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All Journal Jurnal Veteriner El-Hayah : Jurnal Biologi WACANA DIDAKTIKA Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Jurnal Informatika Universitas Pamulang Bioedusiana: Jurnal Pendidikan Biologi Asian Journal of Agriculture Edumedia: Jurnal Keguruan dan Ilmu Pendidikan Indo-MathEdu Intellectuals Journal Natural Science Education Research (NSER) Biology and Education Journal (BaEJ) Indonesian Journal of Biology Education Multi Discere Journal DIDAKTIKA PAIDAGOGIA
Akhmad Fathir
Bagian Klinik Hewan, Fakultas Kedokteran Hewan, Universitas Udayana, Bali
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Journal : Jurnal Veteriner

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Aktivitas Ekstrak Daun Kelor Terhadap Sel-T Helper dan Sel-T Sitotoksik pada Mencit yang Diinfeksi Salmonella thypi (ACTIVITY OF AQUEOUS LEAF EXTRACT OF HORSERADISH TREE ON HELPER T- CELL AND CYTOTOXIC T- CELL IN MICE INFECTED WITH SALMONELLA THYPI) Akhmad Fathir; Muhaimin Rifa’i; Widodo .
Jurnal Veteriner Vol 15 No 1 (2014)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Typhoid fever is caused by Salmonella typhi infection, and it is a still problem in many developingcountries, including Indonesia. Typhoid fever occurs due to T cells, immune system, especially CD4+ andCD8+ T cells, are deficient. This condition can cause S. thypi infects human body cells . The study aim wasto evaluate profile CD4+ and CD8+ T cells in mice spleen (Mus musculus) infected with  S. thypi afterinducted with aqueous leaf extract of horseradish tree. An experimental laboratory studiy was conductedusing completely factorial randomized design. Mice were divided into two groups, ie non infection group(induced with aqueous leaf extract of horseradish tree, at dose 0 mg/kg BW, 14 mg/kg BW, 42 mg/kg BWand 84 mg/kg BW) and infection group, the Micewere infected with S. thypi (induced with aqueous leafextract of horseradish tree, at dose 0 mg/kg BW, 14 mg/kg BW, 42 mg/kg BW and 84 mg/kg BW). The resultshowed that aqueous leaf extract of horseradish tree increased the number CD4+  of and CD8+ T cells  in allgroups of mice in conclusion administration of aqueous leaf extract of horseradish tree at high dose havecauses immunosuppressive in immune system. Aqueous leaf extract of horseradish tree have aimmunostimulatory and immunosuppressive functions in CD4+ and CD8+ T cells.
Co-Authors Alfianto Firdaus Wahyudi Andriansyah Andriansyah Apriyono Rahadiantoro Haikal, Moch. Hendrowati, Retno Linda Tri Antika, Linda Tri Lukluk Ibana Moch Haikal MOHAMMAD HEFNI Muh. Darwis Muhaimin Rifa’i Naja, Faizatun Nurul Maulidatika Qurratul Aini Putri, Alisa Rofiqi, Rofiqi Syarivah, Ulvatus Syarofah, Iin Taufikurrahman Taufikurrahman Ulfa, Winda Maria Usilah, Siti Lala Yallah, Hasbi Yundari, Yundari