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All Journal Althea Medical Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Dolvy Girawan
Division Of Gastroentero-Hepatology, Department Of Internal Medicine, Faculty Of Medicine, Universitas Padjajaran/Dr. Hasan Sadikin General Hospital, Bandung
Medicine & Pharmacology

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Journal : Althea Medical Journal

 1 
Antibacterial Effect of Pulsatilla chinensis towards Staphylococcus aureus, Shigella dysenteriae, and Salmonella typhi Fong, Sim Chee; Mulyana, Yanti; Girawan, Dolvy
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.154 KB)

Abstract

Background: Pulsatilla (P.) chinensis is a kind of traditional Chinese medicine (TCM) that has antibacterial effect. It is used to treat diarrhea, dysentery, and other diseases. The P. chinensis is composed of some potent antibacterial substances including protoanemonin, saponin, oleanolic acid. The study aimed to determine the antibacterial effect of P. chinensis towards staphlococcus aureus, Shigella dysenteriae, and Salmonella typhi.Methods: This was an experimental descriptive study that was conducted in 2014 using two methods, diffusion and dilution method. In diffusion method, 5 holes were made on the agar that bacteria were growing and different concentrations of P. chinensis infusion were placed in different hole. The inhibitory effect was measured by the inhibition zone. In dilution method, 8 test tubes with decreasing concentration of P. chinensis infusion were mixed with the bacteria suspension and Mueller Hinton Solution. The minimal inhibitory concentration (MIC) was measured by the last clear test tube. The test tube with solution that showed absence of bacteria on culture indicated the minimal bactericidal concentration (MBC).Results: In diffusion method, P. chinensis infusion showed inhibitory effect towards S. aureus and bacteriostatic effect towards S. dysenteriae and S. typhi. In dilution method, there was no antibacterial activity detected.Conclusions: P. chinensis infusion has inhibitory effect on S. aureus and bacteriostatic effect on S. dysenteriae and S. typhi. [AMJ.2016;3(2):292–5]DOI: 10.15850/amj.v3n2.467
Effect of Mangosteen Pericarp Extract on Gastric Mucosal Damage Induced by Aspirin Budiono, Jansen; Achadiyani, Achadiyani; Girawan, Dolvy
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.697 KB)

Abstract

Background: Peptic ulcer disease is commonly found in the community. Nonsteroidal anti-inflammatory drug (NSAID) such as aspirin is one of the predisposing factors to ulcers. According to various studies, plant extracts have been shown to produce promising results in the treatment of peptic ulcers. Xanthone, the active substance contained in the mangosteen pericarp extract has been extensively studied for its role in various diseases. The present study was undertaken to identify the effect of mangosteen pericarp extract on gastric mucosal damage.Methods: This study was carried out from September−November 2014 in the Animal Laboratory of the Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung. Thirty two rats were randomly divided into 2 groups with different treatments and were induced by aspirin. Histologic studies were conducted to determine the score of gastric mucosal damage. The parameters used were Wattimena’s criteria for damage of gastric mucosa. Data was analyzed using Chi Square test and the outcome was measured in relative risk.Results: The study revealed a significant association between pretreatment with mangosteen pericarp extract and incidence of gastric mucosal damage induced by aspirin (p < 0.05). Calculation with a modified 2 × 2 table revealed a relative risk of 0.625.Conclusions: Rats pretreated with mangosteen pericarp extract exhibit less gastric mucosal damage, in experimentally aspirin-induced ulcer. [AMJ.2016;3(3):388–91] DOI: 10.15850/amj.v3n3.885
Antibacterial Effect of Pulsatilla chinensis towards Staphylococcus aureus, Shigella dysenteriae, and Salmonella typhi Sim Chee Fong; Yanti Mulyana; Dolvy Girawan
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (33.93 KB)

Abstract

Background: Pulsatilla (P.) chinensis is a kind of traditional Chinese medicine (TCM) that has antibacterial effect. It is used to treat diarrhea, dysentery, and other diseases. The P. chinensis is composed of some potent antibacterial substances including protoanemonin, saponin, oleanolic acid. The study aimed to determine the antibacterial effect of P. chinensis towards staphlococcus aureus, Shigella dysenteriae, and Salmonella typhi.Methods: This was an experimental descriptive study that was conducted in 2014 using two methods, diffusion and dilution method. In diffusion method, 5 holes were made on the agar that bacteria were growing and different concentrations of P. chinensis infusion were placed in different hole. The inhibitory effect was measured by the inhibition zone. In dilution method, 8 test tubes with decreasing concentration of P. chinensis infusion were mixed with the bacteria suspension and Mueller Hinton Solution. The minimal inhibitory concentration (MIC) was measured by the last clear test tube. The test tube with solution that showed absence of bacteria on culture indicated the minimal bactericidal concentration (MBC).Results: In diffusion method, P. chinensis infusion showed inhibitory effect towards S. aureus and bacteriostatic effect towards S. dysenteriae and S. typhi. In dilution method, there was no antibacterial activity detected.Conclusions: P. chinensis infusion has inhibitory effect on S. aureus and bacteriostatic effect on S. dysenteriae and S. typhi. [AMJ.2016;3(2):292–5]DOI: 10.15850/amj.v3n2.467
Propolis of Trigona spp. Protects Mucosa from Aspirin-Induced Gastric Mucosal Damage in Rats Achadiyani Achadiyani; Anindita Laksmi; Dolvy Girawan
Althea Medical Journal Vol 7, No 1 (2020)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v7n1.1677

Abstract

Background: Helicobacter pylori and non-steroid anti-inflammatory drugs are the major causes of peptic ulcer in the world. Indonesian native stingless bee species, Trigona spp., produces propolis that might be effective to protect mucosal damage. The aim of the study was to determine the protective effect of Trigona spp. propolis on aspirin-induced gastric mucosal damage in rats.Methods: This experimental study was conducted from September–November 2013 at Animal Laboratory of Department of Pharmacology and Therapy Faculty of Medicine Universitas Padjadjaran. Healthy male Wistar rats (n=24) aged 2–3 months old and weighed 200–250 grams were randomly divided into three groups. The first group was control negative, the second group was given 100 mg/kg body weight of aspirin, and the third group was given 200 mg/kg body weight of Trigona spp. propolis, one hour before administration of 100 mg/kg body weight of aspirin. After two weeks of treatment, rats were sacrificed by laparotomy to obtain gastric tissues, followed by processing for the paraffin section for histopathological analysis. The grade of gastric mucosal damage was determined under a light microscope. Data were then compared between groups using the Mann-Whitney test.Results: Oral administration of aspirin-induced gastric mucosal damage ranging from grade 0 to grade IV; whereas administration of propolis showed a reduction of gastric mucosal damage’s grade when compared to the aspirin group (p<0.05).Conclusions: Trigona spp. propolis has a protective effect on aspirin-induced gastric mucosal damage. Further study is encouraged to study an optimal dose of aspirin after propolis administration. 
Effect of Mangosteen Pericarp Extract on Gastric Mucosal Damage Induced by Aspirin Jansen Budiono; Achadiyani Achadiyani; Dolvy Girawan
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.697 KB)

Abstract

Background: Peptic ulcer disease is commonly found in the community. Nonsteroidal anti-inflammatory drug (NSAID) such as aspirin is one of the predisposing factors to ulcers. According to various studies, plant extracts have been shown to produce promising results in the treatment of peptic ulcers. Xanthone, the active substance contained in the mangosteen pericarp extract has been extensively studied for its role in various diseases. The present study was undertaken to identify the effect of mangosteen pericarp extract on gastric mucosal damage.Methods: This study was carried out from September−November 2014 in the Animal Laboratory of the Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung. Thirty two rats were randomly divided into 2 groups with different treatments and were induced by aspirin. Histologic studies were conducted to determine the score of gastric mucosal damage. The parameters used were Wattimena’s criteria for damage of gastric mucosa. Data was analyzed using Chi Square test and the outcome was measured in relative risk.Results: The study revealed a significant association between pretreatment with mangosteen pericarp extract and incidence of gastric mucosal damage induced by aspirin (p < 0.05). Calculation with a modified 2 × 2 table revealed a relative risk of 0.625.Conclusions: Rats pretreated with mangosteen pericarp extract exhibit less gastric mucosal damage, in experimentally aspirin-induced ulcer. [AMJ.2016;3(3):388–91] DOI: 10.15850/amj.v3n3.885
Co-Authors Achadiyani Agustanty, Nenny Ali Djumhana Ali Djumhana Angkasa Ramatuan Hamdan Anindita Laksmi Anna Tjandrawati Begawan Bestari Bestari, Muhamad Begawan Dewi, Sumartini Eka Surya Nugraha Emmy Hermiyanti Pranggono Fong, Sim Chee Guntur Darmawan Guntur Darmawan Guntur Darmawan Hadi Jusuf Hadi Jusuf Haryono - Haryono Haryono Hasan, Nadeem S. Hermin Aminah Usman Husain, Okky Iman Supandiman Iman Supandiman Irvan Nugraha Jansen Budiono Jansen Budiono Jessica Cynthia Febryani Juke Roslia Saketi Juke Roslia Saketi M Begawan Bestari Muhammad Begawan Bestari Nenny Agustanti Nugraha, Irvan Nur Atik Pranggono, Emmy Hermiyanti Rasdianto, Devi Novianto Rudi Wisaksana Rudi Wisaksana S A Abdurachman Sim Chee Fong Siti Aminah Abdurachman Siti Aminah Abdurachman Siti Aminah Abdurachman Siti Aminah Abdurachman Stefanie Hadi Supriami Stefanie Yuliana Usman Sumartini Dewi Tan Siauw Koan Usman, Stefanie Yuliana Warko Karnadihardja Yanti Mulyana Yanti Mulyana Yelica Rachmat Yudi Wahyudi Yudi Wahyudi Yudi Wahyudi Yudi Wahyudi Yudi Wahyudi