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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Jurnal Kefarmasian Indonesia
Binar Asrining Dhiani
Fakultas Farmasi Universitas Muhammadiyah Purwokerto,
Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Edukasi Kesehatan dan Cara Penggunaan Obat bagi Tenaga Kerja Migran di Malaysia Sundhani, Elza; Putri, Irsalina Nurul; Dhiani, Binar Asrining
ABDI: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol 7 No 1 (2025): Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat
Publisher : Labor Jurusan Sosiologi, Fakultas Ilmu Sosial, Universitas Negeri Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/abdi.v7i1.1031

Abstract

Malaysia merupakan negara tujuan terdekat dari tenaga kerja migran Indonesia untuk bekerja di luar negeri. Tahun 2026 diproyeksikan tenaga kerja migran Indonesia di Malaysia mencapai 2,7 juta dan 50% merupakan pekerja ilegal yang tidak memiliki akses terhadap fasilitas pendidikan dan kesehatan. Keterbatasan akses tersebut menjadikan kelompok tenaga kerja migran illegal dan anak-anaknya menjadi rentan menghadapi permasalahan kesehatan. Kegiatan ini dilaksanakan dengan menggandeng mitra Sanggar Bimbingan (SB) Kampong Bharu Kuala Lumpur untuk melakukan edukasi Perilaku Hidup Bersih dan Sehat (PHBS) dan cara penggunaan obat yang tepat (DAGUSIBU) kepada orangtua/wali siswa dan guru serta siswa SB untuk mengurangi resiko permasalahan kesehatan. Peserta kegiatan ini sebagian besar berjenis kelamin wanita, dengan pendidikan terakhir setingkat SMA, serta masuk dalam kategori keluaraga dengan pendapatan rendah. Edukasi dilakukan dengan penyampaian materi melalui ceramah interaktif menggunakan media poster dan video edukasi oleh dua narasumber secara berurutan tentang PHBS dan DAGUSIBU dengan diselingi kegiatan beryanyi bersama lagu “Bentuk-bentuk Obat”. Dari hasil evaluasi tingkat pengetahuan peserta dan penilaian kegiatan oleh peserta didapatkan bahwa kegiatan edukasi ini mampu sedikit meningkatkan pengetahuan peserta mengenai PHBS dan DAGUSIBU, dan sebagian peserta menilai bahwa secara keseluruhan kegiatan menarik dan bermanfaat.
Virtual Screening and Comparison of the Binding Effectiveness of Doxorubicin, Paclitaxel, and Ergoloid to ERβ-MDM2 Complex Protein as New Breast Cancer Drug Candidates Salmasfattah, Novyananda; Dhiani, Binar Asrining; Muslikh, Faisal Akhmal; Putra, Galih Satrio
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1325

Abstract

Background: The prevalence of breast cancer continues to increase, it is the second leading cause of death after lung cancer. Estrogen receptor beta (ERβ) has an important role in breast cancer pathology, activation of Akt pathway will trigger E3 ubiquitin ligase murine double minute 2 (MDM2) to ERβ, which will increase the risk of breast cancer. Thus, both proteins have potential as therapeutic agents in breast cancer drug development. This study aims to find breast cancer drug candidates from natural products and compare the effectiveness of these compounds with Doxorubicin and Paclitaxel.Method: ERβ (PDB ID: 3OLS) and MDM2 (PDB ID: 1T4E) proteins were combined using ClusPro 2.0. Doxorubicin and Paclitaxel ligands were obtained from PubChem, there are 842 natural products obtained from the ZINC database, when the energy minimization is reduced to 839 natural products. Virtual screening between proteins and ligands was performed using PyRx 8.0, followed by analysis of amino acid residues resulting from interactions between proteins and ligands using protein interaction calculator (PIC) and protein ligand interaction profiler (PLIP). Results: Ergoloid compounds have the lowest binding affinity compared to doxorubicin and paclitaxel compounds, and are able to interact strongly with the ERβ-MDM2 Protein as determined from the results of interactions between proteins and ligands using PIC and PLIP.Conclusion: Ergoloid compounds can interact well with ERβ-MDM2 Protein. Thus, it can be used as a breast cancer drug candidate in the future. In vitro, in vivo, and biochemical testing needs to be done to confirm this discovery
FORMULASI DAN AKTIVITAS ANTIBAKTERI LOTION MINYAK ATSIRI BUAH ADAS (Foeniculum vulgare Mill) Caesar, Rahma Yuanita; Hapsari, Indri; Dhiani, Binar Asrining
Media Farmasi: Jurnal Ilmu Farmasi Vol. 11 No. 1: Maret 2014
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v11i1.1396

Abstract

Buah  adas  mengandung  minyak  atsiri  antara  lain  anethole,  fenchone  dan  metil chavicol. Senyawa anethole dilaporkan memiliki aktivitas antibakteri  pada bakteri Gram  Positif  dan  Gram  Negatif.  Penelitian  ini  bertujuan  untuk  membuat  lotion minyak  atsiri  dari  buah  adas  dan  menentukan  aktivitas  antibakterinya  terhadap Staphylococcus  aureus  dan  Pseudomonas  aeruginosa.  Penelitian  ini  dilakukan untuk membuat lotion menggunakan minyak atsiri buah adas yang diperoleh dari destilasi  uap  air  dengan  konsentrasi  1,  5,   dan  10%  (Formula  I,  II  dan III). Kemudian  lotion  tersebut  diuji  parameter  fisik  dan  ditentukan  aktivitas antibakterinya.  Hasil  penelitian  menunjukkan  bahwa  semakin  tinggi  konsentrasi minyak  atsiri,  sediaan  lotion  yang  dibuat  memiliki  daya  lekat  dan  viskositas semakin  rendah.  Variasi  konsentrasi  minyak  atsiri  tidak  memberikan  pengaruh pada  sifat organoleptis, pH dan  kestabilan lotion.  Diketahui pula bahwa semakin tinggi  konsentrasi  minyak  atsiri  pada  sediaan  lotion  maka  semakin  tinggi  daya sebar dan diameter zona hambatnya terhadap pertumbuhan Staphylococcus aureusdan  Pseudomonas  aeruginosa. Minyak  atsiri  buah  adas  memiliki  aktifitas antibakteri  setelah  dibuat  dalam  sediaan  lotion  meskipun  lemah.  Formula  yang menunjukkan  aktivitas  antibakteri  yang  paling  tinggi  adalah  formula  III dengan konsentrasi 10% minyak atsiri.
Peningkatan pengetahuan guru dan orang tua siswa taman kanak-kanak tentang penggunaan suplemen vitamin yang tepat Dhiani, Binar Asrining; Nurjanah, Siti; Putri, Narendra Istia; Umam, Ihza Ihtimamul
Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Vol 4 No 2 (2021)
Publisher : University of Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jipemas.v4i2.9138

Abstract

COVID-19 global pandemic increases the usage of vitamin supplement products. However, easy access to purchase and consume the product increases the risk for its misuse. Lack of information and or misinformation available for vitamin supplement product usage leads to its abuse. Teachers' and parents' role in deciding the choice and use of vitamin supplement products for the pupil and children is crucial. Thus, a program was held to provide information about the correct usage of vitamin supplement products for teachers and parents. The program was performed for the teachers and pupil parents of TK Aisyiyah Ledug via online. The attractive audio-visual program materials were delivered via animation video, artistic leaflet, and presentation. The teachers and parents responded positively toward the program. All attendants actively participated, and 100% of attendants agreed that the program was interesting and increased their knowledge on the appropriate usage of vitamin supplement products.
Virtual Screening on Molecules Targeting the Interaction Between Estrogen Receptor Beta and Murine Double Minute 2 Salmasfattah, Novyananda; Nurulita, Nunuk Aries; Dhiani, Binar Asrining
Indonesian Journal of Cancer Chemoprevention Vol 13, No 3 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss3pp184-194

Abstract

Estrogen receptor beta (ERβ) is an isoform of estrogen receptor that plays a role in breast cancer. An E3 ubiquitin ligase, murine double minute 2 (MDM2), can bind to ERβ and degrade it. Virtual screening and protein-protein docking studies are one of the approaches that can be performed to discover FDA-approved drugs targeting the interaction of the ERβ-MDM2 complex. This study aimed to conduct virtual screening of 1615 compounds targeting the interaction between ERβ-MDM2 as an initial study to discover potential breast cancer drugs. Biovia Discovery Studio 2021, ClusPro 2.0, PyRx 8.0, and PyMOL software were utilized in this study. ERβ (PDB ID: 3OLS) and MDM2 (PDB ID: 1T4E) receptors were docked to obtain the ERβ-MDM2 protein complex. The ligands used in the virtual screening were FDA-approved drugs downloaded from the ZINC database. PIC and PLIP web tools were also utilized to analyze the amino acid residues involved in the interaction. The virtual screening results showed that ergotamine was the drug with the lowest energy score (-12.0 kcal/mol) among 1057 drugs and was able to establish the strongest interaction between ERβ-MDM2. In conclusion, based on this computational study, ergotamine strengthens the interaction between ERβ-MDM2 and thus could be used as a candidate for breast cancer drug. Thorough validation of in vitro, biochemical, and in vivo studies are needed to confirm this finding.Keywords: Estrogen receptor beta, breast cancer, protein-protein interaction, MDM2.
Protein-protein Docking Studies of Estrogen Receptor Alpha and TRIM56 Interaction for Breast Cancer Drug Screening Dhiani, Binar Asrining; Nurulita, Nunuk Aries; Fitriyani, Fitriyani
Indonesian Journal of Cancer Chemoprevention Vol 13, No 1 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss1pp46-54

Abstract

Breast cancer is the highest mortality cause in women with cancer. Protein-protein docking for target-based screening is an effective approach in breast cancer drug discovery via estrogen receptor (ER) signaling. TRIM56, an E3 ubiquitin protein ligase, can bind to and stabilize ER alpha. Thus, drug screening that can inhibit or weaken the interaction between ER alpha and TRIM56 is promising to obtain novel yet specific breast cancer drugs. In this study, we performed protein-protein docking studies for ER alpha and TRIM56 interaction and virtual screening for FDA-approved drugs from the ZINC database against ER alpha and TRIM56 complex protein model structure. We utilized Cluspro 2.0, PyRx 0.8, and Pymol 2.4.1 to conduct protein-protein docking, virtual screening, and model structure visualization. PIP and PLIP software were also applied to analyze the amino acid residue between proteins or protein-ligands. Based on the protein-protein docking, ER alpha and TRIM56 established interaction. Utilizing this complex protein as a macromolecule in the virtual screen of 1071 molecules of FDA-approved drugs, we obtain the top five lowest binding energy molecules i.e., dutasteride, dihydroergotamine, nilotinib, ergotamine, and bromocriptine. In addition, the energy binding affinity between ER alpha-dutasteride complex with TRIM56 was weakened in the presence of dutasteride. In conclusion, protein-protein docking between ER alpha-TRIM56 was able to select FDA-approved drugs that could bind to the complex, and dutasteride binding to ER alpha-TRIM56 complex weakened the interaction.Keywords: protein-protein docking, estrogen receptor alpha, TRIM56, breast cancer, ubiquitin.
Co-Authors Adi Garnadi Rahman, Adi Garnadi Anisah Arif Dwi Utomo Astri Puspitasari Caesar, Rahma Yuanita Charisma, Shintia Lintang Dewi Andriyani Didik Setiawan Dwi Hartanti Elis Yuliya Sandi, Elis Yuliya Endah Dwi Setyowati Endah Dwi Setyowati Endah Puspitasari Faisal Akhmal Muslikh Fitriyani Fitriyani Galih Satrio Putra Ihza Ihtimamul Umam Ika Yuni Astuti Indri Hapsari Indri Hapsari M. Dafit Mulyadi Mardhiyyah, Cut Ainul Nabilla, Ishma Yasmin Narendra Istia Putri Nimas Mahataranti Nunuk Aries Nurulita Pri Iswati Utami Putri, Irsalina Nurul Putri, Narendra Istia Rahma Yuanita Caesar Rahma Yuanita Caesar Retno Wahyuningrum Salmasfattah, Novyananda Sarmoko Sarmoko Siti Nurjanah Siti Nurjanah Sudarso Sudarso Sugeng Riyanto Sugeng Riyanto Sundhani, Elza Susanti Susanti Tri Setyo Bayuaji, Tri Setyo Umam, Ihza Ihtimamul Wahyuningrum4, Retno Wiranti Sri Rahayu Yulia Ratnasari Yulianto, Akbar