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All Journal Jurnal Ilmiah Farmasi ILMU KELAUTAN: Indonesian Journal of Marine Sciences Transformasi: Jurnal Pengabdian Masyarakat JURNAL PENGABDIAN KEPADA MASYARAKAT BERITA BIOLOGI Jurnal Kimia Riset Jurnal Biologi Tropis Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Agrotek UMMat JCES (Journal of Character Education Society) Jurnal Riset Akuakultur Scripta Biologica Jurnal Gema Ngabdi ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Abdi Insani Indonesia Natural Research Pharmaceutical Journal (INRPJ) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Pijar MIPA Jurnal Sains dan Kesehatan

Handa Muliasari

Department Of Pharmacy, Faculty Of Medicine, Universitas Mataram

Author-ID : 2604477

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences

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Edukasi dan sosialisasi gerakan masyarakat cerdas menggunakan obat (Gema Cermat) dengan metode CBIA Handa Muliasari; Agus Dwi Ananto; Baiq Sofianti Annisa; Lalu Husnul Hidayat; Candra Eka Puspitasari
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

A community service about the education of Gema Cermat has been conducted in Lebah Sempaga village, West Lombok, NTB. The objective of these activities was to increase people’s knowledge and skills regarding the use of medicines in a right and rational way. The community service was held in three main steps of Community Based Interactive Method, namely presentation of the materials of Gema Cermat by pharmacist leader in NTB, assessments of people’s knowledge before and after socialization by using questionnaires, and evaluation of the participant skills in medicine identifications through the presentation of the participant representations. 23 people are participating in these activities, dominated by females with the age of about 29-50 years old. However, only 13 of them were finishing the questionnaires. Overall, the result of assessments, as well as the evaluation, showed that there was a noticeable improvement in the understanding of people about Gema Cermat, the precise and rational ways in using medicines, with the percentage of 16% increase. Hopefully, people in that area could spread the information to others so that the side effects due to the non-appropriate use of medicines will reduce

In vitro concentration optimization of ethanol extract from Makasar fruit seeds (Brucea javanica L. Merr) as an anti-inflammatory agent Diva Almira; Windah Anugrah Subaidah; Agus Dwi Ananto; Rizqa Fersiyana Deccati; Handa Muliasari
Jurnal Pijar Mipa Vol. 16 No. 5 (2021): November 2021
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Anti-inflammatory medications are necessary to treat excessive inflammation reactions due to injury, infection, or irritation. The emergence of several adverse effects associated with synthetic anti-inflammatory drugs has prompted the continued use of anti-inflammatory agents derived from natural products with low side effects and a high therapeutic effect. While it is well established that the seeds of the Makassar fruit (Brucea javanica (L.) Merr.) ÃÂ have anti-inflammatory activity, the optimal concentration of Makasar fruit seed extract for anti-inflammatory activity is unknown. This study aims to determine the optimal Makassar fruit seed extract concentration as an in vitro anti-inflammatory. The seeds of the Makasar fruit were extracted using the sonication method (3 x 35 minutes) in 96% ethanol and then concentrated using a rotary evaporator. The secondary metabolites of Makasar fruit seed extract were then identified in the test tubes, and the anti-inflammatory activity was determined using the protein denaturation inhibition method. The results indicated that the extract produced had a yield of 10.03%. The Makassar fruit seed extract contains secondary metabolites of phenolics, flavonoids, and terpenoids. Makasar fruit seed extract exhibited the optimum anti-inflammatory activity at a concentration of 1%, with a 55.47%ÃÂ inhibition of protein denaturation.

Penetapan Kadar Fenolik Total Ekstrak Kulit Buah Kopi Robusta (Coffea canephora L.) Di Pulau Lombok Febriyanto Febriyanto; Nisa Isneni Hanifa; Handa Muliasari
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 2, No 2 (2021): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v2i2.5489

ABSTRAKProduksi kopi robusta (Coffea canephora L.) menghasilkan limbah berupa kulit buah kopi dengan proporsi sebesar 40-45%. Kulit buah kopi dilaporkan mengandung senyawa fenolik yang berpotensi sebagai antioksidan. Kadar senyawa fenolik dapat dipengaruhi oleh faktor lingkungan. pulau Lombok memiliki perkebunan kopi yang tersebar hampir diseluruh penjuru pulau. Penelitian ini bertujuan menentukan kadar fenolik total kulit buah kopi robusta yang dikoleksi dari tiga lokasi berbeda di pulau Lombok. Sampel kulit buah kopi diekstraksi menggunakan metode sonikasi dengan pelarut etanol 70% selama 30 menit pada suhu ruang. Penentuan kadar fenolik total menggunakan metode Folin-Ciocalteu dengan standar asam galat. Kadar fenolik total dinyatakan dalam mg equivalent asam galat (GAE) per gram simplisia. Hasil analisis menunjukkan ekstrak kulit buah kopi dari lokasi desa Lamper memiliki kadar fenolik total sebesar 5.6252 ± 0.0658 mg GAE/g, kadar fenolik total ekstrak kulit buah kopi dari desa Keru sebesar 2.6626 ± 0.0892 mg GAE/g, dan kadar fenolik total kulit buah kopi dari desa Sajang sebesar 4.6757 ± 0.0528 mg GAE/g. Ekstrak dari ketiga lokasi berpotensi sebagai antioksidan dilihat dari kadar fenolik total yang berbeda. Berdasarkan hasil penelititan dapat diketahui bahwa kadar fenolik total ekstrak kulit buah kopi dari lokasi lamper lebih tinggi daripada lokasi Sajang dan Keru. Kata kunci: Kulit buah kopi; Kopi robusta (Coffea canephora L.); Kadar fenolik total.ABSTRACT Production of robusta coffee (Coffea canephora L.) produces coffee pulp waste with proportion of 40-45%. Coffee pulp reported contain phenolic compounds that have antioxidants activity. Content of phenolic compounds can be influenced by environmental factors. Lombok Island has coffee plantations that scattered throughout the island. This study aims to determine the total phenolic content of robusta coffee pulp collected from three different locations on the island of Lombok. The coffee pulp samples extracted using the sonication method with 70% ethanol solvent for 30 minutes at room temperature. Determination of the total phenolic content of the extract using the Folin-Ciocalteu method with gallic acid standard. Total phenolic content is expressed in mg equivalent gallic acid (GAE) per gram of simplicia. The results of the analysis showed total phenolic content coffee pulp from Lamper village was 5.6252 ± 0.0658 mg GAE/g, the total phenolic content coffee pulp from Keru village was 2.6626 ± 0.0892 mg GAE/g, and the total phenolic content coffee pulp from Sajang village was 4.6757 ± 0.0528 mg GAE/g. Extract from three different location have the potential as antioxidants. Based on the results of the study, it can be seen thatcoffee pulp extract from Lamper has highest total phenolic content than coffee pulp from Sajang and Keru.Keyword: Coffee pulp; Robusta coffee (Coffea canephora L.); Total phenolic content.

Formulasi Dan Uji Aktivitas Antioksidan Sediaan Masker Peel Off Ekstrak Etanol Daun Jambu Biji ( Psidium guajava L.) Risa Dwi Sosalia; Windah Anugrah Subaidah; Handa Muliasari
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 2, No 2 (2021): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v2i2.5498

ABSTRAKRadikal bebas merupakan substansi yang sangat reaktif dapat menyebakan kerusakan sel kulit sehingga dapat menghilangkan elastisitas kulit serta menyebabkan penuaan dini. Penuaan dini merupakan kondisi penuaan yang terjadi secara cepat. Keadaan ini dapat dicegah dengan senyawa antioksidan yang berasal dari tanaman salah satunya yaitu ekstrak etanol daun jambu biji (Psidium guajava L.) yang mengandung senyawa metabolit sekunder seperti flavonoid, fenolik, dan tanin. Penggunaan ekstrak akan lebih mudah dalam bentuk sediaan seperti masker peel off. Tujuan dari penelitian ini yaitu mengetahui aktivitas antioksidan ekstrak etanol daun jambu biji dan formulasinya sebagai sediaan masker peel off. Daun jambu biji diekstraksi menggunakan metode maserasi dengan pelarut etanol 70%, kemudian dilakukan skrining fitokimia pada ekstrak meliputi flavonoid, fenolik, dan tanin selanjutnya diuji aktivitas antioksidan pada ekstrak dengan metode DPPH. Ekstrak diformulasi menjadi sediaan masker peel off F0 (0%) dan F1(2%)lalu kedua formula diuji sifat fisik (uji organoleptis, pH, homogenitas, viskositas, daya sebar, daya lekat, dan waktu sediaan kering) serta diuji aktivitas antioksidan sediaan dengan metode DPPH. Hasil yang diperoleh menunjukan bahwa ekstrak etanol daun jambu biji positif mengandung flavonoid, tanin dan fenolik serta memiliki aktivitas antioksidan yang sangat kuat dengan nilai IC50 sebesar 23,29±0,2 μg/mL. Uji sifat fisik sediaan masker peel off ekstrak daun jambu biji F0 dan F1 telah memenuhi syarat pH, homogenitas, viskositas, daya sebar, waktu sediaan kering dan daya lekat yang baik. Pengujian aktivitas antioksidan sediaan masker peel off ekstrak etanol daun jambu biji F0 dan F1 diperoleh IC50 berturut-turut yaitu 953,87±6,4 μg/mL dan 79,56±12,1 μg/mL dimana aktivitas antioksidan F0 masuk kategori sangat lemah dan F1 masuk kategori. Hasil aktivitas antioksidan yang diperoleh berbeda signifikan antara ekstrak daun jambu biji dengan sediaan masker peel off ekstrak daun jambu biji berdasarkan uji Anova dengan nilai p>0.05 (p=0,00). Kata kunci: Radikal bebas; Antioksidan; DPPH; Daun Jambu Biji; Masker Peel OffABSTRACTFree radicals are highly reactive substances that can cause skin cell damage so that they can eliminate skin elasticity and cause premature aging. Premature aging is a condition of aging that occurs rapidly. This situation can be prevented by antioxidant compounds derived from plants, one of which is ethanol extract of guava leaves (Psidium guajava L.) which contains secondary metabolites such as flavonoids, phenolics, and tannins. The use of extracts will be easier in dosage forms such as peel off masks. The purpose of this study was to determine the antioxidant activity of guava leaf ethanol extract and its formulation as a peel off mask preparation. Guava leaves were extracted using the maceration method with 70% ethanol solvent, then phytochemical screening was carried out on the extract including flavonoids, phenolics, and tannins and then tested for antioxidant activity in the extract using the DPPH method. The extract was formulated into F0 (0%) and F1 (2%) peel off mask preparations, then both formulas were tested for physical properties (organoleptic test, pH, homogeneity, viscosity, spreadability, adhesion, and dry preparation time) and were tested for antioxidant activity. with the DPPH method. The results showed that the guava leaf ethanol extract was positive for flavonoids, tannins and phenolics and had a very strong antioxidant activity with an IC50 value of 23.29±0,2 μg/mL. Physical properties test of guava leaf extract peel off mask preparations F0 and F1 met the requirements for pH, homogeneity, viscosity, dispersion, dry preparation time and good adhesion. Testing the antioxidant activity of the peel-off mask preparation of guava leaf ethanol extract F0 and F1 obtained IC50 of 953.87±6,4 μg/mL and 79.56±12,1 μg/mL where the antioxidant activity of F0 was in the very weak category and F1 was in the category. The antioxidant activity results obtained were significantly different between guava leaf extract and guava leaf extract peel off mask preparations based on the Anova test with p>0.05 (p=0.00).Keyword: Free radicals; Antioxidants; DPPH; Guava leaves; Peel Off Mask

ANALISIS MAKANAN ALAMI DALAM LAMBUNG DAN MIKROHABITAT LOBSTER PASIR (Panulirus homarus) FASE PUERULUS DI TELUK AWANG Muhsinul Ihsan; Suhirman suhirman; Edi M Jayadi; Reza Sagista; Yuli Eka Hardianti; Wahyu Bintang Ilahi; Handa Muliasari; Lalu Achmad Tantilar Wangsajati Sukmaring Kalih
Jurnal Riset Akuakultur Vol 14, No 3 (2019): (September, 2019)
Publisher : Pusat Riset Perikanan, Badan Riset dan Sumber Daya Manusia Kelautan dan Perikanan

Pulau Lombok memiliki potensi dalam industrialisasi lobster. Aspek makanan alami larva perlu dipahami untuk mendukung pembenihan lobster. Tujuan penelitian ini untuk menganalisis makanan alami dalam lambung dan mikrohabitat lobster pasir (Panulirus homarus) fase Puerulus. Cairan lambung dari sepuluh ekor Puerulus dianalisis dengan metode analisis plankton. Makanan alami di mikrohabitat dikoleksi dengan menyaring seratus liter air laut dari alat tangkap dengan jaring plankton. Makanan alami dalam lambung meliputi fitoplankton dan zooplankton. Fitoplankton terdiri atas satu kelas yaitu bacillariophyceae, tiga ordo yaitu rhabdonematales; naviculales; fragilariales; dan tiga spesies yaitu: Grammatophora marina, Navicula cancellata, dan Synedra radians. Zooplankton terdiri atas kelas oligothriceae ordo choreotrichi spesies Tintinnopsis lobiancoi. Makanan alami di mikrohabitat juga terdiri atas fitoplankton dan zooplankton. Struktur komunitas fitoplankton terdiri atas enam kelas; 26 ordo; dan 39 spesies, sedangkan komunitas zooplankton terdiri atas 10 kelas; 10 ordo; dan 20 spesies. Indeks keanekaragaman makanan alami dalam lambung sebesar 1,39. Rata-rata nilai kelimpahan, indeks keanekaragaman, keseragaman, dan dominansi fitoplankton, serta zooplankton di mikrohabitat berturut-turut 65.744 sel/50 mL; 3,03; 0,82; 0,08; serta 182 sel/50 mL; 1,89; 0,62; 0,3. Grammatophora marina, Navicula cancellata, Synedra radians, dan Tintinnopsis lobiancoi berpotensi sebagai pakan alami larva lobster pasir (Panulirus homarus).Lombok Island has a high potential to be developed as a central area for lobster farming industry due to the abundance of puerulus in the area. One of the requirements to support the industry is by providing the biological aspect information of spiny lobster (Panulirus homarus) especially its local natural diet during the puerulus phase, which is required to develop a sustainable operation of lobster hatchery. This research was aimed to determine the natural diet in the stomach and microhabitat of puerulus of spiny lobster. The natural diet in the stomach fluid of ten Puerulus was determined using plankton analysis method, while the natural diet in the lobster microhabitat was collected by filtering one hundred liters of seawater in the catching media by using plankton nets. The natural diet in the stomach of puelurus includes phytoplankton and zooplankton. Phytoplankton consisted of one class, bacillariophyceae; three ordines, rhabdonematales, naviculales, fragilariales; and three species, Grammatophora marina, Navicula cancellata, and Synedra radians. Zooplankton consisted of class oligothriceae, ordo choreotrichi, species Tintinnopsis lobiancoi. The natural diet in the microhabitat also consisted of phytoplankton and zooplankton. The community structure of phytoplankton consisted of six classes; 26 ordines; and 39 species, while zooplankton consisted of 10 classes; 10 ordines; and 20 species. The diversity index of the natural diet in the puerulus stomach was classified as moderate H’ 1.39. The averages of abundance, diversity, similarity, and dominance index of phytoplankton and zooplankton in the microhabitat were 65,744 cell/50 mL; 3.03; 0.82; 0.08; and 182 cell/50 mL; 1.89; 0.62; 0.3 respectively. Grammatophora marina, Navicula cancellata, Synedra radians, and Tintinnopsis lobiancoi were found to be dominant and have the potential to be developed as the natural hatchery diet for spiny lobster larvae.

EFEK HIPOGLIKEMIK INFUSA DAUN TANAMAN MAKASAR, Brucea javanica (L) Merr, PADA TIKUS HIPERGLIKEMIK YANG DIINDUKSI ALOKSAN Handa Muliasari; Candra Dwipayana Hamdin; Muhsinul Ihsan
Scripta Biologica Vol 4, No 4 (2017)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

Brucea javanica (L) Merr is a local plant used traditionally for diabetic medication in Lombok Island. The B. javanica seed has been recognized to have an antidiabetic effect, while the impact of the leave extract was understudied. The purpose of this research was to determine the effect of B. javanica leaves infusion on the blood glucose level of alloxan-induced diabetic rats. B. javanica leaves extract were applied by soaking leaves into hot water (95°C) to obtain the extract concentration of 5% (w/v). This experiment provides four treatments to rats within 15 days with five replicates for each treatment. The treatments for rats were K1 a positive control, K2 a negative control, K3 a healthy control, and P1 treated with leave infused water. The diabetic condition for K1, K2, and P1 was induced with an intravenous injection of 125 mg/kgBW alloxan monohydrate to the rats. After stable diabetic condition, K1 rats were treated with Glibenclamide (0,25 mg/kgBW), K2 rats were untreated, P1 rats were administered with leaves infused water of B. javanica (L) Merr 3 ml/day. K3 rats were uninduced and untreated. The hypoglycemic effect was observed by estimating the fasting blood glucose level of the rats every three days. After 15 days of treatments, P1 rats blood glucose level reduced by the 13,30%, while K1 rats 22,04%. The decrease in blood glucose level of both K1 and P1 rats have not reached the average blood glucose level of healthy rats. The result of the statistical analysis showed the infused extract effect was not significantly differed compared to positive control (P < 0.05).

PENGARUH VARIASI KONSENTRASI ASAM SITRAT DAN NATRIUM BIKARBONAT TERHADAP SIFAT FISIK GRANUL EFFERVESCENT SARI BUAH DUWET (Syzygim cumini L.) Regita Pramesti; Windah Anugrah Subaidah; Handa Muliasari; Yohanes Juliantoni; Wahida Hajrin
Majalah Farmasi dan Farmakologi Vol. 26 No. 1 (2022): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v26i1.12800

Buah duwet sebagai buah lokal Indonesia memiliki berbagai kandungan senyawa metabolit sekunder yang berkhasiat sebagai antioksidan, antidiabetes, dan antikanker. Buah duwet dapat diformulasikan kedalam sediaan granul effervescent untuk meningkatkan kemudahan penggunaan. Pada sediaan granul effervescent, penambahan konsentrasi asam dan basa yang tidak tepat dapat mempengaruhi sifat fisiknya. Tujuan dari penelitian ini untuk mengetahui pengaruh variasi konsentrasi asam sitrat dan natrium bikarbonat terhadap sifat fisik granul effervescent sari buah duwet. Metode pembuatan granul effervescent menggunakan metode granulasi basah dengan variasi konsentrasi asam sitrat dan natrium bikarbonat pada formula I (20% dan 26,25%), formula II (21,6% dan 28,35%), dan formula III (23,2% dan 30,45%). Granul effervescent yang terbentuk kemudian dievaluasi sifat fisiknya yang meliputi uji hedonik, kadar air, pH, kecepatan alir, sudut diam, dan waktu larut. Hasil pengujian analisis sidik ragam menunjukkan variasi konsentrasi asam sitrat dan natrium bikarbonat memiliki signifikansi (p ≤ 0,05) pada pengujian sifat fisik kadar air, pH, kecepatan alir dan waktu larut. Berdasarkan nilai signifikansi tersebut, dapat disimpulkan bahwa variasi konsentrasi asam sitrat dan natrium bikarbonat berpengaruh terhadap keidealan sifat fisik dari granul effervescent sari buah duwet. Semakin tinggi konsentrasi asam sitrat dan natrium bikarbonat yang ditambahkan, semakin signifikan penurunan kadar air, pH, kecepatan alir, dan waktu larutnya. Namun, variasi konsentrasi asam sitrat dan natrium bikarbonat tidak menyebabkan adanya perbedaan sudut diam.

FORMULATION AND EVALUATION OF ANTI-INFLAMMATORY EMULGEL OF Brucea javanica (L.) Merr SEED EXTRACTS Handa Muliasari; Diva Almira; Windah Anugrah Subaidah
Jurnal Kimia Riset Vol. 7 No. 1 (2022): June
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v7i1.36010

Anti-inflammatory drugs are needed to overcome excessive inflammatory reactions that can interfere with activities. The existence of side effects in the use of synthetic anti-inflammatory drugs causes the search for natural drugs with high therapeutic effects and low side effects to continue. Seeds of Makassar (Brucea javanica (L.) Merr) plant are known to have anti-inflammatory activity. Topical anti-inflammatory administration is currently being developed because it can minimize side effects compared to oral. This study aimed to formulate 96% ethanol extract of Makasar fruit seeds in the form of an emulgel and to determine the physical properties and anti-inflammatory activity of the emulgel in vitro. Makasar fruit seeds were extracted by sonication method using 96% ethanol solvent (3 x 35 minutes). The extract was then formulated into an emulgel preparation with an extract concentration of 1%. Emulgel was then tested for its physical properties and anti-inflammatory activity in vitro using protein denaturation inhibition method. The results showed that the physical properties of emulgel base (F0), extract emulgel (F1), and Na-diclofenac emulgel (F2) met the requirements for homogeneity, pH, adhesion, spreadability, and viscosity tests. F0, F1, and F2 had inhibition percentages of 3.74±1.58%,; 23.07±0.72%; and 33.49±0.29, respectively. According to one-way ANOVA statistical test, the three tested groups had significant differences.

Alih Teknologi Teknik Pewarnaan Menggunakan Antosianin Berbasis Ph Untuk Kain Tenun Khas Lombok Dhony Hermanto; Nurul Ismillayli; Baiq Handayani Rinuastuti; Ulul Khairi Zuryati; Handa Muliasari; Qurnia Aini; Bela Azkiana; Ni Kadek Intan Wulan Sinta Dewi
Jurnal Gema Ngabdi Vol. 4 No. 3 (2022): JURNAL GEMA NGABDI
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jgn.v4i3.261

Dyeing woven yarn using natural dyes is increasingly popular, but the process is complicated, color consistency is low, fades easily and color choices are limited. Service activities in Sukarara Village in the form of socialization and assistance on coloring techniques using pH-based anthocyanins (acidity degrees) were carried out as a solution to these problems. By varying the pH of the anthocyanin solution using buffer 2-10 followed by fixation/mordanting, more color variations (one type of plant extract), consistency and color resistance were achieved. The activity partners are 20 members of the Subahnale Tourism Awareness Group (Pokdarwis). Activities include FGD, interviews, socialization, mentoring and evaluation. The activity was carried out well without significant obstacles with an increase in the average value of partners from 55 to 87. It is hoped that Pokdarwis can synergize with the village government for the sustainability of activities so that the role of woven fabrics positively contributes to the community welfare.

Solvent Optimization for Extraction Mesua ferrea L. Leaves As An Antioxidant Using Simplex Lattice Design Method Handa Muliasari; Luh Putu Intan Paramitha Sari; Aliefman Hakim
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.29302

Mesua ferrea L. leaves methanol extract has the highest antioxidant activity than the other part of the plant. However methanol is toxic solvent, so the using of methanol for extraction may harmful for health and environment. The purpose of this study was to optimize the solvent combination of ethanol and water for extraction of Mesua ferrea L. leaves by using Simplex Lattice Design (SLD) method. The samples were extracted by Ultrasonic Assisted Extraction (UAE) using variation of solvents ethanol 96%, ethanol 50% and water. The solvent combination was optimized by using SLD method based on the Total Phenolic Content of all crude extract. The result showed that the TPC of ethanol 96%, ethanol 50% and water crude extracts were 574.7±66.97 mgGAE/g, 657.8±37.02 mgGAE/g and 524.23±14.48 mgGAE/g respectively. SLD was calculated and the optimal solvent obtained was ethanol 55% with TPC of 626.235± 23 mgGAE/g. The ethanol 55% extract of Mesua ferrea L. leaves has strong antioxidant activity (IC50 57.77) ppm using DPPH method.

Co-Authors Agus Dwi Ananto, Agus Ahmad Wirahadi Aliefman Hakim Anggit Listyacahyani Sunarwidhi Baiq Handayani Rinuastuti Baiq Ressa Puspita Rizma Baiq Sofianti Annisa Bayu Priyambodo Bela Azkiana Candra D. Hamdin Candra Dwipayana Hamdin Candra Dwipayana Hamdin Candra Dwipayana Hamdin Candra Dwipayana Hamdin Candra Eka Puspitasari Dani Syaiful Akbar Devy Shandra Purwati Dhony Hermanto Diva Almira Edi M Jayadi Elliya Rosyada Emmy Yuanita Ernin Hidayati Fahrurazi Fahrurazi Febriyanto Febriyanto Hidayati, Agriana Rosmalina I Made Sudarma Ima Arum Lestarini Indah Permata Sari Lalu Husnul Hidayat Luh Putu Intan Paramitha Sari M. Elyadi Mahacita Andanalusia Muhsinul Ihsan Muhsinul Ihsan Muhsinul Ihsan Muhsinul Ihsan Mujiburrohman Mujiburrohman Ni Kadek Intan Wulan Sinta Dewi Ni Luh Arisa Prahastuti Winastri Nisa Isneni Hanifa Novita Eliya Wardani Novita Eliya Wardani Nur Nadhifah Zahra Qurnia Aini Regita Pramesti Retno Zahara Reza Sagista Risa Dwi Sosalia Riza Rusyiana Rizqa Fersiyana Deccati Rizqa Fersiyana Deccati Romi Juniawan Suhirman suhirman Ulul Khairi Zuryati Ulul Khairi Zuryati Virnia Wanda Utami Wahida Hajrin Wahida Hajrin Wahyu Bintang Ilahi Windah Anugrah Subaidah Yayuk Andayani Yohanes Juliantoni Yuli Eka Hardianti

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