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Yanna Indrayana
Faculty Of Medicine, University Of Mataram
Agriculture, Biological Sciences & Forestry Humanities Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Obstructive Sleep Apnea Risk Level Affect Executive Function Rather than Attention Harahap, Herpan Syafii; Indrayana, Yanna
KEMAS: Jurnal Kesehatan Masyarakat Vol 14, No 2 (2018)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v14i2.14685

Abstract

Obstructive sleep apnea (OSA) is a kind of sleep disorders which is associated with cognitive impairment, either independently or by its strong association with metabolic syndrome. OSA affected attention and executive functions. Since the diagnosis of OSA had limitation, the assessment of OSA risk level by using STOP-BANG Questionnaire instrument in common population is important. This was a cross-sectional study aimed to investigate the effect of OSA risk level determined based on STOP-BANG Questionnaire score to attention and executive functions in 82 subjects. The demographic and clinical characteristics data obtained were age, gender, level of education, hypertension, body mass index (BMI), neck circumference, OSA risk level, and attention and executive functions.  Attention function was assessed by using Forward Digit Span and Trailmaking Test A (TMT-A) instruments, while executive function was assessed by using Backward Digit Span and Verbal Fluency Test instruments. The demographic and clinical characteristics data showed significant higher proportion of male gender, large neck circumference, and hypertension in high risk OSA group. The OSA risk level significantly impaired the executive function but did not impaired attention function.
Pola Pengobatan dan Fungsi Kognitif Pasien Epilepsi di RSJ Mutiara Sukma Harahap, Herpan Syafii; Indrayana, Yanna -; Amalia, Emmy -
Jurnal Kedokteran Brawijaya Vol 29, No. 4 (2017)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2017.029.04.9

Abstract

Epilepsi merupakan suatu gangguan pada sistem saraf pusat yang memiliki dampak neurobiologik, kognitif, psikologik, dan sosial. Penggunaan obat antiepilepsi diperlukan untuk mencegah komplikasi yang ditimbulkan oleh epilepsi. Salah satu komplikasi penting dari epilepsi adalah terjadinya gangguan fungsi kognitif. Penelitian ini bertujuan untuk mengetahui gambaran pola pengobatan dan fungsi kognitif pasien epilepsi di RSJ Mutiara Sukma Provinsi NTB. Sebanyak 97 subjek dilibatkan dalam penelitian potong lintang dengan pengambilan data meliputi usia, jenis kelamin, usia awitan bangkitan, tipe bangkitan, etiologi bangkitan, dan obat antiepilepsi yang digunakan. Fungsi kognitif dari 45 subjek penelitian diperiksa menggunakan instrumen MoCA-INA dan TMT-B. Perbandingan antara jenis OAE yang digunakan dan jumlah subjek dengan gangguan fungsi kognitif dianalisis dengan uji statistik Kai-kuadrat. Hasil penelitian menunjukkan 80,4% subjek mendapatkan monoterapi OAE. Monoterapi yang digunakan antara lain fenitoin (30,9%), karbamazepin (27,8%), dan asam valproat (21,7%). Pada pemeriksaan MoCA-INA, 100% subjek mengalami gangguan fungsi kognitif. Pada pemeriksaan TMT-B, 91,11% subjek memiliki hasil pemeriksaan tidak normal. Tidak terdapat perbedaan jumlah subjek dengan gangguan fungsi kognitif yang bermakna diantara berbagai kelompok yang mendapatkan OAE berbeda (p=0,304). Dapat disimpulkan bahwa sebagian besar pasien epilepsi di RS ini mendapatkan monoterapi OAE fenitoin, mengalami gangguan fungsi kognitif terutama pada domain atensi dan fungsi eksekutif dan tidak ditemukan perbedaan antar jenis pengobatan. 
Hubungan Tingkat Risiko Obstructive Sleep Apnea dan Sindroma Metabolik dengan Fungsi Kognitif Global Harahap, Herpan Syafii; Indrayana, Yanna; Lestari, Rina
Jurnal Kedokteran Brawijaya Vol 30, No 2 (2018)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (191.293 KB) | DOI: 10.21776/ub.jkb.2018.030.02.10

Abstract

Obstructive sleep apnea (OSA) berhubungan dengan peningkatan risiko gangguan fungsi kognitif, dan gangguan fungsi kognitif tersebut juga terkait dengan komponen sindrom metabolik (hipertensi, diabetes melitus, obesitas sentral, dan dislipidemia). Penegakan diagnosis penyakit tersebut membutuhkan keahlian khusus, waktu pemeriksaan yang lama, dan mahal, oleh karena itu penapisan tingkat risiko OSA dengan instrumen sederhana sangat diperlukan. Penelitian ini bertujuan untuk menginvestigasi tingkat risiko OSA dan sindroma metabolik dengan fungsi kognitif global. Desain potong lintang dilakukan dengan melibatkan 89 subjek yang datang dalam acara Car Free Day dan memenuhi kriteria inklusi. Data yang dikumpulkan meliputi usia, jenis kelamin, riwayat hipertensi, dislipidemia, diabetes melitus, indeks massa tubuh (IMT), obesitas sentral, tingkat risiko OSA, dan fungsi kognitif global. Tingkat risiko OSA dinilai dengan menggunakan instrumen STOP-BANG Questionnaire dan fungsi kognitif global menggunakan instrumen Clock Drawing Test (CDT). Hasil penelitian menunjukkan terdapat perbedaan bermakna dalam hal frekuensi subjek dengan tingkat risiko tinggi OSA (p=0,042) dan subjek dengan diabetes melitus (p=0,04) antara kelompok subjek dengan status fungsi kognitif global normal dan menurun. Hasil penelitian juga menunjukkan bahwa hanya satu komponen sindroma metabolik, yaitu hipertensi yang berhubungan dengan tingkat risiko OSA (p<0,001), sedangkan diabetes melitus, obesitas sentral dan dislipidemia tidak. Dapat disimpulkan bahwa tingkat risiko OSA berhubungan dengan status fungsi kognitif global dan komponen sindroma metabolik yang berperan adalah diabetes melitus dan hipertensi.
Serum Homocysteine Level and Ankle-Brachial Index in Peripheral Arterial Disease Indrayana, Yanna; Harahap, Herpan Syafii
KEMAS: Jurnal Kesehatan Masyarakat Vol 15, No 3 (2020)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v15i3.22261

Abstract

Patients with peripheral arterial disease have a higher risk of death compared to normal populations. There are several relatively new risk factors significantly increase the vulnerability to suffering from peripheral arterial disease, one of which is homocysteine. Studies investigating the role of serum homocysteine level as a biomarker of the severity of peripheral arterial disease based on an ankle-brachial index (ABI) in the different populations were still limited and it was never been studied in Mataram. This was a cross-sectional study aimed to investigate the correlation between serum homocysteine level and ABI in 77 peripheral artery disease (PAD) outpatients in Siti Hajar Hospital, Mataram. The diagnosis of PAD was based on ABI<0.9. Fasting serum homocysteine level was examined using the ELISA technique. Characteristic data collected were gender, age, hypertension, diabetes mellitus, and body mass index (BMI) category. There was a significant correlation between the increase of serum homocysteine levels and the decrease of ABI. The main risk factors for peripheral arterial disease in the subjects are hypertension, diabetes mellitus, and overweight/obesity. Serum homocysteine level is a predictor of peripheral arterial disease severity measured using ABI.
Peran Neuroprotektif Cognitive Reserve Dalam Menghambat Progresivitas Gangguan Kognitif Terkait Diabetes Melitus Tipe 2 Harahap, Herpan Syafii; Indrayana, Yanna
Jurnal Kedokteran Vol 9 No 4 (2020): Jurnal Kedokteran volume 9 no 4 2020
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v9i4.432

Abstract

Cognitive impairment is one of the important complications of type 2 diabetes mellitus. Type 2 diabetes mellitus-associated cognitive impairment has wide spectrum, ranging from mild cognitive impairment to dementia. The susceptibility of patients with type 2 diabetes mellitus to experiencing cognitive impairment is also determined by their previous cognitive reserve status. A good cognitive reserve of a patient with type 2 diabetes mellitus will protect him from cognitive impairment. The components of cognitive reserve, including education, occupation, hobbies, and social and physical activities provide a protective effect through neural reserve and neural compensation mechanisms that lead to a serial processes of neurogenesis, production of neurotropic factors, and neurotransmitter regulation. An understanding of the neuroprotective effects of the components of cognitive reserve is very important in determining optimal cognitive impairment management strategies in type 2 diabetes mellitus patients, in such a way that they are still able to carry out daily functional activities properly.
RELATIONSHIP BETWEEN LEVEL OF EDUCATION AND POST-STROKE COGNITIVE STATUS IN HOSPITAL-BASED ISCHEMIC STROKE SURVIVORS Harahap, Herpan Syafii; Indrayana, Yanna; Putri, Setyawati Asih
MNJ (Malang Neurology Journal) Vol. 7 No. 1 (2021): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.01.1

Abstract

Background: Post-ischemic stroke cognitive decline is significantly affecting the quality of life of its survivors. Its prevalence was about 7.5-72% which was mostly determined by the existing of vascular risk factors and cognitive reserve of the subjects. Level of education is one of determinants of cognitive reserve, a factor that affect the susceptibility of subjects to cognitive decline after experiencing ischemic stroke-related neuronal damage. Since level of education is protective for cognitive function, the intervention on it can reduce the occurrence of cognitive decline.Objective: To investigate the relationship between level of education and cognitive status among hospital-based ischemic stroke survivors.Methods: This cross-sectional study involved post-ischemic stroke outpatients in two hospitals. The data collected in this study were demographic data, including level of education, and clinical data as well. The level of education was categorized into ≥12 years and <12 years groups. Cognitive status was assessed using Montreal Cognitive Assessment in Indonesia version (MoCA-Ina) and subjects with score of 26-30 were normal. The relationship between level of education as well as clinical data and cognitive status were analyzed using chi-square test.Results: There were 166 subjects eligible for this study (n=166). The mean age of subjects was 58 years and 68.67% of them were male. Cognitive decline were found 80.12% of subjects (n=133). The level of education was significantly associated with cognitive status of the subjects and hypertension as well.Conclusion: The level of education had significant relationship with cognitive decline in the hospital-based population of ischemic stroke survivors.
HUBUNGAN ASUPAN ASAM FOLAT, VITAMIN B6, DAN VITAMIN B12 DENGAN NILAI ANKLE BRACHIAL INDEX PASIEN PENYAKIT ARTERI PERIFER PADA POPULASI DI KOTA MATARAM Qurniadi, Margian Tri; Indrayana, Yanna; Irawati, Deasy
Jurnal Kedokteran Vol 10 No 2 (2021): Jurnal Kedokteran Juni 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i2.464

Abstract

Background: Peripheral Artery Disease (PAD) is partial to total blockage of blood vessels especially in the leg arteries. Ankle Brachial Index (ABI) can be used as a method of screening and diagnosis of PAD. Excess homocysteine is a risk factor of PAD. Deficiency of folic acid, vitamin B6, and vitamin B12 can disrupt homocysteine metabolism and increase the of PAD indirectly. Method: This study is a cross sectional study conducted at Siti Hajar Islamic Hospital in Mataram. The sample was patients with peripheral artery disease with an ABI value <0,90. The number of research samples was 52. The sampling technique used consecutive sampling method. Data analysis used the Spearman correlation test. Result: The average daily intake of folic acid, vitamin B6, and vitamin B12 in the study sample wass less than 50% of the recommended daily nutritional adequacy rate for Indonesians. The average ABI in the sample was 0,79. The results of the Spearman correlation test between ABI and folic acid intake showed a significance = 0,20 and coefficient correlation = 0,322. The results of the Spearman correlation test between the ABI and vitamin B6 intake showed a significance = 0,167. The results of the Spearman correlation test between ABI and vitamin B12 intake showed a significance = 0,800. Conclusion: There is a significant relationship between ABI and folic acid intake. There is an insignificant relationship between ABI and vitamin B6 and vitamin B12. Keywords: Peripheral Artery Disease, Ankle Brachial Index, Folic Acid, Vitamin B6, and Vitamin B12
Prevalence of Executive Dysfunction in Type 2 Diabetes Mellitus Patients in Mataram Harahap, Herpan Syafii; Indrayana, Yanna; Hunaifi, Ilsa; Habib, Phillip; Asriningrum, Asriningrum
KEMAS: Jurnal Kesehatan Masyarakat Vol 17, No 2 (2021): KEMAS (Article in Press)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v17i2.26462

Abstract

Executive dysfunction is a consequence of type 2 diabetes mellitus decreasing the quality of life of the patients. Currently, its prevalence is still scarce. Early detection of this executive dysfunction is beneficial in improving the clinical outcomes of the patients. This study aims to investigate the prevalence of executive dysfunction among type 2 diabetes mellitus patients in Mataram. This case-control study involving 106 subjects divided into two groups, type 2 diabetes subjects (n=53) and healthy subjects (n=53) in outpatient setting. The data collected from both groups were age, gender, years of education, TMT-B score, and executive function status. The data collected only from type 2 diabetes mellitus group were age, gender, years of education, duration of diabetes, treatments, smoking, hypertension, coronary heart disease, body mass index, and dyslipidemia. There was significant difference in the frequency of executive dysfunction between type 2 diabetes mellitus and healthy subject groups (p<0.05). The prevalence of type 2 diabetes mellitus-associated executive dysfunction was 49.1%. Gender was the only characteristics associated with the prevalence of type 2 diabetes mellitus-associated executive dysfunction (OR=0.25; 95%CI=0.07-0.88, p<0.05). There was a high prevalence of type 2 diabetes mellitus-associated cognitive impairment and it was associated with female gender.
Diseminasi Media Edukasi Metode Pemeriksaan Payudara Sendiri (SADARI) sebagai Upaya Deteksi Dini Kelainan Payudara pada Siswi Sekolah Menengah Atas (SMA) di Kota Mataram Herpan Syafii Harahap; Novrita Padauleng; Nurhidayati Nurhidayati; Yanna Indrayana
Jurnal Gema Ngabdi Vol. 2 No. 2 (2020): Jurnal Gema Ngabdi
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jgn.v2i2.52

Abstract

Breast cancer is one of the main women's health problem in the world, including Indonesia. Efforts to control this disease can be increased through education to the women community about the breast examination method named SADARI. This is simple but effective method to be used as a primary breast cancer prevention strategy. This method aims to find breast abnormalities routinely checked every month in women aged 18 and above. Therefore, educational efforts regarding the SADARI method for female high school students are expected to increase their knowledge about this method. The educational effort was carried out by disseminating information about SADARI method using poster media on female high school students in Mataram City. Pre-test and post-test are used to to evaluate the increase of their knowledge about the SADARI method. About 40 participants from SMAN 2, SMAN 3, SMAN 4, and SMAN 7 Mataram have participated in this dissemination activities of SADARI education method. There was an increase in student knowledge in the four high schools based on differences in the total mean pre-test and post-test scores (56 vs 82, p=0,000) as well as the average differences in each of the high schools, namely 58 vs 88 (SMAN 2); 50 vs 82 (SMAN 3); 52 vs 78 (SMAN 4); 64 vs 80 (SMAN 7). As many as 80% of students (32) experienced an increase in knowledge, and 20% did not show an increase in knowledge. This shows that this dedication activity can significantly increase students' knowledge about SADARI methods.
Bakti Sosial Jantung Sehat: Pengembangan Upaya Preventif Kardiovaskuler dan Peningkatan Kualitas Hidup Lansia Yanna Indrayana; Herpan Syafii Harahap; Dion Setiawan; Amanda Halimi
Jurnal Gema Ngabdi Vol. 2 No. 1 (2020): Jurnal Gema Ngabdi
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jgn.v2i1.55

Abstract

Cardiovascular disease is the major causes of death in the world. Hypertension and diabetes mellitus are the important risk factors for cardiovascular disease. The prevalence of hypertension and diabetes mellitus is higher in the elderly population. Promotive and preventive efforts for the occurrence of hypertension and diabetes mellitus are the important strategies for preventing cardiovascular disease in elderly population. This was a social activity program developingthe preventive strategy against cardiovascular disease and improving of the quality of life of the elderly. This activity program was attended by 66 elderly participants routinely participated in the Panti Sosial Tresna Werdha Puspa Karma, Mataram. This program were consisted of counseling and healthy heart gymnasticsregularly every week for 3 months. The parameters taken in this event are height, body mass index (BMI), abdominal circumference, systolic and diastolic blood pressure, and serum fasting blood glucose (GDP) levels at the beginning and end of the programin order to assess the success of this program in reducingthe risk of suffered from cardiovascular disease. There were significant differences in the mean of body weight, BMI, abdominal circumference, systolic and diastolic blood pressure, and serum GDP levels between the the beginning and end of the programs (p<0.05). This social activity program reduced effectively the risk of cardiovascular disease in the elderly.
Co-Authors Amalia, Emmy - Amanda Halimi Anjely Doni Lasmi Asriningrum Asriningrum Asriningrum, Asriningrum Astrid Claudya Baiq Hilya Kholida Baiq Kania Kartika Yaksa Christabella Natalia Wijaya Deasy Irawati Dewi Suryani Diayanti Tenti Lestari Dion Setiawan Emmy Amalia Emmy Amalia Enny Ratna Indriyani Fatarosdiana Fatarosdiana Fitriannisa Faradina Zubaidi Fransisca Ika Mahardika Habib, Phillip Hasan Amin Hendra Susana Putra Hendra Susana Putra Herpan Syafii Harahap Herpan Syafii Harahap Herpan Syafii Harahap Herpan Syafii Harahap Herpan Syafii Harahap Herpan Syai Harahap Ika Nur Fitria Ilsa Hunaifi Ilsa Hunaifi Ilsa Hunaifi Ilsa Hunaifi Indah Retnowati Indah Retnowati Lillah Faizah Mega Adwiatin Muhammad Ghalvan Sahidu Muhammad Ghalvan Sahidu Muhammad Ghalvan Sahidu Muhammad Ghalvan Sahidu Muhammad Ghalvan Sahidu Muhammad Ibnu Annafi Ni Komang Miraditi Ni Made Amelia Ratnata Dewi Novrita Padauleng Nurhidayati Nurhidayati Nurhidayati Nurhidayati Ocktaviana Saputri, Legis Putri Nurhayati Putri, Setyawati Asih Qisthinadia Hazhiyah Setiadi Qurniadi, Margian Tri Rina Lestari Rina Lestari Rosmalasari Rosmalasari Safat Wahyudi Setyawati Asih Putri Silmi Chairan Andi Silmina Alifiya Stephanie Elizabeth Gunawan Susilawati Ni Nyoman Ayu Yudika Ilhami Rusdi