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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Indonesian Journal of Cancer Chemoprevention Pharmacon JPSCR : Journal of Pharmaceutical Science and Clinical Research Indonesian Journal of Community Services Community Empowerment Jurnal Litbang Edusaintech Jurnal Pengabdian Sumber Daya Manusia Jurnal Farmasi Sains dan Praktis Jurnal Bakti Untuk Negeri Jurnal Ilmiah Sultan Agung International Journal of Cell and Biomedical Science
Nur Anna Chalimah Sadyah
Universitas Islam Sultan Agung, Semarang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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AKURASI UJI KADAR HORMON TIROID STIMULATING HORMON DALAM MENDETEKSI PENYAKIT GRAVES Dewi, Merliany; Sadyah, Nur Anna Chalimah; Sembodo, Tjatur
Jurnal Ilmiah Penelitian Mahasiswa Vol 2, No 3 (2023): Desember 2023
Publisher : Jurnal Ilmiah Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penyakit Graves merupakan penyakit autoimun yang ditandai dengan hipertiroidisme disebabkan adanya antibodi Thyroid-stimulating immunoglobulin (TSI) yang bersirkulasi dalam darah, mengikat, dan mengaktifkan reseptor tirotropin, sehingga kelenjar tiroid tumbuh dan folikel tiroid meningkatkan sintesis hormon tiroid (Ehlers et al., 2019).Penyebab hipertiroid paling banyak adalah penyakit Graves dapat dibuat berdasarkan manifestasi klinis berupa trias Merseburger yang terdiri dari hipertiroid, goiter difus, dan oftalmopati yang juga ditandai dengan adanya pembesaran kelenjar tiroid yang difus.Salah satu tes laboratorium dari uji kadar tiroid adalah TSH (Vitti & Hegedüs, 2018). Untuk membuktikan uji kadar hormon TSH dapat digunakan sebagai uji diagnostik hipertiroid maka perlu dilihat dari sensitivitas dan spesifisitasnya (Dwi Nurcahyani et al., 2017).Penelitian menunjukkan nilai sensitivitas dan spesifitas uji kadar hormon TSH lebih besar dibandingkan sensitivitas dan spesifitas USG, yang menandakan sensitivitas dan spesifisitas uji kadar TSH cukup akurat dalam menegakkan diagnosis hipertiroid pada grave disease. Uji akurasi menggunakan AUC (Area Under the Curve) didapatkan 0.997 dengan akurasi sangat baik.Kata Kunci : Hyperthyroid, Receiver Operating Characteristic, Area Under Curve, Thyroid Stimulating Hormon (TSH), diagnostic test
The Effect of Low Dosage MSC-Conditioned Medium on Urea Levels in Acute Renal Failure Istania, Rizqi Windhu Sri; Kustyah, Azizah Retno; Sa'dyah, Nur Anna Chalimah
International Journal of Cell and Biomedical Science Vol 1 No 2 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i2.17

Abstract

Background: Acute renal failure (ARF) is still associated with a high incidence of morbidity and mortality, as well as a high risk of developing chronic renal failure. ARF is a major public health problem, it is associated with high mortality, morbidity, and long-term risk of chronic kidney disease. One of the assessments of kidney function is the increase in serum urea in the body. The kidneys have an extraordinary ability to regenerate after injury and fully recover, and clinical options are limited to fluid management and dialysis procedures. The development of new strategies in order to increase the ability of kidney regeneration due to ARF, and to maintain kidney function both in the short term and in the long term is needed. This study aims to determine the effect of low-dose MSC-CM on urea levels in ARF. Method: This research is an in vivo research with the type of research Post Test Only Control Group Design. This study used a model of acute renal failure by inducing gentamicin and used 2 research groups, namely the control group (PBS), and the treatment group (MSC-CM 0.2. urea was examined using a spectrophotometer and then analyzed by unpaired t-test. Result: The results of this study showed that the mean urea levels between the control group (19.46 ± 0.56 mg / dL) and the treatment group (13.96 ± 0.73 mg / dL) were significantly different (p <0.05). Conclusion: The conclusion of this study indicated that there was an effect of low-dose of MSC-CM on urea levels in acute renal failure.
Enhancing knowledge and worship quality in Muslim patients with diabetic foot ulcer through DiabetEasy Sadyah, Nur Anna Chalimah; Mulyono, Sri; Satyagraha, Muhammad Thifan
Community Empowerment Vol 10 No 3 (2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.12642

Abstract

Diabetic foot ulcers are a complication of diabetes mellitus that can reduce the quality of life, particularly in terms of religious practices for Muslim patients in Indonesia. This program aims to improve knowledge and worship quality in Muslim patients with diabetic foot ulcers through the DiabetEasy program. This program consists of digital health education based on an application and practical worship training for relevant participants at Sultan Agung Islamic Hospital, Semarang, Indonesia. This activity showed increased understanding and worship quality after the intervention, from 60% to 90%. This indicates that this program can improve understanding and worship quality for Muslim patients with diabetic foot ulcers. This program can be an alternative option as a simple non-pharmacological therapy in promotive, preventive, and rehabilitative efforts for the management of diabetic foot ulcers.
Correlation between haemoglobin, leukocytes, HbA1c, and albumin levels with diabetic foot ulcer severity: a cross-sectional study Sadyah, Nur Anna Chalimah; Nugroho, Heri; Putra, Agung; Riwanto, Ignatius
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2025): June 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i1.41423

Abstract

Diabetic foot ulcers (DFUs) represent a serious complication of diabetes mellitus, associated with significant morbidity and healthcare costs. The progression of DFUs is influenced by systemic and local factors, including haemoglobin levels, leukocyte count, glycated haemoglobin (HbA1c), and serum albumin. This study aims to explore the relationship between these clinical parameters and the severity of DFUs. We enrolled 62 patients with DFUs and classified ulcer severity as mild, moderate, or severe according to the Wagner classification system. Using Spearman’s rank correlation, we found significant associations: lower hemoglobin and albumin levels correlated with more severe ulcers (ρ = -0.34, p= 0.0065; ρ = -0.41, p = 0.00084, respectively), while higher HbA1c and leukocyte counts were associated with increased ulcer severity (ρ = 0.62, p = 0.000; ρ = 0.40, p = 0.0013, respectively). These findings suggest that hematologic and biochemical markers may serve as valuable indicators of DFU progression, potentially guiding clinical decision-making and improving patient outcomes. Further research is needed to elucidate the underlying mechanisms and evaluate targeted interventions for this high-risk population.
The Role of Hypoxic Mesenchymal Stem Cells Conditioned Medium in Increasing Vascular Endothelial Growth Factors (VEGF) Levels and Collagen Synthesis to Accelerate Wound Healing Sunarto, Hadi; Trisnadi, Setyo; Putra, Agung; Sa'dyah, Nur Anna Chalimah; Tjipta, Arya; Chodidjah, Chodidjah
Indonesian Journal of Cancer Chemoprevention Vol 11, No 3 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss3pp134-143

Abstract

Full-thickness wound are areas damage of skin associated with loss of epidermis and dermis. The wound healing mechanism consists proliferation, migration and remodeling. Hypoxic conditional medium of mesenchymal stem cells (HMSCs-CM) contains lots of soluble molecules, such as protein growth factor and cytokine anti-inflammation. The soluble molecule of HMSCs-CM plays a critical role in wound healing by upregulation of VEGF and collagen synthesis. The objective of this study was to evaluate the effect of HMSCs-CM on VEGF and collagen concentrations in rats with incised wounds. The methods of this study were an experimental animal study with post-test only control group design was performed involving 24 Wistar rats. The rats were randomized into four groups consisting of sham, control and two treatment groups (gel of HMSCs-CM at doses of 200 μL and 400 μL). The VEGF levels and collagen density were analyses using ELISA assay and Masson-trichome specific staining, respectively. One-way ANOVA and Post Hoc LSD were used to analyses the data. The results of this study showed that a VEGF levels was significant increased on day 6 with doses-dependent manner. Interestingly, the VEGF levels gradual decrease on day 9. In addition, the decreased of VEGF levels on day 9 in this study in line with our findings in which we found there was a trend in the decreased of collagen density, it indicated the completion of remodeling phase and there has been an acceleration in wound healing. This study demonstrated that HMSCs-CM were able to regulate VEGF levels and collagen synthesis in accelerate wound healing. The role of HMSCs-CM stimulate cutaneous wound healing should be clarified further.Keywords: hypoxic conditional medium of mesenchymal stem cells (HMSCs-CM), vascular endothelial growth factor, collagen synthesis, paracrine factors
Co-Authors Agung Putra Annisa Nurul Hikmah Ayu Pambajeng Puspitaningrum Chodidjah Chodidjah Dewi, Merliany Harka Prasetya Heri Nugroho Hudan Taufiq Ignatius Riwanto, Ignatius Istania, Rizqi Windhu Sri Kustyah, Azizah Retno Minidian Fasitasari Minidian Fasitasari Sabiti, Farroh Bintang Sandra Thertianing Susilo Satyagraha, Muhammad Thifan Sembodo, Tjatur Setyo Trisnadi Sri Mulyono Sri Mulyono Sunarto, Hadi Suparmi Tjipta, Arya