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All Journal Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Berkala Kedokteran Jurnal Berkala Kesehatan Jurnal Sinergitas PkM & CSR Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Homeostasis: Jurnal Mahasiswa Pendidikan Dokter

Alfi Yasmina

Department Of Pharmacology, Faculty Of Medicine, Lambung Mangkurat University, Banjarmasin

Author-ID : 5461767

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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The effect of the implementation of evidence-based drug formulary on antibacterial use in a private hospital at Tanjung Enim, Sumatera Selatan, Indonesia Erna Kristin; Dwi Indria Anggraini; Jarir At Thobari; Alfi Yasmina
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 49, No 1 (2017)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The increase of drug expenditure in the hospital has facilitated the implementation of an evidence-based drug formulary. The aim of this study was to assess the change in antibacterial use after the implementation of an evidence-based drug formulary in a private hospital at Tanjung Enim, Sumatera Selatan, Indonesia. This study used a pre-posttest design. Drug use data in the period before (2010-2011) and after (2012-2013) the formulary implementation were extracted from the hospital medical records. The drug use in the hospital before and after the implementation was compared using t-test and chi-square test, with the significance level of 0.05. Average number of drugs prescribed per prescription after the implementation was similar with that before the implementation (4.4 vs 4.6; p > 0.05). However, the proportion of generic drugs prescribed increased significantly after the formulary implementation (17.0% vs 52.7%; p < 0.05). Moreover, it was still significantly increased when the analysis was conducted only for antibacterial drugs (25.9% vs 72.0%; p < 0.05). Average drug cost per prescription was 34% lower after the intervention (p < 0.05), and the average cost for antibacterial drug was also decreased (26%). The use of antibacterial drugs was significantly decreased after the intervention (12.5% vs 6.9%; p < 0.05). The most often antibacterial drugs prescribed before the interventions were beta-lactams and macrolides; while quinolones were more increasingly used after the intervention. In conclusion, the implementation of evidence-based hospital drug formulary in a private hospital at Tanjung Enim, Sumatera Selatan significantly increase generic drug use and decreased antibacterial use and average drug cost per prescription. Key words : drug formulary – prescribing pattern – generic drug – antibacterial – private hospital

Prevalence and Determinant Factors of Coronary Heart Disease Status in Patients with Heart Failure Anwari Delmi; Dwi Laksono Adiputro; Dona Marisa; Alfi Yasmina
Berkala Kedokteran Vol 17, No 1 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: As a cardiovascular disease, heart failure is one of prime mortality cause in the world. Coronary heart disease has a role in development of heart failure so that it becomes one of heart failure’s major clinical risk factor. This study aimed to calculate the prevalence of and identify the factors that influence coronary heart disease status of heart failure patients at Alamanda ward of RSUD Ulin Banjarmasin in 2016. Factors that were studied consisted of age, sex, family history of heart disease, smoking, diabetes mellitus, and hypertension. This study used analytical observation with cross-sectional approach on medical records that were obtained by purposive sampling method. The result showed 46.4% of 263 heart failure patients had coronary heart disease status. Multivariate analysis inferred hypertension as the factor that influences the coronary heart disease status of heart failure patients (OR = 1.98, 95% CI = 1.06 – 3.71, P = 0.033). Keywords: cardiovascular disease, heart failure, coronary heart disease, hypertension

Antibiotics Susceptibility Pattern in Diabetic Ulcer Patients Mita Rahma Yani; Dewi Indah Noviana Pratiwi; Rahmiati Rahmiati; Noor Muthmainah; Alfi Yasmina
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 27, No 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1652

Diabetic ulcers are a chronic complication of diabetes mellitus and have a high risk of infection. Severe ulcer infectionsare a significant cause of lower-extremity amputations in addition to trauma. Therefore, therapy for diabetic ulcer infectionsmust be performed immediately. This study aimed to determine the bacterial susceptibility pattern to the antibiotic indiabetic ulcer patients. This study was retrospective observational descriptive by taking the results of swab culture andantibiotic susceptibility patterns data in diabetic ulcer patients at Ulin General Hospital, Banjarmasin, in 2016-2018. Theresults showed 41 (62.1%) monomicrobial infections and 25 (37.9%) polymicrobial infections. The number of Gram-negativebacilli (57.4%) was higher than Gram-positive cocci (42.6%). The most common bacterial isolates on pus culture wereStaphylococcus aureus (26.6%), Klebsiella pneumonia (19.1%), and Escherichia coli (12.8%). Antibiotic susceptibility testresults showed that Gram-positive bacteria were sensitive to Tigecycline (100%), Nitrofurantoin (96.9%), and Linezolid(96.8%). Gram-negative bacteria were susceptible to Ertapenem (92.7%), Meropenem, and Amikacin (90.6%). S.aureusisolates were sensitive 100% to Meropenem and Tigecycline. K.peneumoniae and E.coli isolates were susceptible 100% toMeropenem and Amikacin. It was concluded in this study that the prevalence of Gram-negative bacteria in diabetic ulcerinfection was higher than Gram-positive bacteria. The most common isolated Gram-negative bacteria were K.pneumoniaeand E.coli, while the most common Gram-positive bacteria were S.aureus. The most sensitive antibiotics for K.pneumoniaeand E.coli were Meropenem and Amikacin, while the most sensitive antibiotics for S.aureus were Linezolid and Tigecycline.

Antibiotics Susceptibility Pattern of MRSA at Intensive Care Room of Ulin General Hospital Banjarmasin Shania Indah Chineko; Dewi Indah Noviana Pratiwi; Rahmiati Rahmiati; Noor Muthmainnah; Alfi Yasmina
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 27, No 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1649

Infection caused by Methicillin-Resistant Staphylococcus aureus (MRSA) is a healthcare-associated infection thatreceives the most significant attention worldwide due to its resistance. Administration of precise and rational antibiotics canprevent high MRSA rates in hospitals. This study aimed to determine the antibiotic susceptibility pattern of MRSA at theintensive care room of Ulin General Hospital, Banjarmasin, between 2016 and 2018. This study was an observational analyticstudy by taking the results of culture and antibiotic susceptibility pattern data of the MRSA isolated from patients treated atthe intensive care room retrospectively. The results showed 37 data of patients suffering from MRSA at the intensive careroom in 2016-2018, with a percentage of 23.81%, 25.81%, and 35.19%, respectively. The most common sources of MRSAisolate in this study were sputum (32.39%), blood (29.27%), and pus (16.67%). From 2016 to 2017, there was a decreasedsusceptibility to macrolide antibiotics, aminoglycosides such as Gentamicin, and quinolones such as Moxifloxacin. In 2018,there was an increased susceptibility pattern of some antibiotics compared to the previous period. Antibiotics with thehighest susceptibility in period of 2016-2018 were Linezolid, Quinupristin/Dalfopristin, Tigecycline, Nitrofurantoin, andTrimethoprim/Sulfamethoxazole. Also, the antibiotic with the lowest susceptibility was Tetracycline. It was concluded thatthere had been changes in some antibiotics' susceptibility pattern to MRSA within 2016-2018.

EDUKASI PEMBUATAN SEDIAAN ANTISEPTIK TANAMAN HERBAL DI KELURAHAN PEMURUS BARU BANJARMASIN [EDUCATION ON MAKING ANTISEPTIC PREPARATIONS FOR HERBAL PLANTS IN BANJARMASIN KELURAHAN PEMURUS BARU] Lia Yulia Budiarti; Siti Kaidah; Alfi Yasmina
Jurnal Sinergitas PKM & CSR Vol 5, No 1 (2021): April
Publisher : Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/jspc.v5i1.3436

South Kalimantan is ranked sixth as the province with the highest percentage of Covid-19 positive cases in Indonesia. As of July 24, 2020, there were 4,990 (5.7%) confirmed positive cases of Covid-19 in South Kalimantan which is the highest cases occurred in Banjarmasin Regency. Pemurus Baru, an urban village of Banjarmasin Regency is one of the red zone area of Covid-19 positive cases. One of the health protocols to prevent covid-19 exposure is washing hands frequently with antiseptic. Antiseptic liquid can be made from herbal plant ingredients that have antimicrobial efficacy. The development of online technology can be a tool of education and delivery of information that benefits the community. The purpose of this program is to support the Covid-19 prevention efforts through the useful of herbal plants into antiseptic liquid, in order to avoid Covid-19 exposure. The targets of this program are the mothers of health cadres in the working area of Pemurus Baru Community Health Center of Banjarmasin Regency. Education method in this program is counseling on the manufacture of antiseptics from the herbal plant. Education and evaluation of the program are carried out online. The results of this program have a positive impact, the targets of program understand and are able to make antiseptic liquid based on herbs, and motivated to inform to others or communities. BAHASA INDONESIA ABSTRACT: Kalimantan Selatan berada diurutan ke-enam sebagai provinsi dengan persentase tertinggi kasus positif Covid-19 di Indonesia. Pada 24 Juli 2020 didapatkan sebanyak 4.990 (5,7%) kasus terkonfirmasi positif Covid-19 di Kalimantan Selatan dan kasus teringgi terjadi di Kota Banjarmasin. Kelurahan Pemurus Baru Kota Banjarmasin termasuk salah satu kelurahan yang termasuk wilayah zona merah kasus positif Covid-19. Salah satu protokol kesehatan untuk memcegah paparan covid-19 adalah mencuci tangan dengan antiseptik. Sediaan antiseptik tangan dapat dibuat dari bahan tanaman herbal yang berkhasiat antimikroba. Berkembangnya teknologi online dapat menjadi suatu sarana edukasi dan penyampaian informasi yang bermafaat bagi masyarakat. Tujuan kegiatan ini adalah untuk mendukung upaya pencegahan COVID-19 melalui pemanfaatan tanaman herbal menjadi sediaan antiseptik, guna terhindar dari paparan Covid-19. Sasaran kegiatan adalah ibu-ibu kader kesehatan di wilayah kerja Puskesmas Pemurus Baru Banjarmasin. Metode pelaksanaan edukasi berupa penyuluhan tentang pembuatan antiseptik dari sediaan tanaman herbal. Edukasi dan evaluasi kegiatan dilakukan secara online. Hasil dari kegiatan ini dapat berdampak positif, sasaran kegiatan memahami dan mampu membuat sediaan antiseptik berbahan dasar tanaman herbal, serta termotivasi untuk menginformasikannya pada orang lain/masyarakat lainnya.

Meta-Analysis: Relationship of History of Acute Respiratory Infections and Low Birth Weight with Stunting in Toddlers Kharis Faridan; Meitria Syahadatina Noor; Alfi Yasmina; Syamsul Arifin; Harapan Parlindungan Ringoringo
Jurnal Berkala Kesehatan Vol 7, No 2 (2021): JURNAL BERKALA KESEHATAN
Publisher : Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v7i2.10948

Basic Health Research (2018) and National Socio-Economic Survey (2019) showed a high incidence of stunting in Indonesia. History of acute respiratory infection (ARI) and low birth weight (LBW) were studied as factors associated with stunting in under-five children. The research’s objective was to analyze the association between the history of ARI and LBW with the incidence of stunting in under-five children. This study was a meta-analysis. Literature searching was conducted in reputed and accredited journals in PubMed and Google Scholar, published between 2016-2020, analytic observational study design, contained OR/PR/RR with 95% confidence interval, written in English or Indonesian, and available in full-text. The meta-analysis was conducted with RevMan 5.4 application. We included 14 studies. Results showed there was a significant association between history of ARI and the incidence of stunting in under-five children, with pooled OR = 2.48 (95%CI = 1.82-3.40, p < 0.00001, I2 = 0%, p for heterogeneity = 0.66). This study showed there was a significant association between LBW and incidence of stunting, with pooled OR = 2.15 (95% CI = 1.58-2.93, p < 0.00001, I2 = 61%, p for heterogeneity = 0.005). The conclusions were there were significant associations between the history of ARI and LBW with the incidence of stunting in under-five children.

PERBANDINGAN EFEKTIVITAS OBAT GOLONGAN STATIN (SIMVASTATIN, ATORVASTATIN, DAN ROSUVASTATIN) SEBAGAI ANTIINFLAMASI SECARA IN VIVO Ahmad Zaki Hafizi; Agung Biworo; Alfi Yasmina
Homeostasis Vol 2, No 2 (2019)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract:Statins indicated in patients with dyslipidemia are known to have aanti-inflammatory effect. The study was to compare the effectiveness of simvastatin, rosuvastatin, and atorvastatin as anti-inflammatory agent. This study using Rattus norvegicus from the Sprague-Dawley strain with induction of inflammation. 30 rats were classified into 5 groups. The efficacy of anti-inflammatory effect was assessed by measuring the volume of the hind paw oedema. The results showed that the average volume each group was as follows: aspirin -3.67 ml, placebo 21.60 ml, simvastatin 12.50 ml, atorvastatin 7.20ml, and rosuvastatin 3.40ml, which showed significantly different results between groups with the ANOVA and Tukey test (p <0.05), except between rosuvastatin and atorvastatin (p = 0.24). The largest antiinflammatory efficacywas indicated by aspirin, rosuvastatin, atorvastatin, simvastatin, and placebo, consecutively. It can be concluded that there are significant differences efficacy between statin except between rosuvastatin and atorvastatin. Keywords: anti-inflammatory, simvastatin, atorvastatin, rosuvastatin. Abstrak: Statin yang diindikasikan pada pasien dislipidemia diketahui memiliki efek antiinflamasi. Penelitian ini bertujuan untuk membandingan efektivitas obat golongan statin, yaitu simvastatin, rosuvastatin, dan atorvastatin sebagai antiinflamasi. Penelitian menggunakan hewan coba Rattus norvegicus galur Sprague-Dawley dengan induksi inflamasi pada plantar kaki hewan coba. 30 ekor tikus dikelompokkan menjadi 5, yaitu kelompok simvastatin, rosuvastatin, atorvastatin, aspirin, dan plasebo. Efektivitas antiinflamasi dinilai dengan mengukur volume kaki. Hasil penelitian menunjukkan rerata selisih volume kaki pada masing-masing kelompok sebagai berikut: aspirin -3,67 ml, plasebo 21,60 ml, simvastatin 12,50 ml, atorvastatin 7,20 ml, dan rosuvastatin 3,40 ml, yang menunjukkan hasil berbeda bermakna antar kelompok dengan uji ANOVAdan uji Tukey (p < 0,05), kecuali antara kelompok rosuvastatin dan atorvastatin (p = 0,24). Efektifitas antiinflamasinya dari yang paling besar ditunjukkan oleh aspirin, rosuvastatin, atorvastatin, simvastatin, dan plasebo. Dapat disimpulkan bahwa terdapat perbedaan efektivitas yang bermakna antara obat statin sebagai antiinflamasikecuali antara rosuvastatin dan atorvastatin. Kata-kata kunci:anti inflamasi, simvastatin, atorvastatin, rosuvastatin

Pengaruh Terapi Murottal Al-Qur’an terhadap Perbaikan Klinis Anak dengan Autism Spectrum Disorder Larasisca Della Faradilla; Nurul Hidayah; Alfi Yasmina
Homeostasis Vol 3, No 3 (2020)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (252.735 KB)

Abstract: Children with Autism Spectrum Disorder (ASD) require care to keep them participate in their environment. Indirectly, murottal therapy can facilitate children to be more cooperative in learning, which affects children's abilities. This study aimed to determine the effect of murottal Al-Qur'an therapy on the clinical improvement of children with ASD. This study used a quasi-experimental design, with one group pretest-posttest on 12 children at the Center for Disability and Inclusion Education in South Kalimantan. This study used a murottal of Surah Ar-Rahman and an Autism Treatment Evaluation Checklist (ATEC) in aspects of communication skills, social interaction abilities, and sensory-cognitive abilities. The interventions performed 3 times a week for 4 weeks. Data were analysed using paired T test. There were significant differences in communication skills (p=0.003), social interactions abilities (p=0.000), and sensory-cognitive abilities (p=0.000), so there is a significant effect of murottal Al-Qur'an therapy on clinical improvement of children with ASD. Keywords: Autism Spectrum Disorder, murottal Al-Qur’an, communication skills, social interaction abilities, sensory-cognitive abilities Abstrak: Anak dengan Autism Spectrum Disorder (ASD) memerlukan perawatan untuk menjaga mereka tetap berpartisipasi dalam lingkungannya. Ini dapat didukung dengan terapi murottal Al-Qur’an yang secara tidak langsung membuat anak lebih kooperatif dalam pembelajaran, sehingga berefek pada kemampuannya dalam berbagai aspek. Tujuan penelitian adalah untuk mengetahui pengaruh terapi mendengarkan murottal Al-Qur’an terhadap perbaikan klinis anak dengan ASD. Penelitian menggunakan desain quasi experimental, dengan one group pretest-posttest pada 12 anak ASD di Pusat Layanan Disabilitas dan Pendidikan Inklusi Kalimantan Selatan. Instrumen yang digunakan adalah rekaman murottal surah Ar-Rahman dan kuesioner Autism Treatment Evaluation Checklist (ATEC) dalam aspek kemampuan komunikasi, interaksi sosial, dan sensoris-kognitif. Intervensi mendengarkan murottal dilakukan sebanyak 3 kali seminggu selama 4 minggu. Analisis data menggunakan paired t test. Terdapat perbedaan bermakna pada kemampuan komunikasi (p=0,003), interaksi sosial (p=0,000), dan sensoris-kognitif (p=0,000). Dapat disimpulkan bahwa terdapat pengaruh signifikan terapi mendengarkan murottal Al-Qur’an terhadap perbaikan klinis anak dengan ASD dalam ketiga aspek. Kata-kata kunci: Autism Spectrum Disorder, murottal Al-Qur’an, komunikasi, interaksi sosial, sensoris-kognitif

Perbandingan Aktivitas Antibakteri Ekstrak Daun Tanjung dan Daun Jambu Biji terhadap Staphylococcus aureus In Vitro Irhamna Syari Yani Yani; Noor Muthmainah; Alfi Yasmina
Homeostasis Vol 3, No 2 (2020)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.353 KB)

Abstract: Tanjung plants and guava plants are known as plants by the community as herbal medicines. Tanjung leaves contain anti-bacterial substances such as flavonoids, tannins, terpenoids and saponins, while guava leaves are flavonoids and alkaloids. This study aims to determine comparison the antibacterial activity of tanjung and guava leaves S. aureus in vitro. This research uses an experimental method, grouped each cape leaf and guava leaf. One group based on concentrations of 5%, 15%, 25%, and 35% obtained inhibitory zones in cape leaf extract in a row of 8.9 mm, 12.32 mm, 15.49 mm and 17.31 mm, in jamb bji leaf extract were 7.08 mm, 11.09 mm, 11.34 mm and 16.58 mm respectively. Positive control in this study used clindamycin and negative control was aquades. Data analysis was performed with Shapiro-Wilk normality test, Levene’s Test variance homogeneity test obtained normal and non-homogeneous data then continued with the Kruskall-Wallis and Mann Whitney tests with a 95% confidence level. In this study, there was no significant difference between tanjung leaf extract and guava leaf extract. Conclusions, there were no significant differences in the activity of tanjung leaf extract and guava leaf extract to inhibit the growth of S. aureus in vitro. Keywords: Tanjung leaves, guava leaves, Staphylococcus aureus Abstrak: Tanaman tanjung dan tanaman jambu biji merupakan tanaman yang digunakan oleh masyarakat sebagai obat herbal. Daun tanjung mengandung zat anti bakteri seperti flavonoid, tanin, terpenoid dan saponin, sedangkan pada daun jambu biji terdapat flavonoid dan alkaloid. Penelitian ini bertujuan untuk mengetahui perbandingan aktivitas antibakteri daun tanjung dan daun jambu biji terhadap Staphylococcus aureus secara in vitro. Penilitian ini menggunakan metode eksperimental, dikelompokkan masing-masing, satu kelompok berdasarkan konsentrasi 5%, 15%, 25%, dan 35% didapatkan zona hambat pada ekstrak daun tanjung secara berturut-turut sebesar 8,9 mm, 12,32 mm, 15,49 mm dan 17,31 mm, ekstrak daun jambu biji berturut-turut 7,08 mm, 11,09 mm, 11,34 mm dan 16,58 mm. Kontrol psitif pada penelitian ini menggunakan klindamisin dan kontrol negatif adalah aquades. Melakukan analisis data dengan uji normalitas Shapiro-Wilk, uji homogenitas varians Levene’s Test didapatkan data normal dan tidak homogen maka dilanjutkan dengan uji Kruskall-Wallis dan Mann Whitney dengan tingkat kepercyaan 95%. Pada penelitian ini tidak ditemukan berbeda bermakna antara ekstrak daun tanjung dengan ekstrak daun jambu biji.”Kesimpulan padaa peneliitian ini tidak terdapaat perbedaan bermakna pada aktivitas ekstrak daun tanjung dan ekstrak daun jambu biji untuk menghambat pertumbuhan S. aureus secara in vitro. Kata – kata kunci : daun tanjung, daun jambu biji, Staphylococcuss aureus,

PERBANDINGAN EFEKTIVITAS INJEKSI INTRAARTIKULAR ASAM HIALURONAT BERAT MOLEKUL RENDAH BERDASARKAN DURASI PEMBERIAN PADA PASIEN OSTEOARTRITIS LUTUT Een Amalia Pratiwi; I Nyoman Suarjana; Alfi Yasmina
Homeostasis Vol 2, No 3 (2019)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (121.653 KB)

Abstract: Intraarticular hyaluronic acid is often used in clinical practice to relieve knee pain and inflammation, which are clinical manifestations of knee osteoarthritis (OA). This study aimed to determine the difference in effectiveness of weekly intraarticular injection of low molecular weight hyaluronic acid for three times and five times. This study used cohort study design. A total of 128 who met the inclusion criteria were included in this study and classified into two groups, namely, those who received injection for three weeks and five weeks. The effectiveness of the therapy was evaluated by the WOMAC scale questionnaire before and after receiving the injection. Analysis with the unpaired T test showed no significant difference between the two groups (p=0.66). It can be concluded that there was no significant difference in effectiveness of weekly intraarticular injection with low molecular weight hyaluronic acid between three and five time injection. Keywords: hyaluronic acid, duration of administration, knee osteoarthritis Abstrak: Asam hialuronat intraartikular sering digunakan dalam praktik klinis untuk meredakan nyeri dan peradangan lutut, yang merupakan manifestasi klinis dari osteoartritis (OA) lutut. Penelitian ini bertujuan untuk mengetahui perbedaan efektivitas injeksi intraartikular asam hialuronat berat molekul rendah setiap minggu selama tiga kali dan lima kali. Penelitian ini menggunakan rancangan studi kohort. Sebanyak 128 pasien yang memenuhi kriteria inklusi diikutkan dalam penelitian ini dan dibagi menjadi dua kelompok, yaitu yang mendapat injeksi selama tiga minggu dan lima minggu. Efektivitas terapi dievaluasi dengan kuesioner skala WOMAC pada saat sebelum dan sesudah mendapat injeksi. Analisis dengan uji T tidak berpasangan menunjukkan tidak ada perbedaan bermakna antara kedua kelompok (p=0,66). Dapat disimpulkan bahwa tidak terdapat perbedaan efektivitas yang bermakna antara injeksi intraartikular asam hialuronat berat molekul rendah setiap minggu selama tiga kali dan lima kali. Kata-kata kunci: asam hialuronat, durasi pemberian, osteoartritis lutut

Co-Authors Agung Biworo Ahmad Danial Rizkillah Az Zamzami Ahmad Zaki Hafizi Anwari Delmi Arifin Syamsul Dewi Indah Noviana Pratiwi Dini Rizki Aulia Dona Marisa, Dona Dwi Indria Anggraini Dwi Laksono Adiputro Een Amalia Pratiwi Eka Yudha Rahman Erna Kristin Gelvia Awaeh Harapan Parlindungan Ringoringo Hery Poerwosusanta I Nyoman Suarjana Ika Kustiyah Oktaviyanti Irhamna Syari Yani Yani Isnaini Isnaini Jarir At Thobari Kharis Faridan Khatimah, Husnul Larasisca Della Faradilla Lia Yulia Budiarti Meitria Syahadatina Noor Mita Rahma Yani Muthmainah, Noor Muthmainnah, Noor Nadita Arianti Sumarno Nurul Hidayah Oscar Tri Joko Putra Rahmiati Rahmiati Rahmiati Rahmiati Rinny Vebliani Rosinta Dewi Achmadiyah Sasongko Hadi Priyono Shania Indah Chineko Siti Kaidah

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