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All Journal Jurnal Kesehatan JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Mandala Pharmacon Indonesia ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar Jurnal Ilmiah Medicamento JURNAL PENGABDIAN MASYARAKAT YAMASI CERATA
Wahyuddin, Munifah
Universitas Islam Negeri Alauddin Makassar
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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ANALISIS PENGELOLAAN OBAT SEBAGAI DASAR PENGENDALIAN SAFETY STOCK OBAT DI PUSKESMAS GANRA KABUPATEN SOPPENG Khaerani Khaerani; Haeria Haeria; Munifah Wahyuddin; Ika Yulianti
Jurnal Kesehatan The 1st Alauddin Pharmaceutical Conference and Expo (ALPHA-C) 2019
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v0i0.13643

Abstract

Drug management is an important aspect that include of planning, procurement, acceptance, storage, distribution, to the destruction of drugs. Drug management is a very important thing that needs to be considered, considering that with management that is not in accordance with the proper procedures, overlapping problems will occur. The Pharmacy Installation of the Soppeng District Health Office has carried out drug management but there are still a number of problems namely inadequate human resources, and inadequate facilities. This study aims to determine how the management of drugs in the Department of Health and Community Health Center Soppeng Ganra. This research is a descriptive analysis with a quantitative approach using observational methods. Data collection was carried out using the interview method through questionnaires. The results showed that the management of drugs in the Department of Health and Puskesmas Ganra, Soppeng Regency was not optimal because there were still many shortcomings such as controlling safety stock that had not used good calculations. The results of data percentage based on two different methods obtained 3.48% based on the proposed planning in 2018 and 96.51% using the planning method based on the calculation of safety stock.
EFEKTIVITAS SEDIAAN KRIM EKSTRAK UBI UNGU (Ipomoea batatas Poir) TERHADAP Staphylococcus aureus Munifah Wahyuddin; Munadiah Wahyuddin; Nurlia Naim; Nevyanti A.P
Jurnal Kesehatan The 1st Alauddin Pharmaceutical Conference and Expo (ALPHA-C) 2019
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v0i0.13644

Abstract

This study aims to determine the effectiveness of cream preparations from purple yam extract (Ipomoea batatas Poir) in inhibiting the growth of Staphylococcus aureus and to determine the concentration of purple sweet potato extract cream preparations (Ipomoea batatas Poir) which effectively inhibit Staphylococcus aureus. The method used in extraction was extracted using the percolation method. The resulting extract was then formulated in the form of cream preparations with varying concentrations of 10%, 15%, 20% and negative controls. Cream tests performed include organoleptic tests, pH, spreadability and type of cream. In testing the effectiveness of Staphylococcus aureus, using the wells method with Nutrient agar (NA) as a medium. Incubated for 24 hours then measuring the zone of inhibition produced in the medium. The results of research conducted for organoleptic (color and odor) tests with concentrations of 10%, 15%, and 20% are dark purple and have a characteristic odor of cream while negative controls are clear and odorless. In the pH test with concentrations of 10%, 15%, 20% ie 6.5 and negative control 6.4. In testing the spread of power with a concentration of 10%, 15% 20% and negative control respectively were 4.9cm, 5cm, 5.3cm and 4.5cm. In testing cream types with concentrations of 10%, 15%, 20% and negative controls are types of oil in water. For effectiveness testing, the most effective inhibition zone was obtained to inhibit Staphylococcus aureus with a concentration of 20% of 16.63 mm.
KARAKTERISASI MIKROKRISTALIN SELULOSA DARI KULIT JAGUNG PULUT (Zea mays L. Var Ceratina Kulesh) Surya Ningsi; Nining Iklasita; Munifah Wahyuddin; Syamsuri Syakri
Jurnal Kesehatan THE 2nd ALAUDDIN PHARMACEUTICAL CONFERENCE AND EXPO (ALPHA-C) 2020
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v1i1.15294

Abstract

Corn husk is a part of the plant that has a high cellulose fiber content, which is around 44.08%, so it is potentially to be used as a source of raw material of microcrystalline cellulose. The purpose of this research was to synthesize and determine the characteristics of microcrystalline cellulose produced from corn husk. The making of microcrystalline cellulose was carried out in two stages, namely delignification using NaOH solvent with five variations of concentration (7,5%, 10%, 12,5%, 15% and 17,5%) and hydrolyzed using 2,5 N HCl. Characteristic test for microcrystalline cellulose included organoleptic, pH, flow time and stationary angle, FTIR, and XRD. The results showed that microcrystalline cellulose produced from corn husk had characteristics such as fine powder, white and odorless, pH was 7.0, flow time was 0.3 g/sec, a stationary angle was 54o, FTIR analysis showed a typical peak of cellulose namely 3411,05 for O-H and 2900,61 for C-H, with a crystallinity degree was 79%.
THE POTENTIAL OF SORGHUM BICOLOR L. AS A BLOOD GLUCOSE LOWERING AGENT : A REVIEW Dwi Wahyuni Leboe; Nur Syamsi Dhuha; Munifah Wahyuddin; Nur Rezky Rutami A
Jurnal Kesehatan THE 2nd ALAUDDIN PHARMACEUTICAL CONFERENCE AND EXPO (ALPHA-C) 2020
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v1i1.18181

Abstract

The increasing mortality rate in Indonesia due to diabetes mellitus is a health problem in the world, especially in Indonesian. Evidenced by prevalence of diabetes mellitus which increases every year and is estimated in 2030 achieved 21,3 million according by WHO. Pharmacological therapy which cost is relatively expensive and can caused side effects from the use of chemical drugs. For this reason, the importance of finding new alternative therapy. Sorghum bicolor L. is a cereal that has high nutritional value and phytochemical compounds. This research purpose to know contain of Sorghum bicolor L. and the mechanisme   Sorghum bicolor L. as a blood glucose lowering agent. In this research is the literature study method based on primary and secondary data obtained. The database obtained is from Google scholar, Science direct, Research gate, NCBI, MDPI by using keywords. And the analysis of 43 journals obtained were scanned and analyzed in more detail by introduction, method, result, and conclusion of each journal . And the made in the data analysis table. Shows that Sorghum bicolor L. can be used as a blood glucose lowering agent because contain antidiabetic compounds, namely is phenolic compounds of phenolic acid, flavanoids, and tannin. And has a low glycemic index value and high fiber. Which can provide hypoglycemic effects and reduce postprandial blood glucose levels because it a slor digestion, slow gastric emptying, can inhibit the activity of digestive enzymes, namely the activity of α-glucosidase and  α- amylase, increasen insulin sensitivity, and inhibits the process of glucogenesis in the liverblood pressure, broken bones, diabetes, malaria, ulcers, vomiting blood, bleeding, appendicitis and lungs.
EVALUASI PENGGUNAAN OBAT ANTIDIABETIK ORAL PADA PASIEN DIABETES MELITUS TIPE 2 MENGGUNAKAN METODE ATC/DDD DAN DU 90% Nurshalati Tahar; Alifia Putri Febriyanti; Munifah Wahyuddin; Syahifah Auliyah Hasti
Jurnal Kesehatan THE 2nd ALAUDDIN PHARMACEUTICAL CONFERENCE AND EXPO (ALPHA-C) 2020
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v1i1.18380

Abstract

Diabetes mellitus is a chronic metabolic disease caused by the pancreas not producing enough insulin or not being able to use the required insulin effectively. Evaluate the use of oral antidiabetic drugs using ATC Diabetes mellitus is a chronic metabolic disease caused by the pancreas not producing enough insulin or not being able to use the required insulin effectively. Evaluate the use of oral antidiabetic drugs using ATC / DDD and DU 90% methods. Oral antidiabetic used in Makassar Hospita Hospital there are 3 types of metformin as many as 1020 units with a dose per unit that is 500 mg with a total use of 601000 mg 99.56%, more than 48 units with a perunit dose of 60 mg with a total dose of 2520 mg 0 , 41%, the last is 41 units of glimepiride with a perunit dose of 2 mg with a total use of 82 0.01%. Of the 3 types of oral antidiabetic, 3 usage patterns were obtained, namely 84% single metformin, 9% metformin + gliclazide combination pattern and 7% metformin + glimepirid combination. Included in the 90% DU segment or included in the list of incoming drugs is collected 90% of drug use after being sorted from the highest and highest percentage of drug use for compilation and low use is the use of metformin, using the correct use of drugs according to the choice, right dose, right delivery time, exact route and right information.
UJI AKTIVITAS ANTI BAKTERI EKSTRAK ETANOL DAUN DEWANDARU (Eugenia uniflora L) TERHADAP Streptococcus pneumoniae Dan Shigella dysenteriae Munifah Wahyuddin; Sesilia R. Pakadang; Aprilyani Aprilyani
Jurnal Farmasi UIN Alauddin Makassar Vol 5 No 3 (2017): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v5i3.4357

Abstract

Dewandaru merupakan salah satu tanaman yang dijadikan obat tradisional oleh masyarakat secara empiris dapat bermanfaat sebagai obat batuk,disentri dan memiliki aktivitas antibakteri. Pada penelitian ini dilakukan pengujian tentang Uji Aktivitas Anti Bakteri Ekstrak Etanol Daun Dewandaru (Eugenia uniflora L) terhadap Streptococcus pneumoniae dan Shigella dysenteriae . Pengujian dilakukan dengan metode difusi agar menggunakan media Muller Hilton Agar. Amoxicillin sebagai kontrol positif dan Na.CMC 1% sebagai kontrol negatif. Hasil pengujian diameter zona hambat pada  pemberian bahan uji ekstrak dengan konsentrasi 2%, 4% dan 8% terhadap Streptococcus pneumoniae berturut-turut adalah 18,90 mm, 20,84 mm dan 24,30 mm. Hasil pengujian diameter zona hambat pada pemberian bahan uji ekstrak dengan konsentrasi 2%, 4% dan 8% terhadap Shigella dysenteriae berturut-turut adalah 14,61 mm, 15,95 mm dan 26,9 mm. Adapun konsentrasi yang efektif menghambat bakteri Streptococcus pneumoniae yaitu 4% dan konsentrasi yang efektif menghambat bakteri  Shigella dysenteriae yaitu 2%
PENGARUH KONSENTRASI CARBOPOL 940 TERHADAP STABILITAS FISIK SEDIAAN MASKER EKSTRAK BUAH MENGKUDU (Morinda citrifolia L.) SEBAGAI ANTI JERAWAT Munifah Wahyuddin; Ajeng Kurniati; Gusti Ayu Aridewi
Jurnal Farmasi UIN Alauddin Makassar Vol 6 No 1 (2018): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v6i1.5269

Abstract

Penelitian ini bertujuan untuk mengetahui konsentrasicarbopol 940 sebagai gelling agentdalam pembuatan sediaan masker ekstrak buah mengkuduyang memiliki sifat fisik dan stabilitas yang paling baik. Variasi konsentrasi carbopol 940 yang digunakan untuk formula I,II dan III yaitu 1%,1,5%, dan 2%. Stabilitas sediaan ditentukan melalui uji organoleptis, pH, viskositas, homogenitas, sineresis dan daya sebar sebelum dan setelah penyimpanan selama 6 siklus penyimpanan pada suhu 50C dan 25oC.          Hasil penelitian menunjukan bahwa Formula I dengan konsentrasi 1% memiliki sifat dan stabilitas fisik yang paling baik dengan nilai pH sebelum dan setelah penyimpanan dipercepat 6,3 menjadi 5,9, nilai viskositas sebelum dan setelah penyimpanan dipercepat 41360 cP menjadi 40560 cP, daya sebar sebelum dan setelah penyimpanan dipercepat4,2 cm menjadi 4,55 cm. Adapun homogenitas yang dihasilkan tidak ada partikel padat dan hasil sineresis yaitu tidak sineresis.
FORMULASI DAN UJI STABILITAS KRIM ANTIOKSIDAN SARI BUAH NAGA MERAH (Hylocereus polyrhizus) DENGAN MENGGUNAKAN VARIASI EMULGATOR Munifah Wahyuddin
Jurnal Farmasi UIN Alauddin Makassar Vol 8 No 1 (2020): Jurnal Farmasi Edisi Mei
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v8i1.7561

Abstract

 ABSTRAKBuah naga merah merupakan salah satu tanaman yang dijadikan obat tradisional oleh masyarakat secara empiris dapat bermanfaat sebagai antioksidan.Penelitian ini bertujuan untuk memformulasi krim dari sari buah naga merah yang stabil secara fisik. Buah naga merah di juicer hingga mendapatkan sari dan diformulasi menjadi sediaan krim dengan variasi emulgator tween60-span60 dan tween80-span80 dengan masing-masing nilai HLB 8, 10, dan 12. Pengujian yang dilakukan meliputi pemeriksaan organoleptis, homogenitas, pengenceran, disperse larutan zat warna, hantaran listrik, pH, daya sebar dan uji mekanik sediaan krim dengan kandungan zat aktif sari buah naga merah dengan variasi emulgator dan nilai HLB yang berbeda. Uji stabilitas dilakukan dengan cara penyimpanan sediaan pada dua suhu yaitu suhu kamar 27oC dan suhu rendah 5oC. Hasil penelitian menunjukkan sari buah naga merah yang memiliki kestabilan secara fisik berdasarkan uji stabilitas yaitu tween80-span80 dengan nilai HLB 12.Kata Kunci : Sari Buah Naga Merah, Antioksidan, Krim, Uji Stabilitas, HLB
PERBANDINGAN EFEK TERAPI PIRASETAM DAN SITIKOLIN TERHADAP PERBAIKAN FUNGSI KOGNITIF PASIEN STROKE ISKEMIK Munifah Wahyuddin; Arief Nurrochmad; Woro Harjaningsih
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 3, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.200

Abstract

Salah satu dampak yang ditimbulkan stroke berupa gangguan  kognitif. Neuroprotektor seperti pirasetam dan stikolin merupakan obat yang dapat mengatur fungsi serebral dengan  meningkatkan kemampuan kognitif pada otak yang menurun,  namun penggunaannya masih kontroversial dan menjadi  perdebatan berdasarkan penelitian ilmiah. Di beberapa Rumah  sakit yang ada di Makassar, penggunaan kedua neuroprotektor ini yaitu piresetam dan sitikolin banyak digunakan pada pasien stroke iskemik. Tujuan penelitian ini untuk mengetahui efek terapi pirasetam dan sitikolin terhadap perbaikan fungsi kognitif pasien stroke iskemik dilihat dari parameter (MoCA-Ina) The  Montreal Cognitive Assessment versi Indonesia.Penelitian ini merupakan penelitian observasional dengan rancangan studi kohort. Metode pengambilan data dilakukan secara prospektif dimana pasien dikelompokkan dua kelompok,  yaitu 35 pasien kelompok pirasetam dan 27 pasien kelompok sitikolin. Pengukuran efektivitas pirasetam dan sitikolin  dilakukan sebelum dan sesudah (hari ke-7) pemberian terapi dengan menggunakan skala MoCA. Efek terapi dari pirasetam dan sitikolin ditandai dengan adanya peningkatan nilai MoCA.Hasil analisis statistik menunjukkan bahwa pasien stroke iskemik  yang mendapat terapi pirasetam selama 7 hari berdasarkan total domain menunjukkan adanya perbaikan fungsi kognitif yang bermakna 0,000 (p<0,05), tetapi tidak ada perbedaan yang  bermakna pada masing-masing domain kognitif. Pasien stroke iskemik yang mendapat terapi sitikolin berdasarkan total domain,  menunjukkan adanya perbaikan fungsi kognitif yang bermakna yaitu 0,000 (p<0,05) dan pada domain orientasi 0,003 (p<0,05). Terdapat perbedaan yang bermakna pada domain pemikiran konseptual pada hari ke-7 pemberian terapi antara pirasetam 0,31±0,631 dengan sitikolin 0,04±0,192 dengan nilai signifikansi 0,033 (p<0,05), sedangkan untuk (Δ MoCA) tidak ada perbedaan efek antara pirasetam dengan sitikolin dalam perbaikan fungsi  kognitif pasien stroke iskemik dengan nilai signifikansi 0,217 (p>0,05).Kata Kunci: stroke iskemik, pirasetam, sitikolin, MoCA, fungsi kognitif
Activity of Bidens Pilosa Herb Infussion as Antiinflammatory Munifah Wahyuddin; Nurdaonah Nurdaonah; Ferawati Ferawati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.14004

Abstract

Ajeran (Bidens pilosa), traditionally, was widely used to reduce pain and inflammation. This study aims to determine the activity of Ajeran herb infusion as an anti-inflammatory. Determination of activity using 18 mice which were divided into 6 groups. Blank group (I) was given aquadest, groups II, III, IV and V were given Ajeran dry herb infusion with concentrations 10, 20, 30 and 40% w/v, respectively, and group VI was given sodium diclofenac suspension 0,195 mg/ml, each 1 ml. Inflammation induction was performed by administering eggwhite suspension 1% v/v on the sole of the left foot. Foot volume before and after induction were measured as normal and initial edema volume. After that, the mice were given treatment and measurements of foot volume again at 15, 30, 45 and 60 minutes. The test results showed that the infusion of Ajeran and diclofenac sodium could reduce edema starting at 15 minutes, which were 17.8% (II); 20.6% (III); 22.2% (IV); 25% (V); and 15% (VI). It was different with blank group, the volume of edema did not decrease (0%). At 60 minutes, the volume of edema in all groups higher decreased that at 15 minutes, namely 23.4% (I); 28.9 (II); 35.6 (III); 37% (IV); 41.7% (V); and 30% (VI). The conclusion is that the administration of Ajeran infusion can reduce the volume of edema of feet with inflammation of mice.
Co-Authors A. Aulia Maulidha Adinantha, Fauzan Ajeng Kurniati Roddu Alifia Putri Febriyanti Amaliah Kartika Andi Arwini Puspitasari Aprilyani Aprilyani Arief Nurrochmad Arief Nurrochmad Dewi Damayanti Dhela Fitria Dhuha, Nur Syamsi Doloking, Haeria Dwi Wahyuni Dwi Wahyuni Leboe Faridha Yenny Nonci Fauzia Amelia Ferawati Ferawati Gusti Ayu Aridewi H Sanda, Ummu Kalsum Haeria Haeria Harjaningsih, Woro Huriyah Fadhilah Ika Puspita Sari Ika Puspita Sari Ika Yulianti indah Khaerani Khaerani Khaerani Khaerani, Khaerani Leboe, Dwi Wahyuni Maddeppungeng, Nurul Muhlisah Mirsya Awulia Reski Muh. Rusdi Muh. Yasid Alim Muhammad Riswan Mukhriani, Mukhriani Munadiah Wahyuddin Naurah Nazifah Haery Nevyanti A.P Nining Iklasita Nonci, Faridha Yenny Nur Azizah Syahrana Nur Rezky Rutami A Nur Syamsi Dhuha Nurdaonah Nurdaonah Nurfitrah Syamsuddin Nurlia Naim Nursasmita Nurshalati Tahar Nurshalati Tahar Nurshalati Tahar Nursyamsi Dhuha Nurul Afia Wardhani Nurwana Parubak, Gita Arnindya Rabiatul Adawiyah Rauf, Afrisusnawati Rizka Humardewayanti Asdie Rizka Humardewayanti Asdie Sahrul Ramadhan Sesilia R. Pakadang Surya Ningsi Suryaningsi Syahifah Auliyah Hasti Syahrir, Maulidyah Syamsuri Syakri Tahar, Nurshalati Titik Nuryastuti Ummu Khairunnisa Azzahra Vera Olfiana Vera Olfiana Woro Harjaningsih Yuliani Yuliani