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Journal : Sainteknol : Jurnal Sains dan Teknologi

Effervescent Powder Formulation of Ethanol Extract of African Leaves (Vernonia amygdalina) as an α-amylaseInhibitor Norainny Yunitasari; Nasyanka, Anindi Lupita; Luthfi, Sania Al; Ramadhanti, Nadya; Zulfiyana, Lindah Isna
Sainteknol : Jurnal Sains dan Teknologi Vol. 22 No. 1 (2024): June 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/sainteknol.v22i1.2478

Abstract

Vernonia amygdalina or African leaves are reported to have many biological activities, including antidiabetic. However, there are still many people who have not used this plant as an antidiabetic treatment. This research aims to create a medicinal preparation formula in effervescent form with the main ingredient being African leaves. Testing of the dosage formula includes organoleptic tests, water content, pH, and dispersing time. The research results showed that one of the three formulas had better stability after 7 days of storage. After 7 days of storage, the color of the formula became lighter, the pH value changed slightly (7-8), the water content was 2.3% and the dispersion time was 2.00 minutes. This formula can be used as input for further research regarding testing its activity as an antidiabetic through inhibiting alpha-amylase in vitro.
Optimization Formula of Collagen Nanoemulgel from WasteMilkfish (Chanos chanos) Bones as Antiaging Nasyanka, Anindi Lupita; Tiadeka, pemta; Nur Imtihani, Hilya; Octaviary, Niken Laras; Prastiyo, Danu
Sainteknol : Jurnal Sains dan Teknologi Vol. 22 No. 2 (2024): December 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/sainteknol.v22i2.14768

Abstract

Climate change has negative impacts throughout the countries in the world, especially Indonesia, which has a tropical climate. Successful aging can be achieved by building individual self-confidence through prevention and skin aging. Indonesia is a producer of milkfish waste, reaching 5.4 tons/year, which is in line with the increasing center of "Otak-otak" milkfish souvenirs found in Gresik. The waste, especially fishbones, can be synthesized into collagen. The characteristic fishbone collagen waste are in the form of large porous sheets, while particle size is an essential factor in the absorption effectiveness of cosmetics. Therefore, Nanoemulgel is able to overcome this problem. This research aims to produce best collagen nanoemulgel from milkfish bone by physical evaluation with varying ratios of surfactant: cosurfactant in collagen nanoemulgel. The research method was done experimentally by comparing the components Tween 80: PEG 400 F1 (30:30), F2 (40:20), and F3 (35:15) through qualitative and quantitative physical characteristics using one-way anova. Evaluations whose results differ significantly are pH on the 7th day, spreadability, and viscosity. Research results show F2 is the best formula and meets physical stability specifications : particle size 3.89 nm, PDI 0.1906, zeta potential -0.2 mV, pH 4.7±0.04, viscosity 890.1± 4.26 cps, spreading 5.93±0.23 cm.