Nova Rianti Marbun; Mutiara Sinaga; Khairani fitri; Leny Leny
Majalah Farmasetika Vol 8, No 1 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v8i1.36649

Ganggang hydrilla (Hydrilla verticillata L.) merupakan tumbuhan air yang tumbuh di perairan Danau Toba. Ganggang hydrilla mengandung banyak kandungan gizi, klorofil, karotenoid, vitamin C, alkaloid, flavonoid, steroid, saponin, kalsium, magnesium serta mineral dan antioksidan yang dapat dimanfaatkan dalam perkembangan dunia kesehatan, salah satunya adalah dalam bentuk formulasi sediaan gummy candies. Tujuan penelitian ini adalah untuk mengetahui apakah sari ganggang hydrilla (Hydrilla verticillata L.) dapat diformulasikan menjadi sediaan gummy candies yang memenuhi beberapa pengujian fisik dan disukai oleh panelis. Metode pada penelitian ini adalah metode eksperimental. Sediaan gummy candies dibuat dengan konsentrasi 0%, 10%, 15% dan 20%. Pengujian yang dilakukan antara lain skrining fitokimia, pemeriksaan karakteristik simplisia, uji organoleptik, uji pH, uji kadar air, uji kadar abu, uji keseragaman bobot, uji elastisitas, uji kandungan senyawa metabolit sekunder pada sediaan gummy candies. Hasil penelitian menunjukkan ganggang hydrilla memiliki senyawa metabolit sekunder berupa alkaloid, flavonoid dan steroid. Uji organoleptik sediaan pada F0, F1, F2 dan F3 menunjukkan hasil yang sama pada bau khas, rasa manis sedikit asam dan rasa leci, dan tekstur kenyal. Warna kuning transparan – kuning gelap. Sediaan gummy candies memiliki pH pada kisaran 3,3-3,5. Kadar air pada kisaran 12-15,3%, dengan kadar abu 3,3%. Uji keseragaman bobot memenuhi syarat FI edisi III. Uji elastisitas pada F3 mendekati elastisitas gummy candies yang beredar. Kesimpulan penelitian ini adalah sari ganggang hydrilla (Hydrilla verticillata L.) dapat diformulasikan menjadi sediaan gummy candies yang memenuhi beberapa pengujian fisik gummy candies seperti yang tertera pada SNI. Kata kunci: Ganggang Hydrilla, Hydrilla verticilata, Gummy Candies, Danau Toba – Sumatera Utara

UJI AKTIVITAS KRIM ANTI JERAWAT EKSTRAK ETANOL DAUN SEROJA (Nelumbo nucifera G.) TERHADAP BAKTERI Propionibacterium acnes DAN Staphylococcus aureus Khairani Fitri; Tetty Noverita Khairani; Muhammad Andry; Nidia Rizka; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Background; Lotus leaves (Nelumbo nucifera G.) is one of the plants that are potentially in the field of treatment, like antibacterial antiacne. Lotus leaves contain alkaloids, saponins, tannins, flavonoids and steroids are compounds of secondary metabolites in plants that are effective as an antibacterial. Objective; The study aimed to determine the antibacterial activity of lotus leaves ethanol extract against bacteria of Propionibacterium acnes and Staphylococcus aureus. Method; The ethanol extract of lotus leaves was made by maceration method using 96% ethanol as a solvent. The in-vitro antibacterial activity test used the well method with a concentration of 10%, 20% and 30%. Results; The results of the study with concentration of 10%, 20% and 30% have the inhibition zone on the bacteria Propionibacterium acnes where the concentration of 10% of 8.7mm, a concentration of 20% of 12.4mm and a concentration of 30% by 14.5mm. And the zone of inhibition on Staphylococcus aureus bacteria has a 10% concentration of 8.1mm, the concentration of 20% of 11.1mm and a concentration of 30% of 14.1mm. Concentration is the cream of the ethanol extract of the leaves of lotus at a concentration of 30%. Conclusion; The conclusion of this study showed that the ethanol extract of lotus leaves could be formulated in a cream dosage form and has antibacterial activity against Propionibacterium acnes and Staphylococcus aureus bacteria. It is suggested to the next researchers to do fractionation to get better dosage results.

Penyuluhan Pembuatan Simplisia dari Beberapa Tanaman Obat Tradisional pada Masyarakat di Kecamatan Batang Kuis Khairani Fitri; Tety Noverita Khairani; Jacob Tarigan
Jurnal Pengabdian Masyarakat Ilmu Kesehatan Vol 2, No 1 (2021): Edisi Januari
Publisher : LPPM Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/.v2i1.5514

Tanaman obat tradisional merupakan salah satu pengobatan alternatif yang telah lama dilakukan secara turun temurun. Keberhasilan pemanfaatan tanaman obat tradisional ini sangat dipengaruhi oleh pengetahuan masyarakat mengenai manfaat dari setiap jenis tanaman yang berkhasiat. Pemanfaatan tanaman obat tradisional tidak hanya sebagai bumbu masakan, tetapi jika ditekuni dengan sepenuh hati akan memberikan nilai kepuasan, bahkan sebagai penopang kehidupan. Banyak bagian dari tumbuhan bisa digunakan sebagai obat, diantaranya adalah bagian buah, batang, daun dan akar atau umbi. Pengetahuan masyarakat di desa Bakaran Batu Kecamatan Batang Kuis mengenai pemanfaatan obat tradisional untuk pengobatan bisa dikatakan baik, tetapi pengolahan dari bagian tanaman yang bisa dijadikan obat yang salah satunya dijadikan simplisia belumlah mereka ketahui. Simplisia adalah bahan alamiah yang dipakai sebagai obat yang belum mengalami pengolahan apapun juga atau yang baru mengalami proses setengah jadi seperti pengeringan. Simplisia memiliki banyak keunggulan antara lain efek sampingnya relatif lebih kecil daripada obat-obatan kimia karena berasal dari alam, adanya komposisi yang saling mendukung untuk mencapai efektivitas pengobatan, dan lebih sesuai untuk penyakit metabolik dan degeneratif. Tujuan dari program pengabdian masyarakat ini adalah untuk memberi penyuluhan kepada masyarakat di Desa Bakaran Batu Kecamatan Batang Kuis dengan memberikan contoh beberapa jenis tanaman yang bisa digunakan untuk. Selanjutnya bagian tanaman tersebut dijadikan simplisia untuk dijadikan obat. Metode yang digunakan yaitu pemberian penyuluhan berupa ceramah dengan media powerpoint dan pembagian leaflet. Kegiatan ini diharapkan meningkatkan pengetahuan masyarakat mengenai pembuatan simplisia dari tanaman obat untuk dapat digunakan dalam kebutuhan sehari-hari.

FORMULATION AND PHYSICAL STABILITY TESTING OF CREAM SCRUB PREPARATIONS FROM ETHANOL EXTRACT OF Nelumbo nucifera GAERTN FLOWER AND LEAF Khairani Fitri; Tetty Noverita Khairani; Muhammad Andry; Muhammad Amin Nasution; Muhammad Fauzan Lubis; Firman Rezaldi; Jashima Ukhtia
BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan Vol 12, No 1 (2024): JURNAL BIOTIK
Publisher : Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/biotik.v12i1.22952

Nelumbo nucifera is an aquatic plant that thrives in muddy and soggy soil, particularly in swampy environments. Nelumbo nucifera is utilized in traditional medicine for various purposes, including the management of diarrhea, tissue inflammation, and homeostasis. The flowers and leaves of Nelumbo nucifera contain many secondary metabolite chemicals, including flavonoids, alkaloids, tannins, and antioxidants. The objective of this study is to ascertain the feasibility of formulating a cream scrub using the ethanol extract of Nelumbo nucifera flowers and leaves. Additionally, the study attempts to discover if concentrations of 3%, 5%, and 7% of this extract can effectively moisturize the skin. This research technique is based on experimentation, involving the creation of simplicia, the production of extracts, the formulation of body scrub preparations using ethanol extracts of Nelumbo nucifera flowers and leaves, and the subsequent evaluation of these body scrub preparations. This study found that the moisture content of Nelumbo nucifera flower ethanol extract cream increased by 41.2% in F1, 46.5% in F2, and 52.9% in F3. The humidity percentage values for Nelumbo nucifera leaf extract cream were obtained as follows: F1 at 38.8%, F2 at 44.4%, and F3 at 47.7%. The ethanol extract derived from the flowers and leaves of Nelumbo nucifera can be prepared and used as a cream scrub. A cream scrub containing Nelumbo nucifera flower and leaf extract at concentrations of 3%, 5%, and 7% can effectively moisturize the skin.

ANTIBACTERIAL ACTIVITY OF BASIL LEAVES EXTRACT TOWARDS BACTERIA STAPHYLOCOCCUS AUREUS AND STAPHYLOCOCCUS EPIDERMIDIS IN DEODORANT SPRAY Khairani, Tetty Noverita; Fitri, Khairani; Andry, Muhammad; Nasution, Muhammad Amin
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.7542

Body odor is a significant problem and is often encountered in some individuals characterized by excessive odor. A deodorant spray made from basil leaf (Ocimum Basilicum L.) extract is a product used to treat body odor caused by Staphylococcus Aureus and Staphylococcus epidermidis bacteria. The purpose of this study is to assess the efficacy of deodorant spray and basil leaf extract on bacterial activity, as well as the optimal dose of deodorant spray for lowering the activity of these bacteria. Method the research was conducted experimentally, testing antibacterial activity using agar diffusion. The results of the deodorant spray preparation test showed that the preparation was homogeneous, organoleptically brown in color, had a distinctive smell, and had a liquid texture; the pH test results met the requirements for deodorant spray 4.5-6.5. The average diameter of the inhibition zones produced from each preparation were Staphylococcus epidermidis bacteria, positive control 7 mm, negative control 10.1 mm; formula 5% 12.3 mm; formula 10% 13.3 mm; formula 15% 12.7 mm maximum concentration in inhibiting bacteria is formula 10% by 13.3 mm, while the bacteria Staphylococcus Aureus positive control 13 mm, negative control 11.2 mm, 5% formula 13.1 mm; formula 10% 13.4 mm; 15% formula 13.9 mm maximum concentration in inhibiting bacteria is 15% formula 13.9 mm. Based on the inhibitory zone created by 10% basil leaf ethanol extract, Staphylococcus epidermidis bacteria had a 13.3 mm clean zone and Staphylococcus aureus bacteria had a 26.5 mm clean zone.

FORMULASI DAN EVALUASI SEDIAAN KRIM PELEMBAB DAN ANTIOKSIDAN EKSTRAK ETANOL BUAH ARA (Ficus racemosa L.) Muhammad Andry; Hanafis Sastra Winata; Indra Ginting; Khairani Fitri; Tetty Noverita Khairani; Ulfa Melyza; Muhammad Amin Nasution
FORTE JOURNAL Vol 4 No 2 (2024): Edisi Juli 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v4i2.932

Tumbuhan ara (Ficus racemosa L.) sangat memiliki khasiat sebagai antidiare, antiinflamasi, antioksidan dan lain sebagainya. Antioksidan dalam krim berfungsi sebagai pelembab untuk melindungi kulit dari radikal bebas dengan cara membentuk lapisan lemak tipis di permukaan kulit dan memperlambat kerusakan akibat proses oksidasi. Tujuan penelitian adalah untuk membuat formulasi dari sediaan krim pelembab dengan menggunakan ekstrak etanol buah ara (Ficus racemosa L.) sebagai pelembab alami kulit dan menentukan konsentrasi terbaik yang memenuhi persyaratan standar Farmakope Indonesia. Penelitian ini dilakukan secara eksperimental. pembuatan ekstrak buah ara dilakukan dengan cara maserasi, konsentrasi ekstrak buah ara ditambahkan ke dalam sediaan formulasi krim 10%, 20% dan 30%. Pengujian sediaan meliputi uji organoleptis, homogenitas, pH, daya sebar, tipe krim, viskositas, iritasi, hedonik dan stabilitas. Analisis data menggunakan uji anova. Hasil menunjukkan sediaan krim pelembab memenuhi syarat evaluasi fisik sediaan yaitu memiliki tekstur semi solid, dengan aroma pewangi krim, warna pada setiap formula berbeda beda, F0 berwarna putih, formula F1 (10%) coklat muda, F2 (20%) coklat pekat, F3 (30%) Coklat hitam. Semua sediaan homogen dan tidak mengiritasi kulit. Memiliki pH berkisar 5-6,3, daya sebar 5-6,7 cm dengan viskositas 9326-13918 Cs, uji stabilitas dengan metode cycling test selama 12 hari memiliki stabilitas yang baik. Hasil rata-rata persentase peningkatan kelembaban pada F0 (17,77%), F1 (35,57%), F2 (49,87%), F3 (51,93%) dan kontrol positif (56,5%). Hasil analisis data menggunakan uji anova menunjukkan ada perbedaan yang signifikan dari ketiga konsentrasi yang diuji. Berdasarkan hasil penelitian dapat disimpulkan sediaan krim pelembab yang diformulasikan dapat melembabkan kulit secara alami, dan disetiap minggunya terjadi peningkatan kelembaban kulit. dan konsentrasi terbaik sediaan krim pelembab yaitu F3 dengan konsentrasi ekstrak 30%.

Uji Efektivitas Anti-Aging Ekstrak Bunga Kembang Sepatu (Hibiscus rosa-sinensis L.) Dalam Sediaan Masker Clay Tetty Noverita Khairani; Khairani Fitri; Luthvia Luthvia; Leny Leny; Faizah Rahman
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1783

Introduction: Skin aging is a natural degenerative process triggered by internal and external factors, particularly oxidative stress caused by free radicals. Hibiscus rosa-sinensis L. contains flavonoid and anthocyanin compounds which have potential as natural antioxidants to inhibit the skin aging process. Objective: This study aimed to formulate and evaluate a clay mask containing ethanol extract of Hibiscus rosa-sinensis flowers and to test its anti-aging effectiveness on skin condition parameters. Methods: This experimental study involved the preparation of clay masks with three variations of extract concentrations: 2.5% (F1), 5% (F2), and 10% (F3). Physical quality evaluations included homogeneity, pH, stability, drying time, emulsion type, and irritation tests. Anti-aging effectiveness testing was conducted on 15 female volunteers aged 35–60 years using a skin analyzer over 4 weeks with once-weekly application. Measured parameters included moisture, evenness, pore size, spots, and wrinkles. Data were analyzed using the Kruskal-Wallis test followed by the Mann-Whitney test. Results: All formulas met the physical quality requirements with pH values of 6.4–6.7, homogeneous, stable during 12 weeks of storage, and caused no irritation. Formula III (10% concentration) demonstrated the best anti-aging effectiveness with increases in moisture content of 67.5%, decreases in roughness of 42.3%, decreases in pore size of 30.9%, decreases in spots of 32.4%, and decreases in wrinkles of 36.0% after 4 weeks of treatment. However, the effectiveness of Formula III remained lower than that of the commercial clay mask. Conclusion: Ethanol extract of Hibiscus rosa-sinensis can be formulated as a stable and safe anti-aging clay mask. The 10% concentration formula exhibited the best effectiveness in improving skin aging parameters, although further formula optimization is still required to approach the effectiveness of commercial products.

Uji Aktivitas Antibakteri Ekstrak Etanol Daun Seroja (Nelumbo nucifera Gaertn.) terhadap Escherichia coli dan Staphylococcus aureus Khairani Fitri; Tetty Noverita Khairani; Ruth Mayana Rumanti; Sri Handayani; Mintaria Halawa
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1809

Introduction: The increasing occurrence of bacterial infections and antimicrobial resistance has encouraged the investigation of medicinal plants as potential sources of antibacterial compounds. Lotus (Nelumbo nucifera Gaertn.) leaves contain several classes of secondary metabolites that may contribute to antibacterial activity. Objective: This study evaluated the antibacterial activity of lotus leaf ethanol extract against Escherichia coli and Staphylococcus aureus and identified the major classes of secondary metabolites present in the extract. Methods: This laboratory experimental study used lotus leaf extract prepared by maceration with 96% ethanol. The simplicia was characterized and subjected to phytochemical screening. Antibacterial activity was evaluated using the paper-disc diffusion method on Mueller–Hinton agar at extract concentrations of 10%, 15%, and 20%, with clindamycin as the positive control and dimethyl sulfoxide as the negative control. Each treatment was tested in triplicate. Inhibition-zone diameters were analyzed using one-way analysis of variance followed by Tukey's HSD test. Results: The lotus leaf material contained alkaloids, flavonoids, saponins, tannins, steroids, and triterpenoids. Against E. coli, the mean inhibition-zone diameters at concentrations of 10%, 15%, and 20% were 13.60, 15.40, and 16.60 mm, respectively; the corresponding values against S. aureus were 14.56, 15.21, and 18.13 mm. Differences among treatments were statistically significant for both test bacteria (p<0.001). Conclusion: Lotus leaf ethanol extract exhibited concentration-dependent antibacterial activity against E. coli and S. aureus, with the strongest inhibition observed at 20%. Further studies should determine the minimum inhibitory and bactericidal concentrations and characterize the active antibacterial constituents.

Pengaruh Ekstrak Daun Nanas Terhadap Pertumbuhann Candida albicans Dan Malassezia furfur Dalam Bentuk Sediaan Shampo Herbal Hafizhatul Abadi; Tetty Noverita Khairani; Khairani Fitri; Vivi Eulis Diana; Leny Leny; Amalia Juliani Hasibuan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1181

Background: Dandruff is a common scalp problem often caused by the overgrowth of fungi such as Candida albicans and Malassezia furfur. Pineapple leaves (Ananas comosus (L.) Merr.) are known to contain active antifungal compounds, such as alkaloids, flavonoids, saponins, and tannins, making them a potential active ingredient for anti-dandruff preparations. Objective: This study aimed to formulate an herbal anti-dandruff shampoo using pineapple leaf ethanol extract and to evaluate its effectiveness in inhibiting the growth of Candida albicans and Malassezia furfur. Methods: This experimental research used the disc diffusion method with PDA and SDA media to test antifungal inhibition. The shampoo preparations were formulated with varying extract concentrations (10%, 20%, 30%). The evaluation of the preparations included organoleptic tests, homogeneity, pH, foam height, viscosity, stability (cycling test), skin irritation, and hedonic tests. Results: The resulting shampoo preparation had a blackish-brown color, liquid form, and a menthol odor. Evaluation results showed the preparation was homogeneous, with pH values (5.0-5.8), foam height, and viscosity meeting the requirements. The preparation was also stable during the cycling test and did not cause irritation. The antifungal activity test showed that increasing the extract concentration increased the inhibitory power. The formula with a 30% concentration (F3) provided the greatest inhibition against Candida albicans (average 15.76 mm) and Malassezia furfur (average 15.9 mm), which is categorized as strong. Conclusion: Pineapple leaf ethanol extract was successfully formulated into an effective herbal anti-dandruff shampoo preparation, with the 30% concentration being the most optimal. It is recommended that further research investigate the antifungal activity of this extract against other types of fungi and in different dosage forms.

Uji Efektivitas Anti-Aging Ekstrak Bunga Kembang Sepatu (Hibiscus rosa-sinensis L.) Dalam Sediaan Masker Clay Tetty Noverita Khairani; Khairani Fitri; Luthvia Luthvia; Leny Leny; Faizah Rahman
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1783

Introduction: Skin aging is a natural degenerative process triggered by internal and external factors, particularly oxidative stress caused by free radicals. Hibiscus rosa-sinensis L. contains flavonoid and anthocyanin compounds which have potential as natural antioxidants to inhibit the skin aging process. Objective: This study aimed to formulate and evaluate a clay mask containing ethanol extract of Hibiscus rosa-sinensis flowers and to test its anti-aging effectiveness on skin condition parameters. Methods: This experimental study involved the preparation of clay masks with three variations of extract concentrations: 2.5% (F1), 5% (F2), and 10% (F3). Physical quality evaluations included homogeneity, pH, stability, drying time, emulsion type, and irritation tests. Anti-aging effectiveness testing was conducted on 15 female volunteers aged 35–60 years using a skin analyzer over 4 weeks with once-weekly application. Measured parameters included moisture, evenness, pore size, spots, and wrinkles. Data were analyzed using the Kruskal-Wallis test followed by the Mann-Whitney test. Results: All formulas met the physical quality requirements with pH values of 6.4–6.7, homogeneous, stable during 12 weeks of storage, and caused no irritation. Formula III (10% concentration) demonstrated the best anti-aging effectiveness with increases in moisture content of 67.5%, decreases in roughness of 42.3%, decreases in pore size of 30.9%, decreases in spots of 32.4%, and decreases in wrinkles of 36.0% after 4 weeks of treatment. However, the effectiveness of Formula III remained lower than that of the commercial clay mask. Conclusion: Ethanol extract of Hibiscus rosa-sinensis can be formulated as a stable and safe anti-aging clay mask. The 10% concentration formula exhibited the best effectiveness in improving skin aging parameters, although further formula optimization is still required to approach the effectiveness of commercial products.

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