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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Sainteks Pharmacon JURNAL PHARMASCIENCE INDONESIAN JOURNAL OF PHARMACY Pharmascience Archives Pharmacia
Oktavia Indrati, Oktavia
Jurusan Farmasi, Fakultas MIPA, Universitas Islam Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology

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UJI STABILITAS FISIK DAN EFEKTIVITAS ANTIBAKTERI PADA PERESEPAN PUYER ERITROMISIN CHEWABLE TERHADAP BAKTERI Escherichia coli DAN Staphylococcus aureus Herawati, Mutiara; Indrati, Oktavia; Romadhonsyah, Fitra; Purbaningtias, Tri Esti; Dini, Sekti Kartika; Rahmadani, Yusi; Mardatillah, Wahidatun
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art6

Abstract

Background: Pediatric patients frequently receive prescriptions for erythromycin due to its availability in chewable tablet form. Some conditions lead to the powdering of chewable tablets to enhance patient acceptability. Modifying the dosage form of chewable tablets into powder can change the drug's surface, affecting its physical stability and effectiveness against bacteria.Objective: This study aims to determine the physical stability of divided powder and the effectiveness of erythromycin pulveres against E. coli and S. aureus on the 1st to 14th days.Method: For this study, we prepared up to 200 mg of erythromycin powder, typically administering it to pneumonia patients at a dose of 50 mg/kgBW/day. We will evaluate pulveres physical stability through organoleptic and humidity tests. Next, the powder's effectiveness was evaluated using the disk diffusion method (Kirby Bauer) with an erythromycin powder inhibition zone diameter of 25.65 μg containing 15 μg of erythromycin against E. coli and S. aureus bacteria.Results: After day 9, the organoleptic test results showed a slight hardening; however, the moisture balance test results showed the change in humidity percentage was still in the stable range (1.24-2.12%). The inhibition zone (DIZ) of erythromycin powder against S. aureus was 91.7–97.40% bigger than the positive control. The DIZ against E. coli was 44.6–88.70% bigger than the positive control.Conclusion: Erthyromycin powder was stable for 14 days and is effective against S. aureus bacteria.Keywords: Erythromycin, divided powder, S. aureus, E. coli Intisari Latar belakang: Eritromisin sering diresepkan untuk pasien pediatrik karena tersedia dalam bentuk tablet kunyah. Pada beberapa kondisi, tablet kunyah dibuat puyer untuk meningkatkan kenyamanan pasien dalam mengonsumsi obat. Perubahan bentuk sediaan tablet kunyah menjadi puyer dapat memperluas permukaan obat sehingga berisiko mempengaruhi stabilitas fisik sediaan dan efektivitasnya terhadap suatu bakteri. Tujuan: Penelitian ini bertujuan untuk mengetahui stabilitas fisik puyer dan efektivitas puyer eritromisin terhadap E. coli dan S. aureus pada hari ke-1 sampai ke-14.Metode: pengujian ini dilakukan dengan membuat puyer eritromisin dalam dosis 200 mg yang biasa diberikan untuk pasien pneumonia dengan dosis 50 mg/kgBB/hari. Puyer akan diuji stabilitas fisiknya melalui uji organoleptis dan kelembaban. Selanjutnya puyer diuji efektivitasnya menggunakan metode difusi cakram (Kirby Bauer) dengan mengukur diameter zona hambat puyer eritromisin 25,65 μg yang mengandung eritromisin 15 μg terhadap bakteri E. coli dan S. aureus.Hasil: Hasil uji organoleptis menunjukkan adanya sedikit pengerasan setelah hari ke 9 namun hasil uji moisture balance menunjukkan perubahan persentase kelembaban masih pada rentang stabil (1,24-2,12%). Daya hambat puyer eritromisin terhadap S. aureus sebesar 91,7-97,40% dibandingkan kontrol positif, sementara itu, daya hambat terhadap E. Coli berada pada rentang 44,6-88,70. Kesimpulan: Puyer ertiromisin stabil selama 14 hari dan efektif terhadap bakteri S. aureus. Kata kunci: Eritromisin, puyer, S. aureus, E. coli
Co-Authors Ahmad Sastra Kelana Akhmad Kharis Nugroho Ari Wibowo Aris Perdana Kusuma, Aris Perdana Bambang Hernawan Nugroho Citrariana, Shesanthi Dewi Nur Eka Sari Dini, Sekti Kartika Handayani, Fajar Ita Nurma Sari Kurniasari, Devita Lailiana Garna Nurhidayati Lutfi Chabib, Lutfi Mardatillah, Wahidatun Martien, Ronny Muhammad Ikhwan Rizki Mutiara Herawati, Mutiara Perdana Kusuma, Aris Puput Andi Apsari Puspa Dwi Pratiwi Rahmadani, Yusi Rohman, Abdul Romadhonsyah, Fitra Tri Esti Purbaningtias