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All Journal Jurnal Ilmiah Farmasi e-Journal Pustaka Kesehatan Journal of Islamic Pharmacy JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JPSCR : Journal of Pharmaceutical Science and Clinical Research Pharmaceutical Journal of Indonesia Dedication : Jurnal Pengabdian Masyarakat JURNAL FARMASIMED (JFM) SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Pharmademica: Jurnal Kefarmasian dan Gizi Farmasis: Jurnal Sains Farmasi Dedication : Jurnal Pengabdian Masyarakat Journal of Agropharmacy
Ika Norcahyanti
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health Social Sciences Other

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Evaluasi Pengobatan pada Pasien Geriatrik Rawat Inap dengan Stroke di RS Elizabeth Situbondo Periode November 2022‒Agustus 2023 Norcahyanti, Ika; Firandi, Adelia; Mauladi, Zainol Ihsan; Machlaurin, Afifah
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 1 (2025): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i1.102

Abstract

Potentially Inappropriate Medicines (PIMs) cause a significant issue, particularly when dealing with elderly patients. Aging in the elderly results in a decline in physiological body functions, impacting the response to medications. Furthermore, aging leads to decreased elasticity of blood vessels, increasing the risk of cardiovascular diseases such as stroke. The management of stroke requires special attention to minimize the risk of complications and enhance recovery opportunities. This study aims to analyze patient profiles, treatment profiles, and evaluate the treatment based on the Beers Criteria 2019. It is a retrospective descriptive study using a cross-sectional research design and purposive sampling technique for sample selection. The study sample includes elderly patients diagnosed with stroke who were hospitalized at RS Elizabeth Situbondo. Patient medical record data was collected through a specifically designed Data Collection Sheet (DCS) to evaluate drug utilization in these patients. The research findings indicate that the patients are predominantly male (53.2%), aged 60-69 (62.3%), and have a Length of Stay of 1-6 days (84.4%). All patients have payment status through BPJS. The treatment profile involves the administration of medications for stroke management, with ticagrelor as the primary drug (66.2%) and citicoline as the most commonly prescribed supplementary drug (97.4%). Treatment evaluation identified 193 events of drug use that potentially met the 2019 Beers Criteria. The highest category was potentially inappropriate drugs (134 events), with pantoprazole being the most commonly used drug (71 events).
Analisis Minimalisasi Biaya Penggunaan Antiplatelet Pada Pasien Stroke Infark Rawat Inap Wicaksono, Ayssa; Rachmawati, Ema; Norcahyanti, Ika; Aryani, Dhita Evi; Machlaurin, Afifah
Journal of Agropharmacy Vol. 1 No. 1 (2024)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

Antiplatelets are crucial medications in the treatment of ischemic stroke patients. The management of stroke cases in Indonesia incurs substantial costs, reaching Rp. 3.2 billion annually. This study conducted a simple pharmacoeconomic research using Cost Minimization Analysis (CMA) method, utilizing medical records and patient financing data of ischemic stroke inpatients at RSUD Gambiran, Kediri City from January to December 2022. The study adopts a hospital perspective with the same outcome of patient recovery. Out of 659 stroke patients, 100 eligible participants, predominantly male aged 46-65 years with Diabetes Mellitus as the most common comorbidity, were included. Based on antiplatelet therapy profiles, the majority received a combination of clopidogrel and aspirin (65%), while 35% received clopidogrel monotherapy. The largest cost component was service cost amounting to Rp 2,898,606 (59.37%). According to CMA analysis, combination therapy showed cost-saving benefits compared to monotherapy in drug and medical equipment, laboratory, service, and total overall costs. Thus, for ischemic stroke patients with the same outcome of recovery, combination therapy of clopidogrel and aspirin isrecommended over clopidogrel monotherapy.
Evaluasi Penggunaan Antibiotik pada Pasien ISPA Non-pneumonia di Puskesmas Senduro Kabupaten Lumajang Tahun 2019 Pratiwi, Permata Sari; Rachmawati, Ema; Rachmawati, Sinta; Aryani, Dhita Evi; Norcahyanti, Ika; Machlaurin, Afifah; Muhammad Hilmi Afthoni
Journal of Agropharmacy Vol. 1 No. 2 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i2.1330

Abstract

Acute Respiratory Infection (ARI) is an infectious disease of the upper and lower respiratory tract. Non-pneumonic ARI is mostly caused by viral infections so symptomatic therapy can be given, but it can also be caused by bacterial infections so antibiotic therapy is needed. Unwise use of antibiotics can increase bacterial resistance, thereby increasing morbidity and mortality rates. Regular evaluations need to be carried out to reduce the unwise use of antibiotics. The evaluation method that can be used is a quantitative method (ATC/DDD) to determine trends in antibiotic use. This research was conducted on 278 outpatient non-pneumonic ARI patients at the Senduro Lumajang Community Health Center in 2019, with the aim of knowing patient characteristics, antibiotic use profile, and description of antibiotic use using the ATC/DDD method. The results showed that female patients (n=154; 55.4%), were more dominant than male (n=124; 44.6%), patients with the highest age range being 36-45 years (n=70; 25, 2%), the highest diagnosis of ARI was other acute infections of the upper respiratory tract (J06) (n=147; 52.9%), the most commonly used antibiotic was amoxicillin (n=227; 81.6%) and the most rarely used was cefadroxil (n=13; 4.7%). Based on the evaluation results using the ATC/DDD method, it shows that amoxicillin is the antibiotic with the highest DDD value of 7.5 DDD/1000 patients/day and the antibiotic levofloxacin with the lowest DDD value of 0.3 DDD/1000 patients/day.
Evaluasi Perencanaan dan Pengadaan Obat dengan Dana JKN di Puskesmas Rambipuji Jember Norcahyanti, Ika; Firandi, Adelia; Ramadhani, Nuril Izzati Farihatur; Rachmawati, Sinta; Rachmawati, Ema; Aryani, Dhita Evi; Wardhani, Firdha Aprillia; Kusumaningrum , Yunita Dyah
Journal of Agropharmacy Vol. 1 No. 3 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i3.1811

Abstract

Public Health Center is a health facility that organizes drug management activities, including planning and procurement activities. Evaluation needs to assess the success of achieving the objectives and results of the action. Indicators that can use are efficiency indicators published by the Ministry of Health of the Republic of Indonesia and efficiency indicators developed by Pudjaningsih. Rambipuji Public Health Center with spending funds for the most significant drug procurement in Jember Regency in 2020. Therefore, it is necessary to evaluate the results that can improve the quality of service in the next period. This research aims to determine the results of the evaluation of drug planning and procurement with JKN funds at Rambipuji Public Health Center for 2020. This research is descriptive, primary data through interview results. Secondary data includes total funds available, drug procurement funds, Drug Usage Reports, and Drug Demand Sheets for drugs purchased through JKN funds and stock cards. The data is analyzed descriptively, presented in the form of tables supported by interview results. The results showed that the Government of Indonesia had governed drug planning and procurement activities with JKN funds. The percentage indicator of available funds compared to the general funds needed is 114.26%. The percentage indicator of drug procurement fund allocation is 3.46%. Results on percentage indicator procurement conformity with the reality of the use of each drug item amounted to 133.33% and on the procurement frequency indicator of each drug item once a year. Through this research, it can be concluded that the evaluation results on indicators of the efficiency of drug planning and procurement activities at Rambipuji Public Health Center have not been by established standards. This matter was influenced by several factors, including a decrease in the number of patient visits due to the COVID-19 pandemic, changes in the organizational structure in the Jember Health Office that resulted in the frequency of procurement activities only once throughout 2020, and the absence of government regulations that regulate in more detail about the percentage of JKN funds allowed for drug procurement activities.
Evaluasi Penggunaan Antibiotik pada Pasien ISPA non Pneumonia Rawat Jalan dengan pendekatan Drug Utilization 90% Rachmawati, Ema; Norcahyanti, Ika; Aryani, Dhita Evi; Machlaurin, Afifah; Kurniawan, Eka Cahya
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

Acute respiratory infections (ARI) are infections most commonly caused by viruses, and antibiotics are not always necessary. However, antibiotics are still frequently used needlessly in ARI patients. Unreasonably using antibiotics can affect the likelihood of adverse medication reactions, raise medical expenses, and lead to antibiotic resistance. Regular assessments are required to prevent the overuse of antibiotics. This surveillance study uses retrospective and cross-sectional data to monitor antibiotic use. We measured the amount of antibiotic use using the DDD method in combination with DU 90%. Outpatient non-pneumonia ARI patients at the Teja Health Center in the Pamekasan Regency in 2020 served as the study's sample. The study's samples consisted of 193 adult non-pneumonia ARI patients. The kind and quantity of antibiotics used were gathered from patient medical records. The daily consumption of each antibiotic was calculated in DDD/1000 inhabitants/day, then grouped into the DU 90% segment. Six types of antibiotics were used for the therapy of non-pneumonia ARI patients: amoxicillin, erythromycin, co-trimoxazole, chloramphenicol, cefadroxil, and ciprofloxacin. The most widely used antibiotic is co-trimoxazole, valued at 4.71 DDD/1000 inhabitants per day. Two antibiotics are included in the 90% DU segment: co-trimoxazole and amoxicillin. This shows that the selection of antibiotics in ARI cases is increasingly specific. However, the use of co-trimoxazole in the therapy of non-pneumonia ARI needs to be further evaluated to assess the accuracy of drug prescription. This is because co-trimoxazole is not included in one of the antibiotic choices in the therapy management guidelines.
PROFIL DRUG UTILIZATION (DU) 90% DAN KESESUAIAN ANTIBIOTIK PADA PASIEN DEMAM TIFOID DI RS X KABUPATEN WONOGIRI Kusumaningrum, Yunita Dyah; Rachmawati, Ema; Firandi, Adelia; Norcahyanti, Ika
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8821

Abstract

Demam Tifoid merupakan infeksi bakteri Salmonella thypi yang memerlukan terapi dengan antibiotik. Penggunaan antibiotik perlu dilakukan dengan bijak supaya efektif untuk penyembuhan infeksi dan mencegah terjadinya resistensi. World Health Organization (WHO) merekomendasikan penggunaan metode Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) untuk menilai kuantitas penggunaan antibiotik dan dapat dikombinasikan dengan metode Drug utilization (DU) 90% untuk menilai segmen obat dengan penggunaan tinggi. Penelitian ini bertujuan untuk menganalisis penggunaan antibiotik dengan metode DU 90% pada pasien demam tifoid pada tahun 2020-2022 di RS X Wonogiri dan menganalisis kesesuaian pemilihan antibiotik berdasarkan panduan klinik rumah sakit. Penelitian ini merupakan penelitian observasional menggunakan metode cross sectional dengan pengambilan data secara retrospektif. Data penggunaan antibiotik dianalisis dengan menghitung nilai DDD/100 patient-days dan dilanjutkan menghitung segmen DU 90%. Untuk analisis kesesuaian pemilihan antibiotik dihitung dalam persentase kesesuaian terhadap panduan praktik klinik RS X Wonogiri. Hasil penelitian menunjukkan penggunaan antibiotik untuk demam tifoid paling tinggi yaitu tiamfenikol dan seftriakson. Antibiotik dengan nilai DDD/100 patient-days tertinggi tahun 2020-2022 adalah tiamfenikol, berturut-turut sebesar 50,80; 56,63; dan 50,95 DDD/100 patient-days. Antibiotik yang masuk ke dalam segmen DU 90% pada tahun 2020-2022 yaitu tiamfenikol, sefriakson, kloramfenikol, sefoperazon, sefotaksim, levofloksasin, dan seftazidim. Kesesuaian penggunaan antibiotik berdasarkan panduan praktik klinik rumah sakit yaitu 76,39% pada tahun 2020, 58,73% pada tahun 2021, dan 71,28% pada tahun 2022
Co-Authors Afifah, Hanin Antonius N. W. Pratama Antonius Nugraha Widhi Pratama Aryani, Dhita Evi Dhita Evi Aryani Diana Holidah Djoko Wahyono Djoko Wahyono Dwi Koko Pratoko Ema Rachmawati Ema Rachmawati Fania Pratiwi Firandi, Adelia Fransiska Maria Christianty Gustia Alinda Lintarsari Hakimah, Farda Husnun, Khoiriyah Haifa Ika Puspita Dewi, Ika Puspita Kurniawan, Eka Cahya Kusumaningrum , Yunita Dyah Machlaurin, Afifah Machlaurin, Afifah Mauladi, Zainol Ihsan Pratiwi, Permata Sari Ramadhani, Nuril Izzati Farihatur Rizki Laili Fazeri Sinta Rachmawati Sinta Rachmawati Tri Murti Andayani Tri Murti Andayani Wardhani, Firdha Aprillia Wicaksono, Ayssa