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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Panrita Abdi - Jurnal Pengabdian pada Masyarakat SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Molekul: Jurnal Ilmiah Kimia Majalah Farmasetika Budapest International Research in Exact Sciences (BirEx Journal) Borneo Journal of Pharmacy
Syahrani, Achmad
Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Jawa Timur, Indonesia
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Pengaruh Proses Fermentasi pada Daun Centella asiatica oleh Acetobacter tropicalis Terhadap Aktivitas Trombolitik Lailatul Nuraini; Bambang Tri Purwanto; Achmad Syahrani; Riesta Primaharinastiti; Achmad Toto Poernomo
Majalah Farmasetika Vol. 6, Supl. 1, Tahun 2021
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v6i0.36665

Abstract

Agen trombolitik merupakan plasminogen activator yang dapat memecah fibrin menjadi fibrin degradation product (FDP) dan dapat digunakan pada terapi penyakit kardiovaskular. Agen trombolitik dapat diperoleh dari mikroorganisme seperti Acetobacter tropicalis InaCC B374 dan dari tanaman seperti Centella asiatica. Kedua sumber agen trombolitik tersebut dapat dilakukan kombinasi melalui proses fermentasi untuk meningkatkan efek terapetiknya. Proses fermentasi sendiri dipengaruhi oleh beberapa faktor termasuk media fermentasi dan waktu fermentasi. Penelitian ini bertujuan untuk mengetahui pengaruh proses fermentasi terhadap peningkatan aktivitas trombolitik dari hasil fermentasi Centella asiatica oleh Acetobacter tropicalis InaCC B374 pada berbagai variasi waktu fermentasi. Preparasi dilakukan dengan memfermentasi Centella asiatica selama 24, 48, dan 72 jam pada suhu 30°±1°C dengan kecepatan pengocokan 100 rpm kemudian ditentukan aktivitas trombolitiknya dengan metode clot lysis yang dilakukan inkubasi pada suhu 37°±1°C selama 60 menit. Hasil pengujian aktivitas trombolitik menunjukkan bahwa terjadi peningkatan aktivitas trombolitik setelah dilakukan proses fermentasi selama 24, 48 dan 72 jam dan aktivitas trombolitik maksimum tercapai pada hasil fermentasi 72 jam. Centella asiatica yang difermentasi selama 72 jam menunjukkan nilai indeks trombolitik yang paling besar (82,03) jika dibandingkan dengan infusa Centella asiatica tanpa fermentasi (37,39) dan Acetobacter tropicalis InaCC B374 (37,68). Disimpulkan bahwa proses fermentasi Centella asiatica oleh Acetobacter tropicalis InaCC B374 secara signifikan dapat meningkatkan aktivitas trombolitik keduanya
Optimasi Kondisi Sintesis Asam 4-Benzoiloksisinamat Menggunakan Iradiasi Gelombang Mikro Ilham Bagus Sagitaras; Achmad Syahrani; Juni Ekowati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 6 No. 1 (2019): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.163 KB) | DOI: 10.20473/jfiki.v6i12019.37-43

Abstract

Pendahuluan: Salah satu usaha meningkatkan aktivitas asam p-kumarat adalah meningkatkan sifat lipofiliknya. Reaksi benzoilasi gugus fenol asam p-kumarat merupakan salah satu strategi meningkatkan sifat lipofilik. Iradiasi microwave merupakan salah satu alternative metode untuk meningkatkan efisiensi dalam reaksi organik. Selain memiliki kelebihan mempercepat reaksi kimia, penggunaan iradiasi gelombang mikro juga dapat menyebabkan kerusakan struktur kimia produk maupun terjadinya reaksi samping lainnya. Tujuan: Mendapatkan kondisi optimum reaksi sintesis asam 4-benzoiloksisinamat. Metode: asam 4-benzoiloksisinamat disintesis dengan cara mereaksikan asam p-kumarat, benzoil klorida dan piridin sebagai katalis. Reaksi benzoilasi dilakukan dengan iradiasi gelombang mikro pada daya 180, 270, dan 360 Watt. Karakterisasi asam 4-benzoiloksisinamat dilakukan menggunakan alat  spektrometer UV-Vis, FT-IR dan 1H–NMR. Hasil: Persentase hasil yang diperoleh pada daya 180, 270, dan 360 Watt berturut-turut adalah sebagai berikut 49,3%, 58,5%, and 47,7%. Terdapat perbedaan yang signifikan persentase hasil yang diperoleh pada daya 270 Watt dengan persentase hasil pada daya 180 Watt dan 360 Watt, tetapi tidak ada perbedaan bermakna persentase hasil pada daya 180 Watt dan 360 Watt. Persentase hasil terbesar diperoleh selama enam puluh detik pada daya 270 Watt, yaitu 61,4%. Jika reaksi dilakukan lebih dari enam puluh detik, terjadi kerusakan struktur senyawa target. Kesimpulan: Kondisi optimum sintesis asam 4-benzoiloksisinamat menggunakan iradiasi gelombang mikro adalah selama enam puluh detik pada daya 270 Watt.
REVITALISASI USAHA KECIL MENENGAH DHARMA BOGA BOJONEGORO MELALUI PELATIHAN CARA PRODUKSI DAN REGISTRASI PANGAN YANG BAIK SERTA HALAL Isnaeni; Noor Erma Nasution; Sugijanto; Hadi Poerwono; Juni Ekowati; Siswandono; Marcellino Rudyanto; Kholis Amalia Nofianti; Achmad Syahrani; Suzana
Panrita Abdi - Jurnal Pengabdian pada Masyarakat Vol. 5 No. 2 (2021): Jurnal Panrita Abdi - April 2021
Publisher : LP2M Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/pa.v5i2.5754

Abstract

Abstract. The independence of food supply in Indonesia is supported by the abundant diversity of natural ingredients from vegetable, animal and mineral sources. Compared to drugs, dependence on food products in other countries is relatively lower, because the fabrication requires facilities and infrastructure that can be fulfilled domestically. The regulatory system managed by the Republic of Indonesia Drug and Food Control Agency (BPOM-RI) has been implemented to ensure that food products consumed by the public are of high quality, nutritious, safe, halal, and affordable and with a taste that satisfies user communities. Circular-worthy products must at least meet the registration requirements of halal aspects, maximum microbial limits and chemical contamination. The growth of Micro, Small and Medium Enterprises (MSMEs) is also facilitated by the government. Dharma Boga is one of the Small and Medium Enterprises (UKM) in Klangon sub-district, Bojonegoro which is engaged in food production for more than 10 years. Some problems related to registration, halal certification and handling of production, especially food additives that meet requirements, has been communicated to the Community Service Team (PENMAS) Faculty of Pharmacy, Airlangga University (FFUA). Alhamdulillah, PENMAS activities with training materials on how to produce and register good and halal food have been carried out with satisfactory results, although it still needs to be followed up with a partnership for the MSME revitalization program in the future. Of the three parameters used to measure participants' understanding of training material, the average obtained more than 30% showed an increase. For the introduction of the halal logo and the dangers of formaldehyde, 100% of the message is understood. The training involved experts and stakeholders in the authority of the East Java Indonesian Ulama Council and the teaching staff and the Airlangga University Faculty of Pharmacy Testing Service Unit.         Abstrak. Kemandirian penyediaan pangan di Indonesia didukung oleh diversitas bahan alam yang melimpah baik dari sumber nabati, hewani, maupun mineral. Dibandingkan obat, ketergantungan produk pangan pada negara lain relatif lebih rendah, karena fabrikasinya membutuhkan fasilitas dan infrastruktur yang dapat terpenuhi di dalam negeri. Sistem regulasi yang dikelola oleh Badan Pengawas Obat dan Makanan Republik Indonesia (BPOM-RI) telah diberlakukan untuk menjamin produk makanan yang dikonsumsi masyarakat berkualitas, bergizi, aman, halal, dan terjangkau serta dengan rasa yang memuaskan selera masyarakat. Produk yang laik edar minimal harus memenuhi persyaratan registrasi dari aspek halal, batas maksimum mikroba dan cemaran bahan kimia. Tumbuh kembangnya Usaha Mikro, Kecil dan Menengah (UMKM) juga difasilitasi oleh pemerintah. Dharma Boga adalah salah satu Usaha Kecil Menengah (UKM) di kecamatan Klangon, Bojonegoro yang bergerak dibidang produksi makanan selama lebih dari 10 tahun. Beberapa permasalahan terkait registrasi, sertifikasi halal dan penanganan produksi terutama bahan tambahan makanan yang memenuhi persyaratan, telah dikomunikasikan kepada Tim Pengabdian kepada Masyarakat (PENMAS) Fakultas Farmasi Univeritas Airlangga (FFUA). Alhamdulillah kegiatan PENMAS dengan materi pelatihan cara produksi dan registrasi pangan yang baik serta halal telah dilaksanakan dengan hasil yang memuaskan, walaupun masih perlu ditindaklanjuti dengan jalinan kerjasama untuk program revitalisasi UMKM di masa mendatang. Dari tiga parameter yang digunakan untuk mengukur pemahaman peserta terhadap materi pelatihan, rerata yang diperoleh lebih dari 30% menunjukkan peningkatan. Untuk pengenalan logo halal dan bahaya formalin, 100% peserta sudah paham. Pelatihan melibatkan pakar dan pemangku kewenangan dari Majelis Ulama Indonesia Jawa Timur dan para staf pengajar serta Unit Layanan Pengujian Fakultas Farmasi Universitas Airlangga.
Histochemical Changes Liver and Kidney of Mice Exposed to Mercury and Recovery with Nanogold Titik Taufikurohmah; I Gusti Made Sanjaya; Afaf Baktir; Achmad Syahrani
Molekul Vol 11, No 1 (2016)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1312.171 KB) | DOI: 10.20884/1.jm.2016.11.1.197

Abstract

The background of this research is the circulation cosmetic with mercury that occur today in society. The problem of the research is that occur histochemical’s damage liver and kidney after exposure to mercury, and is that nanogold can recovery that damage. The pre-clinical study needed 24 mice (Mus muscullus) were divided into 6 groups, the control is A group, B group was exposed to mercury, Groups C, D, E and F after being exposed to mercury, than recovery by nanogold with concentration each of 5, 10, 15 and 20 ppm. Exposure was performed 1 week and 4 weeks of recovery. Necropsy of mice doing after treatment, liver and kidneys are processed into preparations by blocking with paraffin embedding method. Histochemical staining of liver and kidney tissue with Hematoxylin eosin (HE) to determine changes of cell constituent and staining Van Geyson to determine the structure of collagen constituent. Statistics Manova showed different results between treatment groups. Tissue damage, lysis cell and destruction of collagen can be observed from histochemical techniques for mercury-exposed group compared to the control group. Tissue and collagen recovery process can be observed from group C, D, E and F. The conclusion that the effects of mercury one week exposed through skin give effect to collagen tissue damage at liver and kidneys of mice. 20 ppm of Nanogold can recovery damaged cells and collagen tissue from the liver and kidneys of mice after four weeks of recovery.
Discrepancy of Real Tariffs with INA-CBG’S for Dengue Haemorrhagic Fever Patients in a Hospital in Sidoarjo 2019 Marthy Meliana Ariyanti Jalmav; Amelia Lorensia; Suyanto Suyanto; Achmad Syahrani
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 1 (2021): Budapest International Research in Exact Sciences, January
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i1.1487

Abstract

Dengue Hemorrhagic Fever (DHF) patients in Indonesia reached 129,650 cases with a death toll of 1,071 people in 2015. DHF puts an economic burden on the community and government. This study aims to determine the difference in real cost tariffs and INA CBG's for DHF in a hospital in Sidoarjo, East Java. This cross-sectional study applied a descriptive design, conducted from January to December 2019. The data in this study consisted of characteristic data and differences in real hospital tariffs and INA CBG tariffs for DHF in the hospital treatment room. 625 hospitalized cases were included in this study. This hospital underwent a deficit (loss) of 30% from the difference between the total INA CBG's package tariffs and the total real hospital tariffs in 2019. There is a negative difference between the real hospital tariffs and the tariffs according to INA CBG's in the treatment of dengue fever in a hospital in Sidoarjo which produces losses for the hospital.
Fibrinolytic Protease Activity of Crude Enzyme from Fermented Sunflower (Helianthus annuus) and Common Bean (Phaseolus vulgaris) seeds by Rhizopus microsporus var. oligosporus FNCC 6010 in Solid State Fermentation Rebhika Lusiana; Achmad Toto Poernomo; Achmad Syahrani
Borneo Journal of Pharmacy Vol. 6 No. 3 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i3.4665

Abstract

In the entire world, cardiovascular diseases (CVDs) are the main cause of death. For the treatment of CVDs, microbial fibrinolytic enzymes are highly regarded as novel therapeutic candidates. This study was purposed to determine the fibrinolytic protease activity produced by fungus source, which is Rhizopus microsporus var. oligosporus FNCC 6010 in fermented sunflower (Helianthus annuus) seed and common bean (Phaseolus vulgaris) seed. Fermentation was carried out by solid-state fermentation method at an initial pH of 5, incubation temperature of 33±1°C, and incubation time of 24 hours. The fermented seed was extracted to obtain supernatant as the crude enzyme. The proteolytic activity assay was done by the skimmed milk agar (SMA) plate method to obtain the proteolytic index, and the fibrinolytic activity assay was conducted by the fibrin-agarose plate method to get the fibrinolytic index. The results show that crude enzymes from fermented H. annuus and P. vulgaris seeds by R. microsporus have fibrinolytic protease activity with proteolytic index 2.64 ± 0.01 and 2.23 ± 0.04, respectively. The fibrinolytic index is 2.40 ± 0.06 and 1.64 ± 0.06, respectively. Therefore, the crude enzyme has the potential to be further researched as a candidate for thrombolytic agents. The purification, characterization, and in-depth research are needed to develop enzymes into preparations for preventing and treating CVDs.
Edukasi kesehatan melalui webinar tentang swamedikasi obat modern dan tradisional untuk menjamin efektivitas pengobatan Wiwied Ekasari; Retno Widyowati; Andang Miatmoko; Achmad Syahrani; Tristiana Erawati Munandar; Aty Widyawaruyanti; Suciati Suciati
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 8, No 2 (2024): June
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v8i2.22834

Abstract

AbstrakSwamedikasi merupakan salah satu cara masyarakat untuk mengatasi keluhan penyakit yang tergolong ringan. Tren ini semakin meningkat selama pandemi COVID-19 berlangsung seiring dengan adanya berbagai aturan pembatasan yang membuat hampir seluruh lapisan masyarakat membatasi kegiatan di luar rumah. Sangat penting untuk masyarakat memiliki pengetahuan yang memadai, baik tentang obat modern dan tradisional, untuk menjamin efektivitas obat sehingga kesembuhan atau perbaikan kesehatan yang diharapkan dapat tercapai. Berdasar hal tersebut diselenggarakan  pengabdian kepada masyarakat dalam bentuk penyuluhan guna meningkatkan pemahaman masyarakat mengenai swamedikasi obat modern dan tradisional. Penyuluhan berbasis online dengan metode ceramah dan diskusi melalui webinar melibatkan 305 peserta dari berbagai daerah di Indonesia. Penilaian pemahaman masyarakat melalui pre-test sebelum dan post-test setelah materi webinar diberikan. Hasil analisis menunjukkan bahwa tingkat pengetahuan masyarakat umum meningkat signifikan (p < 0,05) yang ditandai dengan nilai rata-rata pre-test sebesar 54,47 dan nilai rata-rata post-test sebesar 74,89. Sama halnya dengan tingkat pengetahuan tenaga kefarmasian juga meningkat signifikan (p < 0,05) dengan nilai rata-rata pre-test sebesar 75,15 dan nilai rata-rata post-test sebesar 86,59. Berdasar hasil tersebut dapat disimpulkan bahwa pengabdian kepada masyarakat ini berpengaruh terhadap tingkat pengetahuan masyarakat umum dan tenaga kefarmasian mengenai obat modern dan tradisional sehingga dapat menjamin efektivitas pengobatan dan didapatkan mutu kesehatan yang maksimal. Kata kunci: COVID-19; kesehatan masyarakat; obat modern; obat tradisional. AbstractSelf-medication is one way for the community to deal with complaints of ailments that are classified as mild. This trend has increased during the COVID-19 pandemic along with various restrictions that have made almost all levels of society restrict activities outside the home. It is very important for the community to have adequate knowledge, both about modern and traditional medicine, to ensure the effectiveness of the drug so that the expected recovery or health improvement can be achieved. Based on this main problem, the author provides community service in the form of counseling to increase public understanding regarding modern and traditional drug self-medication. Online-based counseling using lecture and discussion methods via webinars involved 305 participants from various regions in Indonesia. Assessment of public understanding through pre-test before and post-test after the webinar material was given. The results of the analysis show that the level of knowledge of the general public has increased significantly (p < 0.05) as indicated by the average pre-test score of 54.47 and the average post-test score of 74.89. Likewise, the level of knowledge of pharmaceutical staff also increased significantly (p < 0.05) with an average pre-test score of 75.15 and an average post-test score of 86.59. Based on these results, it can be concluded that this community service influences the level of knowledge of the general public and pharmaceutical staff regarding modern and traditional medicine so that it can guarantee the effectiveness of treatment and obtain maximum health quality. Keywords: COVID-19; public health; modern medicine; traditional medicine.
Fibrinolytic Protease Production: Impact of Initial pH and Temperature in Solid-State Fermentation by Rhizopus microsporus var. oligosporus FNCC 6010 Rebhika Lusiana; Achmad Toto Poernomo; Achmad Syahrani
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.290-299

Abstract

Background: Fibrinolytic enzyme is one of the cardiovascular disease therapies. Rhizopus microsporus var. oligosporus is microorganism that has been evaluated to produce fibrinolytic protease by fermentation. This study conducted fermentation of helianthi annui semen (sunflower seed) by Rhizopus microsporus var. oligosporus to produce fibrinolytic enzyme. Objective: This study aims to determine the effect of Initial pH and incubation temperature and its optimization in the production of fibrinolytic protease by Rhizopus microsporus var. oligosporus FNCC 6010 in solid-state fermentation on helianthi annui semen (sunflower seed) substrate.  Optimum condition was determined by maximum protease and fibrinolytic activity. Method: A crude enzyme of protease fibrinolytic was obtained from the supernatant extract of fermented sunflower seed. Protease activity was measured by the skimmed milk agar (SMA) plate method, and fibrinolytic activity was determined by the fibrin agar plate method. Result: It was found that the starting pH affects both the proteolytic and fibrinolytic activity of enzymes that are produced in fermentation. The starting pH of 5.0 showed higher fibrinolytic and proteolytic activity values compared to the starting pH of 7.0. The incubation temperature 33±1 °C had the higher activity compared to 28±1 °C or 37±1 °C. Conclusion: Initial pH and incubation temperature affect the proteolytic and fibrinolytic activity of crude enzyme extracted from fermented sunflower seed by Rhizopus microsporus var. oligosporus. The optimum condition for producing fibrinolytic protease in the state fermentation method was an initial pH of 5.0 and an incubation temperature of 33±1°C.
Co-Authors Achmad Toto Poernomo AFAF BAKTIR Amelia Lorensia Andang Miatmoko Aty Widyawaruyanti Bambang Tri Purwanto Hadi Poerwono I GUST MADE SANJAYA Ilham Bagus Sagitaras Isnaeni Juni Ekowati Kholis Amalia Nofianti Lailatul Nuraini Marcellino Rudyanto Marthy Meliana Ariyanti Jalmav Noor Erma Nasution Rebhika Lusiana Rebhika Lusiana Retno Widyowati Riesta Primaharinastiti Siswandono, Siswandono Suciati Suciati Sugijanto Suyanto Suyanto Suzana Titik Taufikurohmah Tristiana Erawati Wiwied Ekasari