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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN JURNAL GIZI INDONESIA Nurse Media Journal of Nursing Jurnal Kedokteran Brawijaya NUTRIRE DIAITA Majalah Kedokteran Bandung Jurnal Manajemen Keperawatan Health Notions Biosaintifika: Journal of Biology & Biology Education JI-KES (Jurnal Ilmu Kesehatan) Medica Hospitalia
Edi Dharmana
Medical Faculty, Diponegoro University, Semarang, Indonesia
Agriculture, Biological Sciences & Forestry Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Deep Breathing Exercise and Active Range of Motion Influence Physiological Response of Congestive Heart Failure Patients Nirmalasari, Novita; Mardiyono, Mardiyono; Dharmana, Edi; Arifin, Thohar
Nurse Media Journal of Nursing Vol 10, No 1 (2020): (April 2020)
Publisher : Department of Nursing, Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.316 KB) | DOI: 10.14710/nmjn.v10i1.25318

Abstract

Background: Dyspnea and physiological changes are clinical manifestations of Congestive Heart Failure (CHF) due to respiratory failure. Deep breathing exercise combined with active range of motion increases respiratory muscles and blood circulation. As a result, it reduces breathing effort and decreases blood pressure.Purpose: This research aimed to analyze the influence of deep breathing exercise and active range of motion (ROM) on physiological response of CHF patients.Methods: This study used a quasi-experiment with pretest-posttest control group design recruiting 32 respondents by stratified random sampling technique. The intervention was done three times a day for three days. Deep breathing exercise for thirty times and continued with active range of motion for five times each movement was given. Digital sphygmomanometer and digital watch were used as measuring instruments. Data were analyzed using independent and paired t-tests.Result: The results showed that there were significant differences in the systole (p=0.000), diastole (p=0.000) and respiratory rates (p=0.003) after the intervention compared to the control group. There was also a significant difference in systolic blood pressure between the intervention and the control group (p=0.003). However, no significant difference in diastole and respiratory rates was found.Conclusion: Deep breathing exercise combined with active range of motion decreases the systole in CHF patients. Further research is expected to lengthen the time of intervention to allow better significance.
MELATONIN MENURUNKAN BERAT BADAN TIKUS WISTAR JANTAN YANG DIBERI MINYAK JELANTAH SELAMA 28 HARI Novianti, Anugrah; Dharmana, Edi; Suci, Nyoman
Jurnal Nutrire Diaita (Ilmu Gizi) Vol 8, No 2 (2016): NUTRIRE DIAITA
Publisher : Lembaga Penerbitan Unversitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47007/nut.v8i2.1612

Abstract

AbstractBackground: Obesity is a risk factor metabolic syndrome and nonalcoholic fatty liver disease. One of the mechanisms that trigger the disease is the increased oxidative stress in obesity people. Melatonin is a powerful antioxidant that can increase the synthesis of endogenous antioxidants in the body, suppress the inflammatory response,inhibit the formation of steatosis and reducing body weight.Objective: To analyze the effect of melatonin supplementation in reducing body weight in male Wistar rats were fed by waste cooking oil.Methods: True experimental study using post-test only control group design. This study was done on 18 male wistar rats were divided into 3 groups: the positive control group (P0) was administrated waste cooking oil, the treated group 1 (P1) was administrated waste cooking oil and 5mg/kgBW melatonin, and the treated group 2 (P2) was administrated waste cooking oil and 10mg/kgBW melatonin for 28 days. Data analysis using One Way ANOVA test and followed by Tukey test to determine the most effective dose of melatonin.Results: There was significant difference in body weight between P2 group and P0 group (p=0,019) with the mean body weight difference was 19,167g lower than P0 group.Conclusion: Melatonin dose of 10mg/kgBW losesbody weight male Wistar rats were fed by waste cooking oil for 28 days. Keywords: Melatonin, on-alcoholic fatty liver, waste cooking oil AbstrakLatar belakang: Obesitas merupakan faktor risiko timbulnya sindrom metabolik dan penyakit perlemakan hati non alkohol. Salah satu mekanisme yang memicu timbulnya penyakit tersebut adalah peningkatan stres oksidatif pada obesitas. Melatonin merupakan antioksidan kuat yang dapat meningkatkan sintesis antioksidan endogen dalam tubuh, menekan respon inflamasi, menghambat pembentukan steatosis dan menurunkan berat badan. Tujuan: Menganalisis pemberian suplemen melatonin dalam menurunkan berat badan pada tikus Wistar jantan yang diberi minyak jelantah.Metode penelitian: True experimental dengan menggunakanpost-test only control group design. Penelitian ini menggunakan 18 ekor tikus, dibagi menjadi 3 kelompok yaitu kelompok kontrol positif (P0) diberi minyak jelantah, kelompok perlakuan 1 (P1) diberi minyak jelantah dan melatonin dosis 5mg/kgBB, kelompok Perlakuan 2 (P2) diberi minyak jelantah dan melatonin dosis 10mg/kgBB selama 28 hari. Analisis data menggunakan uji One Way Anova dan dilanjutkan dengan uji Tukey HSD untuk mengetahui dosis perlakuan mana yang lebih baik.Hasil penelitian: Ada perbedaan bermakna rerata berat badan antara kelompok P2 dan P0 (p=0,019) dengan selisih rerata berat badan kelompok P2 sebesar 19,167 lebih rendah dari kelompok P0. Simpulan: Melatonin dosis 10mg/kgBB menurunkan berat badan tikus wistar jantan yang diberi minyak jelantah selama 28 hari. Kata kunci: Perlemakan hati non alkohol, minyak jelantah
The Experiences and Meanings of Nurses’ Smiles to Patients in the Emergency Department Fitriana, Vera; Santoso, Agus; Dharmana, Edi
Nurse Media Journal of Nursing Vol 11, No 1 (2021): (April 2021)
Publisher : Department of Nursing, Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/nmjn.v11i1.28377

Abstract

Background: Psycho-emotional aspects play an important role in both health services and health workers in the emergency department. Smiles are forms of interactions between nurses and patients that are given in providing health services to patients in terms of nonverbal communication. However, high workloads in the emergency unit may hinder nurses from smiling. Purpose: This study aimed to explore the experiences and meanings of nurses’ smiles to patients in the emergency department.Methods: This study employed a qualitative design with a descriptive phenomenological approach. Thirteen participants were recruited through purposive sampling using the inclusion criteria, such as emergency nurses with more than three years of work experience and nurses who had attended training on effective communication. Data were collected through in-depth interviews with semi-structured questions and analyzed using the Colaizzi’s phenomenological approach. Results: The study generated four themes, namely, the importance of smiles in emergency services, the miracle of smiles, the hindrances for emergency nurses to smile, and that smiles and humor in an emergency situation are important for children. Conclusion: The study concluded that nurses’ smiles had a significant benefit on emergency department services as a form of interpersonal relationship, although the practice still needs to be improved. Nurses are expected to be able to apply smiles in communicating with patients and their families in the emergency departments.
TOPICAL ADMINISTRATION OF ALOE VERA EXTRACT GEL INCREASED THE NUMBER OF MACROPHAGES AND EPITHELIALIZATION IN UVB-INDUCED SUNBURN Tadihoedojo, Ersje Retnowati; Dharmana, Edi; Chodidjah, Chodidjah
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 10, No 1 (2019): June 2019
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1096.102 KB)

Abstract

INTRODUCTION: The UVB exposure may cause sunburn (second degree burn). Aloe vera (AV) is widely used in wound healing, including sunburn.OBJECTIVE: To evaluate the effect of topical Aloe vera extract gel on the number of macrophages and epithelialization in UVB induced sunburn.METHODS: This posttest only-control group design used twenty female BALB/c mice with UVB-induced sunburn randomly divided into 4 groups. Control groups (Cntrl-G) were given a base gel. Group AV-25, AV-50, and AV-75 were topically treated with Aloe vera gel at the concentration of 25%, 50% and 75% respectively for 5 days. On day 5, after terminated, the samples of skin tissue were prepared for histological study using hematoxlyin eosin (HE) staining. Data were analyzed using one way ANOVA, Post-hoc LSD and Pearson correlation.RESULTS: ANOVA analysis showed that the number of macrophages and epithelialization among groups was a significantly difference (p <0.05). Post hoc analysis demonstrated that the mean number of macrophage in AV-75 (6.50), AV-50 (5.13), and AV-25 (3.93) were significantly higher compared to that of Cntrl-G (2.93). The mean of epithelialization AV-75% (25.35), AV-50 (18.15), and AV-25 (15.38), were significantly (p <0.05) higher compared to that of Cntrl-G (9.30). The Pearson correlation test indicated that there is a strong positive correlation (0.88) between the number of macrophages and epithelialization (p <0.05).CONCLUSION: The topical administration of Aloe vera gel extract for five days increased the number of macrophages and epithelialization in sunburned UVB induced sun burn.
Pengaruh Kombinasi Suplementasi Omega 3 dengan Kalori Restriksi Terhadap Penyembuhan Luka Bakar Pada Tikus Sprague Dawley Kajian Pada: Tumor Nekrosis Faktor - Alfa dan Perbaikan Luas Luka Bakar Wibowo, Erwin; Dharmana, Edi; Maharani, Nani; Budijitno, Selamat
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (291.137 KB) | DOI: 10.36408/mhjcm.v7i1.432

Abstract

Latar Belakang: Luka bakar merupakan masalah klinis dengan komplikasi yang sering menyebabkan morbiditas dan mortalitas. Omega 3 memiliki efek anti inflamasi dan restriksi kalori memiliki efek anti oksidan yang diduga mampu mempercepat proses penyembuhan pada luka. Penelitian bertujuan untuk mengetahui apakah kombinasi suplementasi Omega 3 dan restriksi kalori dapat membantu dalam proses penyembuhan luka bakar yang dapat ditinjau dari kadar TNF Alfa dan perbaikan luas luka bakar. Metode: Penelitian eksperimental dengan desain “Randomized post test with control group” pada tikus yang di intervensi luka bakar pada punggungnya. Random alokasi dilakukan untuk membagi tikus Sprague Dawley dalam 4 kelompok yaitu kelompok kontrol(K1) dengan diet biasa, kelompok restriksi kalori(P1), kelompok suplementasi omega 3(P2) dan kelompok kombinasi restriksi kalori dengan suplementasi omega 3 (P3). Data dianalisis dan diolah menggunakan uji hipotesis Kruskall Wallis - Post Hoc test Mann-Whitney. Hasil: Penelitian didapatkan perbedaan bermakna yang signifikan kadar TNF Alfa pada kelompok Kontrol dengan kelompok P1, P2, dan P3 dengan p < 0,001. Luas luka bakar didapatkan hasil bermakna signifikan antar kelompok dengan p < 0,001. Post Hoc test kadar TNF alfa dan luas luka bakar menunjukkan tidak ada perbedaan bermakna antara kelompok P2 dengan P3. Kesimpulan: Kombinasi pemberian suplementasi omega 3 dengan restriksi kalori dapat menurunkan kadar TNF Alfa dan memperkecil ukuran luas luka bakar secara bermakna namun tidak untuk restriksi kalori saja Kata Kunci: penyembuhan luka, Omega 3, Kalori Restriksi, TNF Alfa Background: Burns are clinical problem with complications that often cause morbidity and mortality. Omega 3 has an anti-inflammatory effect and calorie restriction has an anti-oxidant effect which is thougth to accelerate the healing process in wounds. The research aims to determine wheteher the combination of Omega 3 supplementation and calorie restriction is expected to help in the process of healing burns that can be viewed from the level of tumor necrosis factor alpha and large burn healing. Methods: This study an experimental study with design of “randomized post test with control group” in rats given burns to their backs. Random allocation was made to divide Sprague Dawley rats into 4 groups: the control group with a normal diet (K1), the calorie restriction group (P1), the omega 3 supplementation group (P2), and the combination of omega 3 with calorie restriction group (P3). Data were analyzed and processed using the Kruskall Wallis - Post Hoc Mann-Whitney hypothesis test. Results: The study found significant differences in levels of TNF Alpha in the control group with groups P1, P2, and P3 with p<0.001. Burn area showed significant results between groups with p<0.001. Post Hoc tests for levels of TNF alpha and burn area showed no significant diffrence between P2 and P3 groups. Conclusion: The combination of omega 3 supplementation with calorie restriction can significantly reduce TNF alpha levels and significantly reduce the area of burns but not for calorie restriction only. Keywords: wound healing, omega 3, calorie restriction, TNF Alpha
Kombinasi Suplementasi Omega 3 Dengan Restriksi Kalori Terhadap Penyembuhan Luka Bakar Tikus Sprague Dawley Kajian Pada VEGF dan Re-Epitelisasi bayu ardha, doglas rama; Dharmana, Edi; Prabowo, Erik
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (292.808 KB) | DOI: 10.36408/mhjcm.v7i2.517

Abstract

Cedera sel yang luas pada luka bakar melepaskan banyak mediator inflamasi. Respon tubuh yang berlebihan pada keadaan tersebut akan memperberat kerusakan sel yang sudah terjadi. Nurtrisi (lemak) yang cukup seperti omega 3 dapat membantu proses penyembuhan luka serta mencegah infeksi pada luka supaya tidak menjadi luka kronis. Maka dari itu peneliti memilih judul penelitian tentang efektifitas kombinasi suplementasi omega 3 dengan restriksi kalori terhadap penyembuhan luka bakar pada tikus Sprague Dawley, ditinjau dari VEGF dan Re-epitelisasi. Untuk mengetahui tingkat efektifitas suplementasi Omega 3 dan retriksi kalori pada penyembuhan luka bakar. Peneliti dalam melakukan penelitian menggunakan metode penelitian eksperimental dengan menggunakan 1 kelas kontrol dan 3 kelas perlakuan tikus Sprague Dawley, yang diinduksi luka bakar kemudian diberi perlakuan, dan diamati secara berkala. Hasil penelitian didapatkan perbedaan yang signifikan antara kelompok kontrol dan kelompok perlakuan yang di uji dengan one way ANOVA mempunyai nilai p = 0,000 (p < 0,05), dan uji Mann-Whitney didapatkan perbedaan yang signifikan antara kelompok perlakuan 1, 2, 3, dan kelompok kontrol p = 0,025; 0,004; 0,004; 0,004; 0,004, nilai p < 0,05. Dan uji Games-Howell ditunjukkan pada kolom rerata ± SD jika memuat huruf yang berbeda berarti ada perbedaan yang bermakna (p-value <0.05) K1 = 23,3587a ± 0,57556; P1 = 17,1015b ± 2,60108; P2 = 124,1503c ± 15,30168; P3 = 237,5053d ± 0,78263. Kesimpulan yang peneliti dapat bahwa kombinasi suplementasi omega 3 dengan retriksi kalori berpengaruh signifikan terhadap penyembuhan luka bakar pada tikus Sprague Dawley. Kata kunci : Penyembuhan Luka bakar, Sprague Dawley, Omega 3, Retriksi Kalori Extensive cell injury to burns releases inflammatory mediators. It’s led to excessive body response and cause aggravate cell damage that has already occurred. Adequate nutrients (fat) like omega 3 can help the healing process and prevent infection in wounds to become chronic. Therefore the researchers chose the title of the study of the effectiveness combination omega-3 supplementation with calorie restriction for burns in Sprague Dawley rats, in terms of VEGF and Re-epithelialization. To determine the effectiveness of Omega 3 supplementation and calorie restriction when healing burns. The researchers using experimental research methods with 1 control and 3 training classes of Sprague Dawley mice, which were induced by burns were then observed periodically. The results showed a significant difference between the control group and the treatment group tested by one way ANOVA having a value of p = 0,000 (p <0.05), and the Mann-Whitney test found a significant difference between the treatment groups 1, 2, 3, and the control group p = 0.025; 0.004; 0.004; 0.004; 0.004, p value <0.05. And the Games-Howell test is shown in the mean column ± SD if it contains different letters it means there is a significant difference (p-value <0.05) K1 = 23.3587a ± 0.57556; P1 = 17.1015b ± 2.60108; P2 = 124,1503c ± 15.30168; P3 = 237.5053 d ± 0.78263. The researchers concluded that the combination of omega-3 supplementation with calorie retention had a significant effect on burn healing in Sprague Dawley rats. Keywords: Burn Healing, Sprague Dawley, Omega 3, Calorie Restriction
Co-Authors AA Sudharmawan, AA Agung Putra Agus Santoso Amin Samiasih Arifin, Thohar Banundari Rachmawati bayu ardha, doglas rama Budi Laksono Chodidjah Chodidjah Diana Nur Afifah, Diana Nur Elfrida Ratnawati Fitriana, Vera Fransisca Prameshinta H, Fransisca Prameshinta Hardono Susanto, Hardono Hertanto Wahyu Subagio I WAYAN SUDARTA Kiss Jamiatun, Kiss Kuntardjo, Novalia Kurniawati, Dewi M Lisyani Suromo, Lisyani Maria Estela K, Maria Estela Mohamed M.Y. Gadalla, Mohamed M.Y. Mohammad Zen Rahfiludin Nani Maharani Niken Safitri Dyan Kusumaningrum Nirmalasari, Novita Novianti, Anugrah Nyoman Suci W, Nyoman Suci Nyoman Suci Widyastiti Prabowo, Erik RA Kisdjamiatun, RA Safari Wahyu Jatmiko Selamat Budijitno Sofiyetti, Sofiyetti Suci, Nyoman tadihoedojo, ersje retnowati Taufiq R Nasihun, Taufiq R Tjokorda Gde Dalem Pemayun Wibowo, Erwin