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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Jurnal Kefarmasian Indonesia
Binar Asrining Dhiani
Fakultas Farmasi Universitas Muhammadiyah Purwokerto,
Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Molecular Docking Analysis of Acanthus ilicifolius Compounds Toward CUL4B-DDB1-AhR-ERα Complex Protein for Antiosteoporosis Discovery Dhiani, Binar Asrining; Sarmoko, Sarmoko; Wahyuningrum, Retno; Yulianto, Akbar
Pharmaceutical Sciences and Research Vol. 10, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Osteoporosis represents a significant global public health issue, particularly among the aging population. Its incidence reaches 18.3% of the total population, with the highest prevalence observed in elderly postmenopausal women. A key factor in osteoporosis is the decreased expression level of estrogen receptor alpha (ERα), attributed to its degradation by the ubiquitin ligase protein complex Cullin4B (CUL4B), DNA damage binding 1 (DDB1), and aryl hydrocarbon receptor (AhR), collectively known as CUL4BAhR. Acanthus ilicifolius L contains compounds exhibiting antiosteoporosis activity, primarily by inhibiting osteoclastogenesis via RANKL. However, no reports exist of antiosteoporosis agents that act by inhibiting ERα degradation via CUL4BAhR. This study employed an in silico approach to predict active compounds from A. ilicifolius that could inhibit ERα degradation via CUL4BAhR, potentially developing them into antiosteoporosis agents. We utilized the 3D structures of proteins CUL4B-DDB1 (PDB ID:4A0L), AhR (5NJ8), and ERα (1A52) in various molecular docking tools, including ClusPro2.0, PyRx0.8, PyMol, PLIP, and SWISS-MODEL for QMEAN and structure assessment analysis. The ligands tested were acancifoliuside, acanthaminoside, acteoside, isoacteoside, (-)-lyoniresinol, (-)-lyioniresinol-3a-O-β-glucopyranoside, and estradiol. Acteoside displayed lower binding affinity energy (-9.7 kcal/mol) compared to estradiol (-8.9 kcal/mol) and was the lowest among all compounds. Acteoside was found to weaken the interaction between CUL4B-Rbx1 and CUL4B-DDB1 but not between AhR and ERα. Consequently, acteoside could be a viable candidate as an antiosteoporosis agent by inhibiting ERα degradation via the CUL4B-DDB1-AhR pathway. Further biochemical, in vitro, and in vivo studies are required to strengthen this evidence.
Penggunaan Deksametason pada Pasien COVID-19: Systematic Review dan Meta-analisis Mardhiyyah, Cut Ainul; Setiawan, Didik; Dhiani, Binar Asrining
Jurnal Kefarmasian Indonesia VOLUME 13, NOMOR 1, FEBRUARI 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i1.5455

Abstract

COVID-19 is associated with disseminated lung damage in patients, Dexamethasone can reduce lung injury caused by inflammation and there reduce the progression to respiratory failure and prevent death. This systematic review aimed to determine the benefits and safety of Dexamethasone in COVID-19 treatment. The study was performed by a comprehensive literature search which were published in several databases i.e., PubMed, Science Direct, VHL Regional Portal, and ClinicalTrials.gov within the search time of 28 November 2020. Inclusion criteria were articles on the study on COVID-19 patients who received Dexamethasone, observational and experimental studies on the outcomes use evaluation of Dexamethasone. Exclusion criteria are the articles that do not provide control in controlled studies and do not show clear research results on the use of Dexamethasone. An initial search from four databases by entering keywords resulted in 1,046 articles. After screening articles duplication we obtained 835 studies. Finally, 6 articles were obtained after we screened for the article that it can be obtained its full text and 5 articles joined in articles included in the meta-analysis. The analysis showed that Dexamethasone in Covid-19 patients could reduce the incidence of death within 28 days with RR of 0.78 (95% CI 0.57–0.97 P=0.13) compared with Methylprednisolone, Dexamethasone was compared without corticosteroids with RR 0.89 (95% CI 0.82-0.97 P=0.01). Dexamethasone also reduced mechanical ventilator use during treatment with RR 0.95 (95% CI = 0.86-1.05 P = 0.28) compared without corticosteroids. The conclusion from these results: the use of Dexamethasone can reduce the number of deaths in COVID-19 patients, especially severe and critically ill category patients.
Edukasi Kesehatan dan Cara Penggunaan Obat bagi Tenaga Kerja Migran di Malaysia Sundhani, Elza; Putri, Irsalina Nurul; Dhiani, Binar Asrining
ABDI: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol 7 No 1 (2025): Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat
Publisher : Labor Jurusan Sosiologi, Fakultas Ilmu Sosial, Universitas Negeri Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/abdi.v7i1.1031

Abstract

Malaysia merupakan negara tujuan terdekat dari tenaga kerja migran Indonesia untuk bekerja di luar negeri. Tahun 2026 diproyeksikan tenaga kerja migran Indonesia di Malaysia mencapai 2,7 juta dan 50% merupakan pekerja ilegal yang tidak memiliki akses terhadap fasilitas pendidikan dan kesehatan. Keterbatasan akses tersebut menjadikan kelompok tenaga kerja migran illegal dan anak-anaknya menjadi rentan menghadapi permasalahan kesehatan. Kegiatan ini dilaksanakan dengan menggandeng mitra Sanggar Bimbingan (SB) Kampong Bharu Kuala Lumpur untuk melakukan edukasi Perilaku Hidup Bersih dan Sehat (PHBS) dan cara penggunaan obat yang tepat (DAGUSIBU) kepada orangtua/wali siswa dan guru serta siswa SB untuk mengurangi resiko permasalahan kesehatan. Peserta kegiatan ini sebagian besar berjenis kelamin wanita, dengan pendidikan terakhir setingkat SMA, serta masuk dalam kategori keluaraga dengan pendapatan rendah. Edukasi dilakukan dengan penyampaian materi melalui ceramah interaktif menggunakan media poster dan video edukasi oleh dua narasumber secara berurutan tentang PHBS dan DAGUSIBU dengan diselingi kegiatan beryanyi bersama lagu “Bentuk-bentuk Obat”. Dari hasil evaluasi tingkat pengetahuan peserta dan penilaian kegiatan oleh peserta didapatkan bahwa kegiatan edukasi ini mampu sedikit meningkatkan pengetahuan peserta mengenai PHBS dan DAGUSIBU, dan sebagian peserta menilai bahwa secara keseluruhan kegiatan menarik dan bermanfaat.
Virtual Screening and Comparison of the Binding Effectiveness of Doxorubicin, Paclitaxel, and Ergoloid to ERβ-MDM2 Complex Protein as New Breast Cancer Drug Candidates Salmasfattah, Novyananda; Dhiani, Binar Asrining; Muslikh, Faisal Akhmal; Putra, Galih Satrio
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1325

Abstract

Background: The prevalence of breast cancer continues to increase, it is the second leading cause of death after lung cancer. Estrogen receptor beta (ERβ) has an important role in breast cancer pathology, activation of Akt pathway will trigger E3 ubiquitin ligase murine double minute 2 (MDM2) to ERβ, which will increase the risk of breast cancer. Thus, both proteins have potential as therapeutic agents in breast cancer drug development. This study aims to find breast cancer drug candidates from natural products and compare the effectiveness of these compounds with Doxorubicin and Paclitaxel.Method: ERβ (PDB ID: 3OLS) and MDM2 (PDB ID: 1T4E) proteins were combined using ClusPro 2.0. Doxorubicin and Paclitaxel ligands were obtained from PubChem, there are 842 natural products obtained from the ZINC database, when the energy minimization is reduced to 839 natural products. Virtual screening between proteins and ligands was performed using PyRx 8.0, followed by analysis of amino acid residues resulting from interactions between proteins and ligands using protein interaction calculator (PIC) and protein ligand interaction profiler (PLIP). Results: Ergoloid compounds have the lowest binding affinity compared to doxorubicin and paclitaxel compounds, and are able to interact strongly with the ERβ-MDM2 Protein as determined from the results of interactions between proteins and ligands using PIC and PLIP.Conclusion: Ergoloid compounds can interact well with ERβ-MDM2 Protein. Thus, it can be used as a breast cancer drug candidate in the future. In vitro, in vivo, and biochemical testing needs to be done to confirm this discovery
FORMULASI DAN AKTIVITAS ANTIBAKTERI LOTION MINYAK ATSIRI BUAH ADAS (Foeniculum vulgare Mill) Caesar, Rahma Yuanita; Hapsari, Indri; Dhiani, Binar Asrining
Media Farmasi: Jurnal Ilmu Farmasi Vol. 11 No. 1: Maret 2014
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v11i1.1396

Abstract

Buah  adas  mengandung  minyak  atsiri  antara  lain  anethole,  fenchone  dan  metil chavicol. Senyawa anethole dilaporkan memiliki aktivitas antibakteri  pada bakteri Gram  Positif  dan  Gram  Negatif.  Penelitian  ini  bertujuan  untuk  membuat  lotion minyak  atsiri  dari  buah  adas  dan  menentukan  aktivitas  antibakterinya  terhadap Staphylococcus  aureus  dan  Pseudomonas  aeruginosa.  Penelitian  ini  dilakukan untuk membuat lotion menggunakan minyak atsiri buah adas yang diperoleh dari destilasi  uap  air  dengan  konsentrasi  1,  5,   dan  10%  (Formula  I,  II  dan III). Kemudian  lotion  tersebut  diuji  parameter  fisik  dan  ditentukan  aktivitas antibakterinya.  Hasil  penelitian  menunjukkan  bahwa  semakin  tinggi  konsentrasi minyak  atsiri,  sediaan  lotion  yang  dibuat  memiliki  daya  lekat  dan  viskositas semakin  rendah.  Variasi  konsentrasi  minyak  atsiri  tidak  memberikan  pengaruh pada  sifat organoleptis, pH dan  kestabilan lotion.  Diketahui pula bahwa semakin tinggi  konsentrasi  minyak  atsiri  pada  sediaan  lotion  maka  semakin  tinggi  daya sebar dan diameter zona hambatnya terhadap pertumbuhan Staphylococcus aureusdan  Pseudomonas  aeruginosa. Minyak  atsiri  buah  adas  memiliki  aktifitas antibakteri  setelah  dibuat  dalam  sediaan  lotion  meskipun  lemah.  Formula  yang menunjukkan  aktivitas  antibakteri  yang  paling  tinggi  adalah  formula  III dengan konsentrasi 10% minyak atsiri.
Co-Authors Adi Garnadi Rahman, Adi Garnadi Anisah Arif Dwi Utomo Astri Puspitasari Caesar, Rahma Yuanita Charisma, Shintia Lintang Dewi Andriyani Didik Setiawan Dwi Hartanti Elis Yuliya Sandi, Elis Yuliya Endah Dwi Setyowati Endah Dwi Setyowati Endah Puspitasari Faisal Akhmal Muslikh Fitriyani Fitriyani Galih Satrio Putra Ihza Ihtimamul Umam Ika Yuni Astuti Indri Hapsari Indri Hapsari M. Dafit Mulyadi Mardhiyyah, Cut Ainul Nabilla, Ishma Yasmin Narendra Istia Putri Nimas Mahataranti Novyananda Salmasfattah Nunuk Aries Nurulita Nunuk Aries Nurulita Pri Iswati Utami Putri, Irsalina Nurul Rahma Yuanita Caesar Rahma Yuanita Caesar Retno Wahyuningrum Salmasfattah, Novyananda Sarmoko Sarmoko Siti Nurjanah Sudarso Sudarso Sugeng Riyanto Sugeng Riyanto Sundhani, Elza Susanti Susanti Tri Setyo Bayuaji, Tri Setyo Wahyuningrum4, Retno Wiranti Sri Rahayu Yulia Ratnasari Yulianto, Akbar