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All Journal Althea Medical Journal MNJ (Malang Neurology Journal) Health Notions JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Pengabdian Masyarakat dalam Kesehatan AKSONA Eduvest - Journal of Universal Studies Magna Neurologica Journal of Neurointervention and Stroke (JNeViS)
Sita Setyowatie
Department Of Neurology, Faculty Of Medicine, Universitas Airlangga; Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Correlation Between Lactate Dehydrogenase Levels and National Institutes of Health Stroke Scale Scores at the Onset of Acute Ischemic Stroke Fikriyah, Lathifatul; Ardhi, Mohammad Saiful; Setyowatie, Sita
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4391

Abstract

Background: In acute ischemic stroke, reduced oxygen supply may trigger metabolic acidosis and cellular injury. Lactate dehydrogenase (LDH), as an intracellular enzyme, helps generate energy by converting pyruvate to lactate in glycolysis. This study aimed to examine the correlation between serum LDH levels and the National Institutes of Health Stroke Scale (NIHSS) score at the onset of treatment among patients with acute ischemic stroke.Methods: This analytical observational study used cross-sectional design, involving patients with acute ischemic stroke hospitalized at Dr. Soetomo Surabaya Hospital, Indonesia, between February and May 2023. Participants were selected using consecutive sampling. Serum LDH levels and NIHSS score were measured upon admission. The correlation between LDH levels and NIHSS score was analyzed using the Spearman test, with statistical significance set at p<0.05. Results: A total of 30 patients were included, of whom 16 (53.3%) were male. A significant correlation was found between LDH levels and NIHSS scores (p=0.001). The correlation coefficient (r=0.785) indicated a strong positive correlation between serum LDH levels and stroke severity.Conclusions: This study demonstrates a strong positive correlation between LDH levels and NIHSS scores at the onset of acute ischemic stroke treatment. These findings suggest that LDH may serve as a practical early biomarker for assessing stroke severity. Integrating LDH measurement into initial evaluation may facilitate faster risk stratification and support timely clinical decision-making. Further studies with larger sample sizes are needed to validate its prognostic role in routine practice.
An Analysis of Chronotype and Cognitive Function in Pre-Clinical Medical Students at Universitas Airlangga Prayogo, Hana Evangelin; Islamiyah, Wardah Rahmatul; Irwadi, Irfiansyah; Setyowatie, Sita
AKSONA Vol. 6 No. 1 (2026): JANUARY 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v6i1.70271

Abstract

Highlight: The intermediate chronotype was most common among 2020-2021 medical students at Universitas Airlangga, followed by the morning type and the evening type No significant differences in TMT A, TMT B, or PVT scores were observed among the morning, intermediate, and evening chronotypes. Chronotype showed no significant relationship with cognitive outcomes, likely because medical students adapt to rigorous demands requiring sustained focus throughout the day.   ABSTRACT Introduction: Chronotype refers to an individual’s predisposition to engage in activities at specific times of the day. Numerous studies have explored the relationship between chronotype and cognitive function, yet the findings vary across different populations. Objective: This study aimed to identify chronotypes among medical students at Universitas Airlangga and to assess differences in cognitive function and attentional performance between these chronotypes. Methods: We selected participants using a stratified random sampling technique, focusing on cognitive function, attention, and chronotype. Those who met the inclusion criteria provided informed consent and completed the Morningness-Eveningness Questionnaire to determine their chronotype. A total of 65 participants completed the questionnaire and then underwent Trail Making Tests (TMT) A and B at times tailored to their chronotypes: 08:00-10:00 for morning types, 16:00-18:00 for evening types, and 12:00-13:00 for intermediate types. The Psychomotor Vigilance Test (PVT) was uniformly administered between 08:00-10:00. Data were collected and analyzed using Kruskal-Wallis and one-way ANOVA. Results: Of the 65 participants, 18 were identified as morning types, 42 as intermediate types, and 5 as evening types. No significant differences were observed in TMT A or B performance (p > 0.05). Similarly, the PVT results, which assessed lapses, false starts, and average reaction time, showed no significant differences among the three chronotypes (p > 0.05). Conclusion: The intermediate chronotype was the most prevalent among medical students at Universitas Airlangga, followed by morning and evening types. No significant differences were observes in TMT and PVT outcomes across the chronotypes.
The Impact of Elevated Mean Arterial Pressure on Mortality in Spontaneous Subarachnoid Hemorrhage Sani, Achmad Firdaus; Laisari, Taurus; Yahya, Muh. Wildan; Rahmawati, Vita Kusuma; Hamdani, Faishol; Kurniawan, Dedy; Setyowatie, Sita
Journal of Neurointervention and Stroke Vol. 1 No. 1: MAY 2025
Publisher : Neurointervention Working Group of Indonesian Neurological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63937/jnevis-2025.11.2

Abstract

Highlight: Elevated MAP is associated with increased in-hospital mortality in SAH patients High MAP increases the risk of rebleeding, cerebral edema, and vasospasm MAP, age, infection, and hydrocephalus are independent predictors of mortality ABSTRACT Introduction: Subarachnoid hemorrhage (SAH) remains a critical neurological emergency with high mortality and morbidity. Mean arterial pressure (MAP) plays an importance role in cerebral perfusion and hemodynamic stability in SAH patients. However, excessive MAP elevation potentially worsening clinical outcomes. This study investigates the impact of elevated MAP on in-hospital mortality among SAH patients. Objective: This study investigates the impact of elevated MAP on in-hospital mortality among SAH patients.  Method: A retrospective cross-sectional study was conducted using medical records of SAH patients admitted to Dr. Soetomo Academic Medical Center Hospital from 2013 to 2021. A total of 360 patients met the inclusion criteria. MAP was calculated upon admission and categorized as ≥125 mmHg or <125 mmHg. The primary outcome was in-hospital mortality. Logistic regression analysis was performed to assess the association between MAP and mortality while adjusting for confounders. Result: Among 360 SAH patients, 44.8% did not survive hospitalization. The mean age was 54 years, with an initial mean MAP of 117.45±21.6 mmHg. Bivariate analysis showed that MAP ≥125 mmHg significantly increased mortality risk (OR = 1.93; 95% CI: 1.24–2.98; p = 0.002). Multivariate logistic regression identified MAP ≥125 mmHg as an independent predictor of mortality (Adjusted OR = 1.795; p = 0.012), alongside age (Adjusted OR = 2.043; p = 0.004), infection (Adjusted OR = 2.442; p = 0.001), and hydrocephalus (Adjusted OR = 2.174; p = 0.003). Conclusion: Elevated MAP (≥125 mmHg) is significantly associated with increased in-hospital mortality in SAH patients. These findings highlight the importance of early hemodynamic management in SAH to improve patient survival.
Co-Authors Abdurachman Abdurachman Achmad Firdaus Sani, Achmad Firdaus Adrianto, Yudhi Andika Darmawan Wahono Ardhi, M. Saiful Ardhi, Mohammad Saiful Dedy Kurniawan Dewi Setyaning Bastiana Divastuti, Kedyatasya Rae Fahirah Fikriyah, Lathifatul Hamdani, Faishol Ilham Ikhtiar Irwadi, Irfiansyah Islamiyah, Wardah Rahmatul Khairina Khairina Kusuma, Nabila Divandra Laisari, Taurus Muhammad Arief Ardhanu Muhammad Wijdan Rosyich Parenrengi, Muhammad Arifin Prakoso, Raditya Ardra Putra Prayogo, Hana Evangelin Putranto, J.Nugroho Eko Rahmawati, Vita Kusuma Rifqi, Muhammad Andika Sensusiati, Anggraini Dwi Surdji, Almuta'Aaliyati Nur Suryantoro, Satriyo Dwi Thamrin, Husin Valentine, Putri Permata Widodo Widodo Yahya, Muh. Wildan